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Offshore high-grade limemud resources of west coast of India:Economic potential and industrial applications

第24届中国控制与决策会议

作者： Arindam Bhanja Chowdhury anil kulhare Gaurav Raina the Department of Electrical Engineering Indian Institute of Technology Madras the faculty of the Department of Electrical Engineering Indian Institute of Technology Madras

In today’s world, the study and applications of Vertical Take-Off and Landing （VTOL） capable Unmanned Aerial Vehicles （UAVs） have increased vastly. A wide variety of UAVs are currently being employed in both civilian and military sectors. In this paper, our focus will be on the Tilt-rotor UAV. The Tilt-rotor has a rotor on each side of its airframe, tilted to provide both lift and forward thrust to the rotor-craft. We develop a model that aims to enable the Tilt-rotor UAV to hover in one specific position. Because of the under-actuated property of the Tilt-rotor, we design a back-stepping based proportional- derivative （PD） controller. The controller was able to achieve the desired objective of stabilization.

关键词： tilt-rotor Lagrangian back-stepping PD controller.

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Deep Underground Science and Engineering 2024年第2期3卷 163-170页

作者： anil Kumar Adukadukkam Rachna Pillai Mamatha Puthiyathara Kanakamma Marine&Coastal Survey Division Geological Survey of IndiaSalt LakeKolkataWest BengalIndia

Limestone is one of the essential raw materials in the cement,paint,steel,ceramic,glass,chemical,pharmaceutical,paper,and fertilizer *** India,only 8%of the limestone resources are placed under the reserve category,of which 97%is of cement ***,India depends on imports to bridge the demand‐supply gap of steel,blast furnace,and chemical‐grade *** of Geological Survey of India(GSI)to locate alternate sources for limestone led to the discovery of enormous quantities of carbonate minerals called limemud from the continental shelf margin of the west coast of *** carried out systematic studies to explore the nature of the disposition,quality,quantity,and suitability of the offshore limemud for various industrial applications.A preliminary estimate of resources using high‐resolution subbottom profiling and sediment core sample studies established the occurrence of more than 172 billion tonnes of high‐grade(The content of CaCO3 is greater than 80 wt%)limemud in 0.4–28.0m thick stratified sediment layers spread over an area of 18000 ***,physical,mineralogical,beneficiation,and agglomeration studies found the offshore limemud as a potential replacement for limestone in the cement,filler,blast furnace,steel melting shop,lime production,paint,and Grade‐I steel *** assessment of mining and transportation costs indicates that the offshore limemud(USD 5–6/ton)is more cost‐effective than that imported from other countries(USD16‐18/ton).With several advantageous factors like low impurity,mode of occurrence in overburden‐free stratified form,fine‐grained slurry nature,and shallow water depth,sustainable mining of offshore limemud could be a future reality with controllable technological,economic,and environmental challenges.

关键词： beneficiation industrial grade offshore limemud west coast of India

Colorectal cancer cell dormancy:An insight into pathways

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World Journal of Gastroenterology 2024年第33期30卷 3810-3817页

作者： anil Kumar Lekha Saha Department of Pharmacology Post Graduate Institute of Medical Education and ResearchChandigarh 160012India

Cancer cell dormancy(CCD)in colorectal cancer(CRC)poses a significant challenge to effective *** CRC,CCD contributes to tumour recurrence,drug resistance,and amplifying the disease's *** molecular mechanisms governing CCD and strategies for eliminating dormant cancer cells remain largely ***,understanding the molecular mechanisms governing dormancy is crucial for improving patient outcomes and developing targeted *** editorial highlights the complex interplay of signalling pathways and factors involved in colorectal CCD,emphasizing the roles of Hippo/YAP,pluripotent transcription factors such as NANOG,HIF-1αsignalling,and Notch signalling ***,ERK/p38α/β/MAPK pathways,AKT signalling pathway,and Extracellular Matrix Metalloproteinase Inducer,along with some potential less explored pathways such as STAT/p53 switch and canonical and non-canonical Wnt and SMAD signalling,are also involved in promoting colorectal *** their clinical significance,these findings may offer the potential for identifying key dormancy regulator pathways,improving treatment strategies,surmounting drug resistance,and advancing personalized medicine ***,insights into dormancy mechanisms could lead to the development of predictive biomarkers for identifying patients at risk of recurrence and the tailoring of targeted therapies based on individual dormancy *** is essential to conduct further research into these pathways and their modulation to fully comprehend CRC dormancy mechanisms and enhance patient outcomes.

关键词： Colorectal cancer Colorectal cancer cell dormancy Cancer cell dormancy Pathways in colorectal cancer dormancy

Customized scaffolds for large bone defects using 3D‑printed modular blocks from 2D‑medical images

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Bio-Design and Manufacturing 2024年第1期7卷 74-87页

作者： anil AAcar Evangelos Daskalakis Paulo Bartolo Andrew Weightman Glen Cooper Gordon Blunn Bahattin Koc Faculty of Engineering and Natural Sciences Sabanci UniversityIstanbul 34956Türkiye D Bioprinting Laboratory Sabanci University Nanotechnology Research and Application CenterIstanbul 34956Türkiye School of Mechanical Aerospace and Civil EngineeringManchester Institute of BiotechnologyUniversity of ManchesterManchester M139PLUK Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore 639798Singapore School of Pharmacy and Biomedical Sciences University of PortsmouthPortsmouth PO12UPUK

Additive manufacturing(AM)has revolutionized the design and manufacturing of patient-specific,three-dimensional(3D),complex porous structures known as scaffolds for tissue engineering *** use of advanced image acquisition techniques,image processing,and computer-aided design methods has enabled the precise design and additive manufacturing of anatomically correct and patient-specific implants and ***,these sophisticated techniques can be timeconsuming,labor-intensive,and ***,the necessary imaging and manufacturing equipment may not be readily available when urgent treatment is needed for trauma *** this study,a novel design and AM methods are proposed for the development of modular and customizable scaffold blocks that can be adapted to fit the bone defect area of a *** modular scaffold blocks can be combined to quickly form any patient-specific scaffold directly from two-dimensional(2D)medical images when the surgeon lacks access to a 3D printer or cannot wait for lengthy 3D imaging,modeling,and 3D printing during *** proposed method begins with developing a bone surface-modeling algorithm that reconstructs a model of the patient’s bone from 2D medical image measurements without the need for expensive 3D medical imaging or *** algorithm can generate both patient-specific and average bone ***,a biomimetic continuous path planning method is developed for the additive manufacturing of scaffolds,allowing porous scaffold blocks with the desired biomechanical properties to be manufactured directly from 2D data or *** algorithms are implemented,and the designed scaffold blocks are 3D printed using an extrusion-based AM *** and instructions are also provided to assist surgeons in assembling scaffold blocks for the self-repair of patient-specific large bone defects.

关键词： Additive manufacturing Modular scaffolds Large bone defect Customized scaffold design Patient-specific scaffolds

Agile and reactive rabies vaccination techniques in countries with low and middle incomes

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Animal Diseases 2024年第2期4卷 75-77页

作者： Rupak Kandel anil Subedi Sonu Adhikari Department of Animal Breeding and Biotechnology Agriculture and Forestry University(AFU)RampurChitwan 44209Nepal University of New England ArmidaleNSW 2350Australia

Rabies are still a major public health risk in low-and middle-income nations,endangering both human and animal *** is caused by rabies virus(RABV)from the Rhabdoviridae family of the genus *** infection affects the central nervous system,mainly the brain and spinal cord,causing acute encephalitis,which has the highest case fatality rate ever recordednearly 100%.Although all mammals can be infected by RABV,dogs are thought to be the main source of *** bites cause 95%of human cases of rabies,but in endemic areas,this number increases to 99%(Harischandra,Gunesekera et al.2016).

关键词： rabies Rabies acute

Multiplexed fluorescence and scatter detection with single cell resolution using on-chip fiber optics for droplet microfluidic applications

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Microsystems & Nanoengineering 2024年第2期10卷 207-218页

作者： Preksha Gupta Ambili Mohan Apurv Mishra Atindra Nair Neeladri Chowdhury Dhanush Balekai Kavyashree Rai anil Prabhakar Taslimarif Saiyed Discovery Innovation Accelerator Centre for Cellular and Molecular PlatformsBellary RoadBengaluru560065KarnatakaIndia Department of Electrical Engineering Indian Institute of Technology MadrasChennai600036Tamil NaduIndia

Droplet microfluidics has emerged as a critical component of several high-throughput single-cell analysis techniques in biomedical research and *** significant progress in the development of individual assays,multiparametric optical sensing of droplets and their encapsulated contents has been *** current approaches,most commonly involving microscopy-based high-speed imaging of droplets,are technically complex and require expensive instrumentation,limiting their widespread *** address these limitations,we developed the OptiDrop platform;this platform is a novel optofluidic setup that leverages the principles of flow *** platform enables on-chip detection of the scatter and multiple fluorescence signals from the microfluidic droplets and their contents using optical *** highly customizable on-chip optical fiber-based signal detection system enables simplified,miniaturized,low-cost,multiparametric sensing of optical signals with high sensitivity and single-cell resolution within each *** demonstrate the ability of the OptiDrop platform,we conducted a differential expression analysis of the major histocompatibility complex(MHC)protein in response to IFNγ*** results showed the platform’s ability to sensitively detect cell surface biomarkers using fluorescently labeled ***,the OptiDrop platform combines the versatility of flow cytometry with the power of droplet microfluidics to provide wide-ranging,scalable optical sensing solutions for research and diagnostics.

关键词： scatter enable resolution

高速火焰喷涂VC-CuNiCr涂层的耐腐蚀性能

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Journal of Central South University 2024年第5期31卷 1385-1397页

作者： SINGH Vikrant BANSAL Anuj SINGLA anil Kumar KUMAR Vijay Sant Longowal Institute of Engineering and Technology Longowal Sangrur 148106India Industrial and Production Engineering Department Dr B R Ambedkar National Institute of TechnologyJalandhar 144011India

本研究采用高速火焰喷涂(HVOF)沉积技术,将碳化钒(VC)和铜镍铬(CuNiCr)复合涂层应用于SS316不锈钢上,以解决不锈钢在海洋环境中的腐蚀问题。在室温环境下,在3.5%氯化钠溶液中进行电化学腐蚀,通过扫描电子显微镜(SEM)和能量色散光谱(EDS... 详细信息

本研究采用高速火焰喷涂(HVOF)沉积技术,将碳化钒(VC)和铜镍铬(CuNiCr)复合涂层应用于SS316不锈钢上,以解决不锈钢在海洋环境中的腐蚀问题。在室温环境下,在3.5%氯化钠溶液中进行电化学腐蚀,通过扫描电子显微镜(SEM)和能量色散光谱(EDS)对有涂层和未覆涂层样品的表面形貌进行检测。结果表明,涂层内由铜(Cu)、镍(Ni)和铬(Cr)组成的金属间黏合剂在氯化钠介质的影响下发生变质,从而导致出现衬底间的局部点蚀现象。有趣的是,在涂层配方中加入碳化钒(VC)显著地增强了表面的耐腐蚀性能,从而阻止了密闭腐蚀凹坑的出现。在不同类的涂层中,加入VC的效果最好,最小的腐蚀速率为72.38×10^(-3)mm/a,相比之下,SS316基底的腐蚀速率最快。

关键词：高速火焰喷涂碳化钒铜镍铬电化学腐蚀氯化钠溶液

Offset restoration in total hip arthroplasty:Important:A current review

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World Journal of Orthopedics 2024年第8期15卷 696-703页

作者： anil Thomas Oommen Department of Orthopedics Christian Medical College HospitalVellore 632004India

Normal vertical and horizontal offset is essential for hip biomechanics,muscle functioning and gait *** hip arthroplasty(THA)should aim to restore normal offset with implantation of femoral and acetabular *** would be possible with proper preoperative planning,templating and ensuring implant options are available for offset *** is essential for understanding the vertical and horizontal offset change,especially in hip arthritis presenting late with significant limb length discrepancy at *** should include appropriate soft tissue releases and the use of ideal implants to achieve restoration of horizontal and vertical *** correction of horizontal offset at THA for fracture neck of femur could result in abductor fatigue,limp and increased *** of horizontal offset is imperative at THA for a fractured neck of the femur to achieve optimal abductor *** offset is necessary for optimal abductor muscle tension and *** THA for acetabular bone loss would require hip center restoration with the acetabular and femoral offset correction to achieve limb length correction and abductor *** inability to achieve vertical and horizontal offset correction could lead to dislocation or signs of abductor *** vertical and horizontal femur offset restoration is required for normal hip biomechanics,decreased wear and increased longevity.

关键词： Offset Vertical Horizontal Total hip arthroplasty Templating Restoration

Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： Siva S.V.P.Sakamuri anil Sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical