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Antimicrobial approach of abdominal post-surgical infections

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World Journal of Gastrointestinal Surgery 2023年第12期15卷 2674-2692页

作者： Marco Fiore Antonio Corrente Sveva Di Franco aniello alfieri Maria Caterina Pace Francesca Martora Stephen Petrou Claudio Mauriello Sebastiano Leone Department of Women Child and General and Specialized SurgeryUniversity of Campania“Luigi Vanvitelli”Naples 80138Italy Unit of Virology and Microbiology “Umberto I”HospitalNocera Inferiore 84018Italy Department of Emergency Medicine University of California San FranciscoSan FranciscoCA 94143United States Department of General Surgery “Santa Maria delle Grazie”HospitalPozzuoli 80078Italy Division of Infectious Diseases “San Giuseppe Moscati”HospitalAvellino 83100Italy

Abdominal surgical site infections(SSIs)are infections that occur after abdominal *** can be superficial,involving the skin tissue only,or more profound,involving deeper skin tissues including organs and implanted ***,SSIs are large global health problem with an incidence that varies significantly depending on the United Nations’Human Development *** purpose of this review is to provide a practical update on the latest available literature on SSIs,focusing on causative pathogens and treatment with an overview of the ongoing studies of new therapeutic strategies.

关键词： Surgical site infections Multidrug resistance Carbapenem-resistant Enterobacterales Carbapenem-resistant Klebsiella Abdominal post-operative complications Post-surgical infections

Spontaneous bacterial peritonitis due to carbapenemase-producing Enterobacteriaceae:Etiology and antibiotic treatment

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World Journal of Hepatology 2020年第12期12卷 1136-1147页

作者： Marco Fiore Sveva Di Franco aniello alfieri Maria Beatrice Passavanti Maria Caterina Pace Stephen Petrou Francesca Martora Sebastiano Leone Department of Women Child and General and Specialized SurgeryUniversity of Campania“Luigi Vanvitelli”Naples 80138Italy Department of Emergency Medicine Good Samaritan Hospital Medical CenterNY 11795United States Department of Experimental Medicine University of Campania“Luigi Vanvitelli”Naples 80138Italy Division of Infectious Diseases “San Giuseppe Moscati”HospitalAvellino 83100Italy

Carbapenem antibiotics were first introduced in the 1980s and have long been considered the most active agents for the treatment of multidrug-resistant gramnegative *** the last decade,carbapenem-resistant Enterobacteriaceae(CRE)have emerged as organisms causing spontaneous bacterial *** caused by CRE have shown a higher mortality rate than those caused by bacteria sensitive to carbapenem *** antibiotic guidelines for the treatment of spontaneous bacterial peritonitis are insufficient,and rapid deescalation of empiric antibiotic treatment is not widely *** review summarizes the molecular characteristics,epidemiology and possible treatment of spontaneous bacterial peritonitis caused by CRE.

关键词： Spontaneous bacterial peritonitis Carbapenem-resistant Enterobacteriaceae Carbapenem-resistant Klebsiella pneumoniae Cirrhosis

Gut microbiota and nutrient interactions with skin in psoriasis:A comprehensive review of animal and human studies

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World Journal of Clinical Cases 2020年第6期8卷 1002-1012页

作者： Giovanni Damiani Nicola Luigi Bragazzi Thomas S McCormick Paolo Daniele Maria Pigatto Sebastiano Leone Alessia Pacifico Danica Tiodorovic Sveva Di Franco aniello alfieri Marco Fiore Department of Dermatology Case Western Reserve UniversityClevelandOH 44106United States Clinical Dermatology IRCCS Istituto Ortopedico GaleazziMilan 20122Italy Department of Biomedical Surgical and Dental SciencesUniversity of MilanMilan 20122Italy Postgraduate School of Public Health Department of Health SciencesUniversity of GenoaGenoa 16132Italy Department of Medicine Division of Infectious diseases“San Giuseppe Moscati”HospitalAvellino 83100Italy San Gallicano Dermatological Institute IRCCSRome 00144Italy Dermatology Clinic Medical FacultyNis UniversityNis 18000Serbia Department of Women Child and General and Specialized SurgeryUniversity of Campania"Luigi Vanvitelli"Naples 80138Italy

The intestinal tract(i.e.,the gut),is where the body’s nutrients are absorbed,and is simultaneously inhabited by numerous *** increasing body of literature suggests a crucial role for the gut microbiome in modulating systemic inflammatory *** is a chronic systemic inflammatory disease and its pathogenesis is related to the interaction between genetic susceptibility,immune response and environmental *** omics era has allowed physicians to assess different aspects of psoriasis pathogenesis such as the microbiome,infectome,and ***,diet appears to play an important role in modulating disease activity,perhaps by influencing gut *** these observations,we aimed to summarize the current knowledge regarding skin-microbiome-gut-nutrients and psoriasis.

关键词： Gut Microbiota Nutrients Endotypes Exposome Psoriasis

First Italian outbreak of VIM-producing Serratia marcescens in an adult polyvalent intensive care unit, August-October 2018: A case report and literature review

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World Journal of Clinical Cases 2019年第21期7卷 3535-3548页

作者： Maria Rosaria Iovene Vincenzo Pota Massimiliano Galdiero Giusy Corvino Federica Maria Di Lella Debora Stelitano Maria Beatrice Passavanti Maria Caterina Pace aniello alfieri Sveva Di Franco Caterina Aurilio Pasquale Sansone Vettakkara Kandy Muhammed Niyas Marco Fiore Department of Experimental Medicine University of Campania"Luigi Vanvitelli"Naples 80138Italy Department of Women Child and General and Specialized SurgeryUniversity of Campania"Luigi Vanvitelli"Naples 80138Italy Department of Medicine All India Institute of Medical SciencesNew Delhi 110029India

BACKGROUND Carbapenem-resistant Enterobacteriaceae has become a significant public health concern as hospital outbreaks are now being frequently reported and these organisms are becoming difficult to treat with the available *** SUMMARY An outbreak of VIM-producing Serratia marcescens occurred over a period of 11 wk(August,1 to October,18)in patients admitted to the adult polyvalent intensive care unit of the University of Campania“Luigi Vanvitelli”located in *** episodes occurred in three patients(two patients infected,and one patient colonized).All the strains revealed the production of *** After three decades of carbapenem antibiotics use,the emergence of carbapenemresistance in Enterobacteriaceae has become a significant concern and a stricter control to preserve its clinical application is *** is,to our knowledge,the first outbreak of VIM-producing Serratia marcescens in *** policies must be implemented to avoid future outbreaks.

关键词： Serratia marcescens Carbapenamase VIM Intensive care unit Outbreak Case report

Current status of COVID-19 treatment:An opinion review

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World Journal of Virology 2020年第3期9卷 27-37页

作者： Sveva Di Franco aniello alfieri Stephen Petrou Giovanni Damiani Maria Beatrice Passavanti Maria Caterina Pace Sebastiano Leone Marco Fiore Department of Women Child and General and Specialized SurgeryUniversity of Campania“Luigi Vanvitelli”Naples 80138Italy Department of Emergency Medicine Good Samaritan Hospital Medical CenterNew YorkNY 11795United States Department of Biomedical Surgical and Dental SciencesUniversity of MilanMilan 20122Italy Clinical Dermatology IRCCS Instituto Ortopedico GaleazziMilan 20122Italy Division of Infectious Diseases “San Giuseppe Moscati”HospitalAvellino 83100Italy

The pandemic severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has garnered the attention of scientists worldwide in the search for an effective treatment while also focusing on vaccine *** drugs have been used for the management of coronavirus disease 2019(COVID-19),which has affected many hospitals and health centers *** significant results are lacking on the effectiveness of the experimented drugs in reducing COVID-19 morbidity or mortality,as there are very few published randomized clinical *** this,the literature offers some material for study and *** opinion review attempts to address three burning questions on COVID-19 treatment options.(1)What kind of studies are currently published or ongoing in the treatment of patients with COVID-19?(2)What drugs are currently described in the literature as options of treatment for patients affected by the infection?And(3)Are there specific clinical manifestations related to COVID-19 that can be treated with a customized and targeted therapy?By answering these questions,we wish to create a summary of current COVID-19 treatments and the anti-COVID-19 treatments proposed in the recent clinical trials developed in the last 3 mo,and to describe examples of clinical manifestations of the SARS-CoV-2 infection with a cause-related treatment.

关键词： Antiviral drugs Coronavirus COVID-19 SARS-CoV-2 Tocilizumab Eculizumab Enoxaparin Hydroxychloroquine Pandemic Treatment Opinion review

Investigating the role of stratigraphy in large-area physically-based analysis of December 1999 Cervinara shallow landslides

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Journal of Mountain Science 2016年第1期13卷 104-115页

作者： Sabatino CUOMO aniello IERVOLINO Department of Civil Engineering University of SalernoFisciano(sA)84084Italy

The paper describes a large-area analysis of the triggering zones of shallow landslides on a case of unsaturated layered volcanic air-fall(pyroclastic) soil deposits in Cervinara site(18 km^2),Southern *** physically-based model TRIGRS(Transient Rainfall Infiltration-Based Grid Regional Slope-Stability) is used,which is used with either saturated or unsaturated conditions and implemented in a GIS *** addition to using the TRIGRS model to simulate some recent landslides,a new simplified approach is also tested to take into account the actual layered soil *** consistency check of the model and of the input data is performed with reference to slope stable conditions before *** performances of the models are evaluated through the ROC curves and two other quantitative indexes taken from the literature referring to the slope failures caused by December 1999 *** the simplifications and limitations of the present work,both unsaturated conditions and layered stratigraphy are outlined as key factors for the slope stability of shallow deposits of unsaturated coarse-grained soils subjected to short heavy rainfall.

关键词： Shallow landslide Pore pressure Rainfall Modelling Stratigraphy Stability

Synthesis and Characterization of Iron-Rich Glass Ceramic Materials：A Model for Steel Industry Waste Reuse

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Journal of Materials Science & Technology 2016年第11期32卷 1105-1110页

作者： Riccardo Carlini Ilaria alfieri Gilda Zanicchi Francesco Soggia Enos Gombia Andrea Lorenzi Department of Chemistry and Industrial Chemistry University of GenoaVia Dodecaneso 3116146 GenovaItaly Department of Chemistry University of ParmaParco area delle Scienze 17/a43124 ParmaItaly IMEM-CNR Parco Area delle Sdenze 37/a43124 ParmaItaly

Wastes deriving from steel industry, containing large amounts of iron oxides and heavy metals, when collected in landfills are subjected to atmospheric agents, with consequent release of toxic substances in the soil and groundwater. The reuse of these wastes as raw materials for the production of advanced materials is a viable way both to overcome the environmental impact and to reduce the disposal costs,proposing new technologically advanced materials. This work aims to simulate these interesting glassceramics by using glass cullet coming from recycled municipal waste and high amount of iron（III） oxide（from 25 wt% to 50 wt%）, the prevalent component of steel waste. The oxide was mixed with glass cullet and vitrified. The samples composition and the microstructure were investigated by scanning electron microscopy（SEM）, and X-ray diffraction（XRD） was used to evaluate the nature of the crystalline *** chemical stability of the materials, in terms of ionic release into saline solution, was assessed. The electrical behavior of the samples was also investigated by varying the iron ions content and controlling the crystallization process. It is possible to obtain chemically stable materials with a nearly semiconducting behavior.

关键词： Glass-ceramics Electrical properties Leaching tests Iron rich waste Vitrification

Distal pancreatectomy in the new era of minimally invasive surgery: the on-going debate on the cost-effectiveness

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Hepatobiliary Surgery and Nutrition 2019年第6期8卷 659-661页

作者： Giuseppe Quero Claudio Fiorillo Sergio alfieri Digestive Surgery Unit Fondazione Policlinico Universitario A.Gemelli IRCCSCRMPG(Advanced Pancreatic Research Center)Largo A.GemelliRomeItaly UniversitàCattolica del Sacro Cuore Largo A.GemelliRomeItaly

We read with great interest the article of Rodriguez et al.,"Which method of distal pancreatectomy is cost-effective among open,laparoscopic,or robotic surgery?"(1).In the current climate of limited hospital sources and control of medical costs,the authors afford the interesting topic of the cost-effectiveness evaluation of the robot-assisted distal pancreatectomy(RDP)in comparison to the laparoscopic(LDP)and open approaches(ODP).To accomplish this purpose,they focused their attention on both the clinical and the economical outcomes of the three different techniques.

关键词： surgery al. cost

Light Electrospun Polyvinylpyrrolidone Blanket for Low Frequencies Sound Absorption

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Chinese Journal of Polymer Science 2018年第12期36卷 1368-1374页

作者： Joshua Avossa Francesco Brand Francesco Marulo Giuseppe Petrone Stefano Guido Giovanna Tomaiuolo aniello Costantini Dipartimento di Ingegneria Chimica dei Materiali e della Produzione lndustriale (DICMaPI) Universitgt degli Studi di Napoli Federico II Napoli Italy Dipartimento di lngegneria Industriale (DII) Universita degli Studi di Napoli Federico II Napoli Italy

Light polymeric soundproofing materials （density = 63 kg/m3） of interest for the transportation industry were fabricated through electrospinning. Blankets of electrospun polyvinylpyrrolidone （average fiber diameter = （1.6 ± 0.5） or （2.8 ± 0.5） μm） were obtained by stacking disks of electrospun mats. The sound absorption coefficients were measured using the impedance tube instrument based on ASTM E1050 and ISO 10534-2. For a given set of disks （from a minimum of 6） the sound absorption coefficient changed with the frequency （in the range 200-1600 Hz） following a bell shape curve with a maximum （where the coefficient is greater than 0.9） that shifts to lower frequencies at higher piled disks number and greater fiber diameter. This work showed that electrospinning produced sound absorbers with reduced thickness （2-3 cm） and excellent sound-absorption properties in the low and medium frequency range.

关键词： Electrospinning Polyvinylpyrrolidone (PVP) Sound absorption Impedance tube