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An Arabidopsis ABC Transporter Mediates Phosphate Deficiency-Induced Remodeling of Root Architecture by Modulating Iron Homeostasis in Roots

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Molecular Plant 2017年第2期10卷 244-259页

作者： Jinsong Dong Miguel A. PiSeros Xiaoxuan Li Haibing Yang Yu Liu angus S. Murphy Leon V. Kochian Dong Liu Ministry of Education Key Laboratory of Bioinformatics Center for Plant Biology School of Life Sciences Tsinghua University Beijing 100084 China USDA-ARS Robert Holley Center for Agriculture and Health Cornell University ithaca NY 14580 USA Department of Horticulture Purdue University West Lafayette IN 47907-2010 USA State Key Laboratory of Plant Physiology and Biochemistry College of Life Science Zhejiang University Hangzhou 310058 China Department of Plant Science and Landscape Architecture University of Maryland College Park MD 20742 USA GIobal Institute for Food Security University of Saskatchewan Saskatoon S7N 4J8 Canada

The remodeling of root architecture is a major developmental response of plants to phosphate （Pi） deficiency and is thought to enhance a plant＇s ability to forage for the available Pi in topsoil. The underlying mechanism controlling this response, however, is poorly understood. In this study, we identified an Arabidopsis mutant, hps 10 （hypersensitive to Pi starvation 10）, which is morphologically normal under Pi sufficient condition but shows increased inhibition of primary root growth and enhanced production of lateral roots under Pi defi- ciency, hpslO is a previously identified allele （als3-3） of the ALUMINUM SENSITIVE3 （ALS3） gene, which is involved in plant tolerance to aluminum toxicity. Our results show that ALS3 and its interacting protein AtSTAR1 form an ABC transporter complex in the tonoplast. This protein complex mediates a highly electro- genic transport in Xenopus oocytes. Under Pi deficiency, als3 accumulates higher levels of Fe3＋ in its roots than the wild type does. In Arabidopsis, LPR1 （LOW PHOSPHATE ROOT1） and LPR2 encode ferroxidases, which when mutated, reduce Fe3＋ accumulation in roots and cause root growth to be insensitive to Pi defi- ciency. Here, we provide compelling evidence showing that ALS3 cooperates with LPR1/2 to regulate Pi deficiency-induced remodeling of root architecture by modulating Fe homeostasis in roots.

关键词： phosphate deficiency root architecture iron homeostasis ABC transporter ALUMINUM SENSI-TIVE3 AtS TAR1

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Cardiorespiratory and muscular fitness associations with older adolescent cognitive control

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Journal of Sport and Health Science 2021年第1期10卷 82-90,I0001页

作者： Tatsuya T.Shigeta angus A.Leahy Jordan J.Smith Narelle Eather David R.Lubans Charles H.Hillman Department of Psychology Northeastern UniversityBostonMA 02115USA Priority Research Centre for Physical Activity and Nutrition School of EducationUniversity of NewcastleCallaghanNSW 2308Australia Department of Physical Therapy Movement&Rehabilitation SciencesNortheastern UniversityBostonMA 02131USA

Background:Participation in physical activity supports greater cardiorespiratory fitness(CRF),a correlate of cognitive ***,the relationship between muscular fitness(MF)and cognitive control is less *** present study investigated the differential relationship of CRF and MF with cognitive control in older ***:This cross-sectional study involved students(1517 years old,n=541,43%female)from 20 secondary schools who completed tests of inhibition(modified flanker task),working memory(n-back task),CRF(Progressive Aerobic Cardiovascular Endurance Run),and MF(standing long jump and push-up test).Multilevel analyses tested the association between CRF or MF and cognitive outcomes while accounting for the influence of the other fitness variable and relevant demographic ***:CRF predicted response accuracy during incongruent flanker trials,the condition requiring greater *** the working memory task,CRF predicted greater target accuracy and greater d’scores on the 1-back task,requiring lesser amounts of working *** the 2-back task,which requires greater amounts of working memory,CRF also predicted greater target and non-target accuracy and d’***,MF did not predict any cognitive outcomes after adjustment for ***:CRF was selectively related to better performance during task conditions that require greater amounts of inhibition and working *** finding suggests that CRF,but not MF,may benefit cognitive control in older *** selective influence of CRF on older adolescents’cognition highlights the value of aerobic physical activity.

关键词： Adolescence Cognition Physical activity Physical fitness

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Life at the Beijing Film Academy:China in My Viewfinder

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China & The World Cultural Exchange 2000年第3期66卷 40-42页

作者： angus E.McNelis

SincearrivingattheBejingFilmAcademyasvisitingscholarfromCaliforniaStateUniversityNorthridgeinAugust1999,IhavebeenaskedonmoreoccasionsthanIwanttocountthesamequestion:"You'***,sowhycomehere?"Afterbein（共3页)

关键词： Life at the Beijing Film Academy:China in My Viewfinder

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The burden of sepsis in the developed world

The burden of sepsis in the developed world

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国际全身性感染论坛-2011北京

作者： Derek angus University of Pittsburgh Department of Critical Care Medicine University of Pittsburgh School of MedicinePittsburghPennsylvaniaUSA

＜正＞In recent years,a number of large-scale studies have estimated the incidence or prevalence of severe sepsis in many industrialized *** of the studies are focused on patients admitted to an ICU,and most report that 5-15%of ICU patients either have severe sepsis on admission or develop severe sepsis during ***,the number of ICU beds per

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Consent, Choice and the Ends of Health Promotion

Consent, Choice and the Ends of Health Promotion

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The Future of Consent Beijing Workshop

作者： angus Dawson Centre for Professional Ethics Keele UniversityUK

Introduction If there is consensus on anything in bioethics it is that we ought to gain an informed consent before any health related interventions impact upon individuals. However, I don’t think this consensus is ju...

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西方对浦东新区人力资源规划的看法

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上海高教研究 1997年第6期17卷 51-56页

作者： DavidL.angus 美国密西根大学

西方对浦东新区人力资源规划的看法ＤａｖｉｄＬ．Ａｎｇｕｓ１９８８年４月１８日中国总理李鹏宣布建立浦东经济开发区，对此西方有过怀疑。疑问涉及税收政策、劳动法规、进出口法规，但最重要的是有关基础设施硬件的情况。可是，随着... 详细信息

西方对浦东新区人力资源规划的看法ＤａｖｉｄＬ．Ａｎｇｕｓ１９８８年４月１８日中国总理李鹏宣布建立浦东经济开发区，对此西方有过怀疑。疑问涉及税收政策、劳动法规、进出口法规，但最重要的是有关基础设施硬件的情况。可是，随着时间的推移和一批关键性项目的提前竣...

关键词：西方国家浦东新区人力资源规划

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新托福高分口语 4

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丛书名：朗阁新托福应试系列丛书

2008年

作者：（美）angus WHEELER 陈瑜编

本书共分七个单元，主要内容包括：新托福口语考试介绍，口语考试技巧，并附有六个小测试题，书的最后还包含了书的录音及参考答案。本书附有音频MP3，具有一定的实用性，是一本很好的应试参考书。

ISBN: (数字)9787313050700

ISBN: (纸本)7313050704

关键词：语言、文字常用外国语英语

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Macroscopic analysis of time dependent plasticity in Ti alloys

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Journal of Materials Science & Technology 2022年第29期124卷 135-140页

作者： Yi Xiong Phani S.Karamched Chi-Toan Nguyen David M.Collins Christopher M.Magazzeni Edmund Tarleton angus J.Wilkinson Department of Materials University of OxfordParks RoadOxford OX13PHUnited Kingdom Department of Materials and Processes Safran SASafran TechMany-les-Hameaux 78772France School of Metallurgy and Materials University of BirminghamEdgbastonBirmingham B152TTUnited Kingdom Department of Engineering Science University of OxfordParks RoadOxford OX13PJUnited Kingdom

Cold dwell fatigue is the critical technological issue in Ti alloys used in the cooler front sections of aerospace jet *** subjected to a sustained load(stress dwell),the lifetime of these Ti components can be drastically reduced by as much as an order of magnitude[1–4].Without a clear understanding of the effect,safety concerns are raised.

关键词： alloys fatigue lifetime

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Immune function biomarker QuantiFERON-monitor is associated with infection risk in cirrhotic patients

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World Journal of Hepatology 2016年第35期8卷 1569-1575页

作者： Siddharth Sood Lijia Yu Kumar Visvanathan Peter William angus Paul John Gow Adam Gareth Testro Department of Gastroenterology and Hepatology University of Melbourne Royal Melbourne Hospital Liver Transplant Unit Victoria University of Melbourne Innate Immune Laboratory University of Melbourne St Vincent’s Hospital

AIMTo investigate whether a novel immune function biomarker QuantiFERON-Monitor (QFM) can identify cirrhotic patients at greatest risk of infection. METHODSAdult cirrhotic patients on the liver transplant waiting list were recruited for this observational cohort study from a tertiary liver transplant referral unit. The immune function biomarker, QFM was performed using the same method as the widely available Quantiferon-gold assay, and measures output in interferon gamma in IU/mL after dual stimulation of the innate and adaptive immune systems. Ninety-one cirrhotic patients were recruited, with 47 (52%) transplanted on the day of their QFM. The remaining 44 (48%) were monitored for infections until transplant, death, or census date of 1st February 2014. RESULTSCirrhotic patients express a median QFM significantly lower than healthy controls (94.5 IU/mL vs 423 IU/mL), demonstrating that they are severely immunosuppressed. Several factors including model for end stage liver disease, presence of hepatocellular carcinoma, bilirubin, international normalized ratio and haemoglobin were associated with QFM on univariate analysis. Disease aetiology did not appear to impact QFM. On multivariate analysis, only Child-Pugh score and urea were significantly associated with a patient’s immune function as objectively measured by QFM. In the 44 patients who were not transplanted immediately after their blood test and could be monitored for subsequent infection risk, 13 (29.5%) experienced a pre-transplant infection a median 20 d (range 2-182) post-test. QFM P = 0.01) for infection. A very low QFM P = 0.003) with death in three patients who died while awaiting transplantation (HR = 56.6). CONCLUSIONQFM is lower in cirrhotics, allowing objective determinations of an individual’s unique level of immune dysfunction. Low QFM was associated with increased susceptibility to infection.

关键词： Infection Biomarker Immune dysfunction Immune function Immunosuppression Liver Immune system Cirrhosis Mortality

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泛函分析引论 1

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1986年

作者： angus E.TAYLOR

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