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Use of OviTex 1S,reinforced tissue matrix,for the repair of post renal transplant incisional hernias:Four case reports

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World Journal of Clinical Cases 2025年第18期13卷 5-10页

作者： Mariam Abed angus bradley Abbas Ghazanfar Department of Renal Transplantation St George's University HospitalLondon SW170QTUnited Kingdom Renal and Transplant Unit St Georges University Hospitals NHS Foundation TrustLondon SW170QTUnited Kingdom

BACKGROUND Incisional hernia is one of the known complications of renal transplant surgery,with a reported incidence between 1.1%to 3.8%.Depending on the site and extent of incisional hernia,it may require surgery particularly if it contains the trans-planted kidney either partially or *** current common clinical prac-tice is to repair incisional hernias using polypropylene meshes,which have their own risks and *** meshes,which are made from human or animal-derived connective tissue,are also in use and have a less inflammatory ***,hybrid meshes have been *** are composed of both biological and synthetic *** such example is OviTex 1S perma-nent,which is a sterile reinforced tissue matrix composed of ovine(sheep)derived extracellular matrix and monofilament *** this case report,we are sharing our experience with the use of OviTex 1S in the repair of post-renal transplant incisional *** SUMMARY We report four cases of post-renal transplant incisional hernia with a median time of 27 months *** median size of the defect was 15 cm *** was no post-operative *** patient required renal transplant biopsy after mesh repair,which was easily performed compared with polypropylene meshes repaired hernias in the *** The OviTex 1S mesh provides benefits in hernial repairs pKTx,but cost is an issue,and their long-term viability is *** use and reporting will help build a more informed picture.

关键词： Incisional hernia Kidney transplantation Surgical mesh Hybrid mesh End stage renal failure Case report

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Influence of previous plane of nutrition on molecular mechanisms regulating the expression of urea and water metabolism related genes in the rumen and kidney of finishing crossbred angus steers

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Animal Nutrition 2024年第2期17卷 232-243页

作者： Aghata E.Moreira da Silva Arturo Macias Franco bradley S.Ferguson Mozart A.Fonseca College of Agriculture Biotechnology&Natural ResourcesUniversity of NevadaRenoRenoNV 89503USA Department of Animal and Range Sciences Clayton Livestock Research CenterNew Mexico State UniversityClaytonNM 88415USA

This study aimed to understand how molecular mechanisms controlling water and urea metabolism at the finishing phase can be affected by previous plane of nutrition of crossbred angus beef ***-four(n=24)animals were randomly distributed into either a moderate(MP)or high plane of nutrition during the background phase for 85 *** were then blocked by their previous plane and were moved onto a 105-d finishing phase in a 2×2 factorial *** forage-finished group received only high-quality alfalfa hay,whereas the grain-fed group received a high grain diet(80%whole corn and 20%alfalfa hay).By the end of the finishing phase,animals were harvested and tissue samples from the rumen and kidney were *** in gene expression of aquaporins(AQP)-2,-3,-4,-7,ATP1A1,ATP1B1,SGK1,CLIC1(kidney and rumen),UT-A1(kidney only)and UT-B(rumen only),were assayed via real-time qPCR;18S rRNA was used as an endogenous ***-way ANOVA followed by Tukey's post hoc analysis was *** animals were from MP,forage-finishing increased the relative abundance of AQP3(P≤0.05),AQP7(P≤0.05),ATP1B1(P≤0.05),and SGK1(P≤0.05)in the kidney when compared to grain-fed *** the rumen,for the MP group,AQP7 was differentially expressed in both treatments at the finishing phase(P≤0.01),with forage-finished steers having the highest expression of *** the MP group,UT-B had a tendency of presenting a higher expression on grain-fed animals(P=0.075).Overall,these results suggest that previous plane can impact expression of genes associated with water and urea metabolism during the finishing phase,namely AQP3,AQP7,ATP1B1,and SGK1 in the kidney,and AQP7 and UT-B in the *** greatest impact observed on gene expression changes of investigated genes at the finishing phase was reflective of animals backgrounded on the moderate previous plane.

关键词： Gene expression Aquaporin Sodium channel Urea transporter

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