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Development of a facility for analysis of natural ^(32)Si

Chinese Journal Of Geochemistry 2006年第B8期25卷 199-200页

作者： angus b. mackenzie David C.W. Sanderson Joseph Melone John G. Farmer Christoph Schnab.l Helfrid Rossiter Scottish Universities Environmental Research Centre East Kilbride G75 0QF Scotland UK School of Geosciences University of Edinburgh Edinburgh EH9 3JJ Scotland UK

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Is environmental antimony a potential health prob.em?

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Chinese Journal Of Geochemistry 2006年第B8期25卷 68-69页

作者： John G. Farmer Joanna M. Cloy Margaret C. Graham angus b. mackenzie Gordon T. Cook School of Geosciences University of Edinburgh Edinburgh Scotland UK Scottish Universities Environmental Research Centre East Kilbride Scotland UK

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Investigation of lead and zinc dispersion from an ab.ndoned mine site at Tyndrum, Scotland, using tree b.rk measurements

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Chinese Journal Of Geochemistry 2006年第B8期25卷 23-23页

作者： Nurlidia Mansor Ian D. Pulford angus b. mackenzie Environmental Chemistry Department University of Glasgow G12 8QQ Scotland UK Scottish Universities Environmental Research Centre East Kilbride G75 0QF Scotland UK

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Associations and mob.lity of uranium in soils near a depleted uranium (DU) weapons testing site, SW Scotland

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Chinese Journal Of Geochemistry 2006年第B8期25卷 112-112页

作者： Margaret C. Graham John G. Farmer Ian W. Oliver angus b. mackenzie Rob.rt M. Ellam School of GeoSciences University of Edinburgh Edinburgh EH9 3JJ UK Scottish Universities Environmental Research Centne （SUERC） East Kilbride Glasgow G75 OQF UK

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Determining depleted uranium (DU) contamination in soils and salt marsh sediments in the vicinity of DU munitions testing sites in SW Scotland and NW England, UK

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Chinese Journal Of Geochemistry 2006年第B8期25卷 96-96页

作者： Ian W. Oliver angus b. mackenzie Rob.M. Ellam Margaret C. Graham John G. Farmer Scottish Universities Environmental Research Centre East Kilbride United Kingdom School of Geosclences University of Edinburgh Edinburgh United Kingdom

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Large-area nanopatterned graphene for ultrasensitive gas sensing

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Nano Research 2014年第5期7卷 743-754页

作者： Alb.rto Cagliani David Micheal angus mackenzie Lisa Katharina Tschammer Filippo Pizzocchero Kristoffer Almdal Peter b.ggild DTU Nanotech-Center for Nanostructured Graphene (CNG) and Department of Micro- and Nanotechnology Technical University ofDenmark Building 345 ~rsteds Plads 2800 Kgs. Lyngby Denmark

Chemical vapor deposited （CVD） graphene is nanopatterned using a spherical b.ock copolymer etch mask. The use of spherical rather than cylindrical b.ock copolymers allows homogeneous patterning of cm-scale areas without any sub.trate surface treatment. Raman spectroscopy was used to study the con- trolled generation of point defects in the graphene lattice with increasing etching time, confirming that alongside the nanomesh patterning, the nanopatterned CVD graphene presents a high defect density b.tween the mesh holes. The nanopatterned samples showed sensitivities for NO2 of more than one order of magnitude higher than for non-patterned graphene. NO2 concentrations as low as 300 ppt were detected with an ultimate detection limit of tens of ppt. This is the smallest value reported so far for non-UV illuminated graphene chemiresistive NO2 gas sensors. The dramatic improvement in the gas sensitivity is b.lieved to b. due to the high adsorption site density, thanks to the comb.nation of edge sites and point defect sites. This work opens the possib.lity of large area fab.ication of nanopatterned graphene with extremely high densities of adsorption sites for sensing applications.

关键词： graphene gas sensor nitrogen dioxide nanopatteming defects

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Cirrhotic portal hypertension: From pathophysiology to novel therapeutics

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World Journal of Gastroenterology 2020年第40期26卷 6111-6140页

作者： Lakmie S Gunarathne Harinda Rajapaksha Nicholas Shackel Peter W angus Chandana b.Herath Department of Medicine Melbourne Medical SchoolThe University of MelbourneHeidelbergVIC 3084Australia School of Molecular Science College of ScienceHealth and EngineeringLa Trobe UniversityBundooraVIC 3086Australia ANZAC Research Institute ConcordNSW 2139Australia Department of Gastroenterology Austin HealthHeidelbergVIC 3084Australia South Western Sydney Clinical School Faculty of MedicineUniversity of New South WalesIngham Institute for Applied Medical Research1 Campbell StreetLiverpoolNSW 2170Australia

Portal hypertension and b.eeding from gastroesophageal varices is the major cause of morb.dity and mortality in patients with cirrhosis. Portal hypertension is initiated b. increased intrahepatic vascular resistance and a hyperdynamic circulatory state. The latter is characterized b. a high cardiac output, increased total b.ood volume and splanchnic vasodilatation, resulting in increased mesenteric b.ood flow. Pharmacological manipulation of cirrhotic portal hypertension targets b.th the splanchnic and hepatic vascular b.ds. Drugs such as angiotensin converting enzyme inhib.tors and angiotensin Ⅱ type receptor 1 b.ockers, which target the components of the classical renin angiotensin system(RAS), are expected to reduce intrahepatic vascular tone b. reducing extracellular matrix deposition and vasoactivity of contractile cells and thereb. improve portal hypertension. However, these drugs have b.en shown to produce significant offtarget effects such as systemic hypotension and renal failure. Therefore, the current pharmacological mainstay in clinical practice to prevent variceal b.eeding and improving patient survival b. reducing portal pressure is non-selective-b.ockers(NSb.s). These NSb.s work b. reducing cardiac output and splanchnic vasodilatation b.t most patients do not achieve an optimal therapeutic response and a significant proportion of patients are unab.e to tolerate these *** statins, used alone or in comb.nation with NSb.s, have b.en shown to improve portal pressure and overall mortality in cirrhotic patients, further randomized clinical trials are warranted involving larger patient populations with clear clinical end points. On the other hand, recent findings from studies that have investigated the potential use of the b.ockers of the components of the alternate RAS provided compelling evidence that could lead to the development of drugs targeting the splanchnic vascular b.d to inhib.t splanchnic vasodilatation in portal hypertension. This rev

关键词： Portal hypertension Cirrhosis Intrahepatic vascular resistance Hyperdynamic circulatory state Splanchnic vasodilatation Portal b.ood flow Non-selective b.tab.ockers Alternate renin angiotensin system

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Riparian and Riverine Wildlife Response to a Newly Created b.idge Crossing

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Natural Resources 2012年第4期3卷 213-228页

作者： Joshua A. Vance Norse b. angus James T. Anderson West Virginia Department of Transportation Division of Highways Charleston USA West Virginia University Division of Forestry and Natural Resources Morgantown USA

Construction of man-made ob.ects such as roads and b.idges can influence wildlife presence and ab.ndance. We investtigated waterb.rds, songb.rds, anurans, turtles, small mammals, and furb.arers along the Ohio River, WV, at a new b.idge crossing, a 45-year old b.idge, and 1 or 2 islands with no b.idge and at 3 distances from the b.idge or center point at each site (0 m,100 m, and300 m). We sampled 19 waterb.rd, 60 songb.rd, 7 anuran, 5 turtle, 9 small mammal, and 4 furb.arer species. Great b.ue heron (Ardea herodias) ab.ndances were greater at the site with no b.idge. Songb.rd composition differed among sites and b.tween transects under and away from the b.idge with higher ab.ndances or association of rock pigeon (Columb. livia) and cliff swallow (Petrochelidon pyrrhonota) under the b.idges and lower ab.ndances ofCarolinawren (Thryothorus ludovicianus) and common yellowthroat (Geothlypis trichas) under the b.idges. Total small mammal ab.ndance, diversity, and richness were lower under the new b.idge compared to other sites and distances. We conclude that overall the new b.idge is causing minimal relative ab.ndance impacts to wildlife. However, great b.ue heron ab.ndance may b. altered due to noise and activity from the presence of the b.idge and minor short-term impacts to some songb.rds and small mammals directly under the b.idge in the form of hab.tat conversion, fragmentation, and loss due to removal of vegetation is apparent.

关键词： Great b.ue Heron Road Effects Small Mammals Songb.rds Waterb.rds

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Perceptions and Attitudes Towards Shoulder Padding and Shoulder Injury in Rugb. Union

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Journal of Science in Sport and Exercise 2022年第1期4卷 66-73页

作者： angus Hughes Matt Carré Heather Driscoll Department of Mechanical Engineering The University of SheffieldSheffield S102TNUK Advanced Manufacturing Research Centre The University of SheffieldSheffield S605TZUK

Purpose To develop an understanding of the role of shoulder padding in rugb. union b. investigating player perceptions and attitudes towards shoulder padding and extending research into shoulder injuries in *** An online survey was distrib.ted to past and current rugb. players over 13 years old in *** related to the participants’demographic,attitudes to shoulder padding and shoulder injury *** Six hundred and sixteen rugb. players responded to the survey;66.1%of respondents had worn shoulder padding at some *** age group 24-29 years old(ΔR^(2)=0.03,b.−0.53,P=0.015)had an inverse association with padding effectiveness while playing experience groups 1-2 years(ΔR^(2)=0.03,b.0.8,P=0.032),3-5 years(ΔR^(2)=0.03,b.0.70,P=0.002)and 6-9 years(ΔR^(2)=0.03,b.0.41,P=0)had a positive *** are 37.1%of respondents consider-ing shoulder padding to b. effective at preventing cuts and ab.asions with 21.9%finding it very effective;50.3%considered it to b. effective or very effective(9.7%)at preventing contusion;45.5%wore padding for injury prevention,while 19.2%wore padding to protect from reoccurring ***/ligament damage(57.5%)and b.uising(55.5%)were the most com-monly reported *** The primary reason for wearing shoulder padding was as a means of injury *** should focus on quantifying the injury preventive capab.lities of shoulder ***,cuts and ab.asion injuries to the shoulder are prevalent presenting new findings that these injuries are underreported.

关键词： Rugb. union Shoulder padding Protective equipment Epidemiology Attitudes

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Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2016年第35期22卷 8026-8040页

作者： Christopher Leung Chandana b.Herath Zhiyuan Jia Sof Andrikopoulos b.onwyn E b.own Michael J Davies Leni R Rivera John b.Furness Josephine M Forb.s Peter W angus Department of Medicine the University of MelbourneAustin HealthHeidelbergMelbourne Victoria 3084Australia Department of Gastroenterology and Hepatology Austin HealthAustin HospitalHeidelberg MelbourneVictoria 3084 Australia Heart Research Institute Newtown New South Wales 2042Austrulia University of Melb.urne Victoria 3052Australia Metab.lic Research Unit School of MedicineDeakin UniversityVictoria 3216Austrialia Glycation and Diab.tes Complications Group Mater Medical Research InstituteSouth BrisbaneQueensland 4101Australia

AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57b.6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic b.ochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fib.osis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte b.llooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet b. b.king further increased these markers of liver damage, b.t this was ab.ogated b. pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals b.t were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contrib.te to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fib.osis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD.

关键词： Advanced glycation end-products Fructose Steatohepatitis Non-alcoholic fatty liver disease Hepatic fib.osis Oxidative stress

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