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Phosphorylated tau as a toxic agent in synaptic mitochondria: implications in aging and Alzheimer’s disease

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Neural Regeneration Research 2022年第8期17卷 1645-1651页

作者： angie k.Torres Bastián I.Rivera Catalina m.Polanco Claudia Jara Cheril Tapia-Rojas Laboratory of Neurobiology of Aging Centro de Biología Celular y Biomedicina(CEBICEM)Facultad de Medicina y CienciaUniversidad San SebastiánSede Los LeonesSantiagoChile

During normal aging,there is a decline in all physiological functions in the *** of the most affected organs is the brain,where neurons lose their proper synaptic function leading to cognitive *** is one of the main risk.factors for the development of neurodegenerative diseases,such as Alzheimer’s *** of the main responsible factors for synaptic dysfunction in aging and neurodegenerative diseases is the accumulation of abnormal proteins forming *** most studied brain aggregates are the senile plaques,formed by Aβpeptide;however,the aggregates formed by phosphorylated tau protein have gained relevance in the last years by their *** is reported that neurons undergo severe mitochondrial dysfunction with age,with a decrease in adenosine 5′-triphosphate production,loss of the mitochondrial membrane potential,redox imbalance,impaired mitophagy,and loss of calcium buffer ***,abnormal tau protein interacts with several mitochondrial proteins,suggesting that it could induce mitochondrial ***,whether tau-mediated mitochondrial dysfunction occurs indirectly or directly is still unk.own.A recent study of our laboratory shows that phosphorylated tau at Ser396/404(k.own as PHF-1),an epitope commonly related to pathology,accumulates inside mitochondria during normal *** accumulation occurs preferentially in synaptic mitochondria,which suggests that it may contribute to the synaptic failure and cognitive impairment seen in aged ***,we review the main tau modifications promoting mitochondrial dysfunction,and the possible mechanism ***,we discuss the evidence that supports the possibility that phosphorylated tau accumulation in synaptic mitochondria promotes synaptic and cognitive impairment in ***,we show evidence and argue about the presence of phosphorylated tau PHF-1 inside mitochondria in Alzheimer’s disease,which could be considered as an early event

关键词： age pathology aging Alzheimer’s disease hippocampus memory mitochondria PHF-1 phosphorylated tau synaptic mitochondria tau

Photocatalytic carbon dioxide reduction by photocatalyst innovation

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Chinese Chemical Letters 2018年第6期29卷 734-746页

作者： angie Davina Tjandra Jun Huang School of Chemical and Biomolecular Engineering The University of Sydney Laboratory for Catalysis Engineering School of Chemical and Biomolecular Engineering The University of Sydney

The rising CO2 level, population boom and increasing energy demand prompts the need of an efficient and sustainable solution to tack.e the global warming issue. Reduction of greenhouse gas（GHG） emission through the conversion of detrimental CO2 into methanol is one of the most promising solutions for optimising economic and resource efficiency. The utilisation of the abundant and sustainable sunlight to replace thermal and electric energy for CO2 conversion to valuable chemicals is a highly sustainable process and attracted much research interests. Herein, we summarised the catalytic methods for CO2 conversion to methanol, reviewed the photocatalytic properties and efficient photocatalysts, as well as their performance. Carbon [78TD$IF]quantum dots（CQDs） as a new member of the carbon nanomaterials family have attracted increasing attention owing to their excellent photoluminescence property, light harvesting capability, charge recombination suppression and effective electron transport ability. This paper highlighted the multifaceted roles of CQDs in photocatalytic reactions. To this end, the challenges and future directions of CQDs-based photocatalysts have been outlined.

关键词： Carbon quantum dots Photocatalysis applications Carbon dioxide conversion methanol Carbon nanodots

5-HTR2A Polymorphisms rs6311 and rs6313 and major Depressive Disorder: A meta-Analysis

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Journal of Behavioral and Brain Science 2022年第10期12卷 499-513页

作者： k.ystal Castle White angie k. m.donald David m. Compton Behavioral Neuroscience Program Palm Beach Atlantic University West Palm Beach FL USA Hebrew University of Jerusalem Jerusalem Israel Department of Psychology Palm Beach Atlantic University West Palm Beach FL USA

rs6311 and rs6313 are two Single Nucleotide Polymorphisms (SNPs) on the Serotonin Receptor 2A gene (5-HTR2A) in complete link.ge disequilibrium. Numerous gene association studies have examined the relationships between one or both of these two polymorphisms and major Depressive Disorder (mDD), with conflicting results. The present meta-analysis examined 19 case-control gene association studies, 9 of which included rs6311 (n = 3382), and 15 of which included rs6313 (n = 5590). The strength of relationship with mDD was assessed by pooled odds ratios and 95% confidence intervals for both SNPs according to four genetic models. Heterogeneity was measured by Q and I2. Subgrouping was performed by minor allele and by ethnicity. Results were nonsignificant for all models and subgroups, suggesting that genotype alone does not play a major role in genetic susceptibility to depression. The potential for epistatic, epigenetic, and regulatory RNA interactions with these SNPs is discussed, and future areas of research are recommended.

关键词： Genetic Predisposition to Disease Receptors Serotonin Polymorphism Single Nucleotide Genetics Behavioral

~, novel approach for removal of an inflatable penile ;~rosthesis reservoir using laparoscopic instruments

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Asian Journal of Andrology 2017年第1期19卷 132-134页

作者： angie L Staller Courtney m Chang Gavin N Wagenheim Run Wang Division of Urology University of Texas McGovern Medical School Houston Texas 77030USA Department of Urology University of Texas MD Anderson Cancer Center HoustonTexas 77030 USA.

In the setting of an infected inflatable penile prosthesis （IPP）, removal of the reservoir is a surgical challenge. We describe a novel technique for IPP reservoir removal at the time of IPP explantation utilizing laparoscopic instruments. We present two cases of infected IPPs requiring complete removal of all components of the implant. The corporal cylinders and scrotal pump were removed via a single penoscrotal incision.

关键词： infected inflatable penile

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私募股权收购健康机构的利

商学院 2024年第8期 14-14页

作者： angie Basiouny 宾夕法尼亚大学沃顿商学院

一项名为“私募股权在门诊和住院行为健康领域所有权的地域渗透”的研究发现,目前美国有6%的心理健康机构和7%的成瘾治疗机构归私募股权公司所有。沃顿商学院医疗保健管理教授marissak.ng表示:“现在治疗机构非常稀缺,而私募股权公司看... 详细信息

一项名为“私募股权在门诊和住院行为健康领域所有权的地域渗透”的研究发现,目前美国有6%的心理健康机构和7%的成瘾治疗机构归私募股权公司所有。沃顿商学院医疗保健管理教授marissak.ng表示:“现在治疗机构非常稀缺,而私募股权公司看到这一机会,开始真正进入该领域。”

关键词：私募股权沃顿商学院收购所有权心理健康稀缺行为健康机构

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如何处理工作带来的焦虑

商学院 2024年第4期 14-14页

作者： angie Basiouny 宾夕法尼亚大学沃顿商学院

宾夕法尼亚大学沃顿商学院教授莫里斯·施韦策(maurice Schweitzer)在SiriusXm沃顿商业日报广播频道采访时表示:“焦虑不是一件令人感到愉快的事,但我们大多数人很多时候都生活在焦虑中。”施韦策指出,意识到焦虑在工作场所中普遍存在... 详细信息

宾夕法尼亚大学沃顿商学院教授莫里斯·施韦策(maurice Schweitzer)在SiriusXm沃顿商业日报广播频道采访时表示:“焦虑不是一件令人感到愉快的事,但我们大多数人很多时候都生活在焦虑中。”施韦策指出,意识到焦虑在工作场所中普遍存在是至关重要的。管理者需要预见到员工可能经历的焦虑,并采取行动来帮助他们应对。

关键词：宾夕法尼亚大学广播频道施韦策沃顿商学院莫里斯焦虑管理者

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AI带来的管理变革

商学院 2024年第9期 14-14页

作者： angie Basiouny 宾夕法尼亚大学沃顿商学院

作为美国东北大学达莫尔·麦克金商学院院长,戴维·德·克雷默具有丰富的学术和实践经验。他亲眼目赌了企业领导者在将人工智能应用到工作中时所面临的挑战和担忧:他们需要利用人工智能(AI)来提高效率、压制竞争对手、赚取更多利润。

关键词：人工智能应用企业领导者克雷默商学院院长提高效率竞争对手实践经验

Exploring the safety and efficacy of adding k.toconazole to tacrolimus in pediatric renal transplant immunosuppression

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World Journal of Transplantation 2020年第11期10卷 356-364页

作者： Sindy méndez Brook. m Ramay angie Aguilar-González Randall Lou-meda Fundación para el Niño Enfermo Renal-FUNDANIER Hospital Roosevelt GuatemalaGuatemala 01010Guatemala Department of Pharmaceutical Chemistry Universidad del Valle de GuatemalaGuatemala 01015Guatemala

BACk.ROUND Guatemala is a developing country in Central America with limited health *** order to expand successful renal transplant care to children and adolescents at the lowest possible cost,our pediatric renal transplant clinic uses a post-transplant tacrolimus-sparing strategy via inhibition of *** To study the safety,efficacy and the associated cost reduction of k.toconazole in combination with tacrolimus in this pediatric *** A retrospective chart review was carried out among the cohort of pediatric renal transplant recipients treated at the Foundation for pediatric renal patients(Fundación para el Niño Enfermo Renal-FUNDANIER),a pediatric tertiary care renal transplant center in Guatemala City,*** charts were reviewed to ascertain the number of transplant recipients who were transitioned from tacrolimus based immunosuppression to combination therapy with k.toconazole and ***-five post-transplant patients that used k.toconazole combined with tacrolimus were ***,clinical and laboratory data was collected from patient charts before and after the *** Of the 25 patient charts reviewed 12(48%)patients were male and the average patient age was 13 ***-four(96%)transplants were from living *** was a non-significant difference between the mean tacrolimus doses six months and two months prior to k.toconazole:-0.10±0.04(95%CI:0.007,-0.029),P=***,the difference between the mean tacrolimus doses six months prior to k.toconazole initiation and six months after k.toconazole addition was significant:0.06±0.05(95%CI:-0.034,-0.086)Pmus doses were reduced by 45%after the addition of *** levels of tacrolimus ranged between 6.8-8.8 ng/mL during the study period and patients demonstrated an increase in estimated glomerular filtration *** combination of tacrolimus and k.toconazole resulted in a 21%reduction in ***

关键词： Transplant Immunosuppression Tacrolimus k.toconazole Pediatric Chart review

Writing the body in motion

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Writing the body in motion