检索结果-南通市图书馆

Journal of Geriatric Cardiology 2018年第1期15卷 66-75页

作者： Manolis Vavuranakis Konstantinos Kalogeras angelos Michail Kolokathis Dimitrios Vrachatis Nikolaos Magkoutis Gerasimos Siasos Euaggelos Oikonomou Maria Kariori Theodoros Papaioannou Maria Lavda Carmen Moldovan Ourania Katsarou Dimitrios Tousoulis The First Department of Cardiology Hippokration Hospital Medical School National & Kapodistrian University of Athens Ilioupoli Greece

Transcatheter aortic valve implantation （TAVI） carries a significant thromboembolic and concomitant bleeding risk, not only during the procedure but also during the periprocedural period. Many issues concerning optimal antithrombotic therapy after TAVI are still under debate. In the present review, we aimed to identify all relevant studies evaluating antithrombotic therapeutic strategies in relation to clinical outcomes after the procedure. Four randomized control trials （RCT） were identified analyzing the post-TAVI antithrombotic strategy with all of them utilizing aspirin lifelong plus clopidogrel for 3-6 months. Seventeen registries have been identified, with a wide variance among them regarding baseline characteristics, while concerning antiplatelet therapy, clopidogrel duration was ranging from 3-12 months. Four non-randomized trials were identified, comparing single vs. dual antiplatelet therapy after TAVI, in respect of investigating thromboembolic outcome events over bleeding complications. Finally, limited data from a single RCT and a retrospective study exist with regards to anticoagulant treatment during the procedure and the optimal antithrombotic therapy when concomitant atrial fibrillation. In conclusion, due to the high risk and frailty of the treated population, antithrombotic therapy after TAVI should be carefully evaluated. Diminishing ischaemic and bleeding complications remains the main challenge in these patients with further studies to be needed in this field.

关键词： Antiplatelets Antithrombotic Bleeding Stroke Transcatheter aortic valve implantation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An early evaluation of translocation actions for endangered plant species on Mediterranean islands

引用

Plant Diversity 2019年第2期41卷 94-104页

作者： Giuseppe Fenu Gianluigi Bacchetta S.Christodoulou Charalambos Christini Fournaraki Gian Pietro Giusso del Galdo Panagiota Gotsiou angelos Kyratzis Carole Piazza Magdalena Vicens Maria Silvia Pinna Bertrand de Montmollin Centro Conservazione Biodiversità (CCB) Dipartimento di Scienze della Vita e dell'Ambiente (DISVA) Università degli Studi di Cagliari Hortus Botanicus Karalitanus (HBK) Università degli Studi di Cagliari Department of Forests Ministry of Agriculture Rural Development and Environment CIHEAM Mediterranean Agronomic Institute of Chania (MAICh) Department of Biological Geological and Environmental Sciences University of Catania Agricultural Research Institute Ministry of Agriculture Rural Development and Environment Office de l’Environnement de la Corse (OEC) Jardí Botànic de Sóller Foundation (JBS) Mediterranean Plant Specialist Group (IUCN/SSC)

In situ conservation is widely considered a primary conservation strategy. Plant translocation, specifically, represents an important tool for reducing the extinction risk of threatened species. However, thus far, few documented translocations have been carried out in the Mediterranean islands. The CareMediflora project, carried out on six Mediterranean islands, tackles both short-and long-term needs for the insular endangered plants through in situ and ex situ conservation actions. The project approach is based on using ex situ activities as a tool to improve in situ conservation of threatened plant *** island plants(representing 45 taxa) were selected for translocations using common *** the translocations, several approaches were used, which differed in site selection method, origin of genetic material, type of propagative material, planting method, and more. Although only preliminary data are available, some general lessons can be learned from the experience of the CareMediflora project. Among the factors restricting the implementation of translocations, limited financial resources appear to be the most important. Specific preliminary management actions, sometimes to be reiterated after translocation, increase the overall cost, but often are necessary for translocation success. Translocation using juvenile/reproductive plants produces better results over the short term,although seeds may provide good results over the long run(to be assessed in the future). Regardless,plant translocation success can only be detected over long periods; therefore, proper evaluation of plant translocations requires a long-term monitoring protocol. Care-Mediflora project represents the first attempt to combine the existing approaches in a common plant conservation strategy specifically focusing on the Mediterranean islands.

关键词： Care-Mediflora project ex situ conservation in situ conservation Insular flora Threatened plant populations

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Destabilization of HIF-1a by Diabetes, Oxidative Stress, Obesity and Other Related Disorders

引用

Journal of Diabetes Mellitus 2023年第2期13卷 142-162页

作者： angelos Karavasilis Petros Karkalousos Maria Trapali Christina Fountzoula George Albert Karikas Department of Biomedical Sciences School of Health and Care Sciences University of West Attica Athens Greece

One of the most fundamental molecular processes in response to hypoxia is the activation and stabilization of a transcriptional factor called hypoxia induced factor 1a (HIF-1a), which is responsible for the regulation of many downstream effector genes. Multiple key biological pathways such as proliferation, energy metabolism, invasion, and metastasis are governed by these genes. This article discusses the role of hypoxia-inducible factor 1a (HIF-1a) in metabolic and pathological processes, particularly in adipose tissue, oxidative stress, inflammation, diabetes and cancer. HIF1A is a basic helix-loophelix PAS domain containing protein, and is considered as the master transcriptional regulator of cellular and developmental response to hypoxia. HIF-1a regulates the expression of genes involved in angiogenesis, glucose metabolism, inflammation and oxidative stress. In obesity, adipose tissue hypoxia leads to increased expression of HIF-1a, which can lead to chronic inflammation and adipose tissue dysfunction. Another field that HIF-1a is also involved in cancer pathogenesis pathways, such as proliferation, invasion, angiogenesis, and metastasis, and is considered a potential therapeutic target for metabolic/genetic diseases and cancer. Direct and indirect HIF-1 inhibitors have been identified, but only a few have entered clinical trials due to their multiple side effects.

关键词： HIF-1a Diabetes Oxidative Stress Obesity Cancer Angiogenesis Mitochondria

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An Alternative to Flare Gas Processing:A Feasibility Study of Natural Gas to Liquid Processes

引用

材料科学与工程（中英文A版） 2021年第1期11卷 11-25页

作者： angelos A.Panteloglou Zoe D.Ziaka Savvas P.Vasileiadis Department of Catalysis and Environmental Protection School of Technology and Physical SciencesHellenic Open UniversityPatra 26335Greece

The quantities of gas released into the environment during the extraction and processing of crude oil,by flaring,constitute a vast source of mineral wealth which can be used to produce other useful *** processes studied in this paper,as alternatives to the above problem,are the ones used in Shell Pearl Qatar project and Oryx GTL *** projects produce liquid fuels,mainly naphtha and diesel,in addition to more special fuel such as *** paper is a feasibility study of a project that makes use of the flare gas from the State of Texas,U.S.A.,as a feedstock to a process similar to either Shell Pearl Qatar project,or Oryx GTL *** objective of this study is to determine the price range for crude oil over which an investment to similar projects can be *** MS Excel Model was developed in order to perform calculations having as a variable the crude oil price and taking into account all the process and project’s financial *** results of this model showed that a project similar to Shell Pearl Qatar remains profitable in crude oil price above$57.76/barrel,while a project similar to Oryx GTL remains viable for crude oil price over$31.4/*** the price range$55-$60/barrel,the payout of the corresponding to Shell Pearl Qatar project will be in about 15.2 years and 3.3 years for a project similar to Oryx ***,using the financial principles of this study we can apply them to any process in order to determine under what conditions will remain viable.

关键词： Natural gas conversion liquid fuel production membrane reactor technology economical assessments Shell Pearl Qatar process petroleum engineering

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

奉节脐橙果实苯丙氨酸解氨酶活性及其基因表达与果皮褐变的关系

引用

植物生理与分子生物学学报 2006年第3期32卷 381-386页

作者：李正国高雪樊晶杨迎伍李道高 angelos K.Kanellis 重庆大学基因工程研究中心西南大学园艺园林学院 Dept.of Pharmaceutical Sciences Aristotle University of Thessaloniki54124 ThessalonikiGreece

柑橘果皮褐变严重影响果实的商品价值和耐贮性。以奉节脐橙(CitrussinensisOsbeck)果实为材料,通过采后常温、涂蜡、低温、机械损伤等处理研究了果实果皮褐变率、苯丙氨酸解氨酶(PAL)活性及PAL基因在果皮褐变过程中表达水平的变化。结... 详细信息

柑橘果皮褐变严重影响果实的商品价值和耐贮性。以奉节脐橙(CitrussinensisOsbeck)果实为材料,通过采后常温、涂蜡、低温、机械损伤等处理研究了果实果皮褐变率、苯丙氨酸解氨酶(PAL)活性及PAL基因在果皮褐变过程中表达水平的变化。结果表明,涂蜡、损伤处理均极显著地提高果实的果皮褐变率,而低温贮藏可显著降低其发生率;贮藏期间各处理的PAL活性均呈上升趋势,损伤处理PAL活性显著高于对照。果实发生褐变或受到机械损伤后,PAL2、PAL6基因的表达均比对照明显增强。结果首次表明脐橙果实PAL活性变化以及PAL2基因的表达与果皮褐变具有非常密切的关系。

关键词：脐橙(Citrus sinensis Osbeck) 果皮褐变苯丙氨酸解氨酶(PAL) PAL基因表达

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

柑橘果皮生理性病变的发生与控制

引用

重庆大学学报（自然科学版） 2006年第5期29卷 64-68页

作者：高雪李正国杨迎伍 angelos K.Kanellis 重庆大学生物工程学院基因工程中心教育部生物力学与组织工程重点实验室 Dept.of Pharmaceutical Sciences Aristotle University of Thessaloniki54124 ThessalonikiGreece

对柑橘发生的几种常见生理性果皮病变,包括褐斑病、油斑病、果斑等做了简要综述;描述了其在田间和采后的主要病征;对发病机制、影响因素以及各病变间的相互联系与区别进行了阐述;对具体病变的现有控制措施做了细致归纳;为规范柑橘果皮... 详细信息

对柑橘发生的几种常见生理性果皮病变,包括褐斑病、油斑病、果斑等做了简要综述;描述了其在田间和采后的主要病征;对发病机制、影响因素以及各病变间的相互联系与区别进行了阐述;对具体病变的现有控制措施做了细致归纳;为规范柑橘果皮生理性病变的分类,明确发病机理,研究有效的控制及防治措施等提供参考.

关键词：柑橘果皮生理性病变发生控制

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Design and Construction of a Forest Village in Greece

引用

Journal of Environmental Science and Engineering(B) 2018年第2期7卷 47-54页

作者： Sarantis-angelos Liampas Christos Stamatiou Dimitris Farmakis George Tasionas Christodoulos Daoutis and Vasileios Drosos Institute of Forest Engineering Sciences and Surveying Department of Forestry and Management of Environment and Natural ResourcesDemocritus University of ThraceOrestiada 68200Greec

The aim of this paper is the study for the construction of a forest village in the area of Souvardo in Kalavrita in the prefecture of Achaia. This paper presents the history and purpose of forest villages, as well as the laws that govern them. The methodology of the paper is analyzed and the particular characteristics of the study area are examined with the accompaniment of the general characteristics related to the formation of the space. Further, aerial photographs are listed with the help of Google Earth program, giving emphasis to the general plan of the study area. The reception building and the host installation of the forest village are described, as well as the building and topographic plans are designed with the use of AutoCAD and Photoshop programs. Furthermore, the cost of the development project is analyzed. Finally, the conclusions of the study and recommendations to the visitor of the area about sights, natural landscapes and archaeological sites axe given. Criteria for intervention and promotion of tourism and proposals for tourism development in the area, such as ideas for the development of cultural tourism and ecotourism in the region, are suggested.

关键词： Recreational activities cultural tourism ecotourism stonework AutoCAD Photoshop.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cytotoxic T cells isolated from healthy donors and cancer patients kill TGFβ-expressing cancer cells in a TGFβ-dependent manner

引用

Cellular & Molecular Immunology 2021年第2期18卷 415-426页

作者： Morten Orebo Holmström Rasmus Erik Johansson Mortensen angelos Michail Pavlidis Evelina Martinenaite Stine Emilie Weis-Banke Mia Aaboe-Jørgensen Simone Kloch Bendtsen Özcan Met Ayako Wakatsuki Pedersen Marco Donia Inge Marie Svane Mads Hald Andersen Department of Oncology National Center for Cancer Immune TherapyCopenhagen University HospitalHerlevDenmark IO Biotech ApS CopenhagenDenmark Institute for Immunology and Microbiology Copenhagen UniversityCopenhagenDenmark

Transforming growth factor-beta(TGFβ)is a highly potent immunosuppressive *** TGFβis a tumor suppressor in early/premalignant cancer lesions,the cytokine has several tumor-promoting effects in advanced cancer;abrogation of the antitumor immune response is one of the most important tumor-promoting *** several immunoregulatory mechanisms have recently been shown to be targets of specific T cells,we hypothesized that TGFβis targeted by naturally occurring specific T cells and thus could be a potential target for immunomodulatory cancer ***,we tested healthy donor and cancer patient T cells for spontaneous T-cell responses specifically targeting 3820-mer epitopes derived from TGFβ*** identified numerous CD4^(+)and CD8^(+)T-cell responses against several epitopes in TGFβ.Additionally,several ex vivo responses were *** enriching specific T cells from different donors,we produced highly specific cultures specific to several TGFβ-derived *** CD8^(+)T-cell clones specific for both a 20-mer epitope and a 9-mer HLA-A2 restricted killed epitope peptide were pulsed in HLA-A2+target cells and killed the HLA-A2+cancer cell lines THP-1 and ***,stimulation of THP-1 cancer cells with cytokines that increased TGFβexpression increased the fraction of killed *** conclusion,we have shown that healthy donors and cancer patients harbor CD4^(+)and CD8^(+)T cells specific for TGFβ-derived epitopes and that cytotoxic T cells with specificity toward TGFβ-derived epitopes are able to recognize and kill cancer cell lines in a TGFβ-dependent manner.

关键词： Immune regulation TGFbeta cancer T cells adaptive immunity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rehabilitation of Semi-mountainous Forest Area Using Bioclimatic Forest Constructions in Greece

引用

Journal of Environmental Science and Engineering(A) 2018年第2期7卷 82-88页

作者： Sarantis-angelos Liampas Christos Stamatiou Dimitris Farmakis Christodoulos Daoutis George Tasionas Vasileios Drosos Institute of Forest EngineeringSciences and Surveying Department of Forestry and Management of Environment and Natural ResourcesDemocritus University of ThraceOrestiada 68200Greece

Forest constructions are structures erected for serving the forest exploitation and utilization of its products,including *** construction principals of a standard forest village with wooden lodgings apply principles of bioclimatic design and use ecological building *** highlights the area and helps to maintain the natural beauty of the *** analysis of the area of the forest village requires the creation of topographic plan with great *** drawing in AutoCAD in coordinate system HGRS’87 with contour interval 2 meters with the help of geodetic GPS was *** aim of this paper was the rehabilitation of a semi-mountainous area taking into consideration environmental,economic,ergonomic and architectural constrains with the help of Google *** area of the camp outside the village of Dadia of Evros Prefecture was granted by the army to the Forest Office of Soufli and remains unexploited until *** installations were recorded and shown together with the topographic diagram and an image from Google Earth for the *** the proposed facilities are presented in a Google Earth image and in a three-dimensional *** forest village will be composed of 20 wooden lodges with a capacity of 4 persons *** lodges will be designed around the bioclimatic design,in order to exercise the least impact on the natural environment and to meet the needs of residents for a comfortable and relaxed *** landscaping was based on better utilization and lower environmental cost of construction in the landscape.

关键词： Forest constructions forest village geodetic GPS landscape Google Earth AutoCAD

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The genomes of medicinal skullcaps reveal the polyphyletic origins of clerodane diterpene biosynthesis in the family Lamiaceae

引用

Molecular Plant 2023年第3期16卷 549-570页

作者： Haixiu Li Song Wu Ruoxi Lin Yiren Xiao Ana Luisa Malaco Morotti Ya Wang Meytal Galilee Haowen Qin Tao Huang Yong Zhao Xun Zhou Jun Yang Qing Zhao angelos K.Kanellis Cathie Martin Evangelos C.Tatsis National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China University of Chinese Academy of Sciences Beijing 100049China Novogene Bioinformatics Institute BeijingChina Shanghai Key Laboratory of Plant Functional Genomics and Resources Shanghai Chenshan Botanical GardenShanghai Chenshan Plant Science Research CenterChinese Academy of SciencesShanghai 201602 Group of Biotechnology of Pharmaceutical Plants Lab.of PharmacognosyDepartment of Pharmaceutical SciencesAristotle University of Thessaloniki54124 ThessalonikiGreece John Innes Centre Norwich NR47UHUK CEPAMS-CAS-JIC Centre of Excellence for Plant and Microbial Sciences Shanghai 200032China

The presence of anticancer clerodane diterpenoids is a chemotaxonomic marker for the traditional Chinese medicinal plant Scutellaria barbata,although the molecular mechanisms behind clerodane biosynthesis are ***,we report a high-quality assembly of the 414.98 Mb genome of *** into 13 *** phylogenomic and biochemical data,we mapped the plastidial metabolism of kaurene(gibberellins),abietane,and clerodane diterpenes in three species of the family Lamiaceae(Scutellaria barbata,Scutellaria baicalensis,and Salvia splendens),facilitating the identification of genes involved in the biosynthesis of the clerodanes,kolavenol,and *** show that clerodane biosynthesis evolved through recruitment and neofunctionalization of genes from gibberellin and abietane *** the assumed monophyletic origin of clerodane biosynthesis,which is widespread in species of the Lamiaceae,our data show distinct evolutionary lineages and suggest polyphyletic origins of clerodane biosynthesis in the family *** study not only provides significant insights into the evolution of clerodane biosynthetic pathways in the mint family,Lamiaceae,but also will facilitate the production of anticancer clerodanes through future metabolic engineering efforts.

关键词： Scutellaria barbata genome clerodane diterpenoids biosynthesis specialized metabolism evolution

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：