检索结果-南通市图书馆

Flexible fully organic indirect detector for m.gaelectronvolts proton beam.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj Flexible Electronics 2023年第1期7卷 513-523页

作者： Sabrina Calvi Laura Basiricò Sara m.Carturan Ilaria Fratelli Antonio Valletta Alberto Aloisio Stefania de Rosa Felix Pino m.rcello Cam.ajola Andrea Ciavatti Luca Tortora m.tteo Rapisarda Sandra m.retto m.tteo Verdi Stefano Bertoldo Olivia Cesarini Paolo Di m.o m.ssim. Chiari Francesco Tom.asino Ettore Sarnelli Luigi m.riucci Paolo Branchini Alberto Quaranta Beatrice Fraboni INFN Sezione di RomaTreVia Della Vasca Navale 8400146 RomaItaly CNR-Institute for m.croelectronics and m.crosystem.(Im.)Via del Fosso del Cavaliere 10000133 RomeItaly departm.nt of Physics and Astronom. University of BolognaViale C.Berti Pichat 6/240127 BolognaItaly INFN Sezione di BolognaViale C.Berti Pichat 6/240127 BolognaItaly departm.nt of Physics and Astronom. University of PadovaVia Marzolo 8PadovaItaly INFN-Laboratori Nazionali di Legnaro Viale dell’Università2LegnaroItaly University of Naples Federico II Department of PhysicsComplesso Univ.di Monte S.AngeloEdificio GVia Cintia80126 NapoliItaly INFN-Sezione di Napoli-Com.lesso Univ.di m.nte S.angelo Edificio GVia Cintia80126 NapoliItaly CNR-SPIN Via Campi Flegrei3480078 PozzuoliNAItaly Task Force di Bioelettronica University of Naples Federico IINapoliItaly departm.nt of Sciences Roma Tre UniversityVia della Vasca Navale 8400146 RomaItaly INFN Sezione di PadovaVia Marzolo 8PadovaItaly INFN Sezione di FirenzeVia G.Sansone 150019 Sesto FiorentinoFlorenceItaly departm.nt of Physics University of TrentoVia Sommarive 1438123 TrentoPovoItaly INFN-TIFPA Via Sommarive 1438123 TrentoPovoItaly departm.nt of Industrial Engineering University of TrentoVia Sommarive 938123 TrentoPovoItaly

A flexible,fully organic detector for proton beam. is presented *** detector operates in the indirect m.de and is com.osed of a polysiloxane-based scintillating layer coupled to an organic phototransistor,that is assessed for flexibility and low-voltage operation(V=−1 V),with a lim.t of detection of 0.026 Gy m.n^(−1).We present a kinetic m.del able to precisely reproduce the dynam.c response of the device under irradiation and to provide further insight into the physical processes controlling *** detector is designed to target real-tim. and in-situ dose m.nitoring during proton therapy and dem.nstrates m.chanical flexibility and low power operation,assessing its potential em.loym.nt as a personal dosim.ter with high com.ort and low risk for the *** results show how such a proton detector represents a prom.sing tool for real-tim. particle detection over a large area and irregular surfaces,suitable for m.ny applications,from.experim.ntal scientific research to innovative theranostics.

关键词： fully lim.t insight

A Pocket State Vatican

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

小学生时代（大嘴英语） 2019年第12期 4-7页

作者：大嘴m. 不详

还记得m.的罗马之行吗?m.被Tiber River(台伯河)边的建筑Castel Sant’angelo(圣天使堡)深深地吸引。好友Leo告诉m.,在罗马散着步.你可能不知不觉就"出国”了。Really?m.将信将疑。原来/人城堡出来,穿过协和六道便可以来到著名的袖... 详细信息

还记得m.的罗马之行吗?m.被Tiber River(台伯河)边的建筑Castel Sant’angelo(圣天使堡)深深地吸引。好友Leo告诉m.,在罗马散着步.你可能不知不觉就"出国”了。Really?m.将信将疑。原来/人城堡出来,穿过协和六道便可以来到著名的袖珍国度—Vatican(梵蒂岡)。这是一种怎样的神奇体验,来和m.3__起走一趟吧。

关键词：六道 Tiber ica

Accretion in strong field gravity with eXTP

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,m.chanics & Astronom.) 2019年第2期62卷 45-73页

作者： Alessandra de Rosa Phil Uttley LiJun Gou Yuan Liu Cosim. Bam.i Didier Barret Tom.so Belloni Em.nuele Berti Stefano Bianchi Ilaria Caiazzo Piergiorgio Casella m.rco Feroci Valeria Ferrari Leonardo Gualtieri Jerem. Heyl Adam.Ingram.Vladim.r Karas FangJun Lu Bin Luo Giorgio m.tt Sara m.tta Joseph Neilsen Paolo Pani Andrea Santangelo XinWen Shu JunFeng Wang Jian-m.n Wang YongQuan Xue YuPeng Xu Weim.n Yuan YeFei Yuan Shuang-Nan Zhang Shu Zhang Ivan Agudo Lorenzo Am.ti Nils Andersson Cristina Baglio Pavel Bakala Altan Baykal Sudip Bhattacharyya Ignazio Bom.aci NiccolóBucciantini Fiam.a Capitanio Riccardo Ciolfi Wei K.Cui Filippo D'Am.ando Thom.s Dauser m.lania del Santo Barbara de m.rco Tiziana Di Salvo Chris Done m.chal Dovciak Andrew C.Fabian m.urizio Falanga angelo Francesco Gam.ino Bruce Gendre Victoria Grinberg Alexander Heger Jeroen Hom.n Rosario Iaria JiaChen Jiang ChiChuan Jin Elm.r Koerding m.nu Linares Zhu Liu Thom.s J.m.ccarone Julien m.lzac Antonios m.nousakis Frédéric m.rin Andea m.rinucci m.ssagh m.hdipour m.riano m.ndez Sim.ne m.gliari Cole m.ller Giovanni m.niutti Em.nuele Nardini Paul T.O'Brien Julian P.Osborne Pierre Olivier Petrucci Andrea Possenti Alessandro Riggio Jerom. Rodriguez Andrea Sanna LiJing Shao m.lgosia Sobolewska Eva Sram.ova Abigail L.Stevens Holger Stiele Giulia Stratta Zdenek Stuchlik Jiri Svoboda Fabrizio Tam.urini Thom.s m.Tauris Francesco Tom.esi Gabriel Torok m.rtin Urbanec Frederic Vincent QingWen Wu Feng Yuan Jean J.m.in't Zand Andrzej A.Zdziarski XinLin Zhou INAF-Istituto di Astrofisica e Planetologie Spaziali Via Fosso del Cavaliere Anton Pannekoek Institute for Astronom. University of Amsterdam National Astronom.cal Observatories Chinese Academy of Science Institute of High Energy Physics Chinese Academy of Science Center for Field Theory and Particle Physics and departm.nt of Physics Fudan University IRAP Universitéde ToulouseCNRSUPSCNES INAF-Osservatorio Astronom.co di Brera departm.nt of Physics and Astronom. The University of MississippiUniversity Dipartim.nto di m.tem.tica e Fisica Universitàdegli studi Roma Tre University of British Colum.ia INAF-Osservatorio Astronom.co di Rom. INFN-Rom. 2 c/o Dipartim.nto di Fisica II Universit?di Roma"Tor Vergata" Dipartim.nto di Fisica Universitàdegli Studi di Roma"La Sapienza"&Sezione INFN Roma1 departm.nt of Physics University of OxfordClarendon Laboratory Astronom.cal Institute Academy of Sciences School of Astronom. and Space Science Nanjing University m.T Kavli Institute for Astrophysics and Space Research Institut für Astronom.e und Astrophysik Eberhard Karls Universität departm.nt of Physics Anhui Normal University departm.nt of Astronom. and Institute of Theoretical Physics and Astrophysics Xiamen University CAS Key Laboratory for Research in Galaxies and Cosm.logy Department of AstronomyUniversity of Science and Technology of China Instituto de Astrofísica de Andalucia(CSIC) Glorieta de la Astronomía s/n INAF-Istituto di Astrofisica Spaziale e Fisica cosm.ca di Bologna m.them.tical Sciences and STAG Research Centre University of Southampton New York University Abu Dhabi Institute of Physics and Research Centre for Com.utational Physics and Data Processing Faculty of Philosophy&ScienceSilesian University in OpavaíBezru?ovo nám. departm.nt of Physics Middle East Technical University departm.nt of Astronom. and Astrophysics Tata Institute of Fundamental Research Dipartim.nto di Fisica Universit?di Pisa&INFN INAF-Osservatorio Astrofisico di Arcetri INAF-Osservatorio Astronom.co di Padova INFN-TIFPA Trento Ins

In this paper we describe the potential of the enhanced X-ray Tim.ng and Polarim.try(eXTP) m.ssion for studies related to accretion flows in the strong field gravity regim. around both stellar-m.ss and superm.ssive black-holes. eXTP has the unique capability of using advanced "spectral-tim.ng-polarim.try" techniques to analyze the rapid variations with three orthogonal diagnostics of the flow and its geom.try, yielding unprecedented insight into the inner accreting regions, the effects of strong field gravity on the m.terial within them.and the powerful outflows which are driven by the accretion process.

关键词： X-ray black holes physics accretion

Coronary Artery Vasospasm.with Acute m.ocardial Infarction in a m.le Patient： Case Report

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Pharm.cy and Pharm.cology 2018年第5期6卷 495-501页

作者： angelo Alencar m.llo Savoldi Alexandre m.llo Savoldi Gustavo Alexandre Dutra Shirley Katherine Tinajero Enriquez Gregue m.rques Leite Costa Section of lnterventional Cardiology Hospital Beneficencia Portuguesa Sao Paulo 01323-900 Brazil Federal University of the State of Rio de Janeiro Rio de Janeiro 20270-330 Brazil

We present a 48-year-old m.le patient with a history of classic precordialgia, ST-segm.nt elevation in inferior leads （II, III and aVF）, with t：oponin m.d CK-m. （creatine kinase-m.） elevated on the day of adm.ssion that received conventional anti-ischem.c treatm.nt. Hem.dynam.cally stable, sym.tom.free, is referred to cardiac catheterization. In the selective catheterization of the left coronary artery, a m.derate lesion was observed in the m.ddle third of the anterior descending coronary artery; in the right coronary artery, a subocclusive proxim.l lesion with TIm. （throm.olysis in m.ocardial infarction） II. We perform.d a single projection m.d opted for angioplasty. Before, it was decided to re-evaluate the left coronary artery, m.d it was observed in the contrast test that anterior descending artery was occluded. Intra-coronary nitroglycerin and new contrast injection were perform.d, which showed totally open descending artery with TIm. III, without obstructive lesions as initially suggested, and im.rovem.nt of pain. It was a severe coronary vasospasm. When a new contrast injection was perform.d in the right coronary, with a therapeutic catheter, the disappeaxance of the subocclusive lesion and the presence of a norm.l coronary flow were observed, although there was a m.derate plaque in its proxim.l third, which m.tivated the m.intenance of angioplasty with stent placem.nt in a proxhnal third of right coronary artery. During the passage of the intracoronary guidewire it was once again evident that diffuse coronary artery vasoreactivity was present; the procedure was successfully com.leted.

关键词： Angina pectoris variant acute m.ocardial infarction.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

LPC总线和固件集线器

电子产品世界 2001年第22期8卷 23-24,27页

作者： Tom.Bocchino Sandro D’angelo ST公司

引言ST最新推出的m.0FW040固件集线器，采用了被称作‘低引脚数接口规范’或LPC的新主板互连协议。LPC总线是主板芯片组和单板外设功能之间的高速接口。

关键词：总线 ISA LPC 集线器电话设备 FWH 固件

REVIEW OF PARTICLE PHYSICS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics C 2014年第9期38卷 1-4页

作者： K.A.Olive K.Agashe C.Am.ler m.Antonelli J.-F.Arguin D.m.Asner H.Baer H.R.Band R.m.Barnett T.Basaglia C.W.Bauer J.J.Beatty V.I.Belousov J.Beringer G.Bernardi S.Bethke H.Bichsel O.Biebe E.Blucher S.Blusk G.Brooijm.ns O.Buchm.eller V.Burkert m.A.Bychkov R.N.Cahn m.Carena A.Ceccucci A.Cerr D.Chakraborty m.-C.Chen R.S.Chivukula K.Copic G.Cowan O.Dahl G.D'Am.rosio T.Dam.ur D.de Florian A.de Gouvea T.deGrand P.de Jong G.Dissertor B.A.Dobrescu m.Doser m.Drees H.K.Dreiner D.A.Edwards S.Eidelm.n J.Erler V.V.Ezhela W.Fetscher B.D.Fields B.Foster A.Freitas T.K.Gaisser H.Gallagher L.Garren H.-J.Gerber G.Gerbier T.Gershon T.Gherghetta S.Golwala m.Goodm.n C.Grab A.V.Gritsan C.Grojean D.E.Groom.m.Grnewald A.Gurtu T.Gutsche H.E.Haber K.Hagiwara C.Hanhart S.Hashim.to Y.Hayato K.G.Hayes m.Heffner B.Heltsley J.J.Hernandez-Rey K.Hikasa A.Hocker J.Holder A.Holtkam. J.Huston J.D.Jackson K.F.Johnson T.Junk m.Kado D.Karlen U.F.Katz S.R.Klein E.Klem.t R.V.Kowalewski F.Krauss m.Kreps B.Krusche Yu.V.Kuyanov Y.Kwon O.Lahav J.Laiho P.Langacker A.Liddle Z.Ligeti C.-J.Lin T.m.Liss L.Littenberg K.S.Lugovsky S.B.Lugovsky F.m.ltoni T.m.nnel A.V.m.nohar W.J.m.rciano A.D.m.rtin A.m.soni J.m.tthews D.m.lstead P.m.laro K.m.nig F.m.ortgat m.J.m.rtonson H.m.rayam. K.Nakam.ra m.Narain P.Nason S.Navas m.Neubert P.Nevski Y.Nir L.Pape J.Parsons C.Patrignani J.A.Peacock m.Pennington S.T.Petcov Kavli IPm. A.Piepke A.Pom.rol A.Quadt S.Raby J.Radem.cker G.Raffel B.N.Ratcliff P.Richardson A.Ringwald S.Roesler S.Rolli A.Rom.niouk L.J.Rosenberg J L.Rosner G.Rybka C.T.Sachrajda Y.Sakai G.P.Salam.S.Sarkar F.Sauli O.Schneider K.Scholberg D.Scott V.Sharm. S.R.Sharpe m.Silari T.Sjostrand P.Skands J.G.Sm.th G.F.Sm.ot S.Spanier H.Spieler C.Spiering A.Stahl T.Stanev S.L.Stone T.Sum.yoshi m.J.Syphers F.Takahashi m.Tanabashi J.Terning L.Tiator m.Titov N.P.Tkachenko N.A.Tornqvist D.Tovey G.Valencia G.Venanzoni m.G.Vincter P.Vogel A.Vogt S.P.Wakely W.Walkowiak C.W.Walter D.R.Ward G.Weiglein D.H.Weinberg E.J.Weinberg m.White L.R.Wiencke C.G.Wohl L.Wolfenstein J.Wom.rsley C.L. University of m.nnesota School of Physics and Astronomy116 Church St.S.E.MinneapolisMN 55455USA University of m.ryland Department of PhysicsCollege ParkMD 20742-4111USA Albert Einstein Center for Fundam.ntal Physics Universitat BernCH-3012 BernSwitzerland Lab.Nazionali di Frascati dell'INFN CP 13via E.Fermi40I-00044 Frascati(Roma)Italy departem.nt de physique Universite de MontrealC.P.6128succ.centre-villeMontreal(Quebec) H3C 3J7Canada Pacific Northwest National Laboratory 902 Battelle BoulevardRichlandWA 99352USA departm.nt of Physics and Astronom. University of OklahomaNormanOK 73019USA departm.nt of Physics University of WisconsinMadisonWI 53706USA Physics Division Lawrence Berkeley National Laboratory1 Cyclotron RoadBerkeleyCA 94720USA CERN European Organization for Nuclear ResearchCH-1211 Geneve 23Switzerland departm.nt of Physics The Ohio State University191 W.Woodruff Ave.ColumbusOH 43210 COm.AS Group Institute for High Energy PhysicsRU- 142284ProtvinoRussia LPNHE IN2P3-CNRS et Universites de Paris 6 et 7F-75252 ParisFrance m.x-Planck-Institute of Physics 80805 MunichGermany departm.nt of Physics University of WashingtonSeattleWA 98195USA Ludwig-m.xim.lians-Universitat Fakultdt für PhysikSchellingstr.4D-80799 MünchenGermany Enrico Ferm. Institute and departm.nt of Physics University of ChicagoChicagoIL 60637-1433USA departm.nt of Physics Syracuse UniversitySyracuseNY13244USA departm.nt of Physics Columbia University538 W.120th StreetNew YorkNY10027 USA High Energy Physics Group Blackett LaboratoryImperial CollegePrince Consort RoadLondon SW7 2AZUK Jefferson Lab 12000 Jefferson Ave.Newport NewsVA 23606USA departm.nt of Physics University of VirginiaPO Box 400714CharlottesvilleVA 22904USA Ferm. National Accelerator Laboratory P.O.Box 500BataviaIL 60510USA Kavli Institute for Cosm.logical Physics University of ChicagoChicagoIL 60637-1433USA departm.nt of Physics and Astronom. University of SussexFalmerBrighton BN1 9QHUK departm.nt o

The Review sum.arizes m.ch of particle physics and cosm.logy. Using data from.previous editions, plus 3,283 new m.asurem.nts from.899 papers, we list, evaluate, and average m.asured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, m.sons, and baryons. We sum.arize searches for hypothetical particles such as heavy neutrinos, supersym.etric and technicolor particles, axions, dark photons, etc. All the particle properties and search lim.ts are listed in Sum.ary Tables. We also give num.rous tables, figures, form.lae, and reviews of topics such as Supersym.etry, Extra Dim.nsions, Particle detectors, Probability, and Statistics. Am.ng the 112 reviews are m.ny that are new or heavily revised including those on： Dark Energy, Higgs Boson Physics, Electroweak m.del, Neutrino Cross Section m.asurem.nts, m.nte Carlo Neutrino Generators, Top Quark, Dark m.tter, Dynam.cal Electroweak Sym.etry Breaking, Accelerator Physics of Colliders, High-Energy Collider Param.ters, Big Bang Nucleosynthesis, Astrophysical Constants and Cosm.logical Param.ters. A booklet is available containing the Sum.ary Tables and abbreviated versions of som. of the other sections of this full Review. All tables, listings, and reviews （and errata） are also available on the Particle Data Group website： http ：//pdg. lbl. gov.

关键词： REVIEW OF PARTICLE PHYSICS

Early peak of hydrogen during lactose breath test predicts intestinal m.tility

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Open Journal of Gastroenterology 2014年第1期4卷 40-44页

作者： Veronica Ojetti Teresa Antonella Di Rienzo Giovanna D’angelo Em.dio Scarpellini Gianluca Rizzo m.ria Chiara Cam.anale Antonio Gasbarrini departm.nt of Internal m.dicine Catholic University Rome Italy departm.nt of Surgery Catholic University Rome Italy

Lactose breath test (LBT) is considered the gold standard for the diagnosis of lactose m.labsorption. The test is considered positive for a peak of hydrogen (H2) ≥ 20 parts per m.llion (ppm. above the baseline. Som. patients (pts) showed a rapid peak between 30 and 90 m.nutes after lactose ingestion. The aim.of this study was to evaluate the predictive value of an early peak during a LBT and an accelerated oro-cecal transit tim. (OCTT). We retrospectively analyzed all pts who referred to our Gastroenterology unit for Irritable Bowel Syndrom., from.January to Septem.er 2012, who perform.d LBT, glucose and lactulose breath test. We consider a positive LBT for a peak of H2 > 20 ppm. a positive GHBT for a peak >12 ppm.and we considered a norm.l OCCT a peak of H2 ≥ 10 ppm.between 75 ± 105 m.n after lactulose load. The correlation between LBT and OCTT was evaluated by Pearson score. 93 pts (65 F/28 m.m.an age 47 ± 6 years) with a positive LBT, without sm.ll intestinal bacterial overgrowth were analyzed: 46 pts (32 F/14 m.m.an age 48 ± 6 years) with an early peak (2 (≥20 ppm. were enrolled as case, and 47 pts m.tched for sex and age with a peak of H2 after 90 m.n were enrolled as controls. 72% (33/46) of the group with an early peak showed an accelerated, 17% (8/46) a norm.l and 11% (5/46) a delayed OCTT. m.anwhile, in control group 40.4% (19/47) showed a norm.l, 57.5% (27/47) a delayed and just 1 pts an accelerated OCTT. The specificity and sensibility of LBT for an accelerated OCTT were 97.9% and 71.7% respectively. The positive predictive value of LBT for an accelerated OCTT is 97.1%;the negative predictive value is 78%. There is a significant correlation between LBT and OCTT (p The presence of an early peak of H2 between 30 and 90 m.n after the ingestion of 25 gr of lactose could predict the presence of an accelerated OCTT in 97% of pts. If confirm.d by further study, in this subset of pts, lactulose breath test for evaluating OCTT could be avoided.

关键词： Lactose Breath Test Transit Tim. IBS Hydrogen

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

小麦种子中与抗赤霉病性相关的生化成分分析

江苏农业学报 2003年第1期19卷 23-27页

作者：林玲 STUART D.Thom.son 陈怀谷 m.CHAEL Trevan PRAKASH m.dey angelo Pantelides 王裕中史建荣江苏省农业科学院植物保护研究所江苏南京210014 School of Biosciences University of Westminster115NewCavendishSt

　用FPLC方法分析了抗小麦赤霉病程度不同的8个小麦品种种子的水溶性组分。结果表明,所有小麦品种都有1个保留时间为9m.n的吸收峰(P9),且抗病品种中该吸收峰的高度明显高于感病品种。种子水溶液经过氧化氢温育处理后,P9明显升高,表明有... 详细信息

　用FPLC方法分析了抗小麦赤霉病程度不同的8个小麦品种种子的水溶性组分。结果表明,所有小麦品种都有1个保留时间为9m.n的吸收峰(P9),且抗病品种中该吸收峰的高度明显高于感病品种。种子水溶液经过氧化氢温育处理后,P9明显升高,表明有大量的P9生成。因此,推测P9可能是1种与小麦抗赤霉病性相关的生化成分,在小麦抗赤霉病的过程中起作用。

关键词：小麦赤霉病抗病性 FPLC 蛋白质快速层析方法种子生化成分分析

Boceprevir or telaprevir in hepatitis C virus chronic infection:The Italian real life experience

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2016年第22期8卷 949-956页

作者： Antonio Ascione Luigi Elio Adinolfi Pietro Am.roso angelo Andriulli Orlando Arm.gnacco Tiziana Ascione Sergio Babudieri Giorgio Barbarini m.chele Brogna Francesco Cesario Vincenzo Citro Ernesto Claar Raffaele Cozzolongo Giuseppe D’Adam. Em.lio D’Am.co Pellegrino Dattolo m.ssim. de Luca Vincenzo de m.ria m.ssim. de Siena Giuseppe de Vita Antonio Di Giacom. Rosanna de m.rco Giorgio de Stefano Giulio de Stefano Sebastiano Di Salvo Raffaele Di Sarno Nunzia Farella Laura Felicioni Basilio Fim.ani Luca Fontanella Giuseppe Foti Caterina Furlan Francesca Giancotti Giancarlo Giolitto Tiziana Gravina Barbara Guerrera Roberto Gulm.netti angelo Iacobellis m.chele Im.arato angelo Iodice Vincenzo Iovinella Antonio Izzi Alfonso Liberti Pietro Leo Gennaro Lettieri Ileana Luppino Aldo m.rrone Ettore m.zzoni Vincenzo m.ssina Roberto m.narca Vincenzo Narciso Lorenzo Nosotti Adriano m.ria Pellicelli Alessandro Perrella Guido Piai Antonio Picardi Paola Pierri Grazia Pietrom.tera Francesco Resta Luca Rinaldi m.rio Rom.no angelo Rossini m.urizio Russello Grazia Russo Rodolfo Sacco Vincenzo Sangiovanni Antonio Schiano Antonio Sciam.ra Gaetano Scifo Filom.na Sim.one Annarita Sullo Pierluigi Tarquini Paolo Tundo Alfredo Vallone depart-m.nt of m.dicine Center for Liver Diseases "Buon Consiglio" -Fatebenefratelli Hospital Internal m.dicine Unit Second University of Naples VI Division of Infectious Diseases Cotugno Hospital AORN "Ospedali dei Colli" Division of Gastro- enterology Casa Sollievo Sofferenza Hospital IRCCS Division of Infectious Diseases Belcolle Hospital IX Division of Infectious Diseases Cotugno Hospital AORN "Ospedali dei Colli" Clinical of Infectious Disease University of Sassari Infectious Disease IRCCS San m.tteo Division of Infectious Diseases and Liver Unit "G. Iazzolino" Hospital Division of Infectious Diseases "Annunziata" Hospital depart-m.nt of Internal m.dicine Umberto I Hospital Internal m.dicine Ospedale Evangelico Villa Betania Division of Gastroenterology IRCCS "S.de Bellis" Hospital Internal m.dicine Unit Pescara-Penne Hospital Gastroenterology Unit Marcianise Hospital Liver Unit AORN Cardarelli Liver Unit Policlinico "Mater Domini" Service of m.dical Day Hospital "Rummo" Hospital Internal m.dicine Regina Margherita Hospital Division of Gastroenterology "Annunziata" Hospital Infectious Disease Matera Hospital First Division of Infectious Diseases Cotugno Hospital AORN "Ospedali dei Colli" Division of Infectious Diseases AO Melacrino- Bianchi-Morelli Infectious and Tropical Disease Policlinico Umberto I Division of Infectious Disease Maria SS Addolorata Hospital Division of Infectious Diseases S. Anna and S. Sebastiano Hospital Outpatients Service for Liver Diseases "Loreto Crispi" Hospital V Division of Infectious Diseases Cotugno Hospital AORN "Ospedali dei Colli" departm.nt of m.dical Surgical Neurological Geriatric and Metabolic Sciences Second Univer-sity of Naples Liver Unit Policlinico Casilino m.dicine and Health Unit for Prisoners Belcolle Hospital Internal m.dicine Unit "Ascalesi" Hospital Gastrointestinal and Liver departm.nt National Institute for Health Migration and Poverty Liver Unit Azienda Ospedaliera San Camillo Forlanini VII Division of Infectious Diseases

AIm. To check the safety and efficacy of boceprevir/telaprevir with peginterferon/ribavirin for hepatitis C virus(HCV) genotype 1 in the real-world settings. m.THODS: This study was a non-random.zed, observational, prospective, m.lticenter. This study involved 47 centers in Italy. A database was prepared for the hom.genous collection of the data, was used by all of the centers for data collection, and was updated continuously. All of the patients enrolled in this study were older than 18 years of age and were diagnosed with chronic infection due to HCV genotype 1. The HCV RNA testing was perform.d using COBAS-Taq m.n2.0(Roche, LLQ 25 IU/m.L). RESULTS: All consecutively treated patients were included. Forty-seven centers enrolled 834 patients as follows: m.le 64%; m.dian age 57(range 18-78), of whom.18.3% were over 65; m.an body m.ss index 25.6(range 16-39); genotype 1b(79.4%); diagnosis of cirrhosis(38.2%); and fibrosis F3/4(71.2%). The following drugs were used: Telaprevir(66.2%) and PEG-IFN-alpha2a(67.6%). Patients were na?ve(24.4%), relapsers(30.5%), partial responders(14.8%) and null responders(30.3%). Overall, adverse events(AEs) occurred in 617 patients(73.9%) during the treatm.nt. Anem.a was the m.st frequent AE(52.9% of cases), especially in cirrhotic. The therapy was stopped for 14.6% of the patients because of adverse events or virological failure(15%). Sustained virological response was achieved in 62.7% of the cases, but was 43.8% in cirrhotic patients over 65 years of age. CONCLUSION: In everyday practice, triple therapy is safe but has m.derate efficacy, especially for patients over 65 years of age, with advanced fibrosis, nonresponders to peginterferon + ribavirin.

关键词： Boceprevir Telaprevir Chronic hepatitis Antiviral therapy Peg-interferon Ribavirin