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Dismicrobism in inflammatory bowel disease and colorectal cancer: Changes in response of colocytes

World Journal of Gastroenterology 2014年第48期20卷 18121-18130页

作者： Giovanni Tomasello Pietro Tralongo Provvidenza Damiani Emanuele Sinagra Benedetto Di Trapani Marie Noelle Zeenny Inaya Hajj Hussein Abdo Jurjus angelo leone IEMEST Euro-Mediterranean Institute of Science and Technology 90139 Palermo Italy Department of Experimental Biomedicine and Clinical Neurosciences Section of Histology University of Palermo 90133 Palermo Italy AOUP "P Giaccone" School of Medicine University of Palermo 90139 Palermo Italy Fondazione Istituto S. Raffaele-G. Giglio Gastroenterology and Endoscopy Unit Cefalù 90146 Italy Unit of Surgery "Clinica Torina" 9010Palermo Italy Deparment of Anatomy Cell Biology and Physiology American University of Beirut Beirut 1107-2020 Lebanon Department of Biomedical Sciences Oakland University William Beaumont School of Medicine Rochester MI 48309 United States

Patients with inflammatory bowel disease (IBD) have an increased risk of 10%-15% developing colorectal cancer (CRC) that is a common disease of high economic costs in developed countries. The CRC has been increasing in recent years and its mortality rates are very high. Multiple biological and biochemical factors are responsible for the onset and progression of this pathology. Moreover, it appears absolutely necessary to investigate the environmental factors favoring the onset of CRC and the promotion of colonic health. The gut microflora, or microbiota, has an extensive diversity both quantitatively and qualitatively. In utero, the intestine of the mammalian fetus is sterile. At birth, the intestinal microbiota is acquired by ingesting maternal anal or vaginal organisms, ultimately developing into a stable community, with marked variations in microbial composition between individuals. The development of IBD is often associated with qualitative and quantitative disorders of the intestinal microbial flora (dysbiosis). The healthy human gut harbours about 10 different bacterial species distributed in colony forming units which colonize the gastrointestinal tract. The intestinal microbiota plays a fundamental role in health and in the progression of diseases such as IBD and CRC. In healthy subjects, the main control of intestinal bacterial colonization occurs through gastric acidity but other factors such as endoluminal temperature, competition between different bacterial strains, peristalsis and drugs can influence the intestinal microenvironment. The microbiota exerts diverse physiological functions to include: growth inhibition of pathogenic microorganisms, synthesis of compounds useful for the trophism of colonic mucosa, regulation of intestinal lymphoid tissue and synthesis of amino acids. Furthermore, mucus seems to play an important role in protecting the intestinal mucosa and maintaining its integrity. Changes in the microbiota composition are mainly influenced

关键词： Dismicrobism Inflammatory bowel disease Colorectal Cancer Dysbiosis Eubiosis Heat shock proteins

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Groups with Cyclic Outer Automizers

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Algebra Colloquium 2014年第3期21卷 381-398页

作者： Maria Rosaria Celentani Giovanni Cutolo Antonella leone Dipartimento di Matematica e Applieazioni 'R .Caccioppoli' Universita degli Studi di Napoli 'Federico II' Via Cintia Monte S. Angelo 1-80126 Napoli Italy

We consider groups G such that NG（H）/HCG（H） is cyclic for all H ≤ G. More specifically, we characterise locally nilpotent and supersoluble groups with this property.

关键词： automizers locally nilpotent supersoluble soluble groups

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Is there a way out for the 2014 Ebola outbreak in Western Africa?

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Asian Pacific Journal of Tropical Medicine 2015年第10期8卷 757-762页

作者： angelo Andreas Christian Binoun A Egom Peter Kruzliak Emmanuel E.Egom University of Toronto Scarborough Campus University of Ndjamena Faculty of Medicine International Clinical Research Center St.Anne's University Hospital and Masaryk University Egom Clinical and Translational Research Services

The 2014 Ebola outbreak in West Africa,primarily affecting *** leone,and Liberia,has exceeded all previous Ebola outbreaks in the number of cases and in international *** infections only occur frequently in Western Africa,the virus has the potential to spread globally and is classified as a category A pathogen that could be misused as a bioterrorism *** review aims(i) to discuss the latest data to aid our current recommendations for the prevention and control of the Ebola vims infection,(ii) to review its pathophysiology as well as offering insights on the most current data available about Ebola vaccine progress and potential use.

关键词： Ebola virus Infection Prevention Control

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