检索结果-南通市图书馆

Retrobulbar administration of purified anti-nerve growth factor in developing rats induces structural and biochemical changes in the retina and cornea

引用

International Journal of Ophthalmology(English edition) 2021年第2期14卷 209-216页

作者： Luigi Aloe Maria Luisa Rocco Bijorn Omar Balzamino Graziana esposito Alessandra Micera Institute of Cell Biology and Neurobiology CNRLazio 00143RomeItaly Fondazione IRET Ozzano EmiliaBologna 40064Italy Institute of Translational Pharmacology CNRLazio 00133RomeItaly Research and Development Laboratory for Biochemical Molecular and Cellular Applications in Ophthalmological ScienceIRCCSFondazione BiettiRome 00182Italy

AIM:To develop an experimental model of endogenous nerve growth factor(NGF)deprivation by retrobulbar administration of purified neutralizing anti-NGF antibodies in young Sprague-Dawley rats and provide further information on NGF expression in the retina and ***:Sixty old pathogen-free Sprague Dawley rats(p14,post-natal days)were treated with repeated retrobulbar injections of neutralizing anti-NGF(2μL,100μg/m L,every 3 d).After 2 wk(p28),retinal and corneal tissues were investigated for morphological,biochemical,and molecular expression of trkANGFR by using Western blotting or *** as well as protein profile expression were also ***:Chronic retrobulbar neutralizing anti-NGF antibodies changed the distribution of trkANGFR immunoreactivity at retinal level,while no changes were detected for global trkANGFR protein *** contrary,the treatment resulted in the increase of corneal trkANGFR *** tissues showed a decreased rhodopsin expression as well as reduced number of both rhodopsin expressing and total retinal cells,as observed after single cell extraction.A decreased expression of ICAM-1,IL-17 and IL-13 as well as an increased expression of IL-21 typified retinal *** significant changes were observed for corneal ***:The reduced availability of endogenous NGF,as produced by chronic retrobulbar anti-NGF administration,produce a quick response from retinal tissues,with respect to corneal ones,suggesting the presence of early compensatory mechanisms to protect retinal networking.

关键词： anti-nerve growth factor trk^(ANGFR) retina cornea photoreceptors tissue response

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pathology of pancreatic ductal adenocarcinoma:Facts,challenges and future developments

引用

World Journal of Gastroenterology 2014年第38期20卷 13833-13841页

作者： Irene esposito Bj?rn Konukiewitz Anna Melissa Schlitter Günter Kl?ppel Institute of Pathology Technische Universit?t München

Despite major improvements concerning its diagnosis and treatment,pancreatic ductal adenocarcinoma(PDAC) remains an aggressive disease with an extremely poor prognosis. Pathology,as interface discipline between basic and clinical medicine,has substantially contributed to the recent developments and has laid the basis for further progress. The definition and classification of precursor lesions of PDAC and their molecular characterization is a fundamental step for the potential identification of biomarkers and the development of imaging methods for early detection. In addition,by integrating findings in humans with the knowledge acquired through the investigation of transgenic mouse models for PDAC,a new model for pancreatic carcinogenesis has been proposed and partially validated in individuals with genetic predisposition for PDAC. The introduction and validation of a standardized system for pathology reporting based on the axial slicing technique has shown that most pancreatic cancer resections are R1 resections and that this is due to inherent anatomical and biological properties of *** standardized assessment of prognostic relevant parameters represents the basis for the successful conduction of multicentric studies and for the interpretation of their ***,recent studies have shown that distinct molecular subtypes of PDAC exist and are associated with different prognosis and therapy *** prospective validation of these results and the integration of molecular analyses in a comprehensive pathology report in the context of individualised cancer therapy represent a major challenge for the future.

关键词： Pancreatic ductal adenocarcinoma Precursor lesions Atypical flat lesion Molecular subtypes R1 Pancreatic cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Editorial: Special issue on “Internet of things and edge computing in the new 5G era”

引用

Digital Communications and Networks 2021年第2期7卷 167-169页

作者： Xin Su Marek R.Ogiela Chang Choi Christian esposito Kiho Lim the College of Internet of Things Engineering Hohai UniversityChina world scientific associations 不详 University of Napoli Federico II in Italy Department of Computer Science at the University of South Dakota USA.

*** Recently,edge computing has evolved from concept to early-stage implementations because new use cases require a more remote computing and networking approach than a conventional,fully cloud-based *** companies,network providers and cloud companies are testing and launching early commercial products in the developed markets of the United States,Europe,China and Asia *** progress in edge trials continues,key issues remain to be resolved around the most viable location of the edge,the scale of the required edge investment,and the actual business models.

关键词： computing companies Internet

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Breath test for differential diagnosis between small intestinal bacterial overgrowth and irritable bowel disease:An observation on non-absorbable antibiotics

引用

World Journal of Gastroenterology 2007年第45期13卷 6016-6021页

作者： I esposito A de Leone G Di Gregorio S Giaquinto L de Magistris A Ferrieri G Riegler Department of Clinical andExperimental Internal Medicine Second University of NaplesItaly

AIM： To estimate the prevalence of small intestine bacterial overgrowth （SIBO） among patients with an earlier diagnosis of irritable bowel disease （IBS） in our geographical area, and to collect information on the use of locally acting non-absorbable antibiotics in the management of SIBO. METHODS： A non-interventional study was conducted in 73 consecutive patients with a symptom-based diagnosis.. RESULTS： When the patients underwent a ＂breath test＂, 33 （45.2%） showed the presence of a SIBO. Arcer treatment with rifaximin 1200 mg/d for seven days in 32 patients, 19 （59.4%） showed a negative ＂breath test＂ one week later as well as a significant reduction of symptoms, thus confirming the relationship between SIBO and many of the symptoms claimed by patients. In the other 13 patients, ＂breath test＂ remained positive, and a further cycle of treatment with ciprofloxacin 500 mg/d was given for 7 additional days, resulting in a negative ＂breath test＂ in one patient only. CONCLUSION：（1） about half of the patients with a symptomatic diagnosis of IBS have actually SIBO, which is responsible for most of the symptoms attributed to IBS; （2） only a ＂breath test＂ with lactulose （or with glucose in subjects with an intolerance to lactose） can provide a differential diagnosis between IBS and SIBO, with almost identical symptoms; and （3） the use of non-absorbable antibiotics may be useful to reduce the degree of SIBO and related symptoms; it must be accompanied, however, by the correction of the wrong alimentary habits underlying SIBO.

关键词： Small intestine bacterial overgrowth Irritablebowel disease Breath test Rifaximin Hydrogen Non-absorbable antibiotics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evidence for accuracy of pain assessment and painkillers utilization in neuropsychiatric symptoms of dementia in Calabria region,Italy

引用

Neural Regeneration Research 2018年第9期13卷 1619-1621页

作者： Damiana Scuteri Maria Roberta Garreffa Stefania esposito Giacinto Bagetta Maria Diana Naturale Maria Tiziana Corasaniti Preclinical and Translational Pharmacology Department of Pharmacy Health Science and NutritionUniversity of Calabria Pharmacy Unit "Mater Domini" University Hospital Department of Health Sciences University "Magna Graecia" of Catanzaro

During the clinical course of dementia,beside cognitive impairment and memory loss,a very complex challenge is posed by the neuropsychiatric symptoms（NPSs）.Accurate evaluation and treatment of pain impacts positively the agitation of demented patients aged ≥ 65 *** gather information on the utilization of pain killers in demented patients a preliminary survey has been conducted in collaboration with the Calabrian Pharmacovigilance Territorial Service of the health district of Catanzaro（Italy）.The study has taken into consideration the prescriptions of acetylcholinesterase inhibitors and memantine during the period ranging from July 2015 to June 2016 and the percentage of patients treated against pain with non steroidal antinflammatory drugs,opioids,and anticonvulsants have been *** latter have been evaluated statistically for difference between the treatment before（pre） and after（post） the settlement of acetylcholinesterase inhibitors（ACh EI） or memantine *** results do support accuracy in painkillers utilization in the course of dementia in the regional population of Calabria（Italy）.

关键词： Alzheimer's disease dementia neuropsychiatric symptoms pain appropriate prescriptions aromatherapy opioids α2δ-1 ligands

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Lifestyle modifications and erectile dysfunction： Nhat can be expected？

引用

Asian Journal of Andrology 2015年第1期17卷 5-10,I0006页

作者： Maria Ida Maiorino Giuseppe Bellastella Katherine esposito Department of Medical Surgical Neurological Metabolic and Geriatric Science Second University of Naples Piazza L. Miraglia n 2 Department of Clinical and Experimental Medicine Second University of Naples via Pansini n 5 Naples Italy.

Erectile dysfunction （ED） is a common medical disorder whose prevalence is increasing worldwide. Modifiable risk factors for ED include smoking, lack of physical activity, wrong diets, overweight or obesity, metabolic syndrome, and excessive alcohol consumption. Quite interestingly, all these metabolic conditions are strongly associated with a pro-inflammatory state that results in endothelial dysfunction by decreasing the availability of nitric oxide （NO）, which is the driving force of the blood genital flow. Lifestyle and nutrition have been recognized as central factors influencing both vascular NO production, testosterone levels, and erectile function. Moreover, it has also been suggested that lifestyle habits that decrease low-grade clinical inflammation may have a role in the improvement of erectile function. In clinical trials, lifestyle modifications were effective in ameliorating ED or restoring absent ED in people with obesity or metabolic syndrome. Therefore, promotion of healthful lifestyles would yield great benefits in reducing the burden of sexual dysfunction. Efforts, in order to implement educative strategies for healthy lifestyle, should be addressed.

关键词： erectile dysfunction lifestyle changes physical activity Mediterranean diet

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Experimental characterization of Ti6AI4V T joints welded through linear friction welding technique： microstructure and NDE

引用

Advances in Manufacturing 2016年第4期4卷 305-313页

作者： Antonello Astarita Mario Coppola Sergio esposito Mariacira Liberini Leandro Maio Ilaria Papa Fabio Scherillo Antonino Squillace Department of Chemical Materials and ProductionEngineering University of Naples "Federico II" PiazzaleTecchio 80 80125 Naples Italy Fox Bit srl viale Luraghi presso consorzio I1 Sole80038 Pomigliano d'Arco NA Italy Leonardo Company S.p.A.- Aircraft Division Engineering -AT&D Manufacturing and Assembly Research andDevelopment Viale dell'Aeronantica s/n80038 Pomigliano d'Arco NA Italy Department of Industrial Engineering - Aerospace Division University of Naples "Federico II" Via Claudio 21 NaplesItaly

Linear friction welding （LFW） is an innovative solid-state welding technique that allows to manufacture joints with high mechanical properties. This technology has various applications in the aerospace field; in particular it is used to weld massive structural components made of Ti6A14V. This paper deals with the experimental study of Ti6A14V T-joints welded through LFW, with particular focus on the effectiveness of ultrasonic control in detecting and distinguishing welding defects within the joints. Aiming to this scope, joints with different properties were manufactured and tested： some were free from defects but with different metallurgy, and some had different types of defects. The results obtained proved that the ultrasonic control was an effective method to detect and identify defects in linear friction welded titanium joints, moreover it was possible to get information regarding the microstructure and in particular the extension of the different metallurgical zones induced by the welding process.

关键词： Ti6A14V Ultrasonic control Linear frictionwelding (LFW) Microstructure Defects

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Thrombocytopenia in chronic liver disease:Physiopathology and new therapeutic strategies before invasive procedures

引用

World Journal of Gastroenterology 2022年第30期28卷 4061-4074页

作者： Paolo Gallo Francesca Terracciani Giulia Di Pasquale Matteo esposito Antonio Picardi Umberto Vespasiani-Gentilucci Clinical Medicine and Hepatology Unit Campus Bio-Medico UniversityRoma 00128Italy

Chronic liver disease is characterized by several hematological derangements resulting in a complex and barely rebalanced haemostatic *** is the most common abnormality observed in these patients and recent advances have led to researchers focus the attention on the multifactorial origin of thrombocytopenia and on the key role of thrombopoietin(TPO)in its *** thrombocytopenia(platelet count<50000/μL)complicates the management of patients with chronic liver disease by increasing the potential risk of bleeding for invasive procedures,which may be therefore delayed or canceled even if *** the very last years,the development of new drugs which exceed the limits of the current standard of care(platelet transfusions,either immediately before or during the procedure)paves the way to a new scenario in the management of this population of *** agents,such as the TPOreceptor agonists avatrombopag and lusutrombopag,have been developed in order to increase platelet production as an alternative to platelet *** agents have demonstrated a good profile in terms of efficacy and safety and will hopefully allow reducing limitations and risks associated with platelet transfusion,without any delay in scheduled ***,it is expected that patients with chronic liver disease will be able to face invasive procedures with one more string in their bow.

关键词： Thrombocytopenia Chronic liver disease Thrombopoietin agonists Platelet transfusions Avatrombopag Lusutrombopag

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

In-vivo characterization of DALM in ulcerative colitis with high-resolution probe-based confocal laser endomicroscopy

引用

World Journal of Gastroenterology 2011年第5期17卷 677-680页

作者： Giovanni D De Palma Stefania Staibano Saverio Siciliano Francesco Maione Maria Siano Dario esposito Giovanni Persico Department of Surgery and Advanced Technologies Center of Excellence for Technical Innovation in SurgerySection of Diagnostic and Therapeutic EndoscopyUniversity of Naples Federico IISchool of Medicine80131NaplesItaly Department of Biomorphological and Functional Sciences Section of PathologyUniversity of Naples Federico IISchool of Medicine80131NaplesItaly

Recently,the use of confocal laser endomicroscopy(CLE) in the diagnosis of chronic ulcerative colitis(CUC) was *** this brief report we aimed to assess the application of probe-based CLE to characterize colonic mucosa and dysplasia in *** study involved a patient presenting long-standing *** imaging of both the inflamed mucosa,a circumscribed lesion(dysplasiaassociated lesional mass),and adjacent colonic mucosa are demonstrated and the correlation between the CLE and histological *** mucosa and dysplasia showed specific alteration of crypt architecture,cellular infiltration,and vessel architecture with an excellent correlation between CLE and standard histological examination.

关键词： Colonoscopy Confocal laser endomicros-copy Chronic ulcerative colitis Dysplasia-associatedlesional mass Histology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The happy celiac: An oxymoron or a possibility?

引用

Health 2012年第5期4卷 253-258页

作者： Maurizio esposito Department of Haman and Sport Sciences University of Cassino Cassino Italy

Background: Several international studies, confirmed in Italy too, show a hard presence of socio-relational problems inside the celiac population. Methods: Qualitative study involving persons with celiac disease and their families. 25 individual semi-structured interviews were conducted in three Italian regions. Results: Problems of management of social life for celiac persons are experienced, specially in the fields of: school, work, travels and life outside the home. Conclusion: Chronic illness is a “biographical disruption” [1] and the whole society has to be invested to fight the burden of celiac persons in their possibility of access to public life.

关键词： Celiac Social Quality of Life Qualitative Chronic Illness

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：