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Journal of Sport and Health Science 2021年第4期10卷 510-512页

作者： Kimberley L.Way angelo sabag Angela S.Lee Stephen M.Twigg Nathan A.Johnson School of Exercise and Nutrition Sciences Faculty of HealthDeakin UniversityBurwoodVIC 3125Australia Exercise Physiology and Cardiovascular Health Lab University of Ottawa Heart InstituteOttawaON K1Y 4W7Canada NICM Health Research Institute Western Sydney UniversityWestmeadNSW 2145Australia Central Clinical School Faculty of Medicine and HealthUniversity of SydneyCamperdownNSW 2050Australia Department of Endocrinology Diabetes CentreRoyal Prince Alfred HospitalSydneyNSW 2050Australia Discipline of Exercise and Sports Science Faculty of Medicine and HealthUniversity of SydneyLidcombeNSW 2141Australia Boden Collaboration for Obesity NutritionExercise and Eating DisordersUniversity of SydneyCamperdownNSW 2006Australia

Dear editor,We thank Lopes et al.^(1) for their interest in our study and for writing an insightful commentary based on our findings,which were recently published in the Journal of Sport and Health Science,^(2) and for their work.^(3) As noted by the authors,there is consistency in several key findings between our laboratories,and this should serve as a basis for future investigation in this *** agree that there has been little work examining the effect of high-intensity interval exercise(HIIE)on central arterial stiffness.

关键词： al. finding thank

Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli Ali Mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Tedesco angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

Modulation of the intracellular inhibitory checkpoint SHP-1 enhances the antitumor activity of engineered NK cells

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Cellular & Molecular Immunology 2021年第5期18卷 1314-1316页

作者： Aviad Ben-Shmuel Guy Biber Batel sabag Mira Barda-Saad The Mina and Everard Goodman Faculty of Life Sciences Bar-Ilan UniversityRamat-Gan5290002Israel

Natural killer(NK)cells are innate lymphoid cells(ILCs)that eliminate virally infected and cancerous *** cells directly induce target cell death and release cytokines and chemokines that activate the adaptive arm of t... 详细信息

关键词： killer death lymphoid

From the elasticity theory to cosmology and vice versa

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Science China(Physics,Mechanics & Astronomy) 2014年第4期57卷 597-603页

作者： LEVRINO Luca TARTAGLIA angelo Politecnico di Torino Department of Applied Science and Technology Corso Duca degli Abruzzi 2410129 Torino Italy

The paper shows how a generalization of the elasticity theory to four dimensions and to space-time allows for a consistent description of the homogeneous and isotropic universe,including the accelerated *** analogy is manifested by the inclusion in the traditional Lagrangian of general relativity of an additional term accounting for the strain induced in the manifold(*** space-time)by the curvature,be it induced by the presence of a texture defect or by a matter/energy *** additional term is su?cient to account for various observed features of the universe and to give a simple interpretation for the so called dark ***,we show how the same approach can be adopted back in three dimensions to obtain the equilibrium configuration of a given solid subject to strain induced by defects or applied ***,it is shown how concepts coming from the familiar elasticity theory can inspire new approaches to cosmology and in return how methods appropriated to General Relativity can be applied back to classical problems of elastic deformations in three dimensions.

关键词： deformable solids cosmology elastic strain Lagrangian density and tensors

Transformational change in the field of diffuse optics:From going bananas to going nuts

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Journal of Innovative Optical Health Sciences 2020年第1期3卷 1-18页

作者： Sergio Fantini Giles Blaney angelo Sassaroli Department of Biomedical Engineering Tufts University 4 Colby Street MedfordMA 02155USA

The concept of region of sensitivity is central to the field of diffuse optics and is closely related to the Jacobian matrix used to solve the inverse problem in *** is well known that,in diffuse reflectance,the region of sensitivity associated with a given source-detector pair is shaped as a banana,and features maximal sensitivity to the portions of the sample that are closest to the source and the *** have recently introduced a dual-slope(DS)method based on a special arrangement of two sources and two detectors,which results in deeper and more localized regions of sensitivity,resembling the shapes of different kinds of ***,we report the regions of sensitivity associated with a variety of source-detector arrangements for DS measurements of intensity and phase with frequency-domain spectroscopy(modulation frequency:140 MHz)in a medium with absorption and reduced scattering coefficients of 0.1 and 12 cm^(-1),*** main result is that the depth of maximum sensitivity,considering only cases that use source-detector separations of 25 and 35 mm,progressively increases as we consider single-distance intensity(2.0mm),DS intensity(4.6mm),single-distance phase(7.5mm),and DS phase(10.9 mm).These results indicate the importance of DS measurements,and even more so of phase measurements,when it is desirable to selectively probe deeper portions of a sample with diffuse *** is certainly the case in non-invasive optical studies of brain,muscle,and breast tissue,which are located underneath the superficial tissue at variable depths.

关键词： Near-infrared spectroscopy tissue optics diffuse optical tomography frequency domain dual slopes

Comparison between the seismic response of 2D and 3D models of rigid blocks

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Earthquake Engineering and Engineering Vibration 2014年第1期13卷 151-162页

作者： angelo Di Egidio Daniele Zulli Alessandro Contento Department of Civil Engineering Architecture and Environment(DICEAA)University of L'Aquila

A three-dimensional rigid body on the shape of a parallelepiped is modelled in order to rock on a side or a vertex of the base,in order to evaluate the seismic response of rigid blocks lying on a horizontal *** center of mass of the body is considered as eccentric with respect to its geometric *** seismic input,three Italian recorded accelerograms,with different spectral content,are *** study is mainly conducted to highlight the differences between the seismic response of 2D and 3D models of rigid blocks,with the aim to understand if,in some cases,the use of the 3D model of rigid block is required to obtain safer *** fact,the outcomes show that in some ranges of the geometrical and mechanical parameters that characterize the excitation and the body,a two-dimensional model,which is not able to consider the 3D rocking on a vertex,can provide unsafe *** particular,it is found that the overturning process of the three-dimensional block can occur under excitations which are lower than those which overturn a corresponding two-dimensional block.

关键词： seismic excitation 3D rigid block rectangular base rocking overturning

Geology of Mars after the first 40 years of exploration

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Research in Astronomy and Astrophysics 2010年第7期10卷 621-652页

作者： angelo Pio Rossi Stephan van Gasselt International Space Science Institute CH-3012 Hallerstrasse 6 Bern Switzerland Jacobs University Bremen Department of Earth and Space Sciences Campus Ring 1 28759 Bremen Germany Planetary Sciences and Remote Sensing Institute of Geological Sciences Free University of Berlin Malteserstr. 74-100 12249 Berlin Germany

The knowledge of Martian geology has increased enormously in the last 40 yr. Several missions orbiting or roving Mars have revolutionized our understanding of its evolution and geological features, which in several ways are similar to Earth, but are extremely different in many respects. The impressive dichotomy between the two Martian hemispheres is most likely linked to its impact cratering history, rather than internal dynamics such as on Earth. Mars＇ volcanism has been extensive, very longlived and rather constant in its setting. Water was available in large quantities in the distant past of Mars, when a magnetic field and more vigorous tectonics were active. Exogenic forces have been shaping Martian landscapes and have led to a plethora of landscapes shaped by wind, water and ice. Mars＇ dynamical behavior continues, with its climatic variation affecting climate and geology until very recent times. This paper tries to summarize major highlights in Mars＇ Geology, and points to deeper and more extensive sources of important scientific contributions and future exploration.

关键词： planets and satellites Mars -- Geology -- surface processes -- interior processes

The meaning of “coherent” and its quantication in coherent hemodynamics spectroscopy

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Journal of Innovative Optical Health Sciences 2018年第6期11卷 55-77页

作者： angelo Sassaroli Kristen Tgavalekos Sergio Fantini Department of Biomedical Engineering Tufts University MedfordMA 02155USA

We have recently introduced a new technique,coherent hemodynamics spectroscopy(CHS),which aims at characterizing a specic kind of tissue hemodynamics that feature a high level of covariation with a given physiological *** this study,we carry out a detailed analysis of the signicance of coherence and phase synchronization between oscillations of arterial blood pressure(ABP)and total hemoglobin concentration([Hbt]),measured with near-infrared spectroscopy(NIRS)during a typical protocol for CHS,based on a cyclic thigh cuffocclusion and *** though CHS is based on a linear time invariant model between ABP(input)and NIRS measurands(outputs),for practical reasons in a typical CHS protocol,we inducenite“groups”of ABP oscillations,in which each group is characterized by a different *** this reason,ABP(input)and NIRS measurands(output)are not stationary processes,and we have used wavelet coherence and phase synchronization index(PSI),as a metric of coherence and phase synchronization,*** was calculated by using both the wavelet cross spectrum and the Hilbert *** have also used linear coherence(which requires stationary process)for comparison with wavelet *** of surrogate data is used tond critical values for the signicance of covariation between ABP and[Hbt].Because we have found similar critical values for wavelet coherence and PSI by usingve of the most used methods of surrogate data,we propose to use the data-independent Gaussian random numbers(GRNs),for *** using wavelet coherence and wavelet cross spectrum,and GRNs as surrogate data,we have found the same results for the signicance of coherence and phase synchronization between ABP and[Hbt]:on a total set of 20 periods of cuffoscillations,we have found 17 coherent oscillations and 17 phase synchronous *** synchronization assessed with Hilbert transform yielded similar results with 14 phase synchronous *** coherence and wave

关键词： Wavelet coherence phase synchronization near-infrared spectroscopy surrogate data

Study of capillary transit time distribution in coherent hemodynamics spectroscopy

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Journal of Innovative Optical Health Sciences 2015年第2期8卷 78-86页

作者： angelo Sassaroli Jana Kainerstorfer Sergio Fantini Department of Biomedical Engineering Tufts University 4 Colby StreetMedfordMA 02155USA

A recently proposed analytical hemodynamie modell[***,Neurolmage 85,202-221(2014)]is able to predict the changes of oxy,deoxy,and total hemoglobin concentrations(model outputs)given arbitrary changes in blood flow,blood volume,and rate of oygen consumption(model inputs).One asumption of this model is that the capillary compartment is characterized by a single blood transit *** this work,we have extended the original model by considering a distribution of capillary transit times and we have compared the outputs of both models(original and extended)for the case of sinusoidal input signals at different frequencies,which realizes the new technique of coherent hemodynamics spectroscopy(CHS).For the calculations with the original model,we have used the mean value of the distribution of capillary transit times con-sidered in the extended *** have found that,for distributions of capillary transit times having mean values around 1 s and a standard deviation less than about 45%of the mean value,the original and extended models yield the same CHS spectra(i.e.,model outputs versus fre-quency of ocillation)within typical experimental *** wider capillary transit time dis-tributions,the two models yield different CHS *** assuming that Poiseuille's law is valid in the capillary compartment,we have related the distribution of capillary transit times to the distributions of capillary lengths and capillary speed of blood flow to calculate the average capillary and venous *** have found that,for standard deviations of the capillanry transit time distrilbution that are less than about 80%of the mean value,the average capillary saturation is always larger than the venous *** contrast,the average capillary satu-ration may be less than the venous saturation for wider distributions of the capillary transit times.

关键词： Coherent hemodynamics spectroscopy hermodynamie model near-infrared spectros-copy capillary transit time hemoglobin saturation

On the Foundations of Statistical Mechanics: Ergodicity, Many Degrees of Freedom and Inference

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Communications in Theoretical Physics 2014年第10期61卷 469-475页

作者： Sergio Chibbaro Lamberto Rondoni angelo Vulpiani Sorbonne Universités UPMC Univ Paris 06CNRSUMR7190Institut Jean Le Rond d’AlembertF-75005 ParisFrance Kavli Institute for Theoretical Physics China CAS Dip.Scienze Matematiche Politecnico di TorinoC.Duca degli Abruzzi 24TorinoItaly INFN Sezione di TorinoVia P.Giuria 1TorinoItaly Dipartimento di Fisica Università "La Sapienza" RomaItaly ISC-CNR Piazzale A.Moro 2 – 00185 RomaItaly

We review the main aspects of the foundations of statistical mechanics. In particular we explain why many degrees of freedom are necessary, while chaos(in the sense of positive Lyapunov exponents) is only marginally r... 详细信息

关键词： ergodic hypothesis chaos emergent properties statical inference