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Antioxidant treatment for oligoasthenoteratozoospermia and varicocele:a DBPC trial to evaluate the impact of age and body mass index

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Asian Journal of Andrology 2024年第3期26卷 239-244页

作者： Gian Maria Busetto Bernarde F Rodrigues Ashraf Virmani Andrea Checchia Antonella Ninivaggi Anna Ricapito Giovanni Barbieri Piero Fischetti Ugo G Falagario Pasquale Annese Nicola d’Altilia Vito Mancini Matteo Ferro Felice Crocetto angelo porreca Carlo Bettocchi Luigi Cormio Ashok Agarwal Giuseppe Carrieri University of Foggia Foggia 71122Italy Department of Urology and Renal Transplantation Policlinico of FoggiaFoggia 71122Italy Department of Urology Human Reproduction SectionFederal University of Sao PauloSao Paulo 05403-000Brazil Alfasigma Healthscience Utrecht 3528 BGThe Netherlands Urology Unit “G.Tatarella”HospitalCerignola 71042Italy Urology Unit European Institute of Oncology(IEO)IRCCSMilan 20142Italy University of Naples Federico II Naples80126Italy Department of Oncological Urology Veneto Institute of Oncology(IOV)IRCCSPadua 35039Italy Urology Unit “L.Bonomo”HospitalAndria 70031Italy Global Andrology Forum Moreland HillsOH 44022USA

Oxidative stress is one of the main mechanisms responsible for male *** conditions such as varicocele,obesity,advanced age,and lifestyle can lead to an increase in reactive oxygen species,causing an oxidative imbalance in the *** are sensitive to reactive oxygen species and require energy to carry out their main function of fertilizingthe *** reactive oxygen species can affect sperm metabolism,leading to immobility,impaired acrosome reaction,and celldeath,thereby impairing reproductive *** double-blind randomized study evaluated the effect of supplementation withL-carnitine,acetyl-L-carnitine,vitamins,and other nutrients on semen quality in 104 infertile patients with or without varicocele,while also investigating the impact of factors such as obesity and advanced age on *** concentration significantlyincreased in the supplemented group compared to the placebo group(P=0.0186).Total sperm count also significantly increasedin the supplemented group(P=0.0117),as did sperm motility(P=0.0120).The treatment had a positive effect on patients upto 35 years of age in terms of sperm concentration(P=0.0352),while a body mass index(BMI)above 25 kg m^(−2) had a negativeeffect on sperm concentration(P=0.0110).Results were not showing a net benefit in stratifying patients in accordance withtheir BMI since sperm quality increase was not affected by this *** conclusion,antioxidant supplementation may bebeneficial for infertile patients and has a more positive effect on younger patients with a normal weight.

关键词： aging antioxidants body mass index oligoasthenoteratozoospermia varicocele

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Minimally invasive surgical therapies(MISTs)for lower urinary tract symptoms(LUTS):promise or panacea?

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Asian Journal of Andrology 2024年第2期26卷 135-143页

作者： Gian Maria Busetto Andrea Checchia Marco Recchia Edoardo Tocci Ugo G Falagario Gennaro Annunziata Pasquale Annese Nicola d'Altilia Vito Mancini Matteo Ferro Felice Crocetto Octavian Sabin Tataru Luca Di Gianfrancesco angelo porreca Francesco Del Giudice Ettore De Berardinis Carlo Bettocchi Luigi Cormio Giuseppe Carrieri University of Foggia Foggia 71122Italy Department of Urology and Renal Transplantation Policlinico of FoggiaFoggia 71122Italy Urology Unit "G.Tatarlla"HospitalCerignola 71042Italy Urology Unit European Institute of Oncology(IE0)IRCcSMilan 20141Italy University of Naples Federico Il Naples 80126Italy G.E.Palade University of Medicine PharmacyScienceand Technology of Targu MuresTargu Mures 540142Romania Department of Oncological Urology Veneto Institute of Oncology(IOv)IRccSPadua 35128Italy Department of Maternal-Infant and Urological Sciences Sapienza Rome UniversityRoma 00161Italy Urology Unit "L.Bonomo"HospitalAndria 76123Italy

The increasing importance of treatment of lower urinary tract symptoms(LUTS),while avoiding side effects and maintaining sexual function,has allowed for the development of minimally invasive surgical therapies(MiSTs).Recently,the European Association of Urology guidelines reported a paradigm shift from the management of benign prostatic hyperplasia(BPH)to the management of nonneurogenic male *** aim of the present review was to evaluate the efficacy and safety of the most commonly used MisTs:ablative techniques such as aquablation,prostatic artery embolization,water vapor energy,and transperineal prostate laser ablation,and nonablative techniques such as prostatic urethral lift and temporarily implanted nitinol device(iTIND).MiSTs are becoming a new promise,even if clinical trials with longer follow-up are still *** of them are still under investigation and,to date,only a few options have been given as a recommendation for *** cannot be considered as standard of care and are not suitable for all *** and disadvantages should be underlined,without forgetting our objective:treatment of LUTS and re-treatment avoidance.

关键词： aquablation iTIND prostatic artery embolization prostatic urethral lift transperineal prostate laser ablation water vapor energy

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Metastatic Breast Neuroendocrine Cancer in Pregnancy:A Case of an Oncologic Emergency and a Review of Literature

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Maternal-Fetal Medicine 2020年第4期2卷 248-252页

作者： De Luca Caterina Tosto Valentina Badr Dominique A. De Luca Laura porreca Roberta Di Renzo Gian Carlo Department of Obstetrics and Gynecology University Hospital Santa Maria della MisericordiaPerugia 06129Italy Department of Obstetrics and Gynecology University Hospital BrugmannUniversitéLibre de BruxellesBrussels 1020Belgium Department of Obstetrics and Gynecology University Hospital ErasmeUniversitéLibre de BruxellesBrussels 1070Belgium Department of Oncology University Hospital Santa Maria della MisericordiaPerugia 06129Italy.

Breast neuroendocrine carcinoma is a rare *** constitutes less than 0.5%of breast malignancies,and is usually diagnosed in older *** occurrence of this type in young patients during pregnancy is extremely *** 2 cases were previously *** were diagnosed at earlier stage with the appearance of a palpable breast ***,we present the case of a young patient at 28 weeks’gestation admitted for severe diffuse back pain and neurologic deficit due to spinal cord compression at the level of C5 vertebra,and nerve root compression at the level of L5 *** the best of our knowledge,this is the first case of oncologic emergency during pregnancy due to a metastatic poorly differentiated breast carcinoma with neuroendocrine differentiation in the absence of a detectable primary focus of malignancy in the *** also discuss the management and the obstetrical outcome of this patient.

关键词： Neoplasm metastasis Neuroendocrine breast carcinoma Oncologic emergency Pregnancy

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接受治疗的老年高血压患者中隐匿性和白大衣性未控制高血压的预后

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中华高血压杂志 2018年第8期26卷 798-798页

作者： Pierdomenico SD Pierdomenico AM Coccina F porreca E 陈云

接受治疗的老年高血压患者中隐匿性未控制高血压（masked uncontrolled hypertension,MUCH）和白大衣性未控制高血压（white-coat uncontrolled hypertension,WCUCH）的预后并不完全清楚。因此,本研究对动态血压监测确定的MUCH和WCUCH... 详细信息

接受治疗的老年高血压患者中隐匿性未控制高血压（masked uncontrolled hypertension,MUCH）和白大衣性未控制高血压（white-coat uncontrolled hypertension,WCUCH）的预后并不完全清楚。因此,本研究对动态血压监测确定的MUCH和WCUCH的预后进行评估。方法：入选1191例老年高血压患者。

关键词：老年高血压患者高血压诊室血压隐匿性

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在动态血压得到控制的老年高血压患者中非杓型血压和晨峰的预后价值

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中华高血压杂志 2017年第10期25卷 998-998页

作者： Pierdomenico SD Pierdomenico AM Coccina F Lapenna D porreca E 陈云叶鹏

动态血压已控制的高血压患者中非杓型血压和晨峰的独立预后意义还不清楚。研究者在接受治疗且动态血压正常的老年高血压患者中调查动态血压参数与心血管病风险之间的关系。

关键词：老年高血压患者动态血压参数非杓型血压预后价值晨峰心血管病血压正常

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接受治疗的老年高血压患者的动态血压参数与射血分数保留或降低的心力衰竭发病的关系

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中华高血压杂志 2016年第12期24卷 1198-1198页

作者： Pierdomenico SD Pierdomenico AM Coccina F Lapenna D porreca E 陈云叶鹏

动态血压和未来发生心力衰竭风险之间的关联目前还不清楚。本文研究老年高血压患者动态血压参数与发生射血分数降低的心力衰竭（heart failure with reduced ejection fraction,HFREF）或射血分数保留的心力衰竭（heart failure with pr... 详细信息

动态血压和未来发生心力衰竭风险之间的关联目前还不清楚。本文研究老年高血压患者动态血压参数与发生射血分数降低的心力衰竭（heart failure with reduced ejection fraction,HFREF）或射血分数保留的心力衰竭（heart failure with preserved ejection fraction,HFPEF）风险之间的关系。

关键词：老年高血压患者动态血压参数心力衰竭射血分数发病治疗风险

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