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Journal of Bionic Engineering 2019年第3期16卷 503-513页

作者： Laribi Med Amine Carbone giuseppe Zeghloul Said Department of GMSC Pprime Institute CNRS-University of Poitiers - ENSMA - UPR 3346 Poitiers France Department of Mechanical Energy and Management Engineering University of Calabria 87036 Rende Italy CESTER Technical University of Cluj-Napoca Muncii Ave. 103-105 400641 Cluj-Napoca Romania

This paper deals with an optimization approach to design a cable driven parallel robot intended for upper limb rehabilitation tasks. The cable driven parallel robots have characteristics that make them best candidate for rehabilitation exercise purposes such as large workspace, re-configurable architecture, portability and cost effectiveness. Here, both the cable tensions that are needed to move a wristband as well as the workspace need to be carefully optimized for fulfilling the prescribed operation tasks. A specific case of study is addressed in this work by referring to LA RM wire driven exercising device (LAWEX), which is applied to upper limbs exercises. To that end, a motion capture system is used to collect quantitative data on the prescribed workspace of a human upper limb. A specific optimization problem is settled up for considering combining two optimization goals, namely, the smallest robot size reaching a prescribed workspace and the minimum cable tension distributions. A sequence of optimization steps is defined using Genetic Algorithms (GAs) applied to LAWEX robot. The proposed objective function is based on a mathematical formulation of the power of a point with respect to bounding surfaces in combination with a performance index to show the distributions of the minimum cable tensions.

关键词： LAWEX robot design bionic robot cable-driven robots optimization power of the point rehabilitation tasks

Structural and functional aspects of the Helicobacter pylori secretome

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World Journal of Gastroenterology 2014年第6期20卷 1402-1423页

作者： giuseppe Zanotti Laura Cendron Department of Biomedical Sciences University of Padua Department of Biology University of Padua

Proteins secreted by Helicobacter pylori (H. pylori), an important human pathogen responsible for severe gastric diseases, are reviewed from the point of view of their biochemical characterization, both functional and structural. Despite the vast amount of experimental data available on the proteins secreted by this bacterium, the precise size of the secretome remains unknown. In this review, we consider as secreted both proteins that contain a secretion signal for the periplasm and proteins that have been detected in the external medium in in vitro experiments. In this way, H. pylori’s secretome appears to be composed of slightly more than 160 proteins, but this number must be considered very cautiously, not only because the definition of secretome itself is ambiguous but also because the included proteins were observed as secreted in in vitro experiments that were not representative of the environmental situation in vivo. The proteins that appear to be secreted can be grouped into different classes: enzymes (48 proteins), outer membrane proteins (43), components of flagella (11), members of the cytotoxic-associated genes pathogenicity island or other toxins (8 and 5, respectively), binding and transport proteins (9), and others (11). A final group, which includes 28 members, is represented by hypothetical uncharacterized proteins. Despite the large amount of data accumulated on the H. pylori secretome, a considerable amount of work remains to reach a full comprehension of the system at the molecular level.

关键词： Helicobacter pylori Secreted proteins Periplasmic space Secretion signal Secretome

MODELING BINGE DRINKING

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International Journal of Biomathematics 2012年第1期5卷 57-70页

作者： giuseppe MULONE BRIAN STRAUGHAN Dipartimento di Matematica e Informatica Citt5 Universitaria Viale A. Doria 6 95125 Catania Italy Department of Mathematical SciencesUniversity of Durham Durham DH1 3LE UK

We develop a two-stage （four component） model for youths with serious drinking prob- lems and their treatment. The youths with alcohol problems are split into two classes, namely those who admit to having a problem and those who do not. It is shown that the model possesses two steady states, one where people have no alcohol problems and one where there is an endemic state involving those with an alcohol problem. The stability of these states is analyzed and a threshold established such that each state will be stable depending on whether the incidence rate is above or below the threshold. The model is analyzed in the context of actual data.

关键词： Alcohol epidemics equilibria stability binge drinking.

ON MODELING THE GROWTH DYNAMICS OF A STAGE STRUCTURED POPULATION

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International Journal of Biomathematics 2013年第6期6卷 29-52页

作者： giuseppe BUFFONI SARA PASQUALI CNR-IMATI Via Bassini 15 20133 Milano Italy

A Lagrangian modeling approach is applied to the numerical simulation of the temporal dynamics of a stage-structured population. The growth dynamics is determined only by the main biological processes： development of an individual, mortality, reproduction. Different approaches in modeling the development process of an individual are implemented： stochastic advection-diffusion models （backward-forward dispersion models）, and stochastic development models where regression effects, defined as negative development on the status of an individual, are forbidden （forward dispersion models）. Some properties of the residence times of an individual in a stage are investigated： in particular, their role in the calibration of the development models and in the estimation of some parameters introduced in the model equation. As a study case a multi-stage pelagic copepod population is considered. Trying to separate the effects of the main biological processes on the temporal dynamics, numerical simulations have been carried out in some idealized situations： first only the development of the individuals, neglecting mortality and reproduction, is considered; then the mortality process is introduced, and finally both the mortality and reproduction processes. The results of the numerical simulations, are compared and discussed.

关键词： Stage structure residence time in a stage stochastic development models

A Resilient Control Strategy for Cyber-Physical Systems Subject to Denial of Service Attacks:A Leader-Follower Set-Theoretic Approach

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IEEE/CAA Journal of Automatica Sinica 2020年第5期7卷 1204-1214页

作者： giuseppe Franzè Domenico Famularo Walter Lucia Francesco Tedesco DIMES Department Universitàdella CalabriaVia Pietro Bucci 87036Italy CIISE Department Concordia UniversityMontrealQuebec H3G-1M8Canada IEEE

Multi-agent systems are usually equipped with open communication infrastructures to improve interactions efficiency,reliability and *** technologically costeffective,this makes them vulnerable to cyber-attacks with potentially catastrophic *** this end,we present a novel control architecture capable to deal with the distributed constrained regulation problem in the presence of time-delay attacks on the agents’communication *** basic idea consists of orchestrating the interconnected cyber-physical system as a leader-follower configuration so that adequate control actions are computed to isolate the attacked unit before it compromises the system *** on a multi-area power system confirm that the proposed control scheme can reconfigure the leader-follower structure in response to denial ofservice(DoS)attacks.

关键词： Denial-of-service(DoS)attacks distributed model predictive control leader-follower paradigm resilient control

Synthesis, Properties and Potential Applications of Porous Graphene: A Review

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Nano-Micro Letters 2013年第4期5卷 260-273页

作者： Paola Russo Anming Hu giuseppe Compagnini Department of Mechanical and Mechatronics Engineering University of Waterloo Dipartimento di Scienze Chimiche Università degli Studi di Catania Institute of Laser Technology Beijing University of Technology

Since the discovery of graphene, many efforts have been done to modify the graphene structure for integrating this novel material to nanoelectronics, fuel cells, energy storage devices and in many other applications. This leads to the production of different types of graphene-based materials, which possess properties different from those of pure graphene. Porous graphene is an example of this type of materials. It can be considered as a graphene sheet with some holes/pores within the atomic plane. Due to its spongy structure, porous graphene can have potential applications as membranes for molecular sieving, energy storage components and in nanoelectronics. In this review, we present the recent progress in the synthesis of porous graphene. The properties and the potential applications of this new material are also discussed.

关键词： Graphene Porous graphene Gas separation Energy storage

MEMORIES OF BRITTON CHANCE AND THE BRITTON CHANCE AWARD

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Journal of Innovative Optical Health Sciences 2011年第4期4卷 477-478页

作者： giuseppe CICCO Hemorheology and Microcirculation Research Unit Universit"Aldo Moro" BariItaly

Britton Chance has been a person of superlative quality,a close friend,a great teacher and researcher,and a well-known and revered scientist in biochemistry.

关键词： Britton Chance ISOTT

Potential impact of genetically modified Lepidoptera-resistant Brassica napus in biodiversity hotspots： Sicily as a theoretical model

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Insect Science 2018年第4期25卷 562-580页

作者： Barbara Manachini giuseppe Bazan Rosario Schicchi Department of Agricultural Food and Forest Sciences University of Palermo Palermo Italy Department of Biological Chemical and Pharmaceutical Sciences and Technologies University of Palermo Palermo Italy

The general increase of the cultivation and trade of Bt transgenic plants resis- tant to Lepidoptera pests raises concerns regarding the conservation of animal and plant biodiversity. Demand for biofuels has increased the cultivation and importation of oilseed rape （Brassica napus L.）, including transgenic lines. In environmental risk assessments （ERAs） for its potential future cultivation as well as for food and feed uses, the impact on wild Brassicaeae relatives and on non-target Lepidoptera should be assessed. Here we consider the potential exposure of butterflies as results of possible cultivation or natural- ization of spilled seed in Sicily （Italy）. Diurnal Lepidoptera, which are pollinators, can be exposed directly to the insecticidal proteins as larvae （mainly of Pieridae） through the host and through the pollen that can deposit on other host plants. Adults can be exposed via pollen and nectar. The flight periods of butterflies were recorded, and they were found to overlap for about 90% of the flowering period ofB. napus for the majority of the species. In addition, B. napus has a high potential to hybridise with endemic taxa belonging to the B. oleracea group. This could lead to an exposure of non-target Lepidoptera if introgression of the Bt gene into a wild population happens. A rank of the risk for butterflies and wild relatives of oilseed rape is given. We conclude that, in environmental risk assessments, attention should be paid to plant-insect interaction especially in a biodiversity hotspot such as Sicily.

关键词： butterflies cross pollination non-target effect oilseed rape protected areas transgenic crop

Leaky gut, dysbiosis, and enteric glia activation: the trilogy behind the intestinal origin of Parkinson’s disease

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Neural Regeneration Research 2020年第6期15卷 1037-1038页

作者： Luisa Seguella Giovanni Sarnelli giuseppe Esposito Department of Physiology and Pharmacology“V.Erspamer”-Sapienza University RomeItaly(Seguella LEsposito G)Department of Clinical Medicine and SurgeryUniversity of Naples“Federico II”NaplesItaly(Sarnelli G)

Early diagnosis of Parkinson’s disease(PD):how we can improve the therapeutic approach:PD is a neurodegenerative disease characterized by motor dysfunctions(tremor,rigidity,bradykinesia and impaired posture/balance)elicited by selective depletion of dopaminergic(DA)neurons in substantia nigra pars *** neuron loss is associated with neuronal inclusions of the phosphorylatedα-synuclein protein called Lewy body(Shults,2006).Although the underlying neurodegenerative process is not affected,the management of PD patients has been revolutionized with the introduction of levodopa and DA drugs in the routine therapy,which ensures initial symptomatic relief of motor functions through the DA supply in the nigrostriatal *** drugs are currently the best option for treating PD,although their chronic use is associated with progressive dopamine resistance and loss of effectiveness in the recovery of motor *** therapeutic strategies,including agonists of DA receptors,monoamine oxide B inhibitors,and even deep brain stimulation techniques have been developed to overcome these clinical ***,these therapeutic approaches cannot restore PD-compromised functions,as irreversible DA neurodegeneration has occurred in substantia nigra pars compacta when first motor symptoms *** nigrostriatal system is traditionally considered as the first region affected by neuronal impairment in Parkinsonisms;however,α-synuclein aggregation appears in a pre-motor stage of the disease in the enteric nervous system(ENS).

关键词： impaired routine overcome

Horizontal accuracy assessment of very high resolution Google Earth images in the city of Rome,Italy

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International Journal of Digital Earth 2016年第4期9卷 342-362页

作者： giuseppe Pulighe Valerio Baiocchi Flavio Lupia Istituto Nazionale di Economia Agraria via Nomentana 41Roma Dipartimento di Ingegneria Civile Edile e Ambientale(DICEA)UniversitàLa SapienzaRoma

Google Earth(GE)has recently become the focus of increasing interest and popularity among available online virtual globes used in scientific research projects,due to the free and easily accessed satellite imagery provided with global ***,the uses of this service raises several research questions on the quality and uncertainty of spatial data(*** accuracy,precision,consistency),with implications for potential uses like data collection and *** paper aims to analyze the horizontal accuracy of very high resolution(VHR)GE images in the city of Rome(Italy)for the years 2007,2011,and *** evaluation was conducted by using both Global Positioning System ground truth data and cadastral photogrammetric vertex as independent check *** validation process includes the comparison of histograms,graph plots,tests of normality,azimuthal direction errors,and the calculation of standard statistical *** results show that GE VHR imageries of Rome have an overall positional accuracy close to 1 m,sufficient for deriving ground truth samples,measurements,and large-scale planimetric maps.

关键词： Google Earth VHR images GPS accuracy assessment Rome