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Virulence Factors in methicillin-Resistant Staphylococcus aureus Isolated from ICU Units in Brazil

Advances in microbiology 2014年第4期4卷 207-215页

作者： Simone g.Souza guilherme B.Campos Pollianna S.oliveira Daniel S.Sousa Danilo C.C.Da Silva Verena m.santos Aline T.Amorim angelita m.o.g.santos Jorge Timenetsky mariluze P.Cruz Regiane Yatsuda Lucas m.marques Instituto multidisciplinar em Saúde Núcleo de Tecnologia em SaúdeUniversidade Federal da BahiaVitória da ConquistaBrazil Instituto de Ciências Biomédicas Departamento de MicrobiologiaUniversidade de Sao PauloSao PauloBrazil

Species of Staphylococcus are common in hospital infection (HI). methicillin resistant S. aureus (mRSA) has also become a serious problem in Brazilian HI. The aim of this study was to characterize the pathogenicity of methicillin-resistant S. aureus (mRSA) and methicillin-sensitive Staphylococcus aureus (mSSA) isolated in public hospitals. The clinical isolates were obtained from intensive care unit. The mRSA and mSSA strains were genotyped by PCR for detection genes related to virulence factors. moreover, the strains were tested for biofilm formation and cytokine induction in macrophages. Three strains of mRSA (9.68%) expressed the Sea gene, one (3.23%) Seb, 17 (54.84%) Spa and seven (22.58%) had PVL. Two mSSA strains (2.98%) expressed the Sea gene, three (4.48%) Seb, 18 (26.87%) Spa and 11 (16.42%) showed positive results for the PVL gene. There was no expression of Sec and CflA between mRSA and mSSA strains. Among mRSA and mSSA isolates, none statistical differences were observed in biofilm production. The analysis of cytokine induction in the inflammatory response of J774 macrophages by mRSA and mSSA isolates did not show statistical difference. Understanding the mechanisms of pathogenesis of S. aureus could provide important clues for both preventing and treating infection caused by these organisms.

关键词： mRSA mSSA Virulence Factor Hospitalar Infection

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