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predictors of sperm recovery after cryopreservation n testicular cancer

Asian Journal of Andrology 2016年第1期18卷 35-38页

作者： James M Hotaling Darshan p patel Christopher Vendryes Natalya A Lopushnyan angela p presson Chong Zhang charles H Muller Thomas J Walsh Division of Urology Department of Surgery University of Utah Salt Lake City UT 84132 USA Department of Urology University of Illinois-Chicago Chicago IL 60612 USA Department of Urology University of Washington Seattle WA 98195 USA Division of Epidemiology Department of Internal Medicine University of Utah Salt Lake City UT 84132 USA

Our objective was to identify predictors of improved postthaw semen quality in men with testicular cancer banking sperm for fertility preservation. We reviewed 173 individual semen samples provided by 67 men with testicular germ cell tumor （TGCT） who cryopreserved sperm before gonadotoxic treatment between 1994 and 2010 at our tertiary university medical center. Our main outcomes measures were independent predictors for the greater postthaw total motile count （TMC） in men with TGCT. Men with NSGCT were more likely to be younger （p 〈 0.01） and had high cancer stage （Ⅱ or Ⅲ, p 〈 0.01） compared with men with seminoma. In our multiple regression model, NSGCT histology, use of density gradient purification, and fresh TMC 〉 median fresh TMC each had increased odds of a postthaw TMC greater than median postthaw TMC. Interestingly, age, advanced cancer stage （11 or III）, rapid freezing protocol, and motility enhancer did not show increased odds of improved postthaw TMC in our models. In conclusion, men with TGCT or poor fresh TMC should consider preserving additional vials （at least 15 vials） before oncologic treatment. Density gradient purification should be routinely used to optimize postthaw TMC in men with TGCT. Larger, randomized studies evaluating cancer stage and various cryopreservation techniques are needed to assist in counseling men with TGCT regarding fertility preservation and optimizing cryosurvival.

关键词： cryopreservation fertility preservation seminoma testicular neoplasms

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proton-pump inhibitor use does not affect semen luality in subfertile men

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Asian Journal of Andrology 2018年第3期20卷 290-293页

作者： Sorena Keihani James R Craig Chong Zhang angela p presson Jeremy B Myers William O Brant Kenneth I Aston Benjamin R Emery Timothy G Jenkins Douglas T Carrell James M Hotaling Division of Urology Department of Surgery University of Utah Salt Lake City Utah 84132 USA Division of Epidemiology Department of Internal Medicine University of Utah Salt Lake City Utah 84132 USA Andrology and IVF Laboratory Department of Surgery (Urology) University of Utah Salt Lake City Utah 84108 USA

proton-pump inhibitors （ppIs） are among the most widely used drugs worldwide. ppI use has recently been linked to adverse changes in semen quality in healthy men; however, the effects of ppI use on semen parameters remain largely unknown specifically in cases with male factor infertility. We examined whether ppI use was associated with detrimental effects on semen parameters in a large population of subfertile men. We retrospectively reviewed data from 12 257 subfertile men who had visited our fertility clinic from 2003 to 2013. patients who reported using any ppIs for 〉3 months before semen sample collection were included; 7698 subfertile men taking no medication served as controls. Data were gathered on patient age, medication use, and conventional semen parameters; patients taking any known spermatotoxic medication were excluded. Linear mixed-effect regression models were used to test the effect of ppI use on semen parameters adjusting for age. A total of 248 patients （258 samples） used ppIs for at least 3 months before semen collection. In regression models, ppI use （either as the only medication or when used in combination with other nonspermatotoxic medications） was not associated with statistically significant changes in semen parameters. To our knowledge, this is the largest study to compare ppI use with semen parameters in subfertile men. Using ppIs was not associated with detrimental effects on semen quality in this retrospective study.

关键词： infertility proton-pump inhibitors semen analysis sperm quality spermatozoa

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