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The Traditional chinese Medicine Plant Schisandra chinensis as Source of New HIV-1Reverse Transcriptase Inhibitor Scaffolds Effective also on Non-nucleoside Resistant Reverse Transcriptases

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The Traditional Chinese Medicine Plant Schisandra Chinensis ...

Roots and rhizomes of wild Asparagus:Nutritional composition,bioactivity and nanoencapsulation of the most potent extract

第十四届全国中药和天然药物学术研讨会

作者： Xu Lijia Grandi Nicole Del Vecchio claudia corona angela Daniela Mandas Esposito Francesca Parolin cristina tramontano Enzo Institute of Medicinal Plant Development (IMPLAD) University of cagliari University of Padova

＜正＞Background HIV-1 reverse transcriptase（RT）is still an extremely attractive pharmaceutical target for the identification of new inhibitors possibly active on drug resistant *** plants are a rich source of chemical diversity and can be used to identify novel scaffolds to be further developed by chemical *** studies the Traditional chinese Medicine fruit of

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Food Bioscience 2022年第1期45卷 349-360页

作者： Khaoula Adouni Ana Júlio celestino Santos-Buelga Ana M.Gonzalez-Paramas Patrícia Filipe Patricia Rijo Sofia A.costa Lima Salette Reis angela Fernandes Isabel c.F.R.Ferreira Virginia Fernandez-Ruiz Patricia Morales Guido Flamini Lotfi Achour Pedro Fonte Laboratoire de Recherche“Bioressources:Biologie Integrative&Valorisation” Institut Superieur de Biotechnologie de MonastirAvenue Tahar HaddedBP 74Universite de Monastir5000MonastirTunisia cBIOS-Research center for Biosciences&Health Technologies Universidade Lusofona de Humanidades e TecnologiasCampo Grande 3761749-024LisbonPortugal Department of Biomedical Sciences University of Alcal´aCtra.Madrid-Barcelona Km.33.60028871Alcala de HenaresMadridSpain Grupo de Investigacion en Polifenoles(GIP-USAL) Facultad de FarmaciaUniversidad de SalamancaCampus Miguel de UnamunoE-37007SalamancaSpain Research Institute for Medicines(iMed.ULisboa) Faculty of PharmacyUniversidade de LisboaAv.Professor Gama Pinto1649-003LisboaPortugal LAQV REQUIMTEDepartment of Chemical Sciences–Applied Chemistry LabFaculty of Pharmacy10 University of PortoRua Jorge de Viterbo Ferreira 2284050-313PortoPortugal centro de Investigacao de Montanha(cIMO) Instituto Politecnico de BragancaCampus de Santa Apolonia5300-253BragancaPortugal Department of Nutrition and Food Science Faculty of PharmacyComplutense University of Madrid(UCM)Plaza Ramon y Cajal s/n28040MadridSpain Dipartimento di Farmacia University of Pisavia Bonanno 656126PisaItaly centro Interdipartimentale di Ricerca“Nutraceutica e Alimentazione per la Salute”University of Pisa Via del Borghetto 8056124PisaItaly center for Marine Sciences(ccMar) University of AlgarveGambelas Campus8005-139FaroPortugal Department of chemistry and Pharmacy Faculty of Sciences and TechnologyUniversity of AlgarveGambelas Campus8005-139FaroPortugal iBB-Institute for Bioengineering and Biosciences Department of BioengineeringInstituto Superior TecnicoUniversidade de Lisboa1049-001LisboaPortugal Associate Laboratory i4HB—Institute for Health and Bioeconomy at Instituto Superior Tecnico Universidade de LisboaAv.Rovisco Pais1049-001LisboaPortugal

The nutritional composition and bioactive properties of roots and rhizomes of Asparagus stipularis were *** activity of extracts obtained by infusion was evaluated using free radicals scavenging and reducing power *** liver primary cell was used to check the hepatotoxicity of *** revealed that Asparagus samples are likely a source of nutrients,such as dietary fibre and essential fatty ***-DAD-ESI/MS characterization of infusions allowed the identification and quantitation of 7 phenolic compounds,all hydroxycinnamoyl derivatives,with caffeic acid as the most *** infusion contained the highest amounts of these *** also exhibited the highest antioxidant activity in all assays,with Ec_(50) values of 0.44±0.01,0.98±0.03 and 0.64±0.01 mg/mL for DPPH,ABTS and FRAP assays,respectively,with no toxicity towards PLP2 primary cell cultures(GI_(50)>400μg/mL).PLGA nanoparticles loaded with root extract were prepared using solvent-evaporation double emulsion *** size was about 260 nm and a polydispersity index around 0.1,with a zeta potential of about-36 mV,as well as a good encapsulation efficiency of approximately 83%.Their morphology was analysed by SEM and spherical polymeric nanoparticles with a smooth surface were *** and DSc were also performed,which allowed corroborating the efficacy of the encapsulation and to confirm the production of a stable and robust system to load Asparagus *** developed nanoparticles are expected to be used as delivery systems for bioactive compounds of *** and they could be used as an innovative dietary supplement.

关键词： Asparagus stipularis Nutritional composition Antioxidant activity Nanoparticles PLGA

Phenotypic AScOD characterisations of ischaemic stroke in the young at an urban tertiary care centre

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Stroke & Vascular Neurology 2018年第4期3卷 209-214页

作者： angela Liu Mohsen Pirastehfar Daohai Yu Guillermo Linares Department of Neurology Washington University in St LouisSaint LouisMissouriUSA Department of Vascular Neurology UC San DiegoLa JollaCaliforniaUSA Department of clinical Sciences Lewis Katz School of Medicine at Temple UniversityPhiladelphiaPennsylvaniaUSA Department of Stroke and Neurocritical care University of Vermont College of MedicineBurlingtonVermontUSA

Background and purpose Stroke in young individuals is a serious public health *** study aimed to characterise the various phenotypes of ischaemic stroke in a young urban population(≤50 years old)using the AScOD classification system,which assigns a score to five stroke categories:atherosclerosis,small vessel disease(SVD),cardioembolism,other and *** each category,a numerical score represents the degree of causality attributed to the *** This retrospective study cohort was composed of patients from an urban tertiary care academic *** were selected by searching Get With the Guidelines database for adults≤50 years old with ischaemic *** study sample included 175 ischaemic strokes in 157 patients,with 16 subjects *** retrospective chart review,each stroke was scored according to the AScOD classification *** logistic regression analyses were performed to explore each AScOD category’s association with causal risk *** Of possible causal mechanisms,defined as receiving a grade 1 or 2,a cardiovascular aetiology was most prevalent(25.7%),followed by SVD(22.3%),and closely by atherosclerosis(21.1%).Of general phenotypes,defined as receiving a grade 1 or 2 or 3,atherosclerosis was the most prevalent(51.4%),followed by SVD(47.4%),cardioembolism(42.3%)and other(35.4%).31.6%of all strokes were of unclear *** between 45 and 50 years old were more likely to develop a cardioembolic or SVD stroke when compared with subjectsch to AScOD phenotyping,allowing several observations:(1)In patients with advanced atherosclerosis receiving the score A1,the vast majority had systemic atherosclerosis in multiple vascular territories;(2)the cardiac score c2(6),defined as a radiographic pattern highly suggestive of a central embolic source,may overestimate the prevalence of true cardiac disease;(3)incidental laboratory findings may detec

关键词： AScO character category

High-resolution microendoscopy for esophageal cancer screening in china: A cost-effectiveness analysis

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World Journal of Gastroenterology 2015年第18期21卷 5513-5523页

作者： chin Hur Sung Eun choi chung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan angela c.tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy Institute for Technology Assessment Massachusetts General Hospital Harvard Medical School Boston MA 02114 United States Gastrointestinal Unit Massa- chusetts General Hospital Department of Endoscopy Cancer Institute and Hospital Chinese Academy of Medical Sciences Department of Endoscopy The First Hospital of Jilin University Department of Pathology The Mount Sinai Medical Center Icahn School of Medicine Department of Pathology Cancer Institute and Hospital Chinese Academy of Medical Sciences Department of Bioengineering Rice University Baylor Global Initiatives and the Baylor Global Innovation center Baylor College of Medicine

AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(EScc)screening program in ***:A decision analytic Markov model of EScc was *** model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in *** 50-year-old individuals were followed until age 80 or *** compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an *** parameters were estimated from the literature as well as from GLOBOcAN,the cancer Incidence and Mortality Worldwide cancer *** states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and *** EScc incidence transition rates were generated for the average-risk and high-risk *** in chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the consumer Price ***:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(IcER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an IcER of I$11808 per QALY *** endoscopic screening was weakly *** the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the IcER was I$8173 per *** both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing IcERs below the willingness-topay threshold,I$23500 per ***-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s i

关键词： cost-effectiveness analysis Diagnostic imaging Endoscopy Esophageal squamous cell cancer Simulation disease model

Retinoic acid signaling acts as a rheostat to balance Treg function

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cellular & Molecular Immunology 2022年第7期19卷 820-833页

作者： Govindarajan Thangavelu Gabriela Andrejeva Sara Bolivar-Wagers Sujeong Jin Michael c.Zaiken Michael Loschi Ethan G.Aguilar Scott N.Furlan chrysothemis c.Brown Yu-chi Lee cameron McDonald Hyman colby J.Feser angela Panoskaltsis-Mortari Keli L.Hippen Kelli P.MacDonald William J.Murphy Ivan Maillard Geoffrey R.Hill David H.Munn Robert Zeiser Leslie S.Kean Jeffrey c.Rathmell Hongbo chi Randolph J.Noelle Bruce R.Blazar Department of Pediatrics Center for ImmunologyUniversity of MinnesotaMinneapolisMNUSA center for Immunobiology Vanderbilt University Medical CenterNashville TNUSA Department of Pediatrics University of WashingtonSeattleWAUSA Fred Hutchinson cancer Research center SeattleWAUSA Howard Hughes Medical Institute Immunology Program and Ludwig CenterSloan Kettering InstituteMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Department of Microbiology and Immunology.Geisel School of Medicine at Dartmouth Norris Cotton Cancer CenterLebanonUSA Department of Immunology Queensland Institute of Medical Research(QIMR)Berghofer Medical Research Institute and School of MedicineUniversity of QueenslandBrisbaneQLDAustralia Departmentof Dermatology School of MedicineUniversity of California DavisSacramentoCAUSA Division of Hematology/Oncology Department of MedicineUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaPAUSA Georgia cancer center Augusta UniversityAugustaGAUSA Department of Haematology Oncology and Stem Cell TransplantationFaculty of MedicineFreiburg University Medical CentreFreiburgGermany Boston children's Hospital and the Dana-Farber cancer Institute BostonMAUSA Department of Immunology St.Jude Children's ResearchHospitalMemphisTNUSA

Regulatory T cells(Tregs)promote immune homeostasis by maintaining self-tolerance and regulating inflammatory *** certain inflammatory conditions,Tregs can lose their lineage stability and *** studies have reported that ex vivo exposure to retinoic acid(RA)enhances Treg function and ***,it is unknown how RA receptor signaling in Tregs influences these processes in ***,we employed mouse models in which RA signaling is silenced by the expression of the dominant negative receptor(DN)RARαin all T *** the fact that DNRARαconventional T cells are hypofunctional,Tregs had increased cD25 expression,STAT5 pathway activation,mTORc1 signaling and supersuppressor ***,DNRARαTregs had increased inhibitory molecule expression,amino acid transporter expression,and metabolic fitness and decreased antiapoptotic *** function was observed when wild-type mice were treated with a pharmacologic pan-RAR ***,Treg-specific expression of DNRARαresulted in distinct phenotypes,such that a single allele of DNRARαin Tregs heightened their suppressive function,and biallelic expression led to loss of suppression and *** loss of Treg function was not cell intrinsic,as Tregs that developed in a noninflammatory milieu in chimeric mice reconstituted with DNRARαand wild-type bone marrow maintained the enhanced suppressive *** mapping suggested that maintaining Treg stability in an inflammatory milieu requires RA *** findings indicate that RA signaling acts as a rheostat to balance Treg function in inflammatory and noninflammatory conditions in a dose-dependent manner.

关键词： Retinoic acid Tregulatory cells Autoimmunity Metabolism mTORc1 STAT5

Graphene-Oxide Mediated chemodivergent Ring-Opening of cyclobutanols

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chinese Journal of chemistry 2023年第11期41卷 1333-1340页

作者： Andrea Brunetti angela Pintus Lorenzo Lombardi Alessandro Kovtun Federico Mascietti Francesco Bruno Enrico Ravera Manuela Melucci Giulio Bertuzzi Marco Bandini Dipartimento di chimica“Giacomo ciamician” Alma Mater StudiorumUniversitàdi BolognaVia Selmi 240126BolognaItaly Istituto per la Sintesi e la Fotoreattività(ISOF)–cNR Via Gobetti10140129BolognaItaly Magnetic Resonance center(cERM) University of FlorenceVia L.Sacconi 650019 Sesto FiorentinoItaly Department of chemistry“Ugo Schiff” University of FlorenceVia della Lastruccia 350019 Sesto FiorentinoItaly center for chemical catalysis–c3 Alma Mater StudiorumUniversitàdi Bolognavia Selmi 240126BolognaItaly

The chemodivergent ring-opening of cyclobutanols is described under the carbocatalytic assistance of graphene oxide(GO).The protocol enables the synthesis of diversely functionalized dienes or indenes(26 examples)based on the amount of GO ***(XPS and ssNMR)as well as experimental investigations revealed a direct involvement of theπ-domains of GO in tuning the stability of carbocationic intermediates during the reaction.

关键词： carbocatalysis c-c activation Graphene carbocations Methodology and reactions

Sennoside A,from the Traditional chinese Medicine plant Rheum L.,is a New Reverse Transcriptase Inhibitor Effective Against HIV-1 Replication

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Sennoside A,from the Traditional Chinese Medicine plant Rheu...

clinical implications of endogenous testosterone density on prostate cancer progression in patients with very favorable low and intermediate risk treated with radical prostatectomy

第十四届全国中药和天然药物学术研讨会

作者： corona angela Xu Lijia Grandi Nicole Del Vecchio claudia Marta cadeddu Dario Piano Esposito Francesca Parolin cristina tramontano Enzo University of cagliari Institute of Medicinal Plant Development (IMPLAD) University of Padova

＜正＞Background HIV-1 Reverse Transcriptase inhibitors（RTI）are a primary resource for AIDS treatment,but the rapid selection of drug resistance strains requires the identification of novel powerful antiviral *** studies have correlated different categories of phenolic compounds,bioactive constituents Rhubarb,with anti-inflammatory,antioxidant and anticancer activities.

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Asian Journal of Andrology 2023年第5期25卷 556-563页

作者： Antonio Benito Porcaro Alessandro Tafuri Andrea Panunzio clara cerrato Alberto Bianchi Sebastian Gallina Stefano Vidiri Damiano D'Aietti Emanuele Serafin Giovanni Mazzucato Alessandro Princiotta Davide Brusa Matteo Brunelli Vincenzo Pagliarulo Maria angela cerruto AlessandroAntonelli Department of Urology University of VeronaIntegrated University Hospital of VeronaVerona 37126Italy Department of Urology Vito Fazzi HospitalLecce 73100Italy Department of Pathology University of VeronaIntegrated University Hospital of VeronaVerona 37126Italy

We tested the association between endogenous testosterone density(ETD;the ratio between endogenous testosterone[ET]and prostate volume)and prostate cancer(Pca)aggressiveness in very favorable low-and intermediate-risk Pca patients who underwent radical prostatectomy(RP).Only patients with prostate-specific antigen(PSA)within 10 ng ml^(-1),clinical stage T1c,and International Society of Urological Pathology(IsUP)grade group 1 or 2 were *** ET levels up to 350 ng dl^(-1)were classified as *** quantitation density factors were evaluated as the ratio between percentage of biopsy-positive cores and prostate volume(biopsy-positive cores density,BPcD)and the ratio between percentage of cancer invasion at final pathology and prostate weight(tumor load density,TLD).Disease upgrading was coded as ISUP grade group>2,and progression as recurrence(biochemical and/or local and/or distant).Risk associations were evaluated by multivariable cox and logistic regression *** 320 patients,151(47.2%)had intermediate-risk ***(median:402.3 ng dl^(-1))resulted abnormal in 111(34.7%)cases(median ETD:9.8 ng dl^(-1)ml^(-1)).Upgrading and progression occurred in 109(34.1%)and 32(10.6%)cases,*** was predicted by ISUP grade group 2(hazard ratio[HR]:2.290;P=0.029)and upgrading(HR:3.098;P=0.003),which was associated with ISUP grade group 2(odds ratio[OR]:1.785;P=0.017)and TLD above the median(OR:2.261;P=0.001).After adjustment for PSAdensity and bodymass index(BMI),ETDabovethemedianwas positivelyassociatedwithBPcD(OR:3.404;Pcts with abnormal ET were more likely to have higher BPcD(OR:5.566;P=0.002),as well as TLD(OR:14.998;P=0.016).Independently by routinely evaluated factors,as ETD increased,BPcD and TLD increased,but increments were higher for abnormal ET *** very favorable cohorts,ETD may further stratify the risk of aggressive Pca.

关键词： endogenous testosterone density prostate cancer radical prostatectomy tumor progression

Germplasm Innovation of Heat Tolerance in Rice for Irrigated Lowland conditions in the Philippines

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Rice science 2014年第3期21卷 162-169页

作者： Norvie L.MANIGBAS Leslie angela F.LAMBIO Luvina B.MADRID corazon c.cARDENAS Plant Breeding and Biotechnology Division DA-Philippine Rice Research InstituteScience City of MunozNueva Ecija 3119the Philippines crop Science cluster Department of AgronomyU.P.Los BanosCollegeLaguna 4031the Philippines Department of Agriculture-Southern cagayan Research center IguigCagayan3504the Philippines

Heat-tolerant varieties, such as N22 and Dular, which were used in this study, usually have low yield potential and undesirable plant characteristics but combining them with high yielding and improved rice varieties, new heat-tolerant rice genotypes with high yield potential can be achieved. In this study, phenotyping and selecting desirable materials from various crosses were performed under high temperature conditions during the reproductive stage. Screening was performed in the field and glasshouse to select individuals with heat tolerance and high yield potential. Several advanced breeding lines from Gayabyeo/N22 cross produced desirable individuals with heat tolerance, resistance to pests and diseases, and high yield potential. The genetic variation in percent sterility among the selected backcross populations grown in high temperature environments showed that large number of plants can be identified and selected with lower percent sterility.

关键词： heat tolerance high temperature irrigated lowland rice