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Selection criteria in resectable pancreatic cancer: A biological and morphological approach

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World Journal of Gastroenterology 2014年第32期20卷 11210-11215页

作者： Domenico Tamburrino Stefano Partelli Stefano Crippa Alberto Manzoni angela Maurizi Massimo Falconi Pancreatic Surgery Unit Department of Surgery Polytechnic University of Marche Region

Pancreatic ductal adenocarcinoma(PDA) remains one of the most aggressive tumors with a low rate of survival. Surgery is the only curative treatment for PDA, although only 20% of patients are resectable at diagnosis. During the last decade there was an improvement in survival in patients affected by PDA, possibly explained by the advances in cancer therapy and by improve patient selection by pancreatic surgeons. It is necessary to select patients not only on the basis of surgical resectability, but also on the basis of the biological nature of the tumor. Specific preoperative criteria can be identified in order to select patients who will benefit from surgical resection. Duration of symptoms and level of carbohydrate antigen 19.9 in resectable disease should be considered to avoid R1 resection and early relapse. Radiological assessment can help surgeons to distinguish resectable disease from borderline resectable disease and locally advanced pancreatic cancer. Better patient selection can increase survival rate and neoadjuvant treatment can help surgeons select patients who will benefit from surgery.

关键词： Pancreatic ductal adenocarcinoma Pancreatic cancer Borderline resectable pancreatic cancer Pancreatic surgery Pancreatic cancer staging

Morphological integration and functional modularity in the crocodilian skull

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Integrative Zoology 2014年第4期9卷 498-516页

作者： Paolo PIRAS angela DBUSCALIONI Luciano TERESI Pasquale RAIA Gabriele SANSALONE Tassos KOTSAKIS Jorge CUBO Pierre and Marie Curie University ParisFrance Center for Evolutionary Ecology RomeItaly Department of Sciences ‘Roma Tre’UniversityRomeItaly Biology Department Universidad Autónoma de MadridMadridSpain Department of Mathematics and Physics ‘Roma Tre’UniversityRomeItaly Earth Sciences Department Federico II UniversityNaplesItaly Sorbonne Universités UPMC Univ Paris 06UMR 7193ISTePFrance CNRS UMR 7193ISTePParisFrance

We explored the morphological organization of the skull within Crocodylidae,analyzing functional and phylogenetic interactions between its 2 constituent functional modules:the rostrum and the *** used geometric morphometrics to identify localized shape changes,focusing on the differences between the major clades of the crown-group Crocodylia:Alligatoridae and *** used published bite performance data to correlate rostral function with postrostral *** skull modules appear more integrated within Alligatoridae than within *** effects on shape variation are more evident in Alligatoridae than in Crocodylidae,where functional parameters concerning the rostral morphology are proportionally more important than ***-snouted species are characterized by low structural performance,which is significantly associated with a reduction of the pterygoid-quadrate cranial nipper,suggesting that the nipper is important for the ingestion of large food items in generalist *** functional association is coupled with a significant evolutionary allometry at the clade level,while Alligatoridae and Crocodylidae show different degrees of evolutionary allometry for their entire shape and *** postrostrum is more conservative than the rostrum in terms of morphospace occupation,evolutionary allometry and phylogenetic signal.

关键词： crocodilian skull functional performance geometric morphometrics modularity morphological integration

Insights into breast cancer phenotying through molecular omics approaches and therapy response

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Cancer Drug Resistance 2019年第3期2卷 527-538页

作者： Jose E.Belizario angela F.Loggulo Department of Pharmacology Institute of Biomedical SciencesUniversity of São PauloAvenida Lineu Prestes1524São PauloCEP 05508-900Brazil Department of Pathology Paulista School of MedicineFederal University of São PauloRua Sena Madureira1500São PauloCEP 04021-001Brazil.

Breast cancer is the most common cancer in the *** advances in early detection and understanding of the molecular bases of breast cancer biology,approximately 30%of all patients with early-stage breast cancer have metastatic *** cancers are comprised of molecularly distinct subtypes that respond differently to pathway-targeted therapies and neoadjuvant systemic ***,no tumor response is observed in some cases and development of resistance is most commonly seen in patients with heterogeneous breast cancer *** offer better treatment with increased efficacy and low toxicity of selecting therapies,new technologies that incorporate clinical and molecular characteristics of intratumoral heterogeneity have been *** short review provides some examples of integrative omics approaches(genome,epigenome,transcriptome,immune profiling)and mathematical/computational analyses that provide mechanistic and clinically relevant insights into underlying differences in breast cancer subtypes and patients’responses to specific therapies.

关键词： Breast cancer ERBB/HER estrogen receptor progesterone receptor genomics proteomics epigenomics endocrine and targeted therapy

The role of surface functionalization of silica nanoparticles for bioimaging

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Journal of Innovative Optical Health Sciences 2016年第4期9卷 11-26页

作者： Maria C.Gomes angela Cunha Tito Trindade João P.C.Tome QOPNA University of Aveiro 3810-193 AveiroPortugal CICECO and Department of Chemistry University of Aveiro 3810-193 AveiroPortugal CESAM and Department of Biology University of Aveiro 3810-193 AveiroPortugal Centro de Quimica Estrutural Instituto Superior Tecnico Universidade de LisboaAv.Rovisco Pais1049-001 LisboaPortugal Department of Organic and Macromolecular Chemistry Ghent University B-9000 Gent Belgium

Among the several types of inorganic nanoparticles available,silica nanoparticles(SNP)have earned their relevance in biological applications namely,as bioimaging *** fact,uorescent SNP(FSNP)have been explored in this-eld as protective nanocarriers,overcoming some limitations presented by conventional organic dyes such as high photobleaching rates.A crucial aspect on the use of uorescent SNP relates to their surface properties,since it determines the extent of interaction between nanoparticles and biological systems,namely in terms of colloidal stability in water,cellular recognition and internalization,tracking,biodistribution and speci-city,among ***,it is imperative to understand the mechanisms underlying the interaction between biosystems and the SNP surfaces,making surface functionalization a relevant step in order to take full advantage of particle *** versatility of the surface chemistry on silica platforms,together with the intrinsic hydrophilicity and biocompatibility,make these systems suitable for bioimaging applications,such as those mentioned in this review.

关键词： Fluorescent silica nanoparticles bioimaging surface functionalization nanoparticlecell interactions.

Processed beetroot(Beta vulgaris L.)as a natural antioxidant in mayonnaise:Effects on physical stability,texture and sensory attributes

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Food Science and Human Wellness 2016年第4期5卷 191-198页

作者： Vassilios Raikos angela McDonagh Viren Ranawana Garry Duthie Metabolic Health Rowett Institute of Nutrition and HealthUniversity of AberdeenAberdeen AB252ZDScotlandUK

The oxidative and physical stability of the reformulated mayonnaise with processed beetroot was investigated and compared with a control(mayonnaise without beetroot)and a commercially available *** of beetroot had an impact on the structural integrity of the antioxidants ***(960 W for 7 min)was advantageous for preserving the betalain and polyphenol content of beetroot compared to roasting(180◦C for 90 min)and boiling(100◦C for 30 min).The oxidative stability of mayonnaise samples was determined by Rancimat and the thiobarbituric(TBA)*** addition of microwaved beetroot significantly enhanced the oxidative stability of mayonnaise at the end of a storage period of 4 weeks(4◦C).Although no significant differences(P>0.05)were detected between the mayonnaise samples containing beetroot and the commercial control,the latter was less susceptible to oxidation during *** turbiscan stability index(TSI)revealed that the commercial mayonnaise was less prone to destabilization *** the textural parameters increased with the incorporation of *** sensory evaluation revealed that,with the exception of graininess and uniformity,most of the sensory attributes are preserved if not improved with the addition of beetroot.

关键词： Mayonnaise Beetroot Oxidative stability Texture Sensory analysis

Effects of Gamma Irradiation for Sterilization on Aqueous Dispersions of Length Sorted Carbon Nanotubes

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Nano Research 2011年第4期4卷 393-404页

作者： Jeffrey A. Fagan Nancy J. Lin Rolf Zeisler angela R. Hight Walker Polymers Division National Institute of Standards and Technology Gaithersburg MD 20899 USA Analytical Chemistry Division National Institute of Standards and Technology Gaithersburg MD 20899 USA Optical Technology Division. National Institute of Standards and Technology Gaithersburg MD 20899. USA

There is currently great interest in the potential use of carbon nanotubes as delivery vessels for nanotherapeutics and other medical applications. However, no data are available on the effects of sterilization methods on the properties of nanotube dispersions, the form in which most medical applications will be processed. Here we show the effects of gamma irradiation from a 60Co source on the dispersion and optical properties of single-wall carbon nanotubes in aqueous dispersion. Samples of different length-refined populations were sealed in ampoules and exposed to a dose of approximately 28 kGy, a level sufficient to ensure sterility of the dispersions. In contrast to literature results for solid-phase nanotube samples, the effects of gamma irradiation on the dispersion and optical properties of the nanotube samples were found to be minimal. Based on these results, gamma irradiation appears sufficiently non-destructive to be industrially useful for the sterilization of nanotube dispersions.

关键词： Nanotube single-wall nanotube (SWNT) single-wall carbon nanotube (SWCNT) gamma irradiation sterilization dispersion

Alternative feedstock for the production of activated carbon with ZnCl_(2):Forestry residue biomass and waste wood

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Carbon Resources Conversion 2022年第4期5卷 299-309页

作者： Dominik Bosch Jan OBack David Gurtner Sara Giberti angela Hofmann Anke Bockreis Josef Ressel Centre for Production of Activated Carbon from Municipal Residues Department of EnvironmentalProcess and Energy EngineeringMCI–The Entrepreneurial SchoolUniversitaetsstrasse 156020 InnsbruckAustria Unit of Environmental Engineering Department for InfrastructureUniversity of InnsbruckTechnikerstrasse 136020 InnsbruckAustria Department of Environmental Process and Energy EngineeringMCI–The Entrepreneurial SchoolUniversitaetsstrasse 156020 InnsbruckAustria Institute for Chemical and Energy Engineering BOKU-University of Natural Resources and Life ScienceGregor-Mendel-Strasse 331160 ViennaAustria Department of Civil ChemicalEnvironmentaland Materials EngineeringUniversit`a di BolognaVia Zamboni 3340126 BolognaItaly

In order to substitute fossil resources in activated carbon(AC)production,recent efforts have focused on the utilization of renewable raw *** with important wood industries offer two potentially underestimated resource types:forestry residue biomass(FRB)and waste wood(WW).Although these materials are widely available(approx.130 mio.m3a-1 FRB,approx.50 ***^(-1) WW in the EU),they are mostly valorised through energy production,as they are high in ashes and may be contaminated with organics and heavy *** this study,both FRB and WW were treated via one-step pyrolysis for AC ***_(2) was applied as activating agent at pyrolysis temperatures varying from 400 to 600℃ and residence times between 1 and 3 ***,76 samples were prepared and characterized thoroughly via elemental analysis,N_(2)/CO_(2) ad/-desorption,thermogravimetric analysis(TGA),scanning electron microscopy(SEM),and infrared spectroscopy(FTIR).The produced carbons showed specific surface areas of up to 1430 m2g􀀀1 and a pore size distribution with a micropore share of up to 80%.The presence of oxygen-containing functional groups was confirmed via *** feedstock contamination can be mitigated,as minerals and heavy metals could be leached out(up to-99.15%)by an additional wash step and organic contamination undergoes thermal cracking during *** presented study could be a next step in upcycling considerable waste streams from the wood sector through localised and non-fossil-based AC production.

关键词： Sustainable resources Waste wood Forestry residue Activated carbon Chemical activation Pyrolysis Porosity Functionalized surface

Periprocedural management of hemostatic alterations in patients with cirrhosis and vascular liver disorders: a step forward of the American Association for the Study of Liver Diseases

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Hepatobiliary Surgery and Nutrition 2023年第1期12卷 105-109页

作者： Jose Ignacio Fortea angela Puente Javier Crespo Emilio Fabrega Gastroenterology and Hepatology Department Clinical and Translational Research in Digestive DiseasesValdecilla Research Institute(IDIVAL)Marques de Valdecilla University HospitalSantanderSpain

“Time flies over us,but leaves its shadow behind”(Nathaniel Hawthorne,1860,The Marble Faun).The shadow that separates the latest guidance on vascular liver disorders of the American Association for the Study of Liver Diseases(AASLD)from its former counterpart is 12 years long(1,2).Along the course,several guidelines from different societies have been published on this topic(3-7).As acknowledged in the preamble,the lack of high-quality evidence in the field led the AASLD to commission a guidance from an expert panel based on formal review and analysis of the *** thus differs from other guidelines that perform systematic reviews with explicit methods of searching,selection,and rating the quality of evidence and,if appropriate,meta-analysis on certain clinical questions(2).

关键词： Portal hypertension cirrhosis vascular liver disorders hemostasis bleeding thrombosis

Costs resulting from nonprofessional soccer injuries in Switzerland:A detailed analysis

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Journal of Sport and Health Science 2020年第3期9卷 240-247页

作者： angela Gebert Markus Gerber Uwe Pühse Philippe Gassmann Hanspeter Stamm Markus Lamprecht Lamprecht und Stamm Sozialforschung und Beratung Zurich CH8032Switzerland Department of Sport Exercise and HealthSport Science SectionUniversity of BaselBasel CH4052Switzerland Suva(Swiss National Accident Insurance Fund) CH6002 LuzernSwitzerland

Background:Soccer injuries constitute an important public health problem and cause a high economic ***,comprehensive data regarding injury costs in nonprofessional soccer are *** aim of this study was to determine which groups of nonprofessional soccer athletes,injury types,and injury situations caused high injury ***:A cross-sectional,retrospective telephone survey was carried out with a random sample of persons who had sustained a soccer injury between July 2013 and June 2014 and who had reported this accident to the Swiss National Accident Insurance Fund(Suva).One year after the corresponding accident,every injury was linked to its costs and to the answers obtained in the interview about injury setting,injury characteristics,and injury ***,the costs of 702 injuries were ***:The average cost of an injury in nonprofessional soccer amounted to€4030(bias-corrected and accelerated 95%confidence interval(BCa 95%CI):3427-4719).Persons aged 30 years and older experienced 35%of soccer injuries but accounted for 49%of all costs.A total of58%of all costs were the result of injuries that occurred during amateur *** particular,game injuries sustained by players in separate leagues for players aged 30+/40+years led to high average costs of€8190(BCa 95%CI:5036-11,645).Knee injuries accounted for 25%of all injuries and were responsible for 53%of all *** contact and foul play did not lead to above-average costs,twisting or turning situations were highly cost relevant,leading to an average sum of€7710(BCa 95%CI:5376-10,466)per ***:Nonprofessional soccer players aged 30 years and older and particularly players in 30+/40+leagues had above-average injury ***,the prevention of knee injuries,noncontact and nonfoul play injuries,and injuries caused by twisting and turning should be of highest priority in decreasing health care costs.

关键词： Amateur soccer Cost analysis Injury causes Injury characteristics Injury costs