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Add on the next level—the time point of the type I IFN response orchestrates the immune response

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Cellular & Molecular Immunology 2020年第8期17卷 791-793页

作者： angela Wedekind David Fritzsch Andrea Kröger Research Group Molecular Microbiology Institute of Microbiology and Hospital HygieneOtto von Guericke University39120MagdeburgGermany Research Group Innate Immunity and Infection Helmholtz Centre for Infection Research38124BraunschweigGermany

The directed control of an effective cellular or adaptive immune response is the aim of vaccine strategies and tumor *** antibodies prevent the spread of pathogens,while efficient cellular immunotherapy is used to overcome T-cell exhaustion and unresponsiveness toward *** such settings,the type I interferon(IFN)system mediates pleiotropic effects of the immune system that can be either immunostimulating or *** a recent work,De Giovanni et *** a novel regulatory checkpoint by which type I IFN regulates CD4^(+)T-cell *** study dissects the time point of type I IFN induction as a central regulator of the adaptive immune response that determines the balance between humoral and cellular *** findings identify an intriguing and previously undescribed checkpoint that can potentially be manipulated for ***,the authors demonstrate that CD4^(+)T-cell polarization could be influenced by manipulating the IFN response during infection.

关键词： al. vaccine interferon

Wheat leaf senescence and its regulatory gene network

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The Crop Journal 2021年第4期9卷 703-717页

作者： Nigarin Sultana Shahidul Islam angela Juhasz Wujun Ma State Agriculture Biotechnology Centre Murdoch UniversityPerthWA 6150Australia

Wheat leaf senescence is a developmental process that involves expressional changes in thousands of genes that ultimately impact grain protein content(GPC), grain yield(GY), and nitrogen use *** onset and rate of senescence are strongly influenced by plant hormones and environmental factors e.g. nitrogen availability. At maturity, decrease in nitrogen uptake could enhance N remobilization from leaves and stem to grain, eventually leading to leaf senescence. Early senescence is related to high GPC and somewhat low yield whereas late senescence is often related to high yield and somewhat low GPC. Early or late senescence is principally regulated by up and down-regulation of senescence associated genes. Integration of external and internal factors together with genotypic variation influence senescence associated genes in a developmental age dependent manner. Although regulation of genes involved in senescence has been studied in rice, Arabidopsis, maize, and currently in wheat, there are genotypespecific variations yet to explore. A major effort is needed to understand the interaction of positive and negative senescence regulators in determining the onset of senescence. In wheat, increasing attention has been paid to understand the role of positive senescence regulator, e.g. GPC-1, regulated gene network during early senescence time course. Recently, gene regulatory network involved early to late senescence time course revealed important senescence regulators. However, the known negative senescence regulator Ta NAC-S gene has not been extensively studied in wheat and little is known about its value in breeding. Existing data on senescence-related transcriptome studies and gene regulatory network could effectively be used for functional study in developing nitrogen efficient wheat varieties.

关键词： Wheat(Triticum aestivum L.) Senescence Nitrogen use efficiency NAC transcription factor Stay-green

From cradle to grave: neurogenesis, neuroregeneration and neurodegeneration in Alzheimer’s and Parkinson’s diseases

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Neural Regeneration Research 2022年第12期17卷 2606-2614页

作者： Debia Wakhloo Jane Oberhauser angela Madira Sameehan Mahajani Deparment of Neuropathology Stanford UniversitySchool of MedicineStanfordCAUSA

Two of the most common neurodegenerative disorders-Alzheimer’s and Parkinson’s diseases-are characterized by synaptic dysfunction and degeneration that culminate in neuronal loss due to abnormal protein *** intracellular aggregation of hyper-phosphorylated tau and the extracellular aggregation of amyloid beta plaques form the basis of Alzheimer’s disease *** major hallmark of Parkinson’s disease is the loss of dopaminergic neurons in the substantia nigra pars compacta,following the formation of Lewy bodies,which consists primarily of alpha-synuclein ***,the discrete mechanisms that contribute to neurodegeneration in these disorders are still poorly *** neuronal loss and impaired adult neurogenesis have been reported in animal models of these *** these findings remain subject to frequent debate due to a lack of conclusive evidence in post mortem brain tissue from human *** some publications provide significant findings related to axonal regeneration in Alzheimer’s and Parkinson’s diseases,they also highlight the limitations and obstacles to the development of neuroregenerative *** this review,we summarize in vitro and in vivo findings related to neurogenesis,neuroregeneration and neurodegeneration in the context of Alzheimer’s and Parkinson’s diseases.

关键词： alpha-synuclein amyloid beta plaques autophagy dopaminergic neurons human iPSCs mitochondrial dysfunction scRNA sequencing synaptic dysfunction Tau Wallerian degeneration

Synthesis of Water-soluble, Polyester-based Dendrimer Prodrugs for Exploiting Therapeutic Properties of Two Triterpenoid Acids

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Chinese Journal of Polymer Science 2018年第9期36卷 999-999,1000-1010页

作者： Silvana Alfei Gaby Brice Taptue Silvia Catena angela Bisio Dipartimento di Farmacia Sezione di Chimica e Tecnologie Farmaceutiche e Alimentari Università di Genova

Dendrimers are macromolecules characterized by high controlled size, shape and architecture, presence of inner cavities able to accommodate small molecules and many peripheral functional groups to bind target entities. They are of eminent interest for biomedical applications, including gene transfection, tissue engineering, imaging, and drug delivery. The well-known pharmacological activities of ursolic and oleanolic acids are limited by their small water solubility, non-specific cell distribution, low bioavailability, poor pharmacokinetics, and their direct administration could result in the release of thrombi. To overcome such problems, in this paper we described their physical incorporation inside amino acids-modified polyester-based dendrimers which made them highly water-soluble. IR, NMR, zeta potential, mean size of particles, buffer capacity and drug release profiles of prepared materials were reported. The achieved water-soluble complexes harmonize a polycationic character and a buffer capacity which presuppose efficient cell penetration and increased residence time with a biodegradable cell respectful scaffold, thus appearing as a promising team of not toxic prodrugs for safe administration of ursolic and oleanolic acids.

关键词： Polyester-based amino acids-modified dendrimers Physical encapsulation Water-soluble dendriplexes Buffer capacity NMR investigations

Excitonic Eigenstates of Disordered Semiconductor Quantum Wires:Adaptive Wavelet Computation of Eigenvalues for the Electron-Hole Schrodinger Equation

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Communications in Computational Physics 2013年第6期14卷 21-47页

作者： Christian Mollet angela Kunoth Torsten Meier Institut fur Mathematik Universitat PaderbornWarburger Str.100D-33098 PaderbornGermany Department Physik Universitat PaderbornWarburger Str.100D-33098 PaderbornGermany

A novel adaptive approach to compute the eigenenergies and eigenfunctions of the two-particle(electron-hole)Schrodinger equation including Coulomb attraction is *** an example,we analyze the energetically lowest exciton state of a thin one-dimensional semiconductor quantum wire in the presence of disorder which arises from the non-smooth interface between the wire and surrounding *** eigenvalues of the corresponding Schrodinger equation,i.e.,the onedimensional exciton Wannier equation with disorder,correspond to the energies of excitons in the quantum *** wavefunctions,in turn,provide information on the optical properties of the *** reformulate the problem of two interacting particles that both can move in one dimension as a stationary eigenvalue problem with two spacial dimensions in an appropriate weak form whose bilinear form is arranged to be symmetric,continuous,and *** disorder of the wire is modelled by adding a potential in the Hamiltonian which is generated by normally distributed random *** numerical solution of this problem is based on adaptive *** scheme allows for a convergence proof of the resulting scheme together with complexity *** examples demonstrate the behavior of the smallest eigenvalue,the ground state energies of the exciton,together with the eigenstates depending on the strength and spatial correlation of disorder.

关键词： Semiconductor quantum wire disorder Schrodinger equation eigenvalue problem weak formulation bounded and coercive bilinear form adaptive wavelet method convergence complexity ground state energies exciton

Current understanding of grapevine defense mechanisms against the biotrophic fungus (Erysiphe necator), the causal agent of powdery mildew disease

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Horticulture Research 2015年第1期2卷 214-222页

作者： Wenping Qiu angela Feechan Ian Dry Center for Grapevine Biotechnology W.H.Darr School of AgricultureMissouri State UniversityMountain GroveMO 65711USA School of Agriculture&Food Science University College DublinBelfieldDublin 4Ireland CSIRO Agriculture Wine Innovation West BuildingWaite CampusHartley GroveUrrbraeSA 5064Australia

The most economically important disease of cultivated grapevines worldwide is powdery mildew(PM)caused by the ascomycete fungus Erysiphe *** majority of grapevine cultivars used for wine,table grape,and dried fruit production are derived from the Eurasian grape species Vitis vinifera because of its superior aroma and flavor ***,this species has little genetic resistance against *** meaning that grape production is highly dependent on the frequent use of *** integration of effective genetic resistance into cultivated grapevines would lead to significant financial and environmental benefits and represents a major challenge for viticultural industries and researchers *** review will outline the strategies being used to increase our understanding of the molecular basis of *** susceptibility to this fungal *** will summarize our current knowledge of different resistance loci/genes that have evolved in wild grapevine species to restrict PM infection and assess the potential application of these defense genes in the generation of PM-resistant grapevine ***,it addresses future research priorities which will be important in the rapid identification,evaluation,and deployment of new PM resistance genes which are capable of conferring effective and durable resistance in the vineyard.

关键词： agent grape dried

A review of federated learning in renewable energy applications:Potential,challenges,and future directions

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Energy and AI

Energy and AI 2024年第3期17卷 444-457页

作者： Albin Grataloup Stefan Jonas angela Meyer Bern University of Applied Sciences School of Engineering and Computer ScienceQuellgasse 21Biel2501Switzerland Universitàdella Svizzera italiana Faculty of InformaticsVia la Santa 1Lugano-Viganello6962Switzerland Delft University of Technology Department of Geoscience and Remote SensingStevinweg 1Delft2628The Netherlands

Federated learning has recently emerged as a privacy-preserving distributed machine learning *** learning enables collaborative training of multiple clients and entire fleets without sharing the involved training *** preserving data privacy,federated learning has the potential to overcome the lack of data sharing in the renewable energy sector which is inhibiting innovation,research and *** paper provides an overview of federated learning in renewable energy *** discuss federated learning algorithms and survey their applications and case studies in renewable energy generation and *** also evaluate the potential and the challenges associated with federated learning applied in power and energy ***,we outline promising future research directions in federated learning for applications in renewable energy.

关键词： Federated learning Renewable energy Dis tributed learning Data heterogeneity Privacy Data sharing Wind energy Solar energy Buildings Review

Economic optimization of resource-constrained project scheduling:a two-phase metaheuristic approach

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第6期11卷 481-494页

作者： angela H.L.CHEN Chiuh-Cheng CHYU Department of Industrial Engineering and Management Yuan Ze University Department of Finance Nanya Institute of Technology

This paper deals with the problem of project scheduling subject to multiple execution modes with non-renewable resources, and a model that handles some of monetary issues in real world *** objective is to schedule the activities to maximize the expected net present value(NPV) of the project, taking into account the activity costs, the activity durations, and the cash flows generated by successfully completing an *** to the combinatorial nature of this problem, the current study develops a hybrid of branch-and-bound procedure and memetic algorithm to enhance both mode assignment and activity *** for the makespan minimization problem have been made through a set of benchmark problem *** performance is rated on the maximization of the project NPV and computational results show that the two-phase hybrid metaheuristic performs competitively for all instances of different problem sizes.

关键词： Memetic algorithm(MA) Branch and bound(B&B) algorithm Net present value(NPV) Project scheduling problem

Siderophore-Producing Rhizobacteria as a Promising Tool for Empowering Plants to Cope with Iron Limitation in Saline Soils:A Review

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Pedosphere 2019年第4期29卷 409-420页

作者： Maria J.FERREIRA Helena SILVA angela CUNHA Biology Department and Centre for Environmental and Marine Studies(CESAM) University of Aveiro Campus de Santigo

Iron(Fe) bioavailability to plants is reduced in saline soils;however, the exact mechanisms underlying this effect are not yet completely understood. Siderophore-expressing rhizobacteria may represent a promising alternative to chemical fertilizers by simultaneously tackling salt-stress effects and Fe limitation in saline soils. In addition to draught, plants growing in arid soils face two other major challenges: high salinity and Fe deficiency. Salinity attenuates growth, affects plant physiology, and causes nutrient imbalance,which is, in fact, one of the major consequences of saline stress. Iron is a micronutrient essential for plant development, and it is required by several metalloenzymes involved in photosynthesis and respiration. Iron deficiency is associated with chlorosis and low crop productivity. The role of microbial siderophores in Fe supply to plants and the effect of plant growth-promoting rhizobacteria(PGPR) on the mitigation of saline stress in crop culture are well documented. However, the dual effect of siderophore-producing PGPR, both on salt stress and Fe limitation, is still poorly explored. This review provides a critical overview of the combined effects of Fe limitation and soil salinization as challenges to modern agriculture and intends to summarize some indirect evidence that argues in favour of siderophore-producing PGPR as biofertilization agents in salinized soils. Recent developments and future perspectives on the use of PGPR are discussed as clues to sustainable agricultural practices in the context of present and future climate change scenarios.

关键词： aridity bioavailability biofertilizer Fe deficiency high salinity plant growth-promoting rhizobacteria(PGPR) saline stress soil salinization