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High body mass index predicts multiple prostate cancer lymph node metastases after radical prostatectomy and extended pelvic lymph node dissection

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Asian Journal of Andrology 2020年第3期22卷 323-329页

作者： Antonio B Porcaro Alessandro Tafuri marco Sebben Tania Processali marco Pirozzi Nelia Amigoni Riccardo Rizzetto Aliasger Shakir maria angela Cerruto matteo Brunelli Salvatore Siracusano Walter Artibani Department of Urology Azienda Ospedaliera Universitaria Integrata VeronaVerona 37126Italy USC Institute of Urology and Catherine and Joseph Aresty Department of Urology Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Department of Pathology Azienda Ospedaliera Universitaria Integrata VeronaVerona 37126Italy.

Our aim is to evaluate the association between body mass index(BmI)and preoperative total testosterone(TT)levels with the risk of single and multiple metastatic lymph node invasion(LNI)in prostate cancer patients undergoing radical prostatectomy and extended pelvic lymph node *** BmI,basal levels of TT,and prostate-specific antigen(PSA)were evaluated in 361 consecutive patients undergoing radical prostatectomy with extended pelvic lymph node dissection between 2014 and 2017・Patients were grouped into either nonmetastatic,one,or more than one metastatic lymph node invasion *** association among clinical factors and LNI was *** was detected in 52(14.4%)patients:28(7.8%)cases had one metastatic node and 24(6.6%)had more than one metastatic *** the overall study population,BmI correlated inversely with TT(r=-0.256;Pmetastases,BmI inversely correlated with TT(r=-0.282;Pmetastasis,this correlation was *** the overall study population,BmI(odds ratio[OR]=1.268;P=0.005)was the only in dependent clinical factor associated with the risk of multiple metastatic LNI compared to cases with one metastatic *** the nonmetastatic group,TT was lower in patients with BmI>28 kg m^2(Pmedian number of positive nodes was higher in patients with BmI>28 kg m^2(P-0.048).In our study,overweight and obese patients had a higher risk of harboring multiple prostate cancer lymph node metastases and lower TT levels when compared to patients with normal BmI.

关键词： body mass index metastatic prostate cancer multiple lymph node invasion overweight-obesity preoperative testosterone level

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Estimating the prevalence of Echinococcus in domestic dogs in highly endemic for echinococcosis

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Infectious Diseases of Poverty 2018年第1期7卷 761-769页

作者： Cong-Nuan Liu Yang-Yang Xu angela m.Cadavid-Restrepo Zhong-Zi Lou Hong-Bin Yan Li Li Bao-Quan Fu Darren J.Gray Archie A.Clements Tamsin S.Barnes Gail m.Williams Wan-Zhong Jia Donald P.mcmanus Yu-Rong Yang State Key Laboratory of Veterinary Etiological Biology/Key Laboratory of Veterinary Parasitology of Gansu Province/Key Laboratory of Zoonoses of Agriculture ministry/Lanzhou Veterinary Research Institute CAASLanzhou 730046People’s Republic of China The Human Pathology and Immunology Department Ningxia Medical UniversityYinchuanNingxia Hui Autonomous RegionPeople’s Republic of China Neurosurgery Department Tianjin Xiqing HospitalTianjinPeople’s Republic of China molecular Parasitology Laboratory QIMR Berghofer Medical Research InstituteBrisbaneAustralia Research School of Population Health Australian National UniversityCanberraAustralia School of Population Health Infectious Disease Epidemiology UnitUniversity of QueenslandBrisbaneAustralia Queensland Alliance for Agriculture and Food Innovation University of QueenslandGattonAustralia

Background:Cystic echinococcosis(CE)and alveolar echinococcosis(AE)are highly endemic in Xiji County of Ningxia Hui Autonomous Region(NHAR)in China where the control campaign based on dog de-worming with praziquantel has been undertaken over preceding *** study is to determine the current prevalence of Echinococcus granulosus and *** in domestic dogs and monitor the echinococcosis transmission ***:Study villages were selected using landscape patterns(Geographic Information System,GIS)for Echinococcus transmission“hot spots”,combined with hospital records identifying risk areas for AE and CE.A survey of 750 domestic dogs,including copro-sampling and owner questionnaires,from 25 selected villages,was undertaken in 2012.A copro-multiplex PCR assay was used for the specific diagnosis of *** and *** in the *** analysis,using IBm SPSS Statistics,was undertaken,to compare the prevalence of the two Echinococcus *** dogs between four geographical areas of Xiji by theχ^(2)*** analysis of the combinations of outcomes from the questionnaire and copro-PCR assay data was carried out to determine the significant risk factors for dog ***:The highest de-worming rate of 84.0%was found in the northwest area of Xiji County,and significant differences(Pming rates among dogs from the four geographical areas of Xiji were *** highest prevalence(19.7%,59/300)of *** occurred in northwest Xiji,though the highest prevalence(18.1%,38/210)of *** occurred in southwest *** was no significant difference(P>0.05)in the prevalence of *** in dogs from the northwest,southwest,northeast,and southeast of Xiji,but there were significant differences(Pm the four *** of the other independent variables was statistically ***:The results from this study indicate a high prevalenc

关键词： Domestic dog surveys Dog-copro-multiplex PCR assay Co-endemicity of Echinococcus granulosus and E.multilocularis Xiji County Ningxia hui autonomous region(NHAR) P.R.China

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Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars

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Protein & Cell 2010年第1期1卷 82-95页

作者： Isaac m.Westwood Sanjib Bhakta angela J.Russell Elizabeth Fullam matthew C.Anderton Akane Kawamura Andrew W.mulvaney Richard J.Vickers Veemal Bhowruth Gurdyal S.Besra Ajit Lalvani Stephen G.Davies Edith Sim Department of Pharmacology University of OxfordOxford OX13QTUnited Kingdom Chemistry Research Laboratory Department of Organic ChemistryUniversity of OxfordOxford OX13QLUnited Kingdom School of Biosciences University of BirminghamEdgbastonBirmingham B152TTUnited Kingdom Tuberculosis Immunology Group Department of Respiratory MedicineNational Heart and Lung InstituteWright Fleming Institute of Infection and ImmunityImperial College LondonNorfolk PlaceLondon W21PGUnited Kingdom Structure-Based Drug Design Team Sections of Structural Biology and Cancer TherapeuticsInstitute of Cancer ResearchChester Beatty LaboratoriesLondon SW36JBUnited Kingdom Institute of Structural and molecular Biology Department of Biological ScienceBirkbeckUniversity of LondonLondon WC1E 7HXUnited Kingdom

New anti-tubercular drugs and drug targets are urgently needed to reduce the time for treatment and also to identify agents that will be effective against mycobacterium tuberculosis persisting *** have a unique cell *** of the gene for arylamine N-acetyltransferase(NAT)decreases mycobacterial cell wall lipids,particularly the distinctive mycolates,and also increases antibiotic susceptibility and killing within macrophage of mycobacterium bovis *** nat gene and its associated gene cluster are almost identical in sequence in *** BCG and *** gene cluster is essential for intracellular survival of *** have therefore used pure NAT protein for high-throughput screening to identify several classes of small molecules that inhibit NAT ***,we characterize one class of such molecules—triazoles—in relation to its effects on the target enzyme and on both *** BCG and *** most potent triazole mimics the effects of deletion of the nat gene on growth,lipid disruption and intracellular *** also present the structure-activity relationship between NAT inhibition and effects on mycobacterial growth,and use ligand-protein analysis to give further insight into the structure-activity *** conclude that screening a chemical library with NAT protein yields compounds that have high potential as anti-tubercular agents and that the inhibitors will allow further exploration of the biochemical pathway in which NAT is involved.

关键词： N-acetyltransferase mycobacterium tuberculosis triazoles screening

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The Potential of Using Indigenous Pesticidal Plants for Insect Pest Control to Small Scale Farmers in Africa

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American Journal of Plant Sciences 2015年第19期6卷 3164-3174页

作者： angela G. mkindi Kelvin m. mtei Karoli N. Njau Patrick A. Ndakidemi School of materials Energy Water and Environmental Sciences (MEWES) The Nelson Mandela African Institution of Science and Technology Arusha Tanzania

Pesticidal plants are scientifically proven for their effectiveness in controlling insect pests. Their activity is enhanced by active compounds contained, which are known for their repellant and antifeedant potentials to the insects. Use of pesticidal plants by local small scale farmers has been a point of concern following information that majority of farmers do not widely use pesticidal plants despite of an indigenous knowledge that they possess. Improvement of the technologies used by local farmers in previous times, that are easy and effective need to help farmers abstain from the use of synthetic pesticides that are detrimental to the environment and to their own health. This paper reviews the potentiality of pesticidal plants to small holder farmers. It also gives the status of pesticidal plants use, their possible effectiveness against insect pests, persistence as well as the knowledge that indigenous people possess in their use. Again, the paper suggests the need for more instrumental research on practical improvement of indigenous knowledge on the use of pesticidal plants with scientific evidences.

关键词： Insect Pests Pesticidal Plants Environment Health Indigenous Knowledge

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Can non-typeable Haemophilus influenzae carriage surveillance data infer antimicrobial resistance associated with otitis media?

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Pediatric Investigation 2023年第1期7卷 13-22页

作者： Sophia Bowman-Derrick Tegan m.Harris Jemima Beissbarth mariana Kleinecke Katrina Lawrence Teresa m.Wozniak Amy Bleakley angela Rumaseb michael J.Binks Robyn L.marsh Peter S.morris Amanda J.Leach Heidi Smith-Vaughan menzies School of Health Research Charles Darwin UniversityDarwinAustralia Australian e-Health Research Centre CSIRO BrisbaneAustralia Royal Darwin Hospital DarwinAustralia

Importance:In remote communities of the Northern Territory,Australia,children experience high rates of otitis media(Om),commonly caused by non-typeable Haemophilus influenzae(NTHi).Few data exist on antibiotic susceptibility of NTHi from ***:To determine whether population-level nasopharyngeal NTHi antibiotic susceptibility data could inform antibiotic treatment for ***:NTHi isolates(n=92)collected from ear discharge between 2003 and 2013 were selected to time-and age-match NTHi isolates from the nasopharyngeal carriage(n=95).Antimicrobial susceptibility were *** trees and a genome-wide association study(GWAS)were performed to determine the similarity of nasopharyngeal and ear isolates at a population ***:Among 174 NTHi isolates available for antimicrobial susceptibility testing,10.3%(18/174)were resistant to ampicillin and 9.2%(16/174)were resistant to *** numbers of isolates(≤3)were resistant to tetracycline,chloramphenicol,or amoxicillin-clavulanic *** was no statistical difference in the proportion of ampicillin-resistant(P=0.11)or trimethoprim-sulfamethoxazole-resistant isolates(P=0.70)between ear discharge and nasopharynx-derived NTHi *** multi-drug resistant NTHi isolates were *** trees showed no clustering of 187 Haemophilus influenzae isolates based on anatomical niche(nasopharynx or ear discharge),and no genetic variations that distinguished NTHi derived from ear discharge and nasopharyngeal carriage were evident in the ***:In this population-level study,nasopharyngeal and ear discharge isolates did not represent distinct microbial *** results support tracking of population-level nasopharyngeal NTHi antibiotic resistance patterns to inform clinical management of Om in this population.

关键词： Haemophilus influenzae Otitis media Antimicrobial resistance

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Occurrence of pharmaceuticals and perfluorinated compounds and evaluation of the availability of reclaimed water in Kinmen

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Emerging Contaminants 2016年第3期2卷 135-144页

作者： Webber Wei-Po Lai Yen-Ching Lin Hsin-Hsin Tung Shang-Lien Lo angela Yu-Chen Lin Graduate Institute of Environmental Engineering National Taiwan University71-Chou-shan RoadTaipei106Taiwan

Emerging contaminants have commonly been observed in environmental waters but have not been included in water quality assessments at many locations around the *** evaluate the availability of reclaimed water in Kinmen,Taiwan,this study provides the first survey of the distribution of thirty-three pharmaceuticals and five perfluorinated chemicals in lake waters and water from local wastewater treatment plants(WWTPs).The results showed that the target emerging contaminants in Kinmen lakes were at trace ng/L *** addition,most of the target compounds were present in the Jincheng and Taihu WWTP influents at ng/L concentrations levels,of which 5 compounds(erythromycin-H2O(1340 ng/L),ibuprofen(1763 ng/L),atenolol(1634 ng/L),acetaminophen(2143 ng/L),and caffeine(3113 ng/L))reached mg/L *** overall treatment efficiencies of the Jincheng and Taihu WWTPs with respect to these pharmaceuticals and perfluorinated chemicals were poor;half of the compounds were less than 50%*** compounds(sulfamethoxazole,erythromycin-H2O,clarithromycin,ciprofloxacin and ofloxacin)with risk quotient(RQ)values>1 in the effluent should be further investigated to understand their effects on the aquatic *** and advanced treatment units are found necessary to provide high-quality recycled water and sustainable water resources.

关键词： Emerging contaminant Perfluorinated compound Pharmaceutical Water scarcity Wastewater treatment plant

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Validation of Automated Dilution and Transfer methods for Rapid Assessment of Functional Immune Responses to meningococcal Vaccines

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World Journal of Vaccines 2013年第3期3卷 98-101页

作者： angela m. Payne Xu Liu michael J. Caulfield Jon H. Heinrichs Vaccines Basic Research Merck Sharp and Dohme Corp. West Point USA Vaccines Basic Research Merck Sharp and Dohme Corp. West Point USA.

A high-throughput Serum Bactericidal Assay (SBA) was developed to monitor the functional antibody responses to capsular polysaccharide antigens from multiple serotypes of Neisseria meningitidis. This assay measures the ability of an antibody, aided by complement, to mediate killing of bacteria. Functional assays of this type are increasingly used in the quality control arena as potency release tests. Consequently, there has been an enhanced requirement for reproducibility in the performance of this type of assay. Assay validation is, therefore, important to facilitate understanding of the significance of values obtained, and to enable appropriate and informed use of the assay. This study involved the evaluation of the high-throughput serum bactericidal assay including the effects of different dilution and transfer techniques on assay performance. The results presented here demonstrate the repeatability, and the precision and ruggedness of the assay.

关键词： Serum Bactericidal Assay SBA Neisseria meningitides Automation Repeatability

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小鼠大脑中动脉梗死模型VERGE蛋白表达的变化及其机制

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中国老年学杂志 2009年第16期29卷 2059-2060页

作者：王赞姜宏宇纪莉 angela Fendel Dirk.m.Hermann 林卫红吉林大学第一医院吉林长春130021 Zuerich University Hospital Neurology Department ZuerichSwitzerland(CH-8091)

目的探讨VERGE蛋白在小鼠大脑中动脉梗死模型(mCAO)中蛋白表达的变化及其机制。方法C57BL/6小鼠30只,随机分为2组:30 min mCAO模型组、90 min mCAO模型组,制备mCAO模型,应用激光多普勒血流仪进行术中脑血流监测,应用Western印迹法观察... 详细信息

目的探讨VERGE蛋白在小鼠大脑中动脉梗死模型(mCAO)中蛋白表达的变化及其机制。方法C57BL/6小鼠30只,随机分为2组:30 min mCAO模型组、90 min mCAO模型组,制备mCAO模型,应用激光多普勒血流仪进行术中脑血流监测,应用Western印迹法观察各组梗死侧及非梗死侧的VERGE、p-JNK2、p-ERK1/2、P-38蛋白表达的变化。结果30 min、90 min mCAO模型组梗死侧VERGE、p-JNK2的蛋白表达明显增高,p-ERK1/2、P-38蛋白表达无变化;两组mCAO模型非梗死侧的VERGE、p-JNK2、p-ERK1/2、P-38蛋白表达均无变化。结论VERGE蛋白表达在小鼠mCAO的早期明显升高可能与JNK2通路有关而与ERK、P38通路无关。

关键词： VERGE 大脑中动脉梗死机制

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Forage and breed effects on behavior and temperament of pregnant beef heifers

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Journal of Animal Science and Biotechnology 2013年第3期4卷 165-169页

作者： angela R mays michael L Looper Benjamin C Williamson Kenneth P Coffey Wayne K Coblentz Glen E Aiken Charles F Rosenkrans Jr Department of Animal Science University of ArkansasFayetteville AR 72701 USA Department of Agricultural Sciences Morehead StateUniversity327 Reed Hall Morehead KY 40351 USA USDA-ARS US Dairy Forage Research CenterMarshfield WI 54449 USA USDA-ARS Forage Animal Production Research UnitLexingtonKY 40546 USA

Background： Integration of behavioral observations with traditional selection schemes may lead to enhanced animal well-being and more profitable forage-based cattle production ***-influenced（BR;n = 64） and Gelbvieh × Angus（GA;n = 64） heifers consumed either toxic endophyte-infected tall fescue（E＋） or one of two nontoxic endophyte-infected tall fescue（NT） cultivars during two *** were weighed at midpoint and termination of *** behavior（grazing,resting in the shade,lying,or standing without grazing） was recorded（n = 13 visual observations per yr in June and July） for each *** yr 2,exit velocity（EV） and serum prolactin（PRL） were ***： Grazing behavior was influenced（P 0.05） by an interaction between fescue cultivar and breed *** × Angus heifers assigned to E＋ pastures had the lowest percentage of animals grazing and the largest percentage of animals resting in the ***-influenced heifers had faster EV（P 0.001） than GA heifers（0.52 vs.0.74 ± 0.04 s/m,respectively）.Body weight（BW） was affected（P 0.01） by an interaction of tall fescue cultivar and d,and an interaction of tall fescue cultivar and breed *** grazing NT pastures were heavier（P 0.01） than heifers grazing E＋ pastures at midpoint and *** × Angus heifers grazing NT pastures were heavier（P 0.01） than GA and BR heifers grazing E＋ and BR heifers grazing NT *** interaction of forage cultivar and breed type occurred on serum PRL（P 0.01）.Conclusion： Collectively fescue cultivar,EV,and concentrations of serum PRL were associated with grazing *** grazing NT pastures were observed to be grazing more than heifers assigned to E＋ pastures,regardless of breed type,which may have contributed to changes in BW and average daily gain（ADG） in *** of behavioral observations along with traditional selection schemes may lead to enhanced animal well-being and more profitable forage-based cattle prod

关键词： Cattle Endophyte-infected tall fescue Grazing behavior Prolactin Temperament

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Seamless integration of bioelectronic interface in an animal model via in vivo polymerization of conjugated oligomers

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Bioactive materials 2022年第4期7卷 107-116页

作者： Giuseppina Tommasini Gwennael Dufil Federica Fardella Xenofon Strakosas Eugenio Fergola Tobias Abrahamsson David Bliman Roger Olsson magnus Berggren angela Tino Eleni Stavrinidou Claudia Tortiglione Istituto di Scienze Applicate e Sistemi Intelligenti“E.Caianiello” Consiglio Nazionale delle RicercheVia Campi Flegrei 3480078PozzuoliItaly Laboratory of Organic Electronics Department of Science and TechnologyLinkoping UniversitySE-60174NorrkopingSweden Department of Chemistry and molecular Biology University of GothenburgSE-40530GothenburgSweden Chemical Biology&Therapeutics Department of Experimental Medical ScienceLund UniversitySE-22184LundSweden

Leveraging the biocatalytic machinery of living organisms for fabricating functional bioelectronic interfaces,in vivo,defines a new class of micro-biohybrids enabling the seamless integration of technology with living biological ***,we have demonstrated the in vivo polymerization of conjugated oligomers forming conductors within the structures of ***,we expand this concept by reporting that Hydra,an invertebrate animal,polymerizes the conjugated oligomer ETE-S both within cells that expresses peroxidase activity and within the adhesive material that is secreted to promote underwater surface *** resulting conjugated polymer forms electronically conducting and electrochemically activeμm-sized domains,which are inter-connected resulting in percolative conduction pathways extending beyond 100μm,that are fully integrated within the Hydra tissue and the secreted ***,the introduction and in vivo polymerization of ETE-S can be used as a biochemical marker to follow the dynamics of Hydra budding(reproduction)and *** work paves the way for well-defined self-organized electronics in animal tissue to modulate biological functions and in vivo biofabrication of hybrid functional materials and devices.

关键词： In vivo polymerization Bioelectronics interfaces Conjugated oligomers model organism

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