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流行病学和临床研究中数据缺失的多重填补：机会和陷阱

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英国医学杂志中文版 2009年第6期12卷 371-375页

作者： Jonathan A C Sterne Ian R White John B Carlin michael Spratt Patrick Royston michael G Kenward angela m wood James R Carpenter 张清(译) 张孔来(校) Department ofSocial medicine University of BristolBristol BS8 2PR mRC BiostatisticsUnit Institute of PublicHealth CambridgeCB2 0SR Clinical Epidemiologyand BiostatisticsUnit MurdochChildren's ResearchInstitute andUniversityof MelbourneParkville Victoria3052 Australia Cancer andStatistical methodologyGroups MRCClinical Trials UnitLondon NW1 2DA medical StatisticsUnit kondon Schoolof Hygiene andTropical Medicinelondon WC1E 7HT Depamnent ofPublic Health andPrimary Care Instituteof Public HealthCambridge 北京协和医科大学流行病学教研室

许多研究都存在缺失数据。Jonathan

关键词：多重填补数据缺失临床研究流行病学缺失数据填补方法

Small is beautiful–a glycolytic metabolite signals mTORC1 activation in cancer cell metabolism

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Signal Transduction and Targeted Therapy 2020年第1期5卷 299-300页

作者： angela m.Otto munich Institute of BioEngineering Technical University of Munich85748 GarchingGermany

Even though the mTOR complex has been known for decades as a nutrient sensor,being thus in focus for drug targeting in metabolic disease and cancer metabolism,it has remained puzzling how it is able to get a sense of glucose availability in ***,a small metabolite of the glycolytic pathway,dihydroxyacetone phosphate,has been identified by Sabatini and his coworkers,who show how mTORC1-activity is regulated in glucose-starved and replenished cancer cells.

关键词： metabolism cancer mTORC1

Near-field terahertz nonlinear optics with blue light

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Light(Science & Applications) 2023年第5期12卷 838-846页

作者： angela Pizzuto Pingchuan ma Daniel m.mittleman Department of Physics Brown UniversityProvidence RI 02912USA School of Engineering Brown UniversityProvidence RI 02912USA

The coupling of terahertz optical techniques to scattering-type scanning near-field microscopy(s-SNOm)has recently emerged as a valuable new paradigm for probing the properties of semiconductors and other materials on the *** have demonstrated a family of related techniques,including terahertz nanoscopy(elastic scattering,based on linear optics),time-resolved methods,and nanoscale terahertz emission ***,as with nearly all examples of s-SNOm since the technique’s inception in the mid-1990s,the wavelength of the optical source coupled to the near-field tip is long,usually at energies of 2.5 eV or *** in coupling of shorter wavelengths(i.e.,blue light)to the nanotip has greatly inhibited the study of nanoscale phenomena in wide bandgap materials such as Si and ***,we describe the first experimental demonstration of s-SNOm using blue *** femtosecond pulses at 410 nm,we generate terahertz pulses directly from bulk silicon,spatially resolved with nanoscale resolution,and show that these signals provide spectroscopic information that cannot be obtained using near-infrared *** develop a new theoretical framework to account for this nonlinear interaction,which enables accurate extraction of material *** work establishes a new realm of possibilities for the study of technologically relevant wide-bandgap materials using s-SNOm methods.

关键词： scattering optics nonlinear

Cell-type resolved transcriptomic approaches for dissecting selective vulnerability in neurodgeneration

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Neural Regeneration Research 2024年第7期19卷 1411-1413页

作者： Caleb A.wood Nicholas m.Tran Department of Neuroscience Baylor College of MedicineHoustonTXUSA Department of molecular and Human Genetics Baylor College of MedicineHoustonTXUSA

A common feature among neurodegenerative conditions is that ce rtain neuronal populations are selectively vulnerable to loss(Fu et al.,2018).By corollary,other neurons are selectively resilient,suggesting they may possess unique features that support their survival.U nderstanding the basis of neuronal resilience or vulnerability would provide a logical strategy to identify factors that could be targeted therapeutically.

关键词： selective targeted

Tight Rock Wettability and Its Relationship to Other Petrophysical Properties： A montney Case Study

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Journal of Earth Science 2017年第2期28卷 381-390页

作者： Ali Javaheri Hassan Dehghanpour James m.wood University of Alberta Edmonton AB T6G 2R3 Canada Encana Corporation Calgary AB T2P 2S5 Canada

Understanding and modelling the wettability of tight rocks is essential for designing fracturing and treatment fluids. In this paper, we measure and analyze spontaneous imbibition of water and oil into five twin core plugs drilled from the cores of a well drilled in the montney Formation, an unconventional oil and gas play in the Western Canadian Sedimentary Basin. We characterize the samples by measuring the mineralogy using XRD（x-ray diffraction）, total organic carbon content, porosity, and permeability. Interestingly, the equilibrated water uptake of the five samples is similar, while, their oil uptake increases by increasing the core porosity and permeability. We define two wettability indices for the oil phase based on the slope and equilibrium values of water and oil imbibition curves. Both indices increase by increasing porosity and permeability, with the slope affinity index showing a stronger correlation. This observation suggests that part of the pore network has a stronger affinity to oil than to water. We also observe that the two indices decrease by increasing neutron porosity and gamma ray parameters measured by wireline logging tools. The samples with higher gamma ray and neutron porosity are expected to have greater clay content, and thus less effective porosity and permeability.

关键词： spontaneous imbibition wettability petrophysics gamma ray log

mitochondrial transcription factor A （TFAm）： one actor for different roles

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Frontiers in Biology 2012年第1期7卷 30-39页

作者： angela m. S. LEZZA Department of Biochemistry and molecular Biology ＇E. Quagliariello University of Bari Aldo Moro Bari Italy

mitochondrial Transcription Factor A （TFAm） is a nuclear-encoded factor present in mitochondria from allkinds of animals, even with a homologous form in yeast, which has strongly and progressively gained an eminent relevance in the regulation of mitochondrial DNA （mtDNA） functions. This is due to the various functions performed by the protein, which cover a very wide scenario including： replication, transcription, maintenance and eventually repair of mtDNA molecules. In consideration of so many different roles it plays, it can be understood there is a deep interest in its regulation of expression and activity as well as its eventual involvement in pathologies related to a decreased functionality/presence of the mitochondrial genome and the consequences of TFAm induced overexpression.

关键词： TFAm mtDNA transcription replication and maintenance

Influence of bromide exclusion in column leaching on measurement of soil pore volume

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浙江大学学报(农业与生命科学版) 1997年第1期23卷 49-51页

作者：Ｍ．ＷｏｏｄＭ．Ｗｏｎｇ浙江省农业局浙江杭州英国里丁大学英国

Ｍ．Ｗｏｏｄ２；Ｍ．Ｗｏｎｇ２（１浙江省农业厅，杭州３１０００４；２英国里丁大学土壤学系）柱淋溶中溴离子排斥对测定土壤孔隙容积的影响．浙江农业大学学报，１９９７，２３（１）：４６～４８摘要土柱淋溶实验中，溴离子通常作... 详细信息

Ｍ．Ｗｏｏｄ２；Ｍ．Ｗｏｎｇ２（１浙江省农业厅，杭州３１０００４；２英国里丁大学土壤学系）柱淋溶中溴离子排斥对测定土壤孔隙容积的影响．浙江农业大学学报，１９９７，２３（１）：４６～４８摘要土柱淋溶实验中，溴离子通常作为一个孔隙容积淋出液的常规标记物．本研究用溴标记方法，在实验室对英格兰Ｓｏｎｎｉｎｇ土系的土壤进行填装土柱的饱和淋溶试验．结果表明，与标准氚标记水淋溶的氚峰相比，溴离子的淋溶速度比预期的要快．因此推测，由于溴离子在Ｓｏｎｎｉｎｇ土系的土壤中可能发生阴离子排斥现象，故不宜作为估算水分孔隙容积的示踪物．土壤对溴离子的吸附实验也部分证实了上述结果

关键词：溴阴离子排斥孔隙容积土壤吸附柱淋溶

Burn care: The challenges of research

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Burns & Trauma 2013年第3期1卷 105-108页

作者： Fiona m. wood Burns Service of Western Australia Burn Injury Research Unit University of Western Australia Australia

Burn care is an area which has advanced relentlessly over the past decades with improved survival and quality of survival. However, there are many challenges which overshadow the successes. The translation of what we know into clinical practice remains a challenge due to issues on many levels from overcoming personal opinion to resource allocation. We live in a time of exponential increase in knowledge in diverse areas which could be harnessed to improve the lives of those suffering burn injuries. Breaking down silos in education training and research remain challenging and again the allocation of resource is key. Ultimately when the goal is "One World One Standard of Burn Care" the greatest challenge is in education with specific reference to burn injury prevention and first aid.

关键词： Burn injury translational research improved outcomes

Designing the new generation of intelligent biocompatible carriers for protein and peptide delivery

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Acta Pharmaceutica Sinica B 2018年第2期8卷 147-164页

作者： angela m.Wagner margaret P.Gran Nicholas A.Peppas mcKetta Department of Chemical Engineering The University of Texas at Austin Institute for Biomaterials Drug Delivery and Regenerative Medicine The University of Texas at Austin Department of Biomedical Engineering The University of Texas at Austin Department of Pediatrics Dell Medical School The University of Texas at Austin Department of Surgery and Perioperative Care Dell Medical School The University of Texas at Austin Division of Pharmaceutics College of Pharmacy The University of Texas at Austin

Therapeutic proteins and peptides have revolutionized treatment for a number of diseases, and the expected increase in macromolecule-based therapies brings a new set of challenges for the pharmaceutics field. Due to their poor stability, large molecular weight, and poor transport properties,therapeutic proteins and peptides are predominantly limited to parenteral administration. The short serum half-lives typically require frequent injections to maintain an effective dose, and patient compliance is a growing issue as therapeutic protein treatments become more widely available. A number of studies have underscored the relationship of subcutaneous injections with patient non-adherence, estimating that over half of insulin-dependent adults intentionally skip injections. The development of oral formulations has the potential to address some issues associated with non-adherence including the interference with daily activities, embarrassment, and injection pain. Oral delivery can also help to eliminate the adverse effects and scar tissue buildup associated with repeated injections. However, there are several major challenges associated with oral delivery of proteins and peptides, such as the instability in the gastrointestinal(GI)tract, low permeability, and a narrow absorption window in the intestine. This review provides a detailed overview of the oral delivery route and associated challenges. Recent advances in formulation and drugdelivery technologies to enhance bioavailability are discussed, including the co-administration of compounds to alter conditions in the GI tract, the modification of the macromolecule physicochemical properties, and the use of improved targeted and controlled release carriers.

关键词： Oral delivery Hydrogels Protein delivery Peptide delivery Carbohydrates mucoadhesion