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IFC implementation in lifecycle costing

Journal of Harbin Institute of Technology(New Series) 2004年第4期11卷 437-441页

作者： Charlie Fu Ghassan Aouad Amanda Marshall Ponting angela Lee Song Wu School of Construction and Property Management Salford University Salford UKSchool of Construction and Property Management Salford University Salford UKSchool of Construction and Property Management Salford University Salford UKSchool of Construction and Property Management Salford University Salford UKSchool of Construction and Property Management Salford University Salford UK

Life Cycle Costing (LCC) is always a major concern in the Architecture, Engineering and Construction (AEC) industry. This paper presents the implementation of Building Information Modeling (BIM) technology in the development of a lifecycle cost-estimating tool. The IFC (Industry Foundation Classes) model as an interoperable building information model has been adopted as the central data repository to deliver the integrated information of building designs from CAD design systems into the lifecycle-costing database. In this paper, the conceptions and relevant factors, which could affect the LCC estimation, have been introduced. The problems of current LCC applications have been identified as the lack of LCC data and the complexity of LCC exercises. The software application of IFC models and relevant auxiliary are depicted as a solution of the problem identified. The lifecycle costing tool is a part of the nD Modeling tool and as such is based on its integrated interface prototype toolkit and is able to holistically present an IFC model into a 3D virtual reality view, a tree-view and a list of element properties. The functions and some technical points are also detailed in the paper. Through the research, it demonstrates the potential and possibility of implementing BIM methods and techniques, particularly IFCs to enhance the computer applications in the processes of building construction and facility management.

关键词： AEC industry life cycle costing building information modeling industry foundation classes

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The promise of precision medicine:how biomarkers are shaping the future of cholangiocarcinoma treatment

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Hepatobiliary Surgery and Nutrition 2023年第3期12卷 457-461页

作者： Rocio I.R.Macias Lorenza Rimassa angela Lamarca Experimental Hepatology and Drug Targeting(HEVEPHARM) IBSALUniversity of SalamancaSalamancaSpain National Institute for the Study of Liver and Gastrointestinal Diseases(CIBERehd) Carlos III National Health InstituteMadridSpain Department of Biomedical Sciences Humanitas UniversityPieve Emanuele(Milan)Italy Medical Oncology and Hematology Unit Humanitas Cancer CenterIRCCS Humanitas Research HospitalRozzano(Milan)Italy Department of Oncology OncoHealth InstituteFundación Jiménez Díaz University HospitalMadridSpain Department of Medical Oncology The Christie NHS FoundationManchesterUK Division of Cancer Sciences University of ManchesterManchesterUK

Cholangiocarcinoma(CCA)is the second most frequent primary malignant neoplasm of the hepatobiliary ***,CCA is often diagnosed at an advanced stage,when potentially curative surgical treatments are not *** probability of achieving complete resection in patients who undergo surgery is about 25%(1)and even when complete tumor removal is achieved,the risk of recurrence is greater than 50%.Identification and validation of reliable biomarkers is crucial for the early detection,accurate diagnosis,appropriate staging/prognosis,therapy selection and effective monitoring of patients with biliary tract cancers(BTCs)(Figure 1).Achieving early diagnosis remains a challenge to improve survival and,although many promising biomarkers have been identified(2),to date none have reached clinical practice.

关键词： Biliary cancer biomarker immunotherapy precision medicine targeted therapy

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Detection of functional diversity gradients and their geoclimatic filters is sensitive to data types(occurrence ***)and spatial scales(sites ***)

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Plant Diversity 2024年第6期46卷 732-743页

作者： JoséLuiz Alves Silva Alexandre Souza angela Pierre Vitória Laboratório de Ciências Ambientais Universidade Estadual do Norte Fluminense Darcy RibeiroCampos dos GoytacazesRio de JaneiroBrazil Departamento de Ecologia Universidade Federal do Rio Grande do NorteRio Grande do NorteBrazil

Functional diversity(FD)reflects within-and between-site variation of species traits(α-and β-FD,respectively).Understanding how much data types(occurrence-based ***-weighted)and spatial scales(sites ***)change FD and ultimately interfere with the detection of underlying geoclimatic filters is still *** contribute to this debate,we explored the occurrence of 1690 species in 690 sites,abundances of 1198 species in 343 sites,and seven functional traits of the Atlantic Forest woody flora in South *** FD indices were sensitive and dependent on the data type at both scales,with occurrence particularly increasing a richness and dispersion(occurrence>abundance in 80%of the sites)while abundance increased β total,β replacement,and α evenness(abundance>occurrence in 60%of the sites).Furthermore,detecting the effect of geoclimatic filters depended on the data type and was *** the site scale,precipitation seasonality and soil depth had weak effects on α-and β-FD(max.R^(2)=0.11).However,regional-scale patterns of a richness,dispersion,and evenness strongly mirrored the variation in precipitation seasonality,soil depth,forest stability over the last 120 kyr,and cation exchange capacity(correlations>0.80),suggesting that geoclimatic filters manifest stronger effects at the regional ***,the role of edaphic gradients expands the idea of biogeographical filters beyond *** findings caution functional biogeographic studies to consider the effect of data type and spatial scale before designing and reaching ecological conclusions about the complex nature of FD.

关键词： Environmental filtering Historical events Human pressure n-dimensional hypervolume Biodiversity hotspot Tropical forest

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In vitro and in vivo models of acute alcohol exposure

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World Journal of Gastroenterology 2009年第10期15卷 1168-1177页

作者： angela Dolganiuc Gyongyi Szabo Department of Medicine University of Massachusetts Medical School 364 Plantation Street Worcester MA 01605-2324 United States

Alcohol abuse is a global problem due to the financial burden on society and the healthcare system. While the harmful health effects of chronic alcohol abuse are well established, more recent data suggest that acute alcohol consumption also affects human wellbeing. Thus, there is a need for research models in order to fully understand the effect of acute alcohol abuse on different body systems and organs. The present manuscript summarizes the interdisciplinary advantages and disadvantages of currently available human and non-human models of acute alcohol abuse, and identifi es their suitability for biomedical research.

关键词： Models Acute alcohol abuse Human Nonhuman Progress

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Being accompanied to liver discharge clinic: An easy measure to identify potential liver transplant candidates among those previously considered ineligible

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World Journal of Hepatology 2019年第4期11卷 370-378页

作者： Jordan Sack Nilofar Najafian angela DeLisle Simona Jakab Department of Internal Medicine Yale University School of Medicine Northeast Medical Group Yale New Haven Health Section of Digestive Diseases Yale University School of Medicine

BACKGROUND Patients with cirrhosis deemed ineligible for liver transplantation are usually followed in general hepatology or gastroenterology clinics, with the hope of reevaluation once they meet the appropriate criteria. Specific strategies to achieve liver transplant eligibility for these patients have not been *** To assess clinical and sociodemographic factors associated with future liver transplant eligibility among patients initially considered *** This is a retrospective study of patients with cirrhosis considered non-transplant eligible, but without absolute contraindications, who were scheduled in our transitional care liver clinic(TCLC) after discharge from an inpatient liver *** candidacy was assessed 1 year after the first scheduled TCLC *** on clinical and sociodemographic factors were *** Sixty-nine patients were identified and the vast majority were Caucasian men with alcoholic cirrhosis. 46 patients(67%) presented to the first TCLC visit. Seven of 46 patients that showed to the first TCLC visit became transplant candidates,while 0 of 23 patients that no-showed did(15.2% vs 0%, P = 0.08). Six of 7 patients who showed and became transplant eligible were accompanied by family orfriends at the first TCLC appointment, compared to 13 of 39 patients who showed and did not become transplant eligible(85.7% vs 33.3%, P = 0.01).CONCLUSION Patients who attended the first post-discharge TCLC appointment had a trend for higher liver transplant eligibility at 1 year. Being accompanied by family or friends during the first TCLC visit correlated with higher liver transplant eligibility at 1 year(attendance by family or friends was not requested). Patient and family engagement in the immediate post-hospitalization period may predict future liver transplant eligibility for patients previously declined.

关键词： Cirrhosis Transitional clinic Transplant listing Support Family

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LIFE CYCLE ANALYSIS OF THE DECONSTRUCTION OF MILITARY BARRACKS:***,ANNISTON,AL

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Journal of Green Building 2006年第4期1卷 166-183页

作者： Elizabeth O’Brien Bradley Guy angela Stephenson Lindner BCI The Hamer Center Pennsylvania State University Environmental Engineering Sciences University of Florida

Nearly 2.5 million ft^(2)of barracks must be removed from military facilities throughout the *** Protection Agency Region *** integration of manual deconstruction with traditional mechanical demolition methods has been shown to be comparable to traditional demolition methods in terms of cost and time requirements,the life cycle impacts of manual deconstruction on the environment and public health are *** this end,life cycle assessment was applied to extend previous deconstruction studies of barracks at *** in Anniston,*** scenarios were compared with varying degrees of time required for manual deconstruction of the barracks-100%Manual,44%Manual,26%Manual,and 100%*** were collected directly from the site and applied using SimaPro modeling software(PréAssociates,The Netherlands),considering two post-deconstruction *** salvaged using either 100%or 44%Manual deconstruction and reused within a 20-mile radius of the deconstruction site yielded the most favorable environmental and health *** significant impacts involved in the life cycle of diesel fuel required for transportation emphasize the need for developing reuse strategies for deconstructed materials at the regional level.

关键词： life cycle assessment deconstruction demolition salvage

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Patterns of host cell inheritance in the bacterial symbiosis of whiteflies

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Insect Science 2020年第5期27卷 938-946页

作者： Xiao-Rui Xu Na-Na Li Xi-Yu Bao angela E.Douglas Jun-Bo Luan Liaoning Key Laboratory of Economic and Applied Entomology College of Plant ProtectionShenyang Agricutural UniversityShenyangChina Department of Entomology Cornell UniversitIthacaNYUSA Department of Molecular Biology and Genetics Cormell UniversitylthacaNYUSA

Whiteflies possess bacterial symbionts Candidatus Portiera aleyrodidium that are housed in specialized cells called bacteriocytes and are faithfully transmitted via the ovary to insect *** one whitefly species studied previously,Bemisia tabaci MEAMI,transmission is mediated by somatic inheritance of bacteriocytes,with a single bacteriocyte transferred to each oocyte and persisting through embryogenesis to the next ***,we investigate the mode of bacteriocyte transmission in two whiefly species,*** MED,the sister species of MEAM1,and the phylogenetically distant species Trialeurodes *** analysis supported by microscopical studies demonstrates that *** MED bacteriocytes are genetically different from other somatic cells and persist through embryogenesis,as for MEAMI,but *** bacteriocytes are genetically identical to other somatic cells of the insect,likely mediated by the degradation of maternal bacteriocytes in the *** two alternative modes of transmission provide a first demonstration among insect symbioses that the cellular processes underlying vertical transmission of bacterial symbionts can diversify among related host species associated with a single lineage of symbiotic bacteria.

关键词： bacteriocyte inheritance somatic cells symbiont transmission whitefly

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Long-lasting effects of unplanned logging on the seed rain of mixed conifer-hardwood forests in southern South America

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Journal of Forestry Research 2021年第4期32卷 1409-1418页

作者： Alexandre F.Souza angela Luciana deÁvila Maristela M.Araújo Solon Jonas Longhi Departament of Ecology CBRio Grande Do Norte Federal UniversityCentral CampusLagoa NovaNatal 59072-970RNBrazil Forest Growth Department Freiburg Im BreisgauBaden-Vurtemberga Forest Research InstituteWonnhaldestraße 4Freiburg im Breisgau 79104Germany Forest Engineering Postgraduate Program Forestry DepartmentSanta Maria Federal UniversityRoraima Av.s/nCamobiSanta Maria 97105-900RSBrazil

Understanding the effects of disturbance on seed rain is critical to predict changes in forest species composition and *** effects on seed rain in a mixed conifer-hardwood forest complex in southern Brazil were *** year of seed rain data were collected from a large-scale observational experiment in logged and protected forests and quantity and average seed size weighted by species abundance(CWM)were compared between old-growth and logged stands 55 years after logging *** these data,variations in frequency of functional groups of species in the seed rain were examined to see if they could be attributed to *** show that the number of seeds per trap was highly right-skewed,ranging from 13 to 12,788 seeds per trap in one *** rain was affected by logging history,with seed traps in old-growth plots receiving significantly less seeds than traps in logged *** species included mean seed size weighted by species abundance were significantly smaller in logged than in old-growth *** difference persisted after the exclusion of Arawcaria a large-seeded pioneer which was intensively logged,although the difference of seed size between the two forest classes was greatly *** abundance in the seed rain differed significantly from the established tree community,between logged and oldgrowth *** composition of the seed rain was much more variable than the composition of the established tree community and its points more scattered over the ordination space than the points corresponding to the protected *** number of collected seeds across different functional groups of species significantly differed between logged and old-growth *** seed rain of logged forests reflects their arrested succes sion as indicated by reduced abundance of functional groups such as pioneers,large seeded pioneers and A raucaria,as well as reduced functional diversity.S eed rain differences between logged and old-

关键词： Arrested succession Brazil Logging Long-lived pioneers Seed rain

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Natural Products Diversity of Marine Ascidians(Tunicates;Ascidiacea)and Successful Drugs in Clinical Development

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Natural Products and Bioprospecting 2017年第1期7卷 1-111页

作者： Satheesh Kumar Palanisamy N.M.Rajendran angela Marino Department of Chemical BiologicalPharmaceutical and Environmental ScienceUniversity of Messina98166 MessinaItaly Key Laboratory of Engineering Plastics and Beijing National Laboratory for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing 100190China

This present study reviewed the chemical diversity of marine ascidians and their pharmacological applications,challenges and recent developments in marine drug discovery reported during 1994–2014,highlighting the structural activity of compounds produced by these *** date only 5%of living ascidian species were studied from\3000 species,this study represented from family didemnidae(32%),polyclinidae(22%),styelidae and polycitoridae(11–12%)exhibiting the highest number of promising *** to 580 compound structures are here discussed in terms of their occurrence,structural type and reported biological ***-cancer drugs are the main area of interest in the screening of MNPs from ascidians(64%),followed by anti-malarial(6%)and remaining *** approved ascidian compounds mechanism of action along with other compounds status of clinical trials(phase 1 to phase 3)are discussed here *** review highlights recent developments in the area of natural products chemistry and biotechnological approaches are emphasized.

关键词： Cancer Cytotoxicity Diversity Metabolites Pharmacology

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Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR):A critical overview on the most promising applications of molecular scissors in oral medicine

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BIOCELL 2022年第8期46卷 1837-1842页

作者： MARCO TATULLO LUISA LIMONGELLI ROSA MARIA MARANO ALESSANDRA VALLETTA angela TEMPESTA SANDRO RENGO Department of Basic Medical Sciences Neurosciences and Sense OrgansUniversity of Bari Aldo MoroBari74124Italy Department of Interdisciplinary Medicine University of Bari Aldo MoroBari74124Italy Marrelli Health-Tecnologica Research Institute Biomedical SectionStem Cells and Medical Genetics UnitsCrotone88900Italy Department of Neurosciences Reproductive and Odontostomatological SciencesUniversity of Naples Federico IINaples80131Italy

The scientific community is continuously working to translate the novel biomedical techniques into effective medical ***-Cas9 system(Clustered Regularly Interspaced Short Palindromic Repeats-9),commonly known as the“molecular scissor”,represents a recently developed biotechnology able to improve the quality and the efficacy of traditional treatments,related to several human diseases,such as chronic diseases,neurodegenerative pathologies and,interestingly,oral *** course,dental medicine has notably increased the use of biotechnologies to ensure modern and conservative approaches:in this landscape,the use of CRISPR-Cas9 system may speed and personalize the traditional therapies,ensuring a good predictability of clinical *** aim of this critical overview is to provide evidence on CRISPR efficacy,taking into specific account its applications in oral medicine.

关键词： Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR) Dentistry Stem cells

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