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Personalising pancreas cancer treatment:When tissue is the issue

World Journal of Gastroenterology 2014年第24期20卷 7849-7863页

作者： Katrin M Sjoquist Venessa T Chin Lorraine A Chantrill Chelsie O'Connor Chris Hemmings David K Chang angela chou Marina Pajic Amber L Johns Adnan M Nagrial Andrew V Biankin Desmond Yip NHMRC Clinical Trials Centre University of SydneySydney NSW 1450Australia Cancer Care Centre St George HospitalKogarah NSW 2217Australia The Kinghorn Cancer Centre and the Cancer Research ProgramGarvan Institute of Medical ResearchSydney NSW 2010Australia Macarthur Cancer Therapy Centre Campbelltown HospitalCampbelltown NSW 2560Australia St Vincents Hospital Clinical School Sydney UNSW 2010Australia Cancer Therapy Centre Liverpool HospitalLiverpool NSW 2170Australia St John of God Pathology Subiaco WA 6904Australia Department of Surgery Bankstown HospitalEldridge RoadBankstownSydney NSW 2200Australia Faculty of Medicine South Western Sydney Clinical SchoolUniversity of NSWLiverpool NSW 2170Australia Wolfson Wohl Cancer Research Centre Institute of Cancer SciencesUniversity of GlasgowGlasgow G61 1BDUnited Kingdom Department of Anatomical Pathology St.Vincent’s HospitalDarlinghurstSydney NSW 2010Australia West of Scotland Pancreatic Unit Glasgow Royal InfirmaryGlasgow G4 0SFUnited Kingdom Department of Medical Oncology The Canberra HospitalGarran ACT 2605Australia ANU Medical School Australian National UniversityActon ACT 2601Australia

The treatment of advanced pancreatic cancer has not moved much beyond single agent gemcitabine until recently when protocols such as FOLFIRINOX(fluorouracil,leucovorin,irinotecan and oxaliplatin)and nab-paclitaxelgemcitabine have demonstrated some improved *** in technology especially in massively parallel genome sequencing has progressed our understanding of the biology of pancreatic cancer especially the candidate signalling pathways that are involved in tumourogenesis and disease *** has allowed identification of potentially actionable mutations that may be targeted by new biological *** heterogeneity of pancreatic cancer makes tumour tissue collection important with the aim of being able to personalise therapies for the individual as opposed to a one size fits all approach to treatment of the *** paper reviews the developments in this area of translational research and the ongoing clinical studies that will attempt to move this into the everyday oncology practice.

关键词： Pancreatic neoplasms Molecular targeted therapy Ge

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Occurrence of pharmaceuticals and perfluorinated compounds and evaluation of the availability of reclaimed water in Kinmen

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Emerging Contaminants 2016年第3期2卷 135-144页

作者： Webber Wei-Po Lai Yen-Ching Lin Hsin-Hsin Tung Shang-Lien Lo angela Yu-Chen Lin Graduate Institute of Environmental Engineering National Taiwan University71-Chou-shan RoadTaipei106Taiwan

Emerging contaminants have commonly been observed in environmental waters but have not been included in water quality assessments at many locations around the *** evaluate the availability of reclaimed water in Kinmen,Taiwan,this study provides the first survey of the distribution of thirty-three pharmaceuticals and five perfluorinated chemicals in lake waters and water from local wastewater treatment plants(WWTPs).The results showed that the target emerging contaminants in Kinmen lakes were at trace ng/L *** addition,most of the target compounds were present in the Jincheng and Taihu WWTP influents at ng/L concentrations levels,of which 5 compounds(erythromycin-H2O(1340 ng/L),ibuprofen(1763 ng/L),atenolol(1634 ng/L),acetaminophen(2143 ng/L),and caffeine(3113 ng/L))reached mg/L *** overall treatment efficiencies of the Jincheng and Taihu WWTPs with respect to these pharmaceuticals and perfluorinated chemicals were poor;half of the compounds were less than 50%*** compounds(sulfamethoxazole,erythromycin-H2O,clarithromycin,ciprofloxacin and ofloxacin)with risk quotient(RQ)values>1 in the effluent should be further investigated to understand their effects on the aquatic *** and advanced treatment units are found necessary to provide high-quality recycled water and sustainable water resources.

关键词： Emerging contaminant Perfluorinated compound Pharmaceutical Water scarcity Wastewater treatment plant

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Crowdsourcing in health and medical research:a systematic review

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Infectious Diseases of Poverty 2020年第1期9卷 96-96页

作者： Cheng Wang Larry Han Gabriella Stein Suzanne Day Cedric Bien-Gund Allison Mathews Jason JOng Pei-Zhen Zhao Shu-Fang Wei Jennifer Walker Roger chou Amy Lee angela Chen Barry Bayus Joseph D.Tucker 不详 Social Entrepreneurship to Spur Health GuangzhouChina Institute of Global Health and Infectious Diseases University of North Carolina at Chapel HillChapel HillUSA

Background:Crowdsourcing is used increasingly in health and medical *** is the process of aggregating crowd wisdom to solve a *** purpose of this systematic review is to summarize quantitative evidence on crowdsourcing to improve ***:We followed Cochrane systematic review guidance and systematically searched seven databases up to September 4th *** were included if they reported on crowdsourcing and related to health or *** were excluded if recruitment was the only use of *** determined the level of evidence associated with review findings using the GRADE ***:We screened 3508 citations,accessed 362 articles,and included 188 ***-six studies examined effectiveness,127 examined feasibility,and 37 examined *** most common purposes were to evaluate surgical skills(17 studies),to create sexual health messages(seven studies),and to provide layperson cardiopulmonary resuscitation(CPR)out-of-hospital(six studies).Seventeen observational studies used crowdsourcing to evaluate surgical skills,finding that crowdsourcing evaluation was as effective as expert evaluation(low quality).Four studies used a challenge contest to solicit human immunodeficiency virus(HIV)testing promotion materials and increase HIV testing rates(moderate quality),and two of the four studies found this approach saved *** studies suggested that an interactive technology system increased rates of layperson initiated CPR out-ofhospital(moderate quality).However,studies analyzing crowdsourcing to evaluate surgical skills and laypersoninitiated CPR were only from high-income *** studies examined crowdsourcing to inform artificial intelligence projects,most often related to annotation of medical *** was evaluated using different outcomes,limiting the extent to which studies could be ***:Crowdsourcing has been used to improve health in many *** crowds

关键词： Crowdsourcing Innovation Challenge contest Systematic review Medicine Health

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