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Automated Segmentation and Connectivity Analysis for Normal Pressure Hydrocephalus

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Biomedical Engineering Frontiers 2022年第1期3卷 1-13页

作者： angela Zhang Amil Khan Saisidharth Majeti Judy Pham Christopher Nguyen Peter Tran Vikram Iyer Ashutosh Shelat Jefferson chen B.S.Manjunath Vision Research Laboratory Electrical and Computer EngineeringUniversity of CaliforniaSanta BarbaraSanta BarbaraCAUSA chen Lab Department of NeurosurgeryUniversity of CaliforniaIrvine Medical CenterOrangeCAUSA Santa Barbara Cottage Hospital Santa BarbaraCAUSA

Objective and Impact *** propose an automated method of predicting Normal Pressure Hydrocephalus(NPH)from CT scans.A deep convolutional network segments regions of interest from the *** regions are then combined with MRI information to predict *** our knowledge,this is the first method which automatically predicts NPH from CT scans and incorporates diffusion tractography information for *** to their low cost and high versatility,CT scans are often used in NPH *** well-defined and effective protocol currently exists for analysis of CT scans for ***’index,an approximation of the ventricle to brain volume using one 2D image slice,has been proposed but is not *** proposed approach is an effective way to quantify regions of interest and offers a computational method for predicting *** propose a novel method to predict NPH by combining regions of interest segmented from CT scans with connectome data to compute features which capture the impact of enlarged ventricles by excluding fiber tracts passing through these *** segmentation and network features are used to train a model for NPH *** method outperforms the current state-of-the-art by 9 precision points and 29 recall *** segmentation model outperforms the current state-of-the-art in segmenting the ventricle,gray-white matter,and subarachnoid space in CT *** experimental results demonstrate that fast and accurate volumetric segmentation of CT brain scans can help improve the NPH diagnosis process,and network properties can increase NPH prediction accuracy.

关键词： diagnosis network Connectivity

Near-field launching and mapping unidirectional surface plasmon polaritons using an automated dual-tip scanning near-field optical microscope

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Photonics Research 2022年第11期10卷 2628-2641页

作者： NAJMEH ABBASIRAD angela BARREDA YI-JU chen JER-SHING HUANG ISABELLE STAUDE FRANK SETZPFANDT THOMAS PERTSCH Institute of Applied Physics Abbe Center of PhotonicsFriedrich Schiller University Jena07745 JenaGermany Institute of Solid State Physics Friedrich Schiller University Jena07743 JenaGermany Research Department of Nanooptics Leibniz Institute of Photonic Technology07745 JenaGermany Fraunhofer-Institute for Applied Optics and Precision Engineering IOF 07745 JenaGermany

The spatial distribution of electromagnetic fields emitted from the aperture tip of a scanning near-field optical microscope(SNOM), which is called the emission pattern, depends on the geometry of the apex and the material composition of the tip’s coating. In previous works, experimental measurements of the emission pattern from the aperture tip were performed mostly in the far field. Moreover, the corresponding theoretical models were also developed based on these far-field measurements. Here, we have used the automated dual-tip SNOM to systematically characterize the emission from the aperture tip in the near field. In this regard, we have considered three different pairs of excitation and detection tips with distinct geometries. The emission patterns of the excitation tips were mapped using detection tips. Unidirectional surface plasmon polaritons(SPPs) at the surface of a gold platelet were launched by an excitation tip and measured in the near field by the detection tip. The experimental results were numerically reproduced by means of the Bethe–Bouwkamp model. This work puts into evidence the applicability of the automated dual-tip SNOM as the only available characterization technique to measure the emission from aperture tips in the near field. The reported asymmetric SPP radiation patterns can find applications in photonic integrated circuits or in biological and chemical sensing.

关键词： optical excitation field

In vitro expression and analysis of the 826 human G protein-coupled receptors

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Protein & Cell 2016年第5期7卷 325-337页

作者： Xuechen Lv Junlin Liu Qiaoyun Shi Qiwen Tan Dong Wu John J. Skinner angela L. Walker Lixia Zhao Xiangxiang Gu Na chen Lu Xue Pei Si Lu Zhang Zeshi Wang Vsevolod Katritch Zhijie Liu Raymond C. Stevens iHuman Institute ShanghaiTech University Shanghai 201210 China Department of Biological Sciences Bridge Institute University of Southern California Los Angeles CA 90089 USA

G protein-coupled receptors （GPCRs） are involved in all human physiological systems where they are responsible for transducing extracellular signals into cells. GPCRs signal in response to a diverse array of stimuli including light, hormones, and lipids, where these signals affect downstream cascades to impact both health and disease states. Yet, despite their importance as therapeutic tar- gets, detailed molecular structures of only 30 GPCRs have been determined to date. A key challenge to their structure determination is adequate protein expression. Here we report the quantification of protein expression in an insect cell expression system for all 826 human GPCRs using two different fusion constructs. Expression char- acteristics are analyzed in aggregate and among each of the five distinct subfamilies. These data can be used to identify trends related to GPCR expression between dif- ferent fusion constructs and between different GPCR families, and to prioritize lead candidates for future structure determination feasibility.

关键词： G protein-coupled receptors insect,protein expression surface expression analysis fusionconstruct

Proto Kranz-like leaf traits and cellular ionic regulation are associated with salinity tolerance in a halophytic wild rice

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Stress Biology 2022年第1期2卷 587-605页

作者： Miing-Tiem Yong Celymar angela Solis Samuel Amatoury Gothandapani Sellamuthu Raja Rajakani Michelle Mak Gayatri Venkataraman Lana Shabala Meixue Zhou Oula Ghannoum Paul Holford Samsul Huda Sergey Shabala Zhong-Hua chen School of Science Western Sydney UniversityPenrithNSW 2751Australia Tasmanian Institute of Agriculture College of Science and EngineeringUniversity of TasmaniaHobartTasmania 7001Australia Plant Molecular Biology Laboratory M.S.Swaminathan Research FoundationIII Cross StreetTaramani Institutional Area-600113ChennaiIndia Hawkesbury Institute for the Environment Western Sydney UniversityPenrithNSW 2751Australia International Research Centre for Environmental Membrane Biology Foshan UniversityFoshan 528000China

Species of wild rice(Oryza spp.)possess a wide range of stress tolerance traits that can be potentially utilized in breeding climate-resilient cultivated rice cultivars(Oryza sativa)thereby aiding global food *** this study,we conducted a greenhouse trial to evaluate the salinity tolerance of six wild rice species,one cultivated rice cultivar(IR64)and one landrace(Pokkali)using a range of electrophysiological,imaging,and whole-plant physiological *** wild species(***,*** and ***)were found to possess superior salinity stress *** underlying mechanisms,however,were strikingly ***+accumulation in leaves of ***,*** and *** were significantly higher than the tolerant landrace,***+accumulation in mesophyll cells was only observed in ***,suggesting that *** and *** avoid Na+accumulation in mesophyll by allocating Na+to other parts of the *** finding also suggests that *** might be able to employ Na+as osmolyte without affecting its *** study of Na+allocation in leaves will be helpful to understand the mechanisms of Na+accumulation in these *** addition,*** showed Proto Kranz-like leaf anatomy(enlarged bundle sheath cells and lower numbers of mesophyll cells),and higher expression of C4-related genes(e.g.,NADPME,PPDK)and was a clear outlier with respect to salinity tolerance among the studied wild and cultivated Oryza *** unique phylogenetic relationship of *** with C4 grasses suggests the potential of this species for breeding rice with high photosynthetic rate under salinity stress in the future.

关键词： Gas exchange Gene expression Ion flux Na+imaging Oryza sativa Oryza coarctata

固体激光用Nd:Lu_(2)O_(3)透明陶瓷的制备和光学性能研究

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无机材料学报 2021年第2期36卷 210-216页

作者：刘子玉 TOCI Guido PIRRI angela PATRIZI Barbara 冯亚刚陈肖朴胡殿君田丰吴乐翔 VANNINI Matteo 李江中国科学院上海硅酸盐研究所透明光功能无机材料重点实验室上海201899 中国科学院大学材料与光电研究中心北京100049 意大利国家研究委员会国立光学研究所佛罗伦萨50019 意大利国家研究委员会“Carrara”应用物理研究所佛罗伦萨50019

Nd:Lu_(2)O_(3)材料由于具有高热导率、低声子能量和优异的光学特性而成为非常有前景的高功率固体激光器用的增益介质。但Lu_(2)O_(3)单晶的熔点超过2400℃,难以生长,而Lu_(2)O_(3)陶瓷既能在低温下制备,又具有与晶体相当的光学性质和... 详细信息

Nd:Lu_(2)O_(3)材料由于具有高热导率、低声子能量和优异的光学特性而成为非常有前景的高功率固体激光器用的增益介质。但Lu_(2)O_(3)单晶的熔点超过2400℃,难以生长,而Lu_(2)O_(3)陶瓷既能在低温下制备,又具有与晶体相当的光学性质和激光性能从而备受关注。本研究制备了高透明的Nd:Lu_(2)O_(3)陶瓷并对其光学性质和激光性能进行探究。以共沉淀法制备的纳米粉体为原料,采用真空烧结结合热等静压(HIP)两步烧结法制备了1.0at%Nd:Lu_(2)O_(3)透明陶瓷。对制备的粉体、素坯和陶瓷的微结构进行了表征:HIP后处理的陶瓷平均晶粒尺寸是724.2nm。厚度为1.0mm的1.0at%Nd:Lu_(2)O_(3)透明陶瓷在1100 nm处的直线透过率是82.4%,样品在806 nm处的吸收截面为1.50×10^(-20)cm^(2),而根据荧光光谱计算得到的发射截面为6.5×10^(–20)cm^(2)。分别在878.8和895.6 nm波长激发下,1.0at%Nd:Lu_(2)O_(3)透明陶瓷(4)^F3/2→(4)^I11/2跃迁的平均荧光寿命均为169ms。当输出耦合镜的透过率TOC=2.0%时,退火后的1.0at%Nd:Lu_(2)O_(3)透明陶瓷获得了最大输出功率为0.47 W的准连续(QCW)激光输出,斜率效率为8.7%。本研究成功制备了显微结构均匀、高透明度的1.0at%Nd:Lu_(2)O_(3)陶瓷,并展示了其在固体激光增益介质领域的广阔应用潜力。

关键词： Nd:Lu2O3透明陶瓷共沉淀法两步烧结光学性能激光性能

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四个地域小黄鱼肌肉营养成分分析与评价

营养学报 2018年第2期40卷 203-205页

作者：王立改 angela Cornel 楼宝鲁琼詹炜陈睿毅浙江省海洋水产研究所浙江省海水增养殖重点实验室舟山316100 浙江海洋大学舟山316100

小黄鱼（Larimichthys polyactis）,又名小黄花鱼,鲈形目,石首鱼科,黄鱼属,在我国黄海和东海北部均有分布,是我国重要的海产经济鱼类[1],其肉味鲜美、营养价值高。目前尚无不同地域小黄鱼肌肉营养成分、营养价值、氨基酸和脂肪酸含量的... 详细信息

小黄鱼（Larimichthys polyactis）,又名小黄花鱼,鲈形目,石首鱼科,黄鱼属,在我国黄海和东海北部均有分布,是我国重要的海产经济鱼类[1],其肉味鲜美、营养价值高。目前尚无不同地域小黄鱼肌肉营养成分、营养价值、氨基酸和脂肪酸含量的差异研究。

关键词：小黄鱼营养成分氨基酸脂肪酸矿物质元素

黄光激光用Dy,Tb∶LuAG透明陶瓷的制备与性能研究

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发光学报 2022年第11期43卷 1733-1740页

作者：刘强武龙飞李晓英刘子玉陈鹏辉田丰谢腾飞 PIRRI angela TOCI Guido 李江江苏大学材料科学与工程学院江苏镇江212013 中国科学院上海硅酸盐研究所透明光功能无机材料重点实验室上海201899 中国科学院大学材料与光电研究中心北京100049 Istituto di Fisica Applicata“N.Carrara” Consiglio Nazionale delle RicercheCNR-IFACVia Madonna del Piano 10C50019 Sesto Fiorentino(Fi)Italy Istituto Nazionale di Ottica Consiglio Nazionale delle RicercheCNR-INOVia Madonna del Piano 10C50019 Sesto Fiorentino(Fi)Italy

以NH_(4)HCO_(3)为沉淀剂,通过共沉淀法合成了分散性良好的Dy,Tb∶LuAG纳米粉体,并研究了前驱体的热分解行为、粉体的物相及显微形貌。在不添加任何烧结助剂的情况下,采用真空预烧结合热等静压烧结技术首次制备出高透明的Dy,Tb∶LuAG陶... 详细信息

以NH_(4)HCO_(3)为沉淀剂,通过共沉淀法合成了分散性良好的Dy,Tb∶LuAG纳米粉体,并研究了前驱体的热分解行为、粉体的物相及显微形貌。在不添加任何烧结助剂的情况下,采用真空预烧结合热等静压烧结技术首次制备出高透明的Dy,Tb∶LuAG陶瓷,并研究了预烧温度对陶瓷显微形貌及光学质量的影响。当预烧温度为1600℃时,退火后的Dy,Tb∶LuAG陶瓷(厚度为1.5 mm)在578 nm处的直线透过率达到83.6%,平均晶粒尺寸为0.9μm。此外,退火后的3%Dy,1%Tb∶LuAG透明陶瓷在447 nm的吸收截面积为1.3×10^(-21) cm^(2),半高宽为3.0 nm,与商用GaN蓝色激光二极管具有良好的匹配性。研究表明,Dy,Tb∶LuAG透明陶瓷在黄光激光领域具有潜在的应用价值。

关键词： Dy,Tb∶LuAG 透明陶瓷共沉淀法热等静压烧结

A matrigel-free method to generate matured human cerebral organoids using 3D-Printed microwell arrays

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Bioactive Materials 2021年第4期6卷 1130-1139页

作者： cheng chen Venkatakrishnan Rengarajan Andrew Kjar Yu Huang Department of Biological Engineering Utah State UniversityLoganUT84322USA

The current methods of generating human cerebral organoids rely excessively on the use of Matrigel or other external extracellular matrices(ECM)for cell micro-environmental *** embedding is problematic for long-term culture and clinical applications due to high inconsistency and other *** this study,we developed a novel microwell culture platform based on 3D *** platform,without using Matrigel or external signaling molecules(i.e.,SMAD and Wnt inhibitors),successfully generated matured human cerebral organoids with robust formation of high-level features(i.e.,wrinkling/folding,lumens,neuronal layers).The formation and timing were comparable or superior to the current Matrigel methods,yet with improved *** effect of microwell geometries(curvature and resolution)and coating materials(i.e.,mPEG,Lipidure,BSA)was studied,showing that mPEG outperformed all other coating materials,while curved-bottom microwells outperformed flat-bottom *** addition,high-resolution printing outperformed low-resolution printing by creating faithful,isotropically-shaped *** trend of these effects was consistent across all developmental characteristics,including EB formation efficiency and sphericity,organoid size,wrinkling index,lumen size and thickness,and neuronal layer ***,the microwell device that was mPEG-coated,high-resolution printed,and bottom curved demonstrated the highest efficacy in promoting organoid *** platform provided a promising strategy for generating uniform and mature human cerebral organoids as an alternative to Matrigel/ECM-embedding methods.

关键词： Cortical wrinkling Cortical folding 3D culture Biomanufacturing Embryoid body spheroid Microfabrication

Non-escaping frost tolerant QTL linked genetic loci at reproductive stage in six wheat DH populations

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The Crop Journal 2022年第1期10卷 147-165页

作者： Jingjuan Zhang MD Shahidul Islam Yun Zhao Masood Anwar Zaid Alhabbar Maoyun She Rongchang Yang angela Juhasz Guixiang Tang Jiansheng chen Hang Liu Yanjie Jiang Shengnan Zhai Xin Hu Junkang Rong Yingquan Zhang Yebo Qin Qier Liu Zitong Yu Yujuan Zhang Sadegh Balotf Mirza Dowla Sonia Afrin Nandita Roy Md Resad Mallik Md Atik Us Saieed Shanjida Rahman Nigarin Sultana Sarah Al-Sheikh Ahmed Chris Florides Kefei chen Darshan Sharma Nathan Height Ben Biddulph Meiqin Lu Jorge EMayer Wujun Ma Australian-China Joint Centre for Wheat Improvement Western Australian State Agriculture Biotechnology CentreFood Futures InstituteMurdoch UniversitySouth StreetMurdochWA 6150Australia College of Agriculture&Food Zhejiang Agriculture&Forestry UniversityLin’an 311314ZhejiangChina SAGI West Faculty of Science and EngineeringCurtin UniversityBentleyWA 6102Australia Department of Primary Industries and Regional Development Western Australia3 Baron-Hay CourtSouth PerthWA 6151Australia Australian Grain Technologies 12656 Newell HighwayLocked Bag 1100NarrabriNSW 2390Australia Ag RD&IP Consult P/L NerangQLD 4211Australia

Reproductive stage frost poses a major constraint for wheat production in countries such as ***,little progress has been made in identifying key genes to overcome the *** the present study,a severe frost event hit two large-scale field trials consisting of six doubled haploid(DH)wheat populations at reproductive stage(young microspore stage)in Western Australia,leading to the identification of 30 robust frost QTL on 17 *** major 18 QTL with the phenotype variation over 9.5%were located on 13 chromosomes including 2 A,2 B,2 D,3 A,4 A,4 B,4 D,5 A,5 D,6 D,7 A,7 B and7 *** frost QTL were closely linked to the QTL of anthesis,maturity,Zadok stages as well as linked to anthesis related *** of those,six QTL were repetitively detected on the homologous regions on 2 B,4 B,4 D,5 A,5 D,7 A in more than two *** showed that the frost damage is associated with alleles of Vrn-A1 a,Vrn-D1 a,Rht-B1 b,Rht-D1 b,and the high copy number of ***,anthesis QTL and anthesis related genes of Vrn-B1 a and Ta FT3-1 B on chromosomes 5 B and 1 B did not lead to frost damage,indicating that these early-flowering phenotype related genes are compatible with frost tolerance and thus can be utilised in *** results also indicate that wild-type alleles Rht-B1 a and Rht-D1 a can be used when breeding for frost-tolerant varieties without delaying flowering time.

关键词： Anthesis-related genes Wheat DH populations Reproductive stage Non-escaping frost tolerance QTL