检索结果-南通市图书馆

Distinct toll-like receptor expression in monocytes and T cells in chronic HCV infection

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第8期12卷 1198-1204页

作者： angela Dolganiuc Catherine Garcia Karen Kodys Gyongyi Szabo Department of Medicine University of Massachusetts Medical School364 Plantation StreetWorcesterMA 01605-2324United States

AIM： Hepatitis C virus often establishes chronic infections. Recent studies suggest that viral and bacterial infections are more common in HCV-infected patients compared to controls. Pathogens are recognized by Toll-like receptors （TLRs） to shape adaptive and innate immune responses. METHODS： In this study, to infected host to recognize assess the ability of HCV-infected host to recognize invading pathogens, we investigated Toll-like receptor expression in innate （monocytes） and adaptive （T cells） immune cells by realtime PCR. RESULTS： We determined that RNA levels for TLRs 2, 6. 7, 8, 9 and 10 mRNA levels were upregulated in both monocytes and T cells in HCV-infected patients compared to controls. TLR4 was only upregulated in T lymphocytes, while TLR5 was selectively increased in monocytes of HCV-infected patients. MD-2, a TLR4 coreceptor, was increased in patients＇ monocytes and T cells while CD14 and MyD88 were increased only in monocytes. CONCLUSION： Our data reveal novel details on TLR expression that likely relates to innate recognition of pathogens and immune defense in HCV-infected individuals.

关键词： Hepatitis C virus Toll-like receptors T cells Monocytes

Hierarchical dispatch of multiple microgrids using nodal price:an approach from consensus and replicator dynamics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2019年第6期7卷 1573-1584页

作者： Miguel A.VELASQUEZ Oscar TORRES-PEREZ Nicanor QUIJANO angela CADENA Department of Electrical and Electronics Engineering Universidad de los AndesBogotaColombia

A hierarchical approach for the energy management of geographically close microgrids connected through a dedicated AC power network is proposed in this *** proposed approach consists of a two-layer energy management system(EMS)for networked *** the lower layer,each micro grid solves its own economic dispatch problem through a distributed model predictive control approach that respects capacity limits and ramp-rate constraints of distributed *** the upper layer,the energy trading in the network of microgrids decides how to optimally trade the energy based on the marginal cost information from the lower layer in order to improve global optimization objectives,e.g.,social *** order to solve the trading problem,a consensusbased algorithm and a replicator dynamics algorithm are proposed assuming that the marginal cost function of the microgrid is known and *** is shown that both algorithms converge to the same solution,which is equivalent to the minimization of operation *** consensus-based algorithm is extended in order to tackle more general marginal cost functions and trading network ***,the effect of ramp constraints and network limits is *** show the effectiveness of the proposed algorithms for three interconnected microgrids with different characteristics.

关键词： Consensus Economic dispatch Hierarchical control Networked microgrids Ramp limits Replicator dynamics

Siderophore-Producing Rhizobacteria as a Promising Tool for Empowering Plants to Cope with Iron Limitation in Saline Soils:A Review

在线全文

学校读者我要写书评

暂无评论

Pedosphere 2019年第4期29卷 409-420页

作者： Maria J.FERREIRA Helena SILVA angela CUNHA Biology Department and Centre for Environmental and Marine Studies(CESAM) University of Aveiro Campus de Santigo

Iron(Fe) bioavailability to plants is reduced in saline soils;however, the exact mechanisms underlying this effect are not yet completely understood. Siderophore-expressing rhizobacteria may represent a promising alternative to chemical fertilizers by simultaneously tackling salt-stress effects and Fe limitation in saline soils. In addition to draught, plants growing in arid soils face two other major challenges: high salinity and Fe deficiency. Salinity attenuates growth, affects plant physiology, and causes nutrient imbalance,which is, in fact, one of the major consequences of saline stress. Iron is a micronutrient essential for plant development, and it is required by several metalloenzymes involved in photosynthesis and respiration. Iron deficiency is associated with chlorosis and low crop productivity. The role of microbial siderophores in Fe supply to plants and the effect of plant growth-promoting rhizobacteria(PGPR) on the mitigation of saline stress in crop culture are well documented. However, the dual effect of siderophore-producing PGPR, both on salt stress and Fe limitation, is still poorly explored. This review provides a critical overview of the combined effects of Fe limitation and soil salinization as challenges to modern agriculture and intends to summarize some indirect evidence that argues in favour of siderophore-producing PGPR as biofertilization agents in salinized soils. Recent developments and future perspectives on the use of PGPR are discussed as clues to sustainable agricultural practices in the context of present and future climate change scenarios.

关键词： aridity bioavailability biofertilizer Fe deficiency high salinity plant growth-promoting rhizobacteria(PGPR) saline stress soil salinization

Techno-economic assessment of providing control energy reserves with a biogas plant

在线全文

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2018年第4期12卷 763-771页

作者： Ervin Saracevic David Woess Franz Theuretzbacher Anton Friedl angela Miltner Institute of Chemical Environmental and Bioscience EngineeringTU Wien1060 ViennaAustria University of Natural Resources and Life Sciences 1180 ViennaAustria University of Applied Sciences 2700Wiener NeustadtAustria

Grid stability is being challenged by the increasing integration of power plants with volatile power generation into the energy system. Power supply fluctuations must be compensated by energy system flexibility. The storability of the energy carrier enables biogas plants to generate power flexibly. In this study, the technical and economic effects of providing positive secondary control energy reserves with an Austrian biogas plant were assessed. The plant’s main focus lies in biomethane production with the option of heat and power generation through combined heat and power (CHP) units. A detailed simulation model of the investigated biogas plant was developed, which is presented in this work. Ex-post simulations of one year of flexible plant operation were conducted with this model. The findings show that the installed biogas storage capacity is sufficient to provide control energy reserves while simultaneously producing biomethane. Profitability of providing control energy reserves largely depends on the prices at the control energy market and on CHP unit start-up costs. A cost efficiency analysis demonstrated that investing in a hot water tank with a volume of 5 m3 for short-term heat storage turned out to be economically viable.

关键词： biogas plant process simulation control energy reserves economic assessment gas storage

Genotyping ex situ trees of Abies nebrodensis translocated from the original Sicilian population to enrich the gene pool

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Forestry Research 2023年第4期34卷 1095-1106页

作者： Anna De Rogatis Fulvio Ducci Serena Guerri angela Teani Roberta Proietti CREA Research Centre for Agriculture and EnvironmentVia di Saliceto 8040123 BolognaItaly CREA Research Centre for Forestry and WoodViale Santa Margherita 8052100 ArezzoItaly Comprehensive Institute Venturino Venturi of Loro Ciuff enna Arezzo Via Genova 1252024 Loro Ciuff enna(AR)Italy

As a dynamic ex situ conservation strategy,a clonal seed orchard was started in a nursery in Pomaio(POM)in central Italy in 1993 for an assisted migration experiment of Abies nebrodensis(Lojac.)*** artifi cial ex situ populations were planted with this gene pool:a seedling arboretum in Pieve Santo Stefano(PSS)and a small dendrological collection in Papiano(PAP),both originating from the Sicilian relict ***,using AFLP markers,we estimated the relatedness among the relocated genotypes of the three collections to check whether the three collections had suffi cient genetic variability to be considered as additional sources of variability to the original gene pool for the assisted migration *** individual genetic variability was found in the collections;each plant had a diff erent genotype and was confi rmed to belong to its population of *** and PSS trees were shown to be only from the original population of *** species and were derived from a limited set of maternal fertile *** on the Sicilian fi r population inventory,nursery production in Sicily,and structure clustering analysis,close genetic relationships among POM,PAP and several PSS trees(1–35)were ***,the PSS group(36–78)was genetically close to tree 1 of POM and in a lesser proportion to plants 7 and 9 of *** sampling of seedlings used to form batches in the nursery might have infl uenced the structure of the resultant *** genotypes will be useful for enriching the original gene pool.

关键词： Sicilian fir Genotyping Ex situ conservation Gene pool Assisted migration

Food and Drug:A New Direction in the History of Medicine in China

在线全文

学校读者我要写书评

暂无评论

Chinese Medicine and Culture 2023年第3期6卷 265-271页

作者： angela Ki Che Leung Chair Professor of History Joseph Needham-Philip Mao Professor in Chinese HistoryScienceand CivilizationHong Kong Institute for the Humanities and Social SciencesThe University of Hong KongHong Kong 518057China

1 Objects and their histories: unraveling the “black box”The history of object is a burgeoning field in contemporary historical studies. An object, like a “black box,” contains rich information that holds the secret code for knowledge construction. Object is a multifaceted being, consisting of aspects like technology, institution, human–object relationship, and human–nature interaction. Medicine and food inform sophisticated questions about society and ideology.

关键词： knowledge holds History

Antibody-based immunotherapies for Parkinsonian syndromes

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2019年第11期14卷 1903-1904页

作者： Lars Tonges Maria angela Samis Zella Department of Neurology St. Josef-HospitalRuhr-University BochumBochumGermany Neurodegeneration Research Protein Research Unit Ruhr (PURE)Ruhr University BochumBochumGermany Department of Neurology St. Josef-HospitalKatholische Kliniken RuhrhalbinselContilia GruppeEssenGermany

What is the rationale for immunotherapies in Parkinsonian syndromes (PS)? PS are neurodegenerative diseases which are clinically characterized by a hypokinetic phenotype in combination with additional motor and non-motor symptoms. One major pathological hallmark of all PS consists of a non-physiological detrimental accumulation of protein aggregates which appear intracellularly in neurons and glial cells but also in the extracellular space (Wong and Krainc, 2017). Depending on the pathogenic protein, PS can be divided into synucleinopathies, characterized by aggregation of the protein alpha-Synuclein (aSyn), and tauopathies, characterized by aggregation of the protein Tau (Levin et al., 2016;Poewe et al., 2017). Clinical syndromes of synucleinopathies include Parkinson’s disease (PD), multiple system atrophy (MSA) and dementia with Lewy bodies, and tauopathies include progressive supranuclear palsy (PSP) and corticobasal degeneration.

关键词： Parkinsonian syndromes Parkinson’s disease(PD) multiple system atrophy(MSA)

A High Order Sharp-Interface Method with Local Time Stepping for Compressible Multiphase Flows

在线全文

学校读者我要写书评

暂无评论

Communications in Computational Physics 2011年第1期9卷 205-230页

作者： angela Ferrari Claus-Dieter Munz Bernhard Weigand Institute of Aerodynamics and Gasdynamics University of StuttgartPfaffenwaldring 21D-70569 StuttgartGermany Institute of Aerospace Thermodynamics University of StuttgartPfaffenwaldring 31D-70569 StuttgartGermany

In this paper,a new sharp-interface approach to simulate compressible multiphase flows is *** new scheme consists of a high order WENO finite volume scheme for solving the Euler equations coupled with a high order pathconservative discontinuous Galerkin finite element scheme to evolve an indicator function that tracks the material *** the interface our method applies ghost cells to compute the numerical flux,as the ghost fluid ***,unlike the original ghost fluid scheme of Fedkiw et al.[15],the state of the ghost fluid is derived from an approximate-state Riemann solver,similar to the approach proposed in[25],but based on a much simpler *** formulation leads only to one single scalar nonlinear algebraic equation that has to be solved at the interface,instead of the system used in[25].Away from the interface,we use the new general Osher-type flux recently proposed by Dumbser and Toro[13],which is a simple but complete Riemann solver,applicable to general hyperbolic conservation *** time integration is performed using a fully-discrete one-step scheme,based on the approaches recently proposed in[5,7].This allows us to evolve the system also with time-accurate local time *** to the sub-cell resolution and the subsequent more restrictive time-step constraint of the DG scheme,a local evolution for the indicator function is applied,which is matched with the finite volume scheme for the solution of the Euler equations that runs with a larger time *** use of a locally optimal time step avoids the introduction of excessive numerical diffusion in the finite volume *** different fluids have been used,namely an ideal gas and a weakly compressible fluid modeled by the Tait *** tests have been computed to assess the accuracy and the performance of the new high order scheme.A verification of our algorithm has been carefully carried out using exact solutions as well as a comparison with other numerical re

关键词： Sharp interface capturing compressible multiphase flows one-step time-integration time-accurate local time stepping modified ghost fluid method WENO schemes discontinuous Galerkin methods

Unhealthy aging? Featuring older people in television food commercials in China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Nursing Sciences 2020年第S1期7卷 67-73页

作者： Wen Jiao angela Wen-Yu Chang Department of Communication Faculty of Social SciencesUniversity of MacaoChina

Objectives:Advertising messages can affect the public as a risk or protective factor for socially disadvantaged groups,and they may reflect how characters reflect perceptions are perceived in a *** study aimed to investigate how older people are portrayed in televised food commercials from the approach of a healthy aging perspective in contemporary Chinese ***:All televised advertising in the Ad Topic archive were screened against inclusion and exclusion criteria,and a total of 164 commercials from the years of 2016-2019 that portrayed Chinese older people were *** association between the main older characters with the product categories,healthy *** foods,use of health claims,sex,type of spokesperson,companions,and tones and manners were included in the ***:Older people more frequently appeared in unhealthy food products than in healthy food *** claims involving older adults were portrayed adequately,whereas nursing professions as companions of older adults were *** advertising that delivered happy,caring,or warm tones was overwhelmingly ***,the advertising messages circulated in China represent a binary stereotype model of images of older adults'characteristics that reflect ageist and the so-called agelessism,referring to the new application of the look from the approach of social psychology and marketing ***:This study examined aging discrimination reflected in *** exploring the impact of a crisis remain *** is needed to improve the accuracy of advertised healthy older adults and normal aging.

关键词： Advertising Aged Ageism China Food Healthy aging Marketing Stereotypes