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Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients

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World Journal of Virology 2017年第2期6卷 36-45页

作者： Julio Collazos Eulalia Valle-Garay Tomás Suárez-Zarracina angel-hugo montes.jos. a cartón Víctor Asensi Infectious Diseases Hospital de Galdácano Biochemistry and Molecular Biology Hospital Universitario Central de AsturiasOviedo University School of Medicine Infectious Diseases Hospital Universitario Central de AsturiasOviedo University School of Medicine

AIM To investigate the relationships among diverse metalloproteases(MMPs) and their tissue inhibitors(TIMPs) and non-alcoholic liver fibrosis in human immunodeficiency virus(HIV)-infected *** Single nucleotide polymorphisms(SnPs) in MMPs, TnF-α and CCR5 genes, and serum levels of MMPs and TIMPs were determined in HIV-infected individuals with/out hepatitis C virus(HCV) coinfection. A total of 158 patients were included, 57 of whom were HCVcoinfected. All patients drank nol/day. Diverse SnPs(MMP-1-1607 1G/2G, MMP-8-799C/T, MMP-9-1562 C/T, MMP-13-77A/G, TnF-α-308 G/A,CCR5-?32), and serum levels of MMPs(2, 3, 8, 9 and 10) and TIMPs(1, 2 and 4) were assessed. Liver fibrosis was determined by transient elastometry, although other non-invasive markers of fibrosis were also considered. Significant liver fibrosis(F ≥ 2) was defined by a transient elastometry value ≥ 7.1 kP *** A total of 34 patients(21.5%) had liver fibrosis ≥ F2. MMP-2 and TIMP-2 serum levels were higher in patients with liver fibrosis ≥ F2(P = 0.02 and P = 0.03, respectively) and correlated positively with transient elastometry values(P = 0.02 and P = 0.0009, respectively), whereas MMP-9 values were negatively correlated with transient elastometry measurements(P = 0.01). Multivariate analyses showed that high levels of MMP-2(OR = 2.397; 95%CI: 1.191-4.827, P = 0.014) were independently associated with liver fibrosis ≥ F2 in the patients as a whole. MMP-2(OR = 7.179; 95%CI: 1.210-42.581, P = 0.03) and male gender(OR = 10.040; 95%CI: 1.621-62.11, P = 0.013) were also independent predictors of fibrosis ≥ F2 in the HCV-infected subgroup. Likewise, MMP-2, TIMP-2 and MMP-9 were independently associated with transient elastometry values and other non-invasive markers of liver fibrosis. none of the six SnPs evaluated had any significant association with liver fibrosis ≥ *** Certain MMPs and TIMPs, particularly MMP-2, seems to be associated with non-alcoholic liver fibrosis

关键词： Human immunodeficiency virus Hepatitis C virus Liver fibrosis Transient elastometry noninvasive fibrosis markers Metalloproteases Their tissue inhibitors Genetic polymorphisms

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CD300a inhibits CD16-mediated nK cell effector functions in HIV-1-infected patients

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Cellular & Molecular Immunology 2019年第12期16卷 940-942页

作者： Joana Vitallé Iñigo Terrén Ane Orrantia Raquel Pérez-Garay Francesc Vidal joséA.Iribarren Carmen Rodríguez Ana M.López Lirola Enrique Bernal Olatz Zenarruzabeitia Francisco Borrego Immunopathology Group Biocruces Bizkaia Health Research InstituteBarakaldoSpain Hospital Universitari de Tarragona Joan XXIII IISPVUniversitat Rovira i VirgiliTarragonaSpain Servicio de Enfermedades Infecciosas Hospital Universitario DonostiaInstituto de Investigación Sanitaria BiodonostiaDonostia-San SebastiánSpain Centro Sanitario Sandoval Hospital Clínico San CarlosInstituto de Investigación Sanitaria San CarlosMadridSpain Hospital Universitario de Canarias Santa Cruz de TenerifeSpain Department of Clinical Medicine Universidad de Murcia and Hospital General Universitario Reina SofíaMurciaSpain Ikerbasque Basque Foundation for ScienceBilbaoSpain

natural killer(nK)cell-mediated antibody-dependent cellular cytotoxicity(ADCC)through CD16 plays a critical role in antihuman immunodeficiency virus(HIV)responses.1–3 CD300a is a surface receptor highly expressed on nK cells that has the capacity to inhibit nK cell-mediated cytotoxicity in healthy donors.4 The CD300a molecule has been related to several viral infections and is able to diminish the nK cell killing of pseudorabies-infected cells through interactions with its ligands phosphatidylserine and phosphatidylethanolamine.5 In addition,CD300a expression on B and CD4+T lymphocytes is altered during HIV-1 infection,and combined antiretroviral therapy(cart)does not restore nonpathological expression levels.5,6 However,the expression and function of CD300a on nK cells during HIV-1 infection is still *** have determined the surface expression of CD300a on different nK cell subsets and the capacity of this receptor to inhibit CD16-induced nK cell effector functions in healthy and HIV-1 infected individuals.

关键词： CD16 CD30 ADCC

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