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Modulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver by probiotics

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World Journal of Gastroenterology 2014年第42期20卷 15632-15649页

作者： Julio Plaza-Diaz Carolina Gomez-Llorente Luis Fontana angel gil Department of Biochemistry and Molecular Biology Ⅱ School of Pharmacy and Institute of Nutrition and Food Technology "Jose Mataix" Biomedical Research Center University of Granada

The potential for the positive manipulation of the gut microbiome through the introduction of beneficial microbes, as also known as probiotics, is currently an active area of investigation. The FAO/WHO define probiotics as live microorganisms that confer a health benefit to the host when administered in adequate amounts. However, dead bacteria and bacterial molecular components may also exhibit probiotic properties. The results of clinical studies have demonstrated the clinical potential of probiotics in many pathologies, such as allergic diseases, diarrhea, inflammatory bowel disease and viral infection. Several mechanisms have been proposed to explain the beneficial effects of probiotics, most of which involve gene expression regulation in specific tissues, particularly the intestine and liver. Therefore, the modulation of gene expression mediated by probiotics is an important issue that warrants further investigation. In the present paper, we performed a systematic review of the probiotic-mediated modulation of gene expression that is associated with the immune system and inflammation. Between January 1990 to February 2014, PubMed was searched for articles that were published in English using the MeSH terms “probiotics' and 'gene expression' combined with “intestines', 'liver', 'enterocytes', 'antigen-presenting cells', 'dendritic cells', 'immune system', and 'inflammation'. Two hundred and five original articles matching these criteria were initially selected, although only those articles that included specific gene expression results (77) were later considered for this review and separated into three major topics: the regulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver. Particular strains of Bifidobacteria, Lactobacilli, Escherichia coli, Propionibacterium, Bacillus and Saccharomyces influence the gene expression of mucins, Toll-like receptors, caspases, nuclear factor-κ

关键词： Gene expression Immunity Immunotolerance Inflammation Microbiota Probiotics Gut Liver

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Poly-contextural Logic： New Resource for Transdisciplinary Research in Sociology

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Sociology Study 2011年第2期1卷 143-152页

作者： Miguel angel Briceflo gil aCentral University of Venezuela Caracas Venezuela

A couple of decades ago natural phenomena began to be approached from a comprehensive and transdisciplinary point of view, as it was understood that living beings and their environments are not linear but complex. There is no doubt that this perspective of visualizing complexity and working inter- and trans-disciplinarily has to be applied. The reflection on the theoretical observation （i.e., meta-observation） involved in the concept of poly-contexturality is the framework in which a theory of complex systems is possible, which in turn enables an observation that oscillates （a concept of chaos theory） between models structured in a hierarchical order （normally linked to a logical-deductive formalization） and models structured in hetero-hierarchy. And this would allow this reflection to be done in a formalized language that does not follow either the principles of the Aristotelian logic or the postulates of the Kantian transcendental reflection. It is precisely this liberation from the dictates of mono-contextural logic what paves the way to an observation of complexity, in which one or the other language is used to model the states of things, such as the epistemological problems of molecular biology or the social systems. And-what is gaining relevance-it also paves the way to a true transdisciplinary meta-observation, since each discipline chooses its own contexture and only the use of poly-contexturality makes it possible to formulate transdisciplinary relationships within the framework of such meta-logic.

关键词： Poly-contextural logic transdisciplinary non-linear complex systems

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Prognostic role of selection criteria for liver transplantation in patients with hepatocellular carcinoma:Review and bibliometric

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iLIVER 2024年第1期3卷 52-61页

作者： Pamela Scarlett Espinoza Loyola Diana Laura Muratalla Bautista Karen Adela Hernández Bautista Elizabeth gil White JoséAntonio González Moreno Daniel angel Torres del Real Víctor Manuel Páez Zayas Carla Escorza-Molina Fernando Mondragón Rodríguez Omar Vásquez Gómez Luis Jorge Fernández López Paul Santiago Mogrovejo Vázquez Isidoro Aczel Sánchez-Cedillo Víctor Jose Visag Castillo Social Service Internship Universidad Nacional Autónoma de MéxicoMexico City 04510Mexico Social Service Internship Universidad AnahuacMexico City 04510Mexico Department of Surgery Division of Transplantation Surgery Hospital General de MéxicoMexico City 06720Mexico Departament of Gastroenterology Division of HepatologyHospital General de MéxicoMexico City 06720Mexico Departmanet of Anesthesiology Hospital General de MéxicoMexico City 06720Mexico

Hepatocellular carcinoma(HCC)is one of the most common cancers in the world and is one of the leading indications for liver transplantation,liver transplantation is the gold standard treatment for end stage liver *** is based up on radiological characteristics and rarely biopsy *** treatment must be individualized to each patient to improve recurrences and *** this article,we focus on the different selection criteria for liver *** study aimed to investigate the distribution laws and research frontiers of international literature,so as to present holistic bibliometric evaluation of the studies on 5-year survival and disease-free recurrence in 5 years,according to hepatocarcinoma criteria for liver *** paper aims to review and analyze 5-year survival and disease-free recurrence based on hepatocarcinoma criteria for liver *** systematically examines and summarizes distribution characteristics and research frontiers through bibliometric analysis.A bibliographic search was implemented in PubMed/Medline,Clinical Key,Science Direct and Index Medicus with MESH terms,from the year 1996–*** selected for transplantation using the Metroticket 2.0(MT2)criteria had the highest overall survival along with patients selected for transplantation using the Milan Criteria had the best 5-year disease-free *** Metroticket 2.0 criteria(MT2)and Milan Criteria(MC)have shown the most favorable post-transplant outcomes for patients with hepatocellular carcinoma(HCC).However,MC demonstrated the best 5-year disease-free recurrence rate,underscoring the significance of taking into account tumor morphology and biology when determining the eligibility of HCC patients for liver *** distribution characteristics and research frontiers by bibliometrics concerning prognostic role of selection criteria for liver transplantation in patients with hepatocellular carcinoma the collaboration

关键词： Hepatocellular carcinoma Liver transplantation Survival Criteria Recurrence Bibliometrics

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Malignant colorectal polyps

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World Journal of Gastroenterology 2010年第25期16卷 3103-3111页

作者： Luis Bujanda angel Cosme Ines gil Juan I Arenas-Mirave Department of Gastroenterology Donostia Hospital Uni-versity of Basque Country Centro de Investigación Biomédica en Enfermedades Hepáticas y Digestivas 20010 San Sebastián Guipúzcoa Spain University of Basque Country Centro de Investigación Biomédica en Enfermedades Hepáticas y Digestivas 20010 San Sebastián Guipúzcoa Spain

Nowadays, the number of cases in which malignant colorectal polyps are removed is increasing due to colorectal cancer screening programmes. Cancerous polyps are classified into non-invasive high grade neoplasia (NHGN), when the cancer has not reached the muscularis mucosa, and malignant polyps, classed as T1, when they have invaded the submucosa. NHGN is considered cured with polypectomy, while the prognosis for malignant polyps depends on various morphological and histological factors. The prognostic factors include, sessile or pedunculated morphology of the polyp, whether partial or en bloc resection is carried out, the degree of differentiation of the carcinoma, vascular or lymphatic involvement, and whether the polypectomy resection margin is tumor free. A malignant polyp at T1 is considered cured with polypectomy ifit is a pedunculated polyp (Ip of the Paris classification), it has been completely resected, it is not poorly differentiated, the resection edge is not affected by the tumor and there is no vascular or lymphatic involvement. The sessile malignant polyp (Is of the Paris classification) at T1 is considered not cured with polypectomy. Only in some cases (e.g. older people with high surgical risk) local excision(polypectomy or endoscopic submucosal dissection or conventional endoscopic mucosal resection) is considered the definitive treatment.

关键词： Favourable histology Follow-up Malignant polyps Non-invasive high grade neoplasia Treatment

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门诊成人社区获得性肺炎的危险因素:生活方式和共病条件(NEUMO-ES-RISK项目)

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英国医学杂志中文版 2019年第8期22卷 483-483页

作者： Irene Rivero-Calle Miriam Cebey-López Jacobo Pardo-Seco José Yuste Esther Redondo Diego A Vargas Enrique Mascarós Jose Luis Díaz-Maroto Manuel Linares-Rufo Isabel Jimeno angel gil Jesus Molina Daniel Ocana Federico Martinón-Torres 崔晓霞(译) 不详北京协和医院呼吸科

背景社区获得性肺炎(CAP)风险在初级保健中的信息是有限的。我们评估了不同生活方式和共病条件作为初级保健成人CAP的危险因素。方法一项回顾性观察对照研究。使用国家初级保健数据监测系统检索了2009至2013年在西班牙初级保健部门诊断... 详细信息

背景社区获得性肺炎(CAP)风险在初级保健中的信息是有限的。我们评估了不同生活方式和共病条件作为初级保健成人CAP的危险因素。方法一项回顾性观察对照研究。使用国家初级保健数据监测系统检索了2009至2013年在西班牙初级保健部门诊断的成人CAP病例。匹配年龄和匹配性别的对照组采用发病率密度抽样(比例2∶1)。以百分比和比值比来表示关联分析。为了避免偏倚效应,建立二项回归模型。结果51 139例患者和102 372例对照组做比较。平均年龄为61.4(19.9)岁。危险因素与CAP的显著相关性如下:艾滋病[比值比(95%可信区间)5.21(4.35~6.27)]、慢性阻塞性肺病(COPD)[2.97(2.84~3.12)]、哮喘[2.16(2.07~2.26)]、吸烟[1.96(1.91~2.02)]和口腔卫生问题[1.45(1.41~1.49)]。患者组中有危险因素存在的平均患病率为82.2%,对照组为69.2%。CAP患病率的增加与危险因素和年龄的累积有关:1个危险因素时,在18~60岁老人中的风险相关性是1.42,在>60岁人中是1.57;2个危险因素时,是1.88和2.35;≥3个危险因素时,是3.11和4.34。结论成人CAP初级保健中的危险因素普遍较高。主要与危险因素相关的是艾滋病、COPD、哮喘、吸烟、口腔卫生问题。我们的风险叠加结果可以帮助临床医生确定肺炎风险较高的患者。

关键词：社区获得性肺炎危险因素生活方式成人共病慢性阻塞性肺病初级保健门诊

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Prevalence of meeting 24-Hour Movement Guidelines from pre-school to adolescence: A systematic review and meta-analysis including 387,437 participants and 23 countries

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Journal of Sport and Health Science 2022年第4期11卷 427-437页

作者： Miguel angel Tapia-Serrano Javier Sevil-Serrano Pedro Antonio Sanchez-Miguel Jose Francisco Lopez-gil Mark STremblay Antonio Garcıa-Hermoso Department of Didactics of Musical Plastic and Body ExpressionFaculty of Teaching TrainingUniversity of ExtremaduraAvenida de la UniversidadS/NCaceres 10071Spain Department of Physical Activity and Sport Faculty of Sport ScienceUniversity of Murcia(UM)San Javier 30720Spain Healthy Active Living and Obesity Research Group Children’s Hospital of Eastern Ontario(CHEO)Research InstituteOttawaON K1H 8L1Canada Navarrabiomed Public University of Navarra(UPNA)Health Research Institute of Navarra(IdiSNA)Navarra Hospital Complex(CHN)Pamplona 310008Spaia

Background:Meeting the 24-Hour Movement Guidelines(physical activity,screen time,and sleep duration) has been associated with positive health ***,there are no previous meta-analyses that have examined the overall adherence to the 24-Hour Movement Guidelines from pre-school to adolescence across the ***,the main purpose of this systematic review and meta-analysis was to examine the overall(non)adherence to the 24-Hour Movement Guidelines among preschoolers,children,and adolescents ***:Four electronic databases(MEDLINE,Scopus,Web of Science,and Cochrane Database of Systematic Reviews) were searched for quantitative studies published in Spanish and English between January 2016 and May *** that were conducted with apparently healthy participants and reported the overall(non)adherence to the 24-Hour Movement Guidelines in preschoolers and/or children and/or adolescents were ***:Sixty-three studies comprising 387,437 individuals(51% girls) aged 3-18 years from 23 countries were ***,7.12%(95%confidence interval(95%CI):6.45%-7.78%) of youth met all three 24-Hour Movement Guidelines,and 19.21%(95%CI:16.73%-21.69%)met none of the 3 *** sex,adherence to all recommendations was significantly lower in girls(3.75%,95%CI:3.23%-4.27%) than in boys(6.89%,95%CI:5.89%-7.89%)(p <0.001).However,there were no sex differences regarding adherence to any of the 3 individual recommendations(girls,15.66%,95%CI:8.40%-22.92%;boys,12.95%,95%CI:6.57%-19.33%).In terms of age group,adherence to the 3 recommendations was 11.26%(95%CI:8.68%-13.84%),10.31%(95%CI:7.49%-13.12%),and 2.68%(95%CI:1.78%-3.58%) in preschoolers,children,and adolescents,***,8.81%(95%CI:5.97%-11.64%) of preschoolers,15.57%(95%CI:11.60%-19.54%) of children,and 28.59%(95%CI:22.42%-34.75%) of adolescents did not meet any of the *** America was the region with the lowest adherence(all:2.93%;none:3

关键词： Exercise Lifestyle Movement behaviors Sedentary behaviors Youth

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Colorectal cancer prognosis twenty years later

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World Journal of Gastroenterology 2010年第7期16卷 862-867页

作者： Luis Bujanda Cristina Sarasqueta Elisabeth Hijona Lander Hijona angel Cosme Ines gil Jose Luis Elorza Jose I Asensio Santiago Larburu José M Enríquez-Navascués Rodrigo Jover Francesc Balaguer Xavier Llor Xavier Bessa Montserrat Andreu Artemio Paya Antoni Castells Gastrointestinal Oncology Group of the Spanish Gastroenterological Association Department of Gastroenterology Donostia HospitalUniversity of Basque CountryCentro de Investigación Biomédica en Enfermedades Hepáticas y Digestivas(CIBEREHD)20014 San SebastiánSpain Department of Epidemiology Donostia HospitalCIBERESP20014 San SebastiánSpain Department of Surgery Donostia Hospital20014 San SebastiánSpain Department of Gastroenterology General Hospital Department of Gastroenterology Clinic HospitalCIBEREHDIDIBAPS08036 BarcelonaSpain Digestive Diseases and Nutrition Secion University of IllinoisChicagoIL 60607United States Department of Gastroenterology Del Mar Hospital08003 BarcelonaSpain Department of Gastroenterology General Hospital 03010 AlicanteSpain

AIM:To evaluate changes in colorectal cancer(CRC) survival over the last 20 ***:We compared two groups of consecutive CRC patients that were prospectively recruited:Group Ⅰincluded 1990 patients diagnosed between 1980 and ***Ⅱincluded 871 patients diagnosed in ***:The average follow up time was 21 mo(1-229)for GroupⅠand 50 mo(1-73.4)for GroupⅡ.Overall median survival was significantly longer in Group Ⅱthan in GroupⅠ(73 mo vs 25 mo,P<0.001)and the difference was significant for all tumor *** surgical mortality was 8% for GroupⅠand 2% for Group Ⅱ(P<0.001).Only 17% of GroupⅠpatients received chemotherapy compared with 50% of GroupⅡpatients(P<0.001).CONCLUSION:Survival in colorectal cancer patients has doubled over the past 20 *** increase seems to be partly due to the generalization in the administration of chemotherapy and to the decrease of post surgical mortality.

关键词： Colon cancer Prognosis Survival Chemotherapy Surgery

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Dynamical amplification of electric polarization through nonlinear phononics in 2D SnTe

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npj Computational Materials 2020年第1期6卷 155-162页

作者： Dongbin Shin Shunsuke A.Sato Hannes Hübener Umberto De Giovannini Noejung Park angel Rubio Max Planck Institute for the Structure and Dynamics of Matter and Center for Free-Electron Laser Science Luruper Chaussee 149Hamburg 22761Germany Center for Computational Sciences University of TsukubaTsukuba 305-8577Japan Nano-Bio Spectroscopy Group Departamento de Fisica de MaterialesUniversidad del Pas VascoSan Sebastian 20018Spain Department of Physics Ulsan National Institute of Science and TechnologyUNIST-gil 50Ulsan 44919Korea Center for Computational Quantum Physics(CCQ) The Flatiron Institute162 Fifth AvenueNew YorkNY 10010USA

Ultrafast optical control of ferroelectricity using intense terahertz fields has attracted significant *** we show that the nonlinear interactions between two optical phonons in SnTe,a two-dimensional in-plane ferroelectric material,enables a dynamical amplification of the electric polarization within subpicoseconds time *** first-principles time-dependent simulations show that the infrared-active out-of-plane phonon mode,pumped to nonlinear regimes,spontaneously generates in-plane motions,leading to rectified oscillations in the in-plane electric *** suggest that this dynamical control of ferroelectric material,by nonlinear phonon excitation,can be utilized to achieve ultrafast control of the photovoltaic or other nonlinear optical responses.

关键词： nonlinear ferroelectric phonon

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Depolarizing metrics in the biomedical field:Vision enhancement and classification of biological tissues

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Journal of Innovative Optical Health Sciences 2023年第5期16卷 3-19页

作者： Mónica Canabal-Carbia Albert Van Eeckhout Carla Rodríguez Emilio González-Arnay Irene Estévez JoséJ.gil Enrique García-Caurel Razvigor Ossikovski Juan Campos angel Lizana Grup d'Òptica Departamento de Fisica Universitat Autònoma de BarcelonaBellaterra 08193Spain ALBA Synchrotron Light Source Carrer de la Llum 2-26 08290 Cerdanyola del VallèsBarcelonaSpain Servicio deAnatomia Humana Departamento de Ciencias Médicas Básicas Universidad de La Laguna Santa Cruz de Tenerife 38200 Spain Universidad de Zaragoza Pedro Cerbuna 12 Zaragoza 50009Spain LPICM CNRSEcole Polytechnique Institut Politechnique de ParisPalaiseau 91120France

Polarimetry encompasses a collection of optical techniques broadly used in a variety of ***,such techniques have provided their suitability in the biomedical field through the study of the polarimetric response of biological samples(retardance,dichroism and depolarization)by measuring certain polarimetric *** of these features,depolarization,is mainly produced by scattering on samples,which is a predominant efiect in turbid media as biological *** turn,retardance and dichroic efiects are produced by tissue anisotropies and can lead to depolarization *** depolarization is a predominant efiect in tissue samples,we focus on studying difierent depolarization metrics for biomedical *** report the suitability of a set of depolarizing observables,the indices of polarimetric purity(IPPs),for biological tissue *** review some results where we demonstrate that IPPs lead to better performance than the depolarization index,which is a well-established and commonly used depolarization observable in the *** also provide how IPPs are able to significantly enhance contrast between difierent tissue structures and even to reveal structures hidden by using standard intensity ***,we also explore the classificatory potential of IPPs and other depolarizing observables for the discrimination of difierent tissues obtained from ex vivo chicken samples(muscle,tendon,myotendinous junction and bone),reaching accurate models for tissue classification.

关键词： Polarimetry indices of polarimetric purity organic tissues visualization artificial intelligence.

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Giant Spinal Schwannomas. Presentation of Two Cases with Interdisciplinary Surgical Resection

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Open Journal of Modern Neurosurgery 2023年第1期13卷 1-8页

作者： Carlos Erosa Velázquez angel Octavio Soto Hernandez Ricardo Cazares Sergio Ivan Reyna Heredia Apolinar de la Luz Lagunas Cuauhtemoc gil-Ortiz Mejia Andres Jaime Aguirre Universidad Nacional Autónoma de México México City México Centro Médico Nacional 20 de Noviembre ISSSTE México City México

Purpose: To report two quite rare cases of giant schwannomas of the cervical and thoracic spine. Surgical resection is usually the treatment of choice for these neoplasms. Methods: The first patient is a 48-year-old male that came to our department, complaining about weakness and paresthesia of both lower extremities and upper left extremity, and a considerably big dorsal palpable lump. MRI and CT scan were used to diagnose giant cervical schwannoma. Because of the intensity of symptoms, he was subjected to surgery. Multidisciplinary resection involving neurosurgical and oncosurgicalteamn was performed for intravertebral and extravertebral approaches. The second patient is a 55-year-old female that came to the hospital complaining about incapacitating pain and dysesthesia involving T6, T7, and T8 dermatomes, with no other deficits. MRI and CT scan were used to diagnose giant thoracic schwannoma. Because of the intensity of the pain, surgery was decided as the treatment of choice. Video assisted thoracoscopic surgery was performed and total resection was achieved, with improvement of the symptoms. Results: Both patients showed complete remission of the symptoms, with no major deficits after surgery. Conclusion: Although infrequent, giant spinal schwannomas may be the cause of visible lumps in the back with radicular symptoms. When asymptomatic, conservative treatment could be viable, but when they present symptoms, surgery offers good results.

关键词： Spinal Schwannomas Giant Schwannomas Interdisciplinary Surgery

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