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Prevalence and Factors Associated with Vitamin D Deficiency in Patients with COVID-19 in Parakou in 2021

Open Journal of Epidemiology 2023年第4期13卷 385-400页

作者： Ibrahim Mama Cissé Yawa Yayra Vanesa Léonie Adaba Ahoya Christophe Fabien Gounongbé angel dodji dossou Mênonli Adjobimey Rose Mikponhoué Antoine Vikkey Hinson Paul Ayelo Moutawakilou Gomina Department of Medicine and Medical Specialities Faculty of Medicine University of Parakou Parakou Benin UER of Biochemistry Faculty of Medicine University of Parakou Parakou Benin National Directorate of Hospital Medicine Ministry of Health Cotonou Parakou Benin Department of Medicine and Medical Specialities University of Abomey-Calavi Abomey-Calavi Benin

Introduction: Coronavirus 19 disease (COVID-19) often presents several serious complications in patients. 25-hydroxyvitamin D [25(OH)D] deficiency is considered a risk factor for severe forms of the disease. Objective: The objective of this work was to determine the prevalence and factors associated with vitamin D deficiency in patients with COVID-19 in Parakou in 2021. Methods: The method used was a descriptive and analytical cross-sectional study with prospective data collection that covered the period of August 1, 2021, to December 30, 2021. It concerned patients with COVID-19, symptomatic or not, in the commune of Parakou, selected by non-probability sampling. The 25(OH)D assay was performed by an enzyme immunoassay using the heterogeneous phase competition technique. Logistic regression was used to determine the factors associated with 25(OH)D deficiency at the 5% threshold. Results: A total of 197 patients with COVID-19 were included in the study with a mean age of 35.4 ± 15.2 years;with a female predominance (52.3%). The overall prevalence of 25(OH)D deficiency was 31.5% (95% CI [25.1 - 38.5]);it was 32.0% in females and 30.8% in males. 25(OH)D deficiency was more observed in patients ≥ 60 years than in patients < 60 years with no significant difference (p = 0.121), and in females (32.0%) than in males (30.8%) with no significant difference either (p = 0.857). Diabetes (p = 0.036), overweight or obesity (p = 0.032), severe disease forms (p = 0.003) and rhinitis (p = 0.009) were significantly associated with 25(OH)D deficiency. Conclusion: One-third of patients with COVID-19 in Parakou in 2021 were 25(OH)D deficient. 25(OH)D deficiency is associated with the severe form of the disease and with comorbidities justifying supplementation of this vitamin to patients with COVID-19.

关键词： COVID-19 25-OH-Vitamin D Parakou

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Usefulness of a Clinico-Biological Francois’Score in the Diagnosis of Acute Appendicitis:Experience of the University Hospital Center of Parakou,Benin

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Surgical Science 2018年第3期9卷 91-96页

作者： Montcho Adrien Hodonou Bio Tamou-Sambo Salako Alexandre Allode Roméo Romaric Gbédolo Djifid Morel Séto Selome Romaric Tobome Moise Francis dossou dodji Emile Mensah Department of Surgery and Specialties Teaching HospitalMedicine SchoolUniversity of ParakouParakouBenin Saint John of God Hospital Center of Tanguieta TanguietaBenin Teaching Hospital of Porto-Novo Faculty of Health ScienceUniversity of Abomey CalaviCotonouBenin

Introduction: Diagnostic wanderings of acute appendicitis are responsible for serious complications or abusive appendectomies. Existing Clinico-biological scores are efficient. Objective: To determine the diagnostic efficiency of Fran?ois’ score in acute appendicitis. Methodology: over 10 months, all the patients admitted in the CHUD-Parakou Emergency Department for pain in the right iliac fossa had been examined by resident students who calculated Fran?ois’ score. After verification by the surgeon, patients were put into three categories: category 1 score ≥ 2;category 2, score between -6 and 2;category 3, score below -6. Sensitivity and specificity were calculated. Results: out of 54 patients selected (29 men and 25 women), 29 were classified as group 1;19 as group 2 and 6 as group 3. An ultrasound was performed in all patients in group 2, and signs in favor of appendicitis were found in 12 patients. Of the 41 appendicectomies performed, the histologic analysis of 33 operative specimens found a pathological appendix. Sensitivity, specificity and negative predictive value per group were 100%. It has prevented almost in one every four patients (24.07%) an abusive appendectomy. Conclusion: This score would reduce diagnostic wanderings and target patient groups for imaging studies.

关键词： Acute Appendicitis Francois Score Sensitivity Specificity Resource-Limited Countries

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