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Profile of Autoantibodies and Clinical Symptoms in Guinean Patients with Connective Tissue Diseases

Open Journal of Immunology 2024年第1期14卷 1-10页

作者： Mariama Sadjo Diallo Doufin Traore Adame diouf Djiba Kaba Issiaga Diallo Doudou Georges Massar Niang Alimou Camara Oumar Mouctar Diallo Boh Fanta Diane Abdoulaye Barry Ouo-Ouo Yaramon Kolie Moustapha Mbow Aly Badra Kamissoko Djibril Sylla Babacar Mbengue Mohamed Cisse Faculté des Sciences et Techniques de la Santé Université Gamal Abdel Nasser de Conakry Conakry Guinée Laboratoire de Biologie Moléculaire Nestor BANGOURA/Helene LABROUSSE H&#244pital de jour Donka CHU Donka Conakry Guinée Centre d’Excellence Africain Pour la Prévention et le Contrô le des Maladies Transmissibles Conakry Guinée Laboratoire d’Immunologie Université Cheikh Anta Diop Dakar Sénégal Service de Dermatologie-Vénérologie CHU Donka Conakry Guinée Service de Rhumatologie H&#244pital National Ignace Deen Conakry Guinée Service de Médecine Interne CHU Donka Conakry Guinée

Connective tissue diseases (CTDs) are Autoimmune diseases (AIDs) characterized by the appearance of autoantibodies, which are diagnostic markers. Investigations of these autoantibodies play a major role in the management of several autoimmune diseases. The objective of this study was to describe the profile of anti-ENA antibodies according to the clinical symptoms of mixed CTDs in Conakry teaching Hospital. We performed a cross-sectional study during six months. A total of 20 patients was recruited and we measured antibodies using the ELISA technique. The mean age of our patients was 36.5 years, with a predominance of females. Cutaneous and rheumatological signs were the main clinical manifestations. SLP was the most frequent CTDs;the threshold of ENA antibodies positivity was higher in scleroderma with and SLP. Anti-ENA identification reveals the frequency of anti-SSA (83.33%), anti-U1RNP (66.66%) and anti-histone (50%) antibodies. Antinuclear antibodies (ANA) react with various components of the cell nucleus. Their detection is of major interest in the diagnosis of CTDs. Our results highlight the importance of determining the specificity of these antibodies to guide differential diagnosis.

关键词： Autoantibodies Extractible Nuclear Antigen (ENA) Connective Tissue Diseases ELISA

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Contribution of Bone Scintigraphy in the Diagnosis of a Case of SAPHO in the Nuclear Medicine Department of Idrissa Pouye General Hospital (Dakar, Senegal)

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Open Journal of Medical Imaging 2024年第1期14卷 1-9页

作者： El Hadji Amadou Lamine Bathily Kalidou Gueye Serigne Moussa Badiane Mamoudou Salif Djigo Gora Thiaw Ousseynou Diop Olatounde Herbert Fachinan Papa Mady Sy Alfonse Rodrigue Djiboune Kokou Fofo Toussaint Adambounou Louis Augustin Diaga diouf Boucar Ndong Gora Mbaye Omar Ndoye Mounibé Diarra Mamadou Mbodj Nuclear Medicine Department Idrissa Pouye General Hospital (HOGIP) Dakar Senegal Biophysical Laboratory FMPO Cheikh Anta Diop University (UCAD) Dakar Senegal Biophysical Laboratory UFR2S Gaston Berger University (UGB) Saint-Louis Senegal Nuclear Medicine Department Hospital Dalal Jamm Dakar Senegal Laboratory of Physical and Pharmaceutical Biophysics FMPO Cheikh Anta Diop University Dakar Senegal Biophysical Laboratory University of Lome Lome Togo

Introduction: The acronym SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis) is a syndrome combining osteoarticular and cutaneous manifestations. It occurs mainly between the ages of 30 and 50. Sternocostoclavicular hyperostosis is one of the main distinguishing features. We report a case of SAPHO in Dakar diagnosed by bone scintigraphy. Observation: 28-year-old Senegalese women presented with left shoulder pain and relative functional impotence for over 2 years. Examination revealed right sternoclavicular hyperostosis and left shoulder pain on palpation. Questioning revealed a history of acne and hyperostosis of the right first toe. Bone scintigraphy, performed after injection of 630 MBq of 99mTc-HMDP, revealed: hyperfixation of the bilateral (right++) manubrio-sternal and sternoclavicular junction, producing the classic bull’s horn image;hyperfixation of the left shoulder with an inflammatory appearance;hyperfixation of the sacroiliac joints suggestive of bilateral sacroiliitis;hyperfixation of the right first toe;two mandibular hyper fixations probably related to dental damage. This scintigraphic appearance in one was strongly suggestive of SAPHO syndrome. Conclusion: SAPHO syndrome, related to spondyloarthropathy, associates cutaneous and osteoarticular signs. It is characterized by frequent delays in diagnosis due to poor recognition. Soy is an invaluable diagnostic tool, enabling us to assess the extent of the disease and its evolution.

关键词： SAPHO Bone Scintigraphy Young Woman Senegalese

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Iodine 131 Treatment in Graves’ Disease in a West African Country: Preliminary Study about 25 Cases in Senegal

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Open Journal of Biophysics 2024年第1期14卷 56-72页

作者： El Hadji Amadou Lamine Bathily Serigne Moussa Badiane Mamoudou Salif Djigo Gora Thiaw Kalidou Gueye Ousseynou Diop Boucar Ndong Kokou Fofo Toussaint Adambounou Alphonse Rodrigue Djiboune Papa Mady Sy Mamadou Soumbounou Mohamed Chekhma Louis Augustin Diaga diouf Gora Mbaye Omar Ndoye Mounibé Diarra Mamadou Mbodj Nuclear Medicine Department General Hospital of Idrissa Pouye (HOGIP) Dakar Senegal Biophysical Laboratory Cheikh Anta Diop University (UCAD) Dakar Senegal Biophysical Laboratory Gaston Berger University (UGB) Saint-Louis Nuclear Medicine Department Hospital Dalal Jamm Dakar Senegal Biophysical Laboratory University of Lome Lome Togo Laboratory of Physical and Pharmaceutical Biophysics Cheikh Anta Diop University Dakar Senegal

Introduction: Graves’ disease is the most common cause of hyperthyroidism. Its treatment uses synthetic antithyroid drugs but the use of aggressive radical therapy such as surgery or non-aggressive therapy such as iodine-131 is not uncommon. Treatment of Graves’ disease with radioactive iodine or iratherapy is a simple, inexpensive, well-tolerated treatment. It was introduced in Senegal in 2016. We report through this work the preliminary assessment of the only nuclear medicine service in Senegal in the management of Graves’ disease by iodine-131. Patients and Methods: Retrospective study of the first cases of Graves’ disease treated with iratherapy in Senegal. Socio-demographic, clinical, paraclinical, therapeutic and evolutionary aspects were studied. Radiation protection rules have been implemented and contraception has been effective for six months in women of childbearing age. Results: 25 patients were collected with a mean age of 45 years, twenty women (80%), a family goiter in 24% and a psycho-affective context in 64% of cases. Thyrotoxicosis syndrome was associated with goiter in 68% of patients and exophthalmos in 64%. Thyroid ultrasound performed in 20 patients showed vascular goiter in 80% and thyroid scintigraphy in 3 patients, homogeneous and diffuse hyperfixation. TRAK dosed in 8 patients was still positive. All patients had received first-line medical treatment. The average duration of this treatment was more than 18 months in 92%. The empirically used iodine-131 activity averaged 15.35 mCi. Oral corticosteroid therapy was prescribed in 7 patients for the prevention of malignant orbitopathy. No early side effects were noted. The remission rate at 3 months was 52% and at 6 months was 88% to 92%. Conclusion: The effectiveness of radioactive iodine, in particular ablative doses in the treatment of hyperthyroidism, is no longer to be demonstrated. Taking into account our socioeconomic context, iratherapy should be a treatment of choice for hyperthyroidism

关键词： Graves’ Disease Iratherapy Iodine-131 Senegal

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Modeling of the Photovoltaic Module Operating Temperature for Various Weather Conditions in the Tropical Region

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Fluid Dynamics & Materials Processing 2022年第5期18卷 1275-1284页

作者： Mame Cheikh diouf Mactar Faye Ababacar Thiam Alphousseyni Ndiaye Vincent Sambou Efficiency and Energetic Systems Research Group Alioune Diop UniversityBambeySenegal Laboratoire Eau EnergieEnvironnement et Procédés Industriels(LE3PI)UniversitéCheikh Anta DiopBambeySenegal

The operating temperature is a critical factor affecting the performances of photovoltaic(PV)*** this work,relevant models are proposed for the prediction of this operating temperature using data(ambient temperature and solar irradiance)based on real measurements conducted in the tropical *** each weather condition(categorized according to irradiance and temperature levels),the temperatures of the PV modules obtained using the proposed approach is compared with the corresponding experimentally measured *** results show that the proposed models have a smaller Root Mean Squared Error than other models developed in the literature for all weather conditions,which confirms the reliability of the proposed framework.

关键词： Photovoltaic operating temperature PV module weather condition

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Influence Through Confluence

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ChinAfrica 2023年第11期15卷 42-43页

作者： ALY diouf 不详

The construction of Africa’s third-largest UN office compound in Dakar set to raise diplomatic clout of Senegal A long line of buildings can be seen in Diamniadio, a new metropolis being developed 40 km east of Senegalese capital Dakar. The brand-new, intelligent city will ease congestion in the capital and will be ready in 10 years, housing an international industrial park, ministerial buildings.

关键词： capital housing Africa

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Senegal Kicks Off Vaccination The inoculation campaign in Senegal starts off well with arrival of Chinese vaccines

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ChinAfrica 2021年第4期13卷 38-39页

作者： Aly diouf 不详

On February 17,Senegal received 200,000 vaccines from the Chinese company *** vaccine offered a breath of relief to a country severely hit by the COVID-19 *** President Macky Sall personally traveled to the Blaise Dia... 详细信息

关键词： travel doses vaccines

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Building Foundation

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ChinAfrica 2020年第7期12卷 48-49页

作者： Aly diouf 不详

Chinese tile manufacturer sets up factory in Senegal On January 14, Senegalese President Macky Sall cut the ribbon and inaugurated the country’s first ceramic tile manufacturing plant. This plant is owned by Twyford Ceramics, a Chinese company owned by Keda Industrial Group and Sunda International Group, is located in Sindia, which is at the very heart of the triangle formed by Mbour, Thies and Dakar.

关键词： owned ceramic triangle

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A Sustainable Solution For Urban Mobility

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ChinAfrica 2022年第10期14卷 44-45页

作者： ALY diouf 不详

The all-electric Bus Rapid Transit route in Dakar, built by China Road and Bridge Corp., is set become operational in 2023 Every working day, traffic on the African Union roundabout, midway between Dakar’s popular Colobane area and the Cheikh Anta Diop University, is a nightmare for drivers. It could take ages to pass through this 2-km-long route, which is one of the key crossing points of Senegal’s ambitious Bus Rapid Transit (BRT) initiative to decongest the metropolis.

关键词： Transit BRT Urban

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Approaching the Finish Line—— The Chinese initiative to build West Africa’s longest bridge in Foundiougne has reached the last stretch

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ChinAfrica 2021年第10期13卷 40-41页

作者： Aly diouf 不详

The Chinese initiative to build West Africa’s longest bridge in Foundiougne has reached the last stretch A business group, EIG, made up of Chinese firms, is in charge of building what will eventually be Senegal’s an... 详细信息

关键词： eventually fir Africa

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Grown in Africa--Senegalese farmers grow Chinese vegetables on African soil

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ChinAfrica 2020年第4期12卷 44-45页

作者： Aly diouf 不详

On this typical February morning,the weather is cool and pleasant in Sangalkam,an agglomeration near Dakar,the capital city of *** far from the main square,a green and white sign at the entrance of a compound,flanked by the flags of China and Senegal,informs passersby in both French and Mandarin:"Agricultural Technical Cooperation and Assistance *** from the Chinese Government."

关键词： farmers Agricultural soil

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