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后危机时代航空工业的突围与崛起——基于广义虚拟经济视角的“三新”之道

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广义虚拟经济研究 2011年第4期2卷 76-84页

作者：陈昂中航工业广义虚拟经济研究所北京100012

2008年全球金融危机对人类社会产生深远影响,后危机时代,人类社会面临转变发展方式的命题,航空工业面临着产业环境重大变化,产业链运营困难重重等重大挑战。从广义虚拟经济的品牌价值塑造、商业模式创新、集成网络构建的"三新"之道出发... 详细信息

2008年全球金融危机对人类社会产生深远影响,后危机时代,人类社会面临转变发展方式的命题,航空工业面临着产业环境重大变化,产业链运营困难重重等重大挑战。从广义虚拟经济的品牌价值塑造、商业模式创新、集成网络构建的"三新"之道出发,航空工业才有可能走出危机,同时在人类发展方式转变的进程中存在巨大的机遇。

关键词：广义虚拟经济三新航空工业

Efficacy and safety of PD-1 blockade plus long-course chemoradiotherapy in locally advanced rectal cancer(NECTAR):a multi-center phase 2 study

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1721-1729页

作者： Zhengyang Yang Jiale Gao Jianyong Zheng Jiagang Han ang Li Gang Liu Yi Sun Jie Zhang Guangyong chen Rui Xu Xiao Zhang Yishan Liu Zhigang Bai Wei Deng Wei He Hongwei Yao Zhongtao Zhang Department of General Surgery Beijing Friendship HospitalCapital Medical UniversityState Key Lab of Digestive HealthNational Clinical Research Center for Digestive DiseasesBeijingChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Air Force Medical UniversityXi'anChina Department of General Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Department of General Surgery Beijing Xuanwu HospitalCapital Medical UniversityBeijingChina Department of General Surgery Tianjin Medical University General HospitalTianjinChina Department of Anorectal Tianjin People's HospitalTianjinChina Department of Radiology Beijing Friendship Hospital Capital Medical UniversityBeijingChina Department of Pathology Beijing Friendship HospitalCapital Medical UniversityBeijingChina Department of Thoracic Surgery/Institute of Thoracic Oncology West China HospitalSichuan UniversityChengduChina

Adding PD-1 blockade in the neoadjuvant regimens for locally advanced rectal cancer(LARC)patients with microsatellite stable(MsS)/mismatch repair-proficient(pMMR)tumors is an attractive,but debatable *** phase 2,multicenter,prospective,single-arm study enrolled patients from 6 centers from June 2021 to November *** advanced rectal cancer(LARC,cT_(3-4a)N_(0)M_(0) and cT_(1-4a)N_(1-2)M_(0))patients aged≥18 years with the distance from distal border of tumor to anal verge≤10 cm(identified by Magnetic Resonance Imaging)were qualifed for *** patients received long-course radiotherapy(50 Gy/25 fractions,2 Gy/fraction,5 days/week)and three 21-day cycles capecitabine(850-1000 mg/m2,bid,po,day1-14)and three 21-day cycles tislelizumab(200 mg,***,day8)as *** mesorectal excision(TME)was 6-12 weeks after the end of radiotherapy to achieve radical resection.A total of 50 patients were enrolled in this *** pathological complete response rate was 40.0%[20/50,95%confidence interval(CI):27.61-53.82%],while 15(30.0%,95%CI:19.1-43.75%),9(18.0%,95%CI:9.77-30.8%),2(4.0%,95%CI:1.10-13.46%)patients respectively achieved grade 1,2,and 3 tumor ***-related adverse events(TRAEs)occurred in 28(56.0%)LARC patients,including 26(52.0%)with grade I-II and 2(4.0%)with grade II(1 with grade 3 immune-related colitis and 1 with grade 3 rash).PD-1 blockade plus long-course chemoradiotherapy(CRT)showed promising therapeutic effects according to pathological complete response rate and is well-tolerated in LARC patients.A larger randomized controlled study is desired to further validate the above findings.

关键词： rectal cancer phase

High-density lipoprotein regulates angiogenesis by affecting autophagy via miRNA-181a-5p

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Science China(Life Sciences) 2024年第2期67卷 286-300页

作者： Bi-ang Kang Hua-Ming Li Ya-Ting chen Meng-Jie Deng Yan Li Yue-Ming Peng Jian-Jun Gao Zhi-Wei Mo Jia-Guo Zhou Zhi-Jun Ou Jing-Song Ou Division of Cardiac Surgery Cardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China NHC key Laboratory of Assisted Circulation(Sun Yat-sen University) Guangzhou 510080China Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China Division of Vascular Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Pharmacology Cardiac and Cerebral Vascular Research CenterZhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Division of Hypertension and Vascular Diseases Department of CardiologyCardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Provincial Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China

We previously demonstrated that normal high-density lipoprotein(nHDL)can promote angiogenesis,whereas HDL from patients with coronary artery disease(d HDL)is dysfunctional and impairs *** plays a critical role in angiogenesis,and HDL regulates ***,it is unclear whether n HDL and d HDL regulate angiogenesis by affecting *** cells(ECs)were treated with n HDL and d HDL with or without an autophagy ***,endothelial nitric oxide synthase(e NOS)expression,miRNA expression,nitric oxide(NO)production,superoxide anion(O2^(·-))generation,EC migration,and tube formation were evaluated.n HDL suppressed the expression of miR-181a-5p,which promotes autophagy and the expression of e NOS,resulting in NO production and the inhibition of O2^(·-)generation,and ultimately increasing in EC migration and tube formation.d HDL showed opposite effects compared to n HDL and ultimately inhibited EC migration and tube *** found that autophagy-related protein 5(ATG5)was a direct target of ***5 silencing or miR-181a-5p mimic inhibited n HDL-induced autophagy,e NOS expression,NO production,EC migration,tube formation,and enhanced O2^(·-)generation,whereas overexpression of ATG5 or miR-181a-5p inhibitor reversed the above effects of d ***5 expression and angiogenesis were decreased in the ischemic lower limbs of hypercholesterolemic low-density lipoprotein receptor null(LDLr^(-/-))mice when compared to C57BL/6 ***5 overexpression improved angiogenesis in ischemic hypercholesterolemic LDLr^(-/-)*** together,nHDL was able to stimulate autophagy by suppressing miR-181a-5p,subsequently increasing e NOS expression,which generated NO and promoted *** contrast,d HDL inhibited angiogenesis,at least partially,by increasing miR-181a-5p expression,which decreased autophagy and e NOS expression,resulting in a decrease in NO production and an increase in O2^(·-)*** findings reveal a nov

关键词： high-density lipoprotein angiogenesis autophagy ATG5 miRNA endothelial nitric oxide synthase

Photonic-dispersion neural networks for inverse scattering problems

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Light(Science & Applications) 2021年第10期10卷 1819-1828页

作者： Tongyu Li ang chen Lingjie Fan Minjia Zheng Jiajun Wang Guopeng Lu Maoxiong Zhao Xinbin cheng Wei Li Xiaohan Liu Haiwei Yin Lei Shi Jian Zi State Key Laboratory of Surface Physics Key Laboratory of Micro-and NanoPhotonics Structures(Ministry of Education)and Department of PhysicsFudan UniversityShanghai 200433China Shanghai Engineering Research Center of Optical Metrology for Nano-fabrication(SERCOM) Shanghai 200433China Institute of Precision Optical Engineering School of Physics Science and EngineeringTongji UniversityShanghai 200092China National Institute of Metrology Beijing 100029China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

Inferring the properties of a scattering objective by analyzing the optical far-field responses within the framework of inverse problems is of great practical ***,it still faces major challenges when the parameter range is growing and involves inevitable experimental ***,we propose a solving strategy containing robust neuralnetworks-based algorithms and informative photonic dispersions to overcome such challenges for a sort of inverse scattering problem—reconstructing grating *** two typical neural networks,forward-mapping type and inverse-mapping type,we reconstruct grating profiles whose geometric features span hundreds of nanometers with nanometric sensitivity and several seconds of time consumption.A forward-mapping neural network with a parameters-to-point architecture especially stands out in generating analytical photonic dispersions accurately,featured by sharp Fano-shaped ***,to implement the strategy experimentally,a Fourier-optics-based angle-resolved imaging spectroscopy with an all-fixed light path is developed to measure the dispersions by a single shot,acquiring adequate *** forward-mapping algorithm can enable real-time comparisons between robust predictions and experimental data with actual noises,showing an excellent linear correlation(R2>0.982)with the measurements of atomic force *** work provides a new strategy for reconstructing grating profiles in inverse scattering problems.

关键词： scattering dispersion neural

^(137)Cs-γ辐照及5-氮杂胞苷处理毛竹种子对其实生苗甲基化水平的影响

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核农学报 2017年第2期31卷 218-224页

作者：陈昂周明兵汤定钦浙江农林大学林业与生物技术学院/亚热带森林培育国家重点实验室培育基地浙江临安311300

为了研究药物和辐照对毛竹甲基化水平的影响,采用0、25、50、100、250μmol·L-1的5-氮杂胞苷和0、10、20、30、40、60、90、120 Gy的^(137)Cs-γ射线分别处理毛竹种子,并利用高效液相色谱技术,采用外标法测定实生苗叶片的甲基化水平。... 详细信息

为了研究药物和辐照对毛竹甲基化水平的影响,采用0、25、50、100、250μmol·L-1的5-氮杂胞苷和0、10、20、30、40、60、90、120 Gy的^(137)Cs-γ射线分别处理毛竹种子,并利用高效液相色谱技术,采用外标法测定实生苗叶片的甲基化水平。结果表明,5-氮杂胞苷处理毛竹种子后,甲基化水平下降,其中250μmol·L-1处理后甲基化水平为20.8%,下降最显著;低剂量的辐照处理对甲基化的影响不明显,而在高剂量的γ射线胁迫下,DNA甲基化程度下降至26.0%,达到极显著水平。本研究揭示了辐照与基因组甲基化水平间的相关性,为毛竹辐照诱变和甲基化抑制育种提供了科学依据。

关键词：毛竹实生苗 5-氮杂胞苷辐照诱变 DNA甲基化高效液相色谱

对我国体育素养概念的理解——基于对Physical Literacy的解读

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体育科学 2017年第6期37卷 41-51页

作者：陈思同刘阳唐炎陈昂上海体育学院体育教育训练学院上海200438 北卡罗莱纳州大学格林斯堡分校健康与人类科学学院运动人体机能学系格林斯堡27412

Physical Literacy是当前国际体育教育学者关注的研究热点,与我国体育素养概念有着相似的背景、价值、特性和发展路径。在我国体育素养概念发展存在不足的情况下,可以借鉴Physical Literacy的概念进一步推动我国体育素养概念的发展。研... 详细信息

Physical Literacy是当前国际体育教育学者关注的研究热点,与我国体育素养概念有着相似的背景、价值、特性和发展路径。在我国体育素养概念发展存在不足的情况下,可以借鉴Physical Literacy的概念进一步推动我国体育素养概念的发展。研究旨在:1)回顾我国体育素养的概念;2)系统阐释Physical Literacy的概念,在汉语环境中解释这一概念;3)参考Physical Literacy的价值为我国学界进一步发展体育素养的概念提供经验,也为我国学校体育的发展提供启示。通过文献梳理和比较分析:1)我国体育素养的概念存在"概念失真"、价值窄化、定义不清晰和属性不明确等不足;2)Physical Literacy概念可以被翻译为"体育素养",是人类在整个生命过程中维持身体活动所需的综合能力;3)借鉴Physical Literacy的价值和理念,我国体育素养的概念可以被理解为"人类在生命过程中获得利于全人生存发展的运动要素的综合,包括体育意识、体育知识、体育行为、体育技能、体质水平"。建议进一步理解体育素养概念的价值,通过扎实的操作研究和社会行动,探索体育素养概念的深层次价值。此外,学校体育环境是发展体育素养的有效环境。

关键词：学校体育 Physical Literacy 体育素养体质健康

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类矩形土压平衡盾构施工引起的地表变形

浙江大学学报（工学版） 2018年第2期52卷 317-324页

作者：张雪辉陈吉祥白云陈昂黄德中同济大学地下建筑与工程系上海200092 同济大学岩土及地下工程教育部重点实验室上海200092 上海隧道工程有限公司上海200232

针对类矩形盾构施工的扰动控制问题,基于弹性力学Mindlin解,考虑刀盘正面附加推力、壳体与土体之间摩阻力、同步注浆压力以及土体损失4种因素的共同作用,采用数值积分法和叠加原理对地表变形进行计算分析.结果表明:4种因素共同作用下类... 详细信息

针对类矩形盾构施工的扰动控制问题,基于弹性力学Mindlin解,考虑刀盘正面附加推力、壳体与土体之间摩阻力、同步注浆压力以及土体损失4种因素的共同作用,采用数值积分法和叠加原理对地表变形进行计算分析.结果表明:4种因素共同作用下类矩形盾构掘进地表相当范围内表现为沉降,最大收敛沉降约为33mm,开挖面前方的沉降影响主要集中在前方10m范围;同步注浆压力产生的地表隆起可以部分抵消土体损失引发的沉降,因而合理的同步注浆有利于沉降控制;4类因素中,正面附加推力和盾壳摩阻力产生的地表变形很小.理论结果与实测数据基本吻合,可为后期类矩形盾构隧道施工的扰动控制提供理论参考.

关键词：类矩形盾构正面附加推力壳体摩阻力同步注浆压力土体损失地表变形

“技术崇拜”与“漠视竞争”:青年草根滑板组织的社群特征

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体育学刊 2023年第1期30卷 67-73页

作者：昂晨郭吉茹薛岚浙江师范大学体育与健康科学学院浙江金华321000 西安体育学院研究生部陕西西安710068

滑板社群是由青年主导的草根体育组织。运用参与式观察与访谈法深入探究滑板社群特征。研究认为:(1)“技术崇拜”赋予“个人运动”的圈群化聚集意义。滑板社群基于滑板技术的亚文化资本积累方式建立“新秩序”,确立社群边界、完成内部... 详细信息

滑板社群是由青年主导的草根体育组织。运用参与式观察与访谈法深入探究滑板社群特征。研究认为:(1)“技术崇拜”赋予“个人运动”的圈群化聚集意义。滑板社群基于滑板技术的亚文化资本积累方式建立“新秩序”,确立社群边界、完成内部分层并联系社群成员关系。(2)“漠视竞争”保留“随聚随散”的圈群化活动特征。滑板社群的技术传习过程强调独立实践,基于平等互助形成“展示-互鉴”的群体传习方式。技术评价过程强调“真实性”,忠实于“内行”评价,理性崇拜技术本身,通过仪式化活动唤起共鸣。(3)滑板社群的生存之道在于达成“技术崇拜”和“漠视竞争”两种社群特征之间的平衡。根据滑板社群特征,提出意识、制度、赛事等方面的引导建议。

关键词：体育文化草根体育组织滑板青年文化身体技术

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微博社区的动态节点自适应增量交互优化

计算机工程与科学 2019年第2期41卷 370-377页

作者：邱云飞陈昂辽宁工程技术大学软件学院辽宁葫芦岛125105

大多数的社区发现方法是基于网络拓扑结构和边缘密度来进行最佳社区确定,但是这些方法具有非常高的计算复杂度,对网络的形式和类型非常敏感。为解决这些问题,提出基于动态节点自适应增量模型的微博社区交互优化算法,该算法在优化每个社... 详细信息

大多数的社区发现方法是基于网络拓扑结构和边缘密度来进行最佳社区确定,但是这些方法具有非常高的计算复杂度,对网络的形式和类型非常敏感。为解决这些问题,提出基于动态节点自适应增量模型的微博社区交互优化算法,该算法在优化每个社区内成员的交互作用的基础上,利用贪婪算法有效地搜索最优社区的候选,无需遍历所有节点。该模型可快速、准确地测量社区内部和社区之间的交互作用差异。最后,在基准测试网络和搜狐微博平台抓取数据上的仿真测试显示,所提算法在召回率、准确率、算法计算时间以及网络覆盖率等指标上,要优于选取的对比算法。

关键词：微博社区发现动态节点自适应交互优化