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Diabetes and high-glucose could upregulate the expression of receptor for activated C kinase 1 in retina

World Journal of Diabetes 2024年第3期15卷 519-529页

作者： Jian Tan ang xiao Lin Yang Yu-Lin Tao Yi Shao Qiong Zhou Department of Ophthalmology The First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Diabetic retinopathy(DR)is a major ocular complication of diabetes mellitus,leading to visual *** pigment epithelium(RPE)injury is a key component of the outer blood retinal barrier,and its damage is an important indicator of *** for activated C kinase 1(RACK1)activates protein kinase C-ε(PKC-ε)to promote the generation of reactive oxygen species(ROS)in RPE cells,leading to ***,we hypothesize that the activation of RACK1 under hypoxic/high-glucose conditions may promote RPE cell apoptosis by modulating PKC-ε/ROS,thereby disrupting the barrier effect of the outer blood retinal barrier and contributing to the progression of *** To investigate the role and associated underlying mechanisms of RACK1 in the development of early *** In this study,Sprague-Dawley rats and adult RPE cell line-19(ARPE-19)cells were used as in vivo and in vitro models,respectively,to explore the role of RACK1 in mediating PKC-εin early ***,the impact of RACK1 on apoptosis and barrier function of RPE cells was also investigated in the former *** Streptozotocin-induced diabetic rats showed increased apoptosis and upregulated expression of RACK1 and PKC-εproteins in RPE cells following a prolonged ***,ARPE-19 cells exposed to high glucose and hypoxia displayed elevated mRNA and protein levels of RACK1 and PKC-ε,accompanied by an increases in ROS production,apoptosis rate,and monolayer ***,silencing RACK1 significantly downregulated the expression of PKC-εand ROS,reduced cell apoptosis and permeability,and protected barrier *** RACK1 plays a significant role in the development of early DR and might serve as a potential therapeutic target for DR by regulating RPE apoptosis and barrier function.

关键词： Diabetic retinopathy Receptor for activated C kinase 1 Protein kinase C-ε Adult retinal pigment epithelium cell line-19

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多道次拉伸和感应电流处理5052铝合金的力学性能和显微组织演变

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Transactions of Nonferrous Metals Society of China 2024年第1期34卷 65-79页

作者：王世鹏崔晓辉肖昂余卓行杜志浩中南大学轻合金研究院长沙410083 中南大学机电工程学院长沙410083 中南大学高性能复杂制造国家重点实验室长沙410083

提出一种多道次拉伸和感应电流处理(IEPT)相结合的复合成形方法,采用TEM和EBSD揭示感应电流对材料显微组织和力学性能的影响规律。结果表明,采用4次拉伸5%和拉伸后放电,材料伸长率比原始材料增加145%。预拉伸试样经过IEPT处理后,强度下... 详细信息

提出一种多道次拉伸和感应电流处理(IEPT)相结合的复合成形方法,采用TEM和EBSD揭示感应电流对材料显微组织和力学性能的影响规律。结果表明,采用4次拉伸5%和拉伸后放电,材料伸长率比原始材料增加145%。预拉伸试样经过IEPT处理后,强度下降、塑性提高,材料的位错密度下降,晶粒变形结构向亚结构转变,同时晶粒尺寸略有增加。感应电流减弱材料的各向异性,出现新的//TD织构。电塑性效应和焦耳热效应的结合增强位错运动和空位移动。采用ANSYS软件模拟板料的温度分布,最高温度达到144.7℃。材料强度的理论计算结果与实验数据一致。

关键词： 5052铝合金感应电流织构演变焦耳热模拟强度计算

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低本高效人脸识别系统设计的汽车记忆座椅模块开发

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科学技术与工程 2024年第13期24卷 5443-5449页

作者：肖森安嘉骏高雨李伟亮刘晓昂河北工业大学亚利桑那工业学院天津300401 河北工业大学机械工程学院天津300401

近年来,记忆座椅作为一种新型的座椅形式,因其简便的操作过程受到广大消费者的青睐。但是目前国内外绝大多数的记忆座椅仍然面临着成本高、调节准确度低的问题。为改善车主的使用体验,提出一种座椅自适应调节电控模块,基于人脸识别技术... 详细信息

近年来,记忆座椅作为一种新型的座椅形式,因其简便的操作过程受到广大消费者的青睐。但是目前国内外绝大多数的记忆座椅仍然面临着成本高、调节准确度低的问题。为改善车主的使用体验,提出一种座椅自适应调节电控模块,基于人脸识别技术,通过更加简洁高效的代码使得操作更加便捷、调节更加准确。首先,通过单片机使用OpenCV确定最佳人体识别方案;然后运用微型控制器(microcontroller unit,MCU)自动控制技术进行座椅控制系统的电路设计及电控程序的编写;最后使用STM32单片机运行电控模块并进行验证,识别成功率达92%。研究结果显示,该人脸识别系统在保证了识别准确率的同时控制了成本,结合汽车中的记忆座椅后对于简化座椅调整流程、改善用户实际体验效果具有实际意义。

关键词：记忆座椅电控模块人脸识别哈尔特征 OpenCV 树莓派

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内镜腰椎间盘切除术后复发的因素及预测模型

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中国矫形外科杂志 2024年第9期32卷 775-780页

作者：梁啸李东儒陈筱王叶新李衍朋高龙飞孟纯阳济宁医学院附属医院脊柱外科山东济宁272000 济宁医学院临床医学院山东济宁272000

[目的]探讨经皮内镜腰椎间盘切除术(percutaneous lumbar endoscopic discectomy,PELD)后复发性椎间盘突出(recurrent lumbar disc herniation,rLDH)的影响因素并建立预测模型。[方法]回顾性分析2017年1月—2020年1月作者采用PELD治疗的腰椎间盘突出症的286患者的临床资料。根据术后3年内是否出现复发分为复发组和未复发组,采用单因素比较和多因素逻辑回归分析,筛选出复发的相关因素,并建立数学预测模型,采用受试者工作特征(ROC)曲线等分析以评估模型的临床价值。[结果]286例患者中,44例确诊为复发,占15.4%;242例未复发,占84.6%。单因素比较表明,复发组的BMI[(25.8±3.0)vs(24.2±3.3),P=0.004]和病程[(17.9±18.3)个月vs(10.7±16.8)个月,P=0.01]均显著大于未复发组;复发组的术前影像Modic改变显著多于未复发组[无/有,(30/14)vs(206/36),P=0.006];复发组术前影像测量椎间ROM显著大于未复发组[(9.3±3.4)°vs(7.1±2.8)°,P<0.001];复发组经椎间孔入路手术比率显著大于未复发组[TF/IL,(29/15)vs(114/128),P=0.022]。逻辑回归表明,BMI(OR=1.154,95%CI 1.031~1.291,P=0.013)、病程(OR=1.023,95%CI 1.005~1.042,P=0.013)、Modic改变(OR=3.143,95%CI 1.369~7.070,P=0.007)、椎间ROM(OR=1.264,95%CI 1.126~1.419,P<0.001)和手术入路(椎间孔/椎板间)(OR=2.104,95%CI 1.007~4.396,P=0.048)是复发的独立危险因素。按逻辑回归得出预测模型,其预测值ROC分析的曲线下面积为(AUC)为0.787(95%CI 0.721~0.853);模型校准曲线与实际曲线一致性较好;决策曲线分析表明,风险阈值为10%~50%时,该模型可产生较大净获益。[结论]本研究表明BMI、病程、术前Modic改变、术前椎间ROM和手术入路是PELD术后rLDH的危险因素。本研究得出预测rLDH模型可能帮助临床医生判断术后复发风险。

关键词：腰椎间盘突出症经皮内镜椎间盘切除术复发性椎间盘突出危险因素预测模型

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Tongue diagnosis based on hue-saturation value color space: controlled study of tongue appearance in patients treated with percutaneous coronary intervention for coronary heart disease

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Intelligent Medicine 2023年第4期3卷 252-257页

作者： Yumo Xia Qingsheng Wang xiao Feng Xin’ang xiao Yiqin Wang Zhaoxia Xu Basic Medical College Shanghai University of Traditional Chinese MedicineShanghai 201203China

Objective To analyze the characteristics of tongue imaging color parameters in patients treated with percutaneous coronary intervention(PCI)and non-PCI for coronary atherosclerotic heart disease(CHD),and to observethe effects of PCI on the tongue images of patients as a basis for the clinical diagnosis and treatment of patientswith *** This study used a retrospective cross-sectional survey to analyze tongue photographs and medicalhistory information from 204 patients with CHD between November 2018 and July *** images ofeach subject were obtained using the Z-BOX Series traditional Chinese medicine(TCM)intelligent diagnosisinstruments,the SMX System 2.0 was used to transform the image data into parameters in the HSV color space,and finally the parameters of the tongue image between patients in the PCI-treated and non-PCI-treated groupsfor CHD were *** Among the 204 patients,112 were in the non-PCI treatment group(38 men and 74 women;average age of(68.76±9.49)years),92 were in the PCI treatment group(66 men and 26 women;average age of(66.02±10.22)years).In the PCI treatment group,the H values of the middle and tip of the tongue and the overall coating of thetongue were lower(P<0.05),while the V values of the middle,tip,both sides of the tongue,the whole tongueand the overall coating of the tongue were higher(P<0.05).Conclusion The color parameters of the tongue image could reflect the physical state of patients treated withPCI,which may provide a basis for the clinical diagnosis and treatment of patients with CHD.

关键词： Objective evaluation Tongue diagnosis Coronary heart disease Percutaneous coronary intervention Hue-saturation value color space Traditional Chinese medicine syndromes

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汽车空调流体管路的气动噪声分析与优化

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机械设计与制造 2024年第7期 269-272页

作者：万里翔闵海娇刘晓昂王新玲西南交通大学机械工程学院四川成都610031 雪龙集团有限公司浙江宁波315806

以汽车空调风道为研究对象,在Fluent中采用RNG模型和LES模型对管路进行稳态和瞬态计算,对风道出口风量进行试验验证,并采用声类比法计算风道出风口的噪声。根据仿真分析结果,采用响应面法,以出风口1管路的转角半径、出风口2管路左、右... 详细信息

以汽车空调风道为研究对象,在Fluent中采用RNG模型和LES模型对管路进行稳态和瞬态计算,对风道出口风量进行试验验证,并采用声类比法计算风道出风口的噪声。根据仿真分析结果,采用响应面法,以出风口1管路的转角半径、出风口2管路左、右管壁的移动距离为设计变量,以出风口2的风量占比为优化目标对空调管路的结构进行优化。最后对优化前、后的管路进行了流场和声场对比分析。结果表明,与原模型相比,优化后风道出风口2的风量比例由20.75%提升到了25.25%,出风口的噪声下降最大值为5.15dB。

关键词：空调风道气动噪声计算流体力学响应面法

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Recent progress in single crystal perovskite X-ray detectors

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Science China(Information Sciences) 2024年第3期67卷 5-19页

作者： xiao LIU Jun REN Yu-ang CHEN Xiangshun GENG Dan XIE Tian-Ling REN School of Integrated Circuits Tsinghua University Beijing National Research Center for Information Science and Technology (BNRist)

Perovskites have attracted extensive attention as radiation detection material due to their long carrier diffusion length and lifetime, high absorption coefficient, and flexible manufacturing process. Compared with polycrystalline structures, single crystal perovskites improve the performance of optoelectronic devices due to their low defect state density, better photoelectric characteristics, and chemical ***, we review the recent progress of single crystal perovskite X-ray detectors. First, we briefly introduced the basic concepts, detection mechanisms, figure of merits of perovskite X-ray detectors, and the preparation methods of single crystal perovskites. Then, we summarized the significant advancements in single crystal perovskite X-ray detectors in recent times. Finally, we discussed the critical challenges and some practicable solutions for developing high-performance X-ray detectors.

关键词： single crystal perovskites carrier transport radiation detection X-ray detectors X-ray imaging

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Differences of aroma development and metabolic pathway gene expression between Kyoho and 87-1 grapes

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Journal of Integrative Agriculture 2021年第6期20卷 1525-1539页

作者： JI xiao-hao W ang Bao-liang Wang xiao-di W ang xiao-long LIU Feng-zhi Wang Hai-bo Research Institute of Pomology Chinese Academy of Agricultural Sciences/Key Laboratory of Biology and Genetic Improvement of Horticultural Crops(Germplasm Resources Utilization)Ministry of Agriculture/Key Laboratory of Mineral Nutrition and Efficient Fertilization for Deciduous FruitsLiaoning ProvinceXingcheng 125100P.R.China

Aroma is an important quality trait of grapes and often the focus of consumers,viticulturists and grapevine *** is a hybrid between Vitis vinifera and Vitis labrusca with a strawberry-like scent,while 87-1 is an early-ripening mutant of Muscat hamburg,belonging to Vitis vinifera,with a rose *** this study,we compared their aroma compositions and concentrations during berry development by headspace-SPME combined with gas chromatography-mass spectrometry(GC-MS),and analyzed the expression differences of enzyme-encoding genes in the LOX-HPL,MEP and MVA metabolic pathways by *** esters were detected in Kyoho during the whole berry development and they were abundant after veraison,but no esters were detected in 87-1 *** was the dominant terpene among the 14 terpenes detected in 87-1 berries,while limited amounts of terpenes were detected in Kyoho ***-PCR analysis indicated that the low expression of VvAAT might explain the low content of ester volatiles in 87-1 berries,and the low expression of coding genes in the MEP pathway,especially VvPNLin Ner1,might be the reason for the low content of volatile terpenes in Kyoho *** results from this work will promote our understanding of aroma metabolic mechanisms of grapes,and offer some suggestions for grape aromatic quality improvement.

关键词： grape Kyoho 87-1 aroma LOX-HPL MEP gene expression

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A novel power-on-reset circuit for passive UHF RFID tag chip

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Journal of Semiconductors 2018年第12期39卷 173-179页

作者： ang Wang Lina Yu Dehua Wu Shibo Fu Wanlin Ga Wan'ang xiao Institute of Semiconductors Chinese Academy of SciencesBeijing 100083China College of Information and Electrical Engineering China Agricultural UniversityBeijing 100083China School of Microelectronics University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Agricultural Informationization Standardization Ministry of Agriculture and Rural AffairsBeijing 100083China

A novel power-on-reset(POR) circuit with simple architecture, small values of capacitances, ultralower power consumption, and self-adjustable delay time of reset pulse for passive UHF RFID tags is presented in this paper. A proposed delay element was adopted for the features of small capacitances and wide power supply rise time range. An inverter was used as a two-inputs logic device to simplify the architecture of the circuit. The technology used for design and simulation is SMIC 0.18 μm RF. Simulation results show that the circuit functions well under different process corners with different power supply rise time, and is able to generate a POR signal after the power supply is briefly powered off. The static power consumption is less than 30 pA. Moreover, the circuit operates properly along with other modules of analog front-end.

关键词： RFID analog circuit power-on-reset ultra-lower power delay element

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Poland＇s syndrome in women： 24 cases study and literature review

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Chinese Medical Journal 2012年第18期125卷 3283-3287页

作者： ZHU Lin ZENG ang Wang xiao-jun LIU Zhi-fei ZHang Hai-lin Plastic Surgery Department Peking Union Medical CollegeHospital Chinese Academy of Medical SciencesChina Beijing 100032

Background Since its first description in 1841, numerous variations and treatments of Poland＇s syndrome （congenital deficiency of the pectoralis major muscle associated with brachysyndactyly） have been reported. None of the reports, however, involved female Chinese patients. Methods A retrospective study of 24 female patients was conducted to guide the selection of methods of surgical reconstruction. The patients were divided into three groups according to the degree of thoracic tissue development. Type I （mild）： Limited tissue loss which can be treated with simple filling with autologous fat and/or an artificial breast implant. Type II （moderate）： Moderate thoracic tissue hypoplasia where the breast parenchyma can still offer adequate implant coverage. Mammoplasty using a latissimus dorsi muscular flap with an implant was performed in this group. The flap was used to fill the infraclavicular hollow, and the implant was placed in the dual-plane pocket. Type Ⅲ （severe）： Severe thoracic tissue hypoplasia, without sufficient parenchyma to offer implant coverage. A latissimus dorsi muscular flap was used to form a total submuscular pocket in which an implant was placed. Results The numbers of Type Ⅰ, Ⅱ, and Ⅲ patients were 15, 3, and 6, respectively. All of the flaps and injected fat demonstrated good survival. Satisfactory cosmetic results were exhibited during the follow-up period of 1 to 9 years. Conclusions Although this group of patients showed varied conditions, they can be roughly divided into three types according to the degree of thoracic tissue development. In our experience, this classification is simple and useful in choosing the breast reconstruction options.

关键词： Poland's syndrome pectoralis major muscle aplasia congenital breast malformation latissimus dorsi muscular flap

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