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World Journal of Diabetes 2021年第10期12卷 1704-1718页

作者： Pamela Gaitán-González Rommel Sánchez-Hernández José-Antonio Arias-Montaño angélica rueda Department of Biochemistry Centro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalCiudad de México 07360Mexico Department of Physiology Biophysics and NeurosciencesCentro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalCiudad de México 07360Mexico

Metabolic syndrome is a pre-diabetic state characterized by several biochemical and physiological alterations,including insulin resistance,visceral fat accumulation,and dyslipidemias,which increase the risk for developing cardiovascular *** syndrome is associated with augmented sympathetic tone,which could account for the etiology of pre-diabetic *** review summarizes the current knowledge of the pathophysiological consequences of enhanced and sustainedβ-adrenergic response in pre-diabetes,focusing on cardiac dysfunction reported in diet-induced experimental models of pre-diabetic *** research reviewed indicates that both protein kinase A and Ca^(2+)/calmodulin-dependent protein kinase Ⅱ play important roles in functional responses mediated byβ1-adrenoceptors;therefore,alterations in the expression or function of these kinases can be *** review also outlines recent information on the role of protein kinase A and Ca^(2+)/calmodulin-dependent protein kinase Ⅱ in abnormal Ca^(2+)handling by cardiomyocytes from diet-induced models of pre-diabetic cardiomyopathy.

关键词： Ca^(2+)/calmodulin-dependent protein kinase II Protein kinase A Metabolic syndrome Pre-diabetes Pre-diabetic cardiomyopathy β-Adrenoceptors

Impact of Bubbles on Mechanical Performances in a Borosilicate Glass

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 25-29页

作者： LI Chengxing LI Dongfeng MA Shilong QIAO ang ZHENG Qingshuang China Helicopter Research and Development Institute Jingdezhen 333001China State Key Laboratory of Silicate Materials for Ar-chitectures Wuhan University of TechnologyWuhan 430070China

To analyze the impact of bubbles on the mechanical behavior of glasses,by controlling the refining time,we prepared three borosilicate glasses with the same composition and different *** the analysis software integrated within the optical microscope,the diameter and number of the bubbles on the surface of three borosilicate glasses were *** the hardness and crack initiation resistance(CR),we built the relationship between the porosity and the mechanical performance of these borosilicate glasses.

关键词： bubbles oxide glass hardness creak initiation resistance

Receiver tube heat transfer analysis of a CCP collector designed based on branched fractals geometry

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International Journal of Agricultural and Biological Engineering 2020年第5期13卷 56-62页

作者： angélica Palacios Darío Amaya Olga Ramos GAV Research Group Universidad Militar Nueva GranadaBogota 110111Colombia

For the development of systems related to renewable energy and specifically for thermo-solar energy,it is essential to study and analyze the different thermal phenomena of heat transfer,in search of the best conditions that allow strengthening the *** such as radiation,convection,and conduction are highly studied,from the field of materials to the field of infrastructure,finding day to day optimal solutions that guarantee a great use of the solar resource available on the earth's *** study presented the results of heat transfer analysis on a receiver pipe in a CCP;designed using the theory of branched fractal geometry to improve the heat transfer associated with concentrating solar capture systems.A fractal structure as a branch or arboreal fractal type network,influenced thermal and electrical parameters,as electrical resistance,thermal resistance,and convective heat transfer,so increasing the level branch heat transfer can be enhancement along of the *** use of renewable energies in agriculture benefits the industrial processes that require a continuous power system,due to climatic conditions and geographical location is not a guarantee in food production fields,which reason solar capture systems contribute to food dehydration processes,water heating,refrigeration,and energy production.

关键词： heat transfer fractal geometry solar collector fractality fractal dimension parabolic cylindrical concentrator

Early performance of two tropical dry forest species after assisted migration to pine-oak forests at different altitudes:strategic response to climate change

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Journal of Forestry Research 2020年第4期31卷 1215-1223页

作者： Pilar angélica Gómez-Ruiz Cuauhtémoc Sáenz-Romero Roberto Lindig-Cisneros Catedrática CONACYT Centro de Investigaciónde Ciencias Ambientales CICAFacultad de Ciencias NaturalesUniversidad Autónoma del CarmenCiudad del CarmenCampecheMexico Instituto de Investigaciones Agropecuarias y Forestales Universidad Michoacana de San Nicolás de Hidalgo(IIAFUMSNH)MoreliaMexico Instituto de Investigaciones en Ecosistemas y Sustentabilidad(IIES) Universidad Nacional Autónoma de MéxicoCampus MoreliaMoreliaMexico

Assisted migration has been proposed as a strategy for adaptive management of forest species in response to expected effects of climate change,but it is controversial for several *** dry forests are among the most threatened ecosystems in the *** Mexico,historically,land-use change and deforestation have been decreasing forest cover,and climate change is shifting the potential distribution of different forest types,exacerbating the risk of local *** altitudinal migration could be a feasible strategy for reducing local extinctions in response to climate change and lack of landscape *** objective was to evaluate survival and growth of Albizia plurijuga and Ceiba aesculifolia,two tropical deciduous forests species in *** transplanted 4-month-old seedlings to experimental raised beds at three altitudes(2100,2400 and 2700 m a.s.l.),exceeding their upper regional limit of distribution(2000 m a.s.l.).We also tested seed germination at each *** monitored the experiment for 10 *** both species,as altitude increased and cold weather was more prevalent,plant performance *** species,differences in individual growth were significant among *** survival was 18.5%for *** and 24.5%for *** species had higher survival and better growth at lower altitude,and no seedling emergence at any *** conclude that assisted migration can be implemented for each species by an upward attitudinal shift within,and not exceeding,400 m beyond their present upper altitudinal limit of *** results indicate that for many species that show altitudinal gradients at regional scales,unless current climate conditions change,the potential to establish outside their range is minimal.

关键词： Albizia plurijuga Ceiba aesculifolia Climate change Fabaceae Forest management Mitigation strategy Range expansion

A Numerical Study Comparing the Effect on Residual Stresses of Two Different Types of Projectiles During Shot Peening

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Computers, Materials & Continua 2016年第3期51卷 203-215页

作者： J.Solórzano-López F.A.García-Pastor angélica Flores-Luna UNAM Facultad de QuímicaCiudad de MéxicoMéxico Cinvestav Unidad Saltillo CoahuilaMéxico TecNM Instituto Tecnológico de Tláhuac IIICiudad de MéxicoMéxico

Shot peening is a widely used technique to improve fatigue life in metallic *** processing technique introduces a subsurface compressive residual stress field through a plastic deformation of the surface caused by the impact of a large number of high-speed *** are a number of parameters that affect the residual stress field depth and *** effects of the impact angle,shot speed and shot geometry are currently being *** particular,substituting spherical cast shots by cylindrical cut wire shots is an attractive option,especially in terms of *** effect of shot geometry on residual stresses,however,needs to be further *** industrial-scale experimentation is costly and cumbersome,mathematical modeling offers a convenient alternative to carry out this type of *** present work shows a comparison between the residual stresses generated by the impact of spherical and cylindrical projectiles on a steel *** threedimensional model was developed using ABAQUS finite element commercial software(Release 6.12,Dassault Systémes,France).The results show that cylindrical shots generate residual stress fields t hat a re higher in magnitude than t hose generated by a spherical ***,the residual stress field of cylindrical shots impacting the surface at an oblique angle shows an important degree of *** effect is not found when spherical shots impact the surface at the same oblique angle.

关键词： Shot Peening Finite element method Residual Stresses

溶解有机质N/C比值的分布格局及其对湖泊增温和营养富集的响应

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湖泊科学 2025年第1期37卷 97-111页

作者：陈铭胡盎韩磊王建军湖南农业大学资源学院长沙410128 中国科学院南京地理与湖泊研究所湖泊与流域水安全重点实验室南京211135

溶解有机质(DOM)是水生生态系统的重要能量和营养源,其N/C等元素化学计量学能够反映湖泊沉积物营养物质来源,相关研究有助于揭示全球变暖和水体富营养化的影响机制。本研究聚焦高分辨率质谱技术所获DOM的N/C比值,通过Meta分析从宏观角... 详细信息

溶解有机质(DOM)是水生生态系统的重要能量和营养源,其N/C等元素化学计量学能够反映湖泊沉积物营养物质来源,相关研究有助于揭示全球变暖和水体富营养化的影响机制。本研究聚焦高分辨率质谱技术所获DOM的N/C比值,通过Meta分析从宏观角度考察全球湖泊、河流、海洋和泥炭地等多生境N/C比值的全球分布情况。结果表明,河流水体、沉积物和污水等生境的N/C均值(分别为0.050±0.062、0.050±0.014和0.083±0.084)均显著高于泥炭地(0.026±0.037);水体N/C比值主要受海拔(即温度)、pH、氨氮和溶解有机碳等显著影响,而泥炭地等陆地N/C比值主要受pH、总溶解有机氮和溶解有机碳的影响。进一步,依托云南老君山海拔梯度开展模拟温度变化和营养富集的微宇宙实验定量解析其影响机制,并根据沉积物DOM分子转换数将总分子划分为高活性和低活性两类,探究总分子及其两类组分的N/C比值对温度和营养富集的响应规律。溶解有机质N/C均值为0.112±0.020,其中高活性分子(0.119±0.017)显著高于低活性分子(0.109±0.034)。总分子N/C比值主要受亚硝酸盐和硝酸盐等营养盐的影响,相对总贡献率为63.43%;高活性分子N/C比值主要受营养盐和能量供应(比如溶解有机碳、总有机碳和叶绿素a等)的影响,而低活性分子N/C比值主要受营养盐的影响。结构方程模型分析表明,营养富集对总分子N/C比值的影响高于温度,主要通过能量供应和营养盐的间接作用而产生影响;对于高活性分子,营养盐主要通过能量供应的间接作用影响N/C比值;而对于低活性分子,主要通过营养盐发挥直接作用。本研究结果首次探讨了全球不同生境N/C比值的分布格局,揭示了沉积物溶解有机质N/C比值对全球变暖和营养富集的响应规律和机制,为更好理解和预测未来全球变化背景下溶解有机碳稳定性提供科学参考。

关键词：溶解有机质氮碳比湖泊沉积物全球变暖富营养化

Non-oxygenic Photosynthesis in the Sulphurous Lake Cisó,North-eastern Spain

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Acta Geologica Sinica(English Edition) 2014年第S1期88卷 41-42页

作者： angélica angLS LI Yiliang Department of Earth Sciences The University of Hong Kong

1 Introduction Situated in the Iberian Peninsula,Lake Cisóis a sulphide-rich lake that belongs to the Ba?oles karstic system in Girona,north-eastern part of *** Cisóis holomictic,and covers a small area of around 65... 详细信息

关键词： Lake Cisó non-oxygenic photosynthesis sulphurous lake evolution microbial diversity

The detrimental effects of lipopolysaccharideinduced neuroinflammation on adult hippocampal neurogenesis depend on the duration of the pro-inflammatory response

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Neural Regeneration Research 2019年第5期14卷 817-825页

作者： Martha Pérez-Domínguez Evangelina ávila-Mu?oz Eduardo Domínguez-Rivas angélica Zepeda Departamento de Medicina Genómica y Toxicología Ambiental Instituto de Investigaciones Biomédicas.Universidad Nacional Autónoma de MéxicoCDMX

Adult hippocampal neurogenesis is a finely tuned process regulated by extrinsic factors. Neuroinflammation is a hallmark of several pathological conditions underlying dysregulation of neurogenesis. In animal models, lipopolysaccharide(LPS)-induced neuroinflammation leads to a neurogenic decrease mainly associated to the early inflammatory response. However, it is not well understood how the neuroinflammatory response progresses over time and if neurogenesis continues to be diminished during the late neuroinflammatory response. Moreover, it is unknown if repeated intermittent administration of LPS along time induces a greater reduction in neurogenesis. We administered one single intraperitoneal injection of LPS or saline or four repeated injections(one per week) of LPS or saline to young-adult mice. A cohort of new cells was labeled with three 5-bromo-2-deoxyuridine injections(one per day) 4 days after the last LPS injection. We evaluated systemic and neuroinflammation-associated parameters and compared the effects of the late neuroinflammatory response on neurogenesis induced by each protocol. Our results show that 1) a single LPS injection leads to a late pro-inflammatory response characterized by microglial activation, moderate astrocytic reaction and increased interleukin-6 levels. This response correlates in time with decreased neurogenesis and 2) a repeated intermittent injection of LPS does not elicit a late pro-inflammatory response although activated microglia persists. The latter profile is not accompanied by a continued longterm hippocampal neurogenic decrease. Hereby, we provide evidence that the neuroinflammatory response is a dynamic process that progresses in a milieu-dependent manner and does not necessarily lead to a neurogenic decrease, highlighting the complex interaction between the immune system and neurogenesis.

关键词： dentate gyrus subgranular zone inflammation microglia astrocytes IL-6 cytokines cell proliferation neural progenitor cells immature neurons long-term short-term adult hippocampal neurogenesis

Validation of CFD-DEM simulation of a liquid-solid fluidized bed by dynamic analysis of time series

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Particuology 2022年第9期20卷 75-87页

作者： Julia Picabea Mauricio Maestri Miryan Cassanello Gabriel Salierno Cataldo De Blasio María angélica Cardona Daniel Hojman Héctor Somacal Departamento de Industrias Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresCiudad UniversitariaIntendente Güiraldes 2160C1428EGABuenos AiresArgentina CONICET-Universidad de Buenos Aires Instituto de Tecnología de Alimentos y Procesos Químicos-ITAPROQCiudad UniversitariaIntendente Güiraldes 2160 C1428EGABuenos AiresArgentina Faculty of Science and Engineering Abo Akademi UniversityRantakatu 265100 VaasaFinland Laboratorio de Diagnósticos por Radiaciones Dep.Física ExperimentalComisión Nacional de Energía AtómicaBKNA1650 San MartínBuenos AiresArgentina CONICET C1033AAJ Buenos AiresArgentina Escuela de Ciencia y Tecnología Universidad de San MartínBKNA 1650 San MartínBuenos AiresArgentina

Liquid-solid fluidized beds(LSFB)modeling validation is crucial for establishing design rules and monitor-ing ***,it generally relies on comparing global variables,which overlook dynamic features that influence reaction *** work aims to implement time series analysis tools to compare Radioactive Particle Tracking data with a simulation consisting of Computational Fluid Dynamics cou-pled with Discrete-Element *** have been performed in a pilot-scale LSFB of calcium alginate spheres fluidized with a calcium chloride *** Diks'test indicates that the simulation can capture the LSFB *** also allows diagnosing flow regime transitions from the *** of solid dispersion coefficients and mixing times predicted by the simulation are in good agreement with the experiments.

关键词： Liquid-solid fluidization CFD-DEM Dynamic comparison Radioactive particle tracking

Vat-based photopolymerization 3D printing:From materials to topical and transdermal applications

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Asian Journal of Pharmaceutical Sciences 2024年第4期19卷 1-19页

作者： angélica Gra Sara Bom Ana M.Martins Helena M.Ribeiro Joana Marto Research Institute for Medicine(iMed.ULisboa) Faculty of PharmacyUniversidade de LisboaLisbonPortugal

Three-dimensional(3D)printing is an innovative manufacturingmethod with the potential to revolutionize topical and transdermal dosage ***,it is established that Vatbased photopolymerization(VP)3D printing technologies offer superior printing efficiency and versatility compared to other 3D printing technologies available on the ***,there are some limitations that impair their full application in pharmaceutical contexts,such as the lack of a range of biocompatiblematerials for topical and transdermal *** reviewarticle explores all types of VP-based 3D printing and discusses the relevance of implementing this kind of *** start with a detailed description of the printing process,focusing on the commercial materials available and lab-made resins proposed by different *** also review recent studies in this field,which mainly focus on the fabrication of transdermal devices based on microneedle *** the future,it is expected that the manufacturers of 3D printers invest in modifications to the printing apparatus to allow the simultaneous printing of different resins and/or compound types,which will open frontiers to the personalization of treatment approaches.

关键词： Vat-based photopolymerization 3D printing Topical delivery Transdermal delivery Resins Photoinitiators