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Evidence for the Sa.e Use of the Extra.t from the Bra.ilia. a.nica. <i>Solida.o chilensis</i>Meyen, in Prima.y Hea.th Ca.e

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Chinese Medicine 2012年第1期3卷 4-8页

作者： angélica a. mercandeli Geisila.e P. Bessa.Sila. N. Ronchi Ta.ia.a.P. S. Sega.o a.y G. da.Silva Universida.e Vila.Velha Rua Comissário José Dantas de Melo Vila Velha Brazil

In Bra.il, the Na.iona. Policy on Medicina. Pla.ts ha. stimula.ed the use of pla.ts in prima.y hea.th ca.e, va.ida.ing the tra.itiona. medicine a.d pointing to the la.k of a.consistent set of evidence tha. supports their uses a.d indica.ions by ethnobota.y a.d ethnopha.ma.ology. This pa.er a.ms to ma.e a.systema.ic review of the scientific litera.ure to ga.her evidence on indica.ions a.d sa.ety of use of extra.ts of Solida.o chilensis. The bibliogra.hic resea.ch wa. ca.ried out using terms deriva.e from the title, a.d a.l the published pa.ers were downloa.ed, covering a. lea.t the la.t five yea.s, a.d it wa. focused on preclinica. a.d clinica. studies with extra.ts of S. chilensis in the da.a.a.es of Web of Science, BIREME, SciELO, PubMed, Scirus a.d Highwire. Phytochemica. a.a.ysis ca.ried out on ma.y studies showed tha. a.ong the chemica. constituents of S. chilensis a.e sesqui- a.d diterpenes, fla.onoids a.d other substa.ces, a.d the diterpene solida.enone wa. identified a. a.ma.ker of the extra.t tha. ha. demonstra.ed ga.troprotective a.tivity in different experimenta. models of ulcer induced in a.ima.s without signs of toxicity a. doses a.ove 600 mg/kg. a.other studies show tha. the a.ti-infla.ma.ory effect in ra.s ha. been given by inhibiting the exuda.ion of leukocytes, especia.ly neutrophils, a. well a. through inhibition of myeloperoxida.e, a.enosine dea.ina.e, a.d tumor necrosis fa.tor-α (TNF-α), decrea.ed induction of nitric oxide synthesis a.d levels of interleukin-1β. Studies show tha. solida.enone a. a.concentra.ion of 100 mg/kg showed a.tivity simila. to la.sopra.ole (20 mg/kg), the effect occurs without changes in the ga.tric mucosa.or on a.id secretion. The a.ueous a.d a.coholic extra.ts showed a.ti-infla.ma.ory a.tivity a.d ma. a.t in a.sa.isfa.tory wa. in ca.es involving the infla.ma.ory response, such a. injuries due to tra.ma. repetitive stress, pa.n, a.d hea.ing. The inhibition of a.ti-infla.ma.ory response is on the ba.e of a.l these described

关键词： Sa.e Use Prima.y Hea.th Ca.e Tra.itiona. Knowledge a.ti-Infla.ma.ory

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Stress tensors a.d qua.tifica.ion of fra.ture pa.terns to a.a.yze connectivity a.d potentia. fluid flow in a.mesa.la.dform of the Northern a.des

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Journa. of Mounta.n Science 2024年第1期21卷 271-291页

作者： Ga.CÍa.a.Ia. Sergio VELa.DIa.Fra.cisco a.Va.EZ angélica Sa.a.RIa.GÓMEZ JoséD Ta.a.ONa.Yessenia.Va.Ga. Ma.ía.Ca.ila Escuela.de Geología Universidad Industrial de SantanderCra.27 Calle 9BucaramangaColombia Escuela.de Física Universidad Industrial de SantanderCra.27 Calle 9BucaramangaColombia

This work a.plies stress tensors inversions a.d qua.tifica.ion of fra.ture pa.terns a.ong the Mesa.de Los Sa.tos, in the Ea.tern Cordillera.of Colombia. to better understa.d the potentia. fluid flow. It thus contributes to the conceptua. hydrogeologica. model. The a.ea.wa. subdivided into three blocks, sepa.a.ed by the NW Potreros a.d the Los Sa.tos fa.lts, ha.ing minor inner fa.lts of different orienta.ions. This sepa.a.ion fa.ilita.es the a.a.ysis of the fra.tures mea.ured in the field, which in genera. show high dip angles a.d a.conjuga.e geometry in the northern block, tension fra.tures(Mode I) in the centra. block, a.d a.ra.dom distribution in the southwestern block. WinTensor trea.ment of slickensides yielded a.ma.imum horizonta. stress(SHma.) of 111o, which coincides with the WNW-ESE tensor observed from the conjuga.e a.d tension joints. We then used Fra. Pa.Q to genera.e interpola.ion ma.s of fra.ture intensity a.d density. The ma.s show the highest va.ues in the centra. block a.d the lowest in the northern block,where the precipita.ion is higher, ca.sing intensive rock wea.hering a.d homogeniza.ion of the fra.ture pla.es. a.though the highest va.ues of connectivity by line a.e found to the south of the mesa. we suggest the possibility of grea.er flow from the recha.ge zone(NE) a.ong bedding pla.es a.d open NW-SE fra.tures.

关键词： Mesa.de Los Sa.tos Colombia Win-Tensor Fra.Pa. Strike-slip fa.lts Fra.tured a.uifers

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Meta.olomics for the dia.nosis of bla.der ca.cer: a.systema.ic review

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a.ia. Journa. of Urology 2024年第2期11卷 221-241页

作者： Herney a.drés Ga.cía.Perdomo angélica Ma.ía.Dávila.Ra.goza.Ferna.do Korkes Division of Urology/Urooncology Department of SurgerySchool of MedicineUniversidad del ValleCaliColombia UROGIV Resea.ch Group School of MedicineUniversidad del ValleCaliColombia Urologic Oncology Division of UrologyABC Medical SchoolSao PauloBrazil

Objective: Meta.olomics ha. been extensively utilized in bla.der ca.cer (BCa. resea.ch, employing ma.s spectrometry a.d nuclea. ma.netic resona.ce spectroscopy to compa.e va.ious va.ia.les (tissues, serum, blood, a.d urine). This study a.med to identify potentia. bioma.kers for ea.ly BCa.***: a.sea.ch stra.egy wa. designed to identify clinica. tria.s, descriptive a.d a.a.ytica. observa.iona. studies from da.a.a.es such a. Medline, Emba.e, Cochra.e Centra. Register of Controlled Tria.s, a.d La.in a.erica. a.d Ca.ibbea. Litera.ure in Hea.th Sciences. Inclusion criteria.comprised studies involving BCa.tissue, serum, blood, or urine profiling using widely a.opted meta.olomics techniques like ma.s spectrometry a.d nuclea. ma.netic resona.ce. Prima.y outcomes included description of meta.olites a.d meta.olomics profiling in BCa.pa.ients a.d the a.socia.ion of meta.olites a.d meta.olomics profiling with BCa.dia.nosis compa.ed to control pa.ients. The risk of bia. wa. a.sessed using the Qua.ity a.sessment of Studies of Dia.nostic ***: The sea.ch stra.egy yielded 2832 studies, of which 30 ca.e-control studies were included. Urine wa. predomina.tly used a. the prima.y sa.ple for meta.olite identifica.ion. Risk of bia. wa. often unclea. inpa.ient selection, blinding of the index test, a.d reference sta.da.d a.sessment, but no a.plicability concerns were observed. Meta.olites a.d meta.olomics profiles a.socia.ed with BCa.dia.nosis were identified in glucose, a.ino a.ids, nucleotides, lipids, a.d a.dehydes ***: The identified meta.olites in urine included citric a.id, va.ine, tryptopha., ta.rine, a.pa.tic a.id, uridine, ribose, phosphocholine, a.d ca.nitine. Tissue sa.ples exhibited eleva.ed levels of la.tic a.id, a.ino a.ids, a.d lipids. Consistent findings a.ross tissue, urine, a.d serum sa.ples revea.ed downregula.ion of citric a.id a.d upregula.ion of la.tic a.id, va.ine, tryptopha., ta.rine, gluta.ine, a.pa.tic a.id, uridine, rib

关键词： Meta.olite Meta.olomics Bla.der ca.cer Meta.olomicsprofile

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a.multi-pla.form a.a.ysis of huma. gingiva. crevicula. fluid revea.s ferroptosis a. a.releva.t regula.ed cell dea.h mecha.ism during the clinica. progression of periodontitis

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Interna.iona. Journa. of Ora. Science 2024年第2期16卷 265-279页

作者： a.fredo Torres M.angélica Michea.Ákos Végvári Ma.ion a.ce Va.entina.Pérez Ma.cela.a.cota.a.icia.Mora.es Rola.do Verna. Ma.ricio Budini Roma. a.Zuba.ev Fermín E.González La.ora.ory of Experimenta. Immunology&Ca.cer Faculty of DentistryUniversity of ChileSantiagoChile Depa.tment of Conserva.ive Dentistry Faculty of DentistryUniversity of ChileSantiagoChile Division of Chemistry I Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSweden Periodonta. Biology La.ora.ory Faculty of DentistryUniversidad de ChileSantiagoChile La.ora.ory of Cellula. a.d Molecula. Pa.hology Institute for Research in Dental SciencesFaculty of DentistryUniversity of ChileSantiagoChile

Ferroptosis is implicated in the pa.hogenesis of numerous chronic-infla.ma.ory disea.es,yet its a.socia.ion with progressive periodontitis rema.ns *** investiga.e the involvement a.d significa.ce of ferroptosis in periodontitis progression,we a.sessed sixteen periodontitis-dia.nosed *** progression wa. clinica.ly monitored over twelve weeks via.weekly clinica. eva.ua.ions a.d gingiva. crevicula. fluid(GCF)collection wa. performed for further *** metrics,proteomic da.a.in silico methods,a.d bioinforma.ics tools were combined to identify protein profiles linked to periodontitis progression a.d to explore their potentia. connection with *** western blot a.a.yses va.ida.ed key ***,a.single-cell RNa.sequencing(scRNa.seq)da.a.et(GSE164241)for gingiva. tissues wa. a.a.yzed to elucida.e cellula. dyna.ics during periodontitis *** progression wa. identified a. occurring a. a.fa.ter ra.e tha. tra.itiona.ly *** sa.ples from progressing a.d non-progressing periodonta. sites showed qua.tita.ive a.d qua.ita.ively distinct proteomic *** a.dition,specific biologica. processes a.d molecula. functions during progressive periodontitis were revea.ed a.d a.set of hub proteins,including SNCa.Ca.,HBB,SLC4a.,a.d a.K1 wa. strongly a.socia.ed with the clinica. progression sta.us of ***,we found specific proteins-drivers or suppressors-a.socia.ed with ferroptosis(SNCa.FTH1,HSPB1,CD44,a.d GCLC),revea.ing the co-occurrence of this specific type of regula.ed cell dea.h during the clinica. progression of ***,the integra.ion of qua.tita.ive proteomic da.a.with scRNa.seq a.a.ysis suggested the susceptibility of fibrobla.ts to *** a.a.yses revea. proteins a.d processes linked to ferroptosis for the first time in periodonta. pa.ients,which offer new insights into the molecula. mecha.isms of progressive periodonta. *** findings ma. le

关键词： finding progression fa.ter

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a.tra.sfer lea.ning enha.ced physics-informed neura. network for pa.a.eter identifica.ion in soft ma.eria.s

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a.plied Ma.hema.ics a.d Mecha.ics(English Edition) 2024年第10期45卷 1685-1704页

作者： Jing’ang ZHU Yiheng XUE Zishun LIU Interna.iona. Center for a.plied Mecha.ics State Key Laboratory for Strength and Vibration of Mechanical StructuresSchool of Aerospace EngineeringXi’an Jiaotong UniversityXi’an 710049China

Soft ma.eria.s,with the sensitivity to va.ious externa. stimuli,exhibit high flexibility a.d *** prediction of their mecha.ica. beha.iors requires a.va.ced hyperela.tic constitutive models incorpora.ing multiple ***,identifying multiple pa.a.eters under complex deforma.ions rema.ns a.cha.lenge,especia.ly with limited observed *** this study,we develop a.physics-informed neura. network(PINN)fra.ework to identify ma.eria. pa.a.eters a.d predict mecha.ica. fields,focusing on compressible Neo-Hookea. ma.eria.s a.d *** improve a.cura.y,we utilize sca.ing techniques to norma.ize network outputs a.d ma.eria. *** fra.ework effectively solves forwa.d a.d inverse problems,extra.ola.ing continuous mecha.ica. fields from spa.se bounda.y da.a.a.d identifying unknown mecha.ica. *** explore different a.proa.hes for imposing bounda.y conditions(BCs)to a.sess their impa.ts on *** enha.ce efficiency a.d genera.iza.ion,we propose a.tra.sfer lea.ning enha.ced PINN(TL-PINN),a.lowing pre-tra.ned networks to quickly a.a.t to new *** TL-PINN significa.tly reduces computa.iona. costs while ma.nta.ning *** work holds promise in a.dressing pra.tica. cha.lenges in soft ma.eria. science,a.d provides insights into soft ma.eria. mecha.ics with sta.e-of-the-a.t experimenta. methods.

关键词： soft ma.eria. pa.a.eter identifica.ion physics-informed neura. network(PINN) tra.sfer lea.ning inverse problem

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First record of a.norma. body colora.ion in a.rockfish Seba.tes korea.us(Scorpa.noidei:Seba.tida.)from coa.ta. wa.er of China.ba.ed on morphologica. cha.a.teristics a.d DNa.ba.coding

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Journa. of Ocea.ology a.d Limnology 2024年第2期42卷 640-646页

作者： ang LI Hua. Wang Changting a. Shufang LIU Yellow Sea.Fisheries Resea.ch Institute Chinese Academy of Fishery SciencesQingdao 266071China La.ora.ory for Ma.ine Fisheries Science a.d Food Production Processes Laoshan LaboratoryQingdao 266071China

The first record of a.norma. body colora.ion in Seba.tes korea.us Kim a.d Lee,1994,from the Yellow Sea.of China.wa. documented ba.ed on morphologica. cha.a.teristics a.d DNa.*** two rockfish specimens were collected from the coa.ta. wa.ers of Qingda.,China.a.d the whole body a.d a.l fins of them were *** the two red-colored rockfish,there were tiny deep red spots on ea.h fin,2 red ra.ia. stripes behind a.d below the eyes a.d 1 la.ge deep red blotch on the opercula.while the simila. stripe a.d spot pa.terns a.e a.so present in the *** specimens with norma. body *** counta.le cha.a.teristics of the two specimens a.e in the range of the morphometry of *** further cla.ify the species identity a.d ta.onomic sta.us of the two specimens,DNa.ba.code a.a.ysis wa. ca.ried *** genetic dista.ce between the red-colored rockfish a.d *** wa. 0,a.d the minimum net genetic dista.ces between the red-colored rockfish a.d other Seba.tes species except for *** were 3.0%,which exceeds the threshold of species *** phylogenetic a.a.ysis showed tha. the DNa.ba.coding sequences of the two red-colored rockfish clustered with the *** *** a.ove results of DNa.ba.code a.a.ysis a.so support tha. the two red-colored rockfish could be identified a. the species of *** mecha.ism of color va.ia.ion in *** is desira.le for further resea.ch a.d the species could be a. idea. model to study the color-driven specia.ion of the rockfishes.

关键词： a.norma. body colora.ion Seba.tes korea.us coa.ta. wa.er of China Yellow Sea morphologica. cha.a.teristics DNa.ba.coding

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Influence of la.er pa.a.eters on the microstructures a.d surfa.e properties in la.er surfa.e modifica.ion of biomedica. ma.nesium a.loys

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Journa. of Ma.nesium a.d a.loys 2024年第1期12卷 72-97页

作者： Chee Ying Ta. Cuie Wen Hua.Qia. ang School of Engineering RMIT UniversityMelbourneVictoria 3001Australia

Biodegra.a.le impla.ts from ma.nesium(Mg)a.loys ha.e emerged in the biomedica. field especia.ly in the orthopedic a.d ca.diova.cula. stent a.plications owing to their low density,high specific strength,excellent ma.hina.ility,good biocompa.ibility,a.d *** prima.y shortcoming of Mg-ba.ed impla.ts is their low corrosion resista.ce in the physiologica. environment,which results in prema.ure mecha.ica. integrity loss before a.equa.e hea.ing a.d the production of excessive hydrogen ga.,which is ha.mful to the body tissues a.d nega.ively a.fects the biocompa.ibility of the *** surfa.e modifica.ion ha. recently received a.tention beca.se it ca. improve the surfa.e properties such a. surfa.e chemistry,roughness,topogra.hy,corrosion resista.ce,wea. resista.ce,hydrophilicity,a.d thus cell response to the surfa.e of the *** composition a.d microstructures including textures a.d pha.es of la.er-trea.ed surfa.es depend la.gely on the la.er processing pa.a.eters(input la.er power,la.er sca. velocity,frequency,pulse dura.ion,pressure,ga. circula.ion,working time,spot size,bea. foca. position,a.d la.er tra.k overla.)a.d the thermophysica. properties of the substra.e(solubility,melting point,a.d boiling point).This review investiga.es the impa.ts of va.ious la.er surfa.e modifica.ion techniques including la.er surfa.e melting,la.er surfa.e a.loying,la.er cla.ding,la.er surfa.e texturing,a.d la.er shock peening,a.d highlights their significa.ce in improving the surfa.e properties of biodegra.a.le Mg a.loys for impla.t ***,we explore how different la.er process pa.a.eters a.fect its composition,microstructure,a.d surfa.e properties in ea.h la.er surfa.e modifica.ion technique.

关键词： Biocompa.ibility Biodegra.a.ility Corrosion Impla.t a.plications La.er surfa.e modifica.ion Ma.nesium a.loys

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Secure sta.e estima.ion for cyber-physica. systems with unknown input sliding mode observer

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Control Theory a.d Technology 2024年第2期22卷 244-253页

作者： Pa.pa. Zhang Yuwei Ren Yixia. Fang ang Liu School of Informa.ion Science a.d Engineering Shandong Normal UniversityJinan250358ShandongChina School of Informa.ion Engineering Shandong Management UniversityJinan250357ShandongChina

In recent yea.s, cyber a.ta.ks ha.e posed grea. cha.lenges to the development of cyber-physica. systems. It is of grea. significa.ce to study secure sta.e estima.ion methods to ensure the sa.e a.d sta.le opera.ion of the system. This pa.er proposes a.secure sta.e estima.ion for multi-input a.d multi-output continuous-time linea. cyber-physica. systems with spa.se a.tua.or a.d sensor a.ta.ks. First, for spa.se sensor a.ta.ks, we propose a. a.a.tive switching mecha.ism to mitiga.e the impa.t of spa.se sensor a.ta.ks by filtering out their a.ta.k modes. Second, a. unknown input sliding mode observer is designed to not only observe the system sta.es, sensor a.ta.k signa.s, a.d mea.urement noise present in the system but a.so countera.t the effects of spa.se a.tua.or a.ta.ks through a. unknown input ma.rix. Fina.ly, for the design of a. unknown input sliding mode sta.e observer, the fea.ibility of the observing system is demonstra.ed by mea.s of Lya.unov functions. a.ditiona.ly, simula.ion experiments a.e conducted to show the effectiveness of this method.

关键词： Spa.se a.ta.ks Cyber-physica. systems Unknown input sliding mode Secure sta.e estima.ion a.a.tive switching mecha.ism

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Epidemiology of work-rela.ed ha.d a.d wrist injuries in a.referra. center: a.descriptive study

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World Journa. of Orthopedics 2024年第7期15卷 650-659页

作者： angélica M Rodríguez Ginna.P Toca.chón Jessica.T Villa.ba.Luis M Pombo a.íba. a.Teherán Ga.riel Ca.ero-Ra.os Ka.en P a.a.a.Gerha.d M a.ero Resea.ch Center Fundación Universitaria Juan N.CorpasBogotá111321Colombia Red Cross Cruz Roja Colombiana-Seccional Cundinamarca BogotáBogotá111221Colombia Vigila.cia.Epidemiológica Instituto Nacional de SaludBogotá111321Colombia

Ba.KGROUND Occupa.iona. ha.d a.d wrist injuries(OHWIs)a.count for 25%of work-rela.ed a.cidents in low-a.d middle-income *** Colombia.more tha. 500000 occupa.iona. a.cidents occurred in 2021,a.d a.though the ra.e declined to less tha. 5%in 2020 a.d 2021,a. lea.t one in four a.cidents involved a.ha.d or wrist *** To describe the OHWIs in workers seen a. the emergency room a. a.second-level hospita. in *** a. observa.iona. study wa. performed using da.a.from workers who experienced OHWIs a.d a.tended a.second-level hospita.,between June,2020 a.d Ma.,*** overa.l frequency of OHWIs,a. well a. their distribution by sociodemo-gra.hic,clinica.,a.d occupa.iona. va.ia.les,a.e ***,a.socia.ion pa.terns between sex,a.a.omica. a.ea.fingers,ha.d,wrist),a.d type of job were a.a.yzed by correspondence a.a.ysis(Ca..RESULTS There were 2.101 workers trea.ed for occupa.iona. a.cidents,423(20.3%)were ca.es of OHWIs,which ma.nly a.fected men(93.9%)with a.media. a.e of 31 yea.s a.d who worked ma.nly in mining(75.9%).OHWIs were more common in the right upper extremity(55.3%)a.d comprised different types of injuries,such a. contusion(42.1%),la.era.ion(27.9%),fra.ture(18.7%),a.d crush injury(15.6%).They prima.ily a.fected the pha.anges(95.2%),especia.ly those of the first finger(25.7%).The Ca. showed a.socia.ions between the injured a.a.omica. a.ea.a.d the worker’s job tha. differed in men a.d women(expla.ned va.ia.ce>90%).CONCLUSION One out of five workers who suffered occupa.iona. a.cidents in Cundina.a.ca.Columbia.ha. a. OHWI,a.fecting ma.nly ma.es employed in *** occupa.iona. profile is likely to lea. to prolonged reha.ilita.ion,a.d perma.ent functiona. *** results might be useful for a.justing preventive mea.ures in cluster risk groups.

关键词： a.cidents Occupa.iona. Epidemiology Ha.d injuries Wrist injuries Occupa.iona. hea.th

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Recent a.va.ces in In-Memory Computing:Exploring Memristor a.d Memtra.sistor a.ra.s with 2D Ma.eria.s

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Na.o-Micro Letters 2024年第7期16卷 1-30页

作者： Hangbo Zhou Sifa. Li Ka.-Wee ang Yong-Wei Zhang Institute of High Performa.ce Computing(IHPC) Agency for ScienceTechnology and Research(A*STAR)1 Fusionopolis Way#16-16 ConnexisSingapore 138632Republic of Singapore Depa.tment of Electrica. a.d Computer Engineering National University of Singapore4 Engineering Drive 3Singapore 117583Republic of Singapore Institute of Ma.eria.s Resea.ch a.d Engineering Agency for ScienceTechnology and Research(A*STAR)2 Fusionopolis WaySingapore 138634Republic of Singapore

The conventiona. computing a.chitecture fa.es substa.tia. cha.-lenges,including high la.ency a.d energy consumption between memory a.d processing *** response,in-memory computing ha. emerged a. a.promising a.terna.ive a.chitecture,ena.ling computing opera.ions within memory a.ra.s to overcome these *** devices ha.e ga.ned significa.t a.tention a. key components for in-memory computing due to their high-density a.ra.s,ra.id response times,a.d a.ility to emula.e biologica. *** these devices,two-dimensiona.(2D)ma.eria.-ba.ed memristor a.d memtra.sistor a.ra.s ha.e emerged a. pa.ticula.ly promising ca.dida.es for next-genera.ion in-memory computing,tha.ks to their exceptiona. performa.ce driven by the unique properties of 2D ma.eria.s,such a. la.ered structures,mecha.ica. flexibility,a.d the ca.a.ility to form *** review delves into the sta.e-of-the-a.t resea.ch on 2D ma.eria.-ba.ed memristive a.ra.s,encompa.sing critica. a.pects such a. ma.eria. selection,device perfor-ma.ce metrics,a.ra. structures,a.d potentia. ***,it provides a.comprehensive overview of the current cha.lenges a.d limita.ions a.socia.ed with these a.ra.s,a.ong with potentia. *** prima.y objective of this review is to serve a. a.significa.t milestone in rea.izing next-genera.ion in-memory computing utilizing 2D ma.eria.s a.d bridge the ga. from single-device cha.a.teriza.ion to a.ra.-level a.d system-level implementa.ions of neuromorphic computing,levera.ing the potentia. of 2D ma.eria.-ba.ed memristive devices.

关键词： 2D ma.eria.s Memristors Memtra.sistors Crossba. a.ra. In-memory computing

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