检索结果-南通市图书馆

Novel pharmacological therapy in type 2 diabetes mellitus with established cardiovascular disease: Current evidence

World Journal of Diabetes 2019年第5期10卷 291-303页

作者： Leonardo Pozo Fatimah Bello Andres Suarez Francisco E ochoa-Martinez Yamely Mendez Chelsea H Chang Salim Surani University of Texas Rio Grande Valley-Doctors Hospital at Renaissance Internal Medicine Residency Program Faculty of Medicine Universidad Autonoma de Nuevo LeonUniversity Hospital "Dr. José Eleuterio González" Faculty of Medicine "Dr. Alberto Romo Caballero" Universidad Autonoma de Tamaulipas Medical Critical Care Services Christus Spohn Hospitals-Corpus Christi

Cardiovascular diseases(CVDs) remain the leading cause of death in the world and in most developed countries. Patients with type 2 diabetes mellitus(T2DM)suffer from both microvascular and macrovascular diseases and therefore have higher rates of morbidity and mortality compared to those without T2DM. If current trends continue, the Center for Disease Control and Prevention estimates that 1 in 3 Americans will have T2DM by year 2050. As a consequence of the controversy surrounding rosiglitazone and the increasing prevalence of diabetes and CVDs, in 2008 the Food and Drug Administration(FDA) established new expectations for the evaluation of new antidiabetic agents, advising for pre and,in some cases, post-marketing data on major cardiovascular events. As a direct consequence, there has been a paradigm shift in new antidiabetic agents that has given birth to the recently published American Diabetes Association/European Association for the Study of Diabetes consensus statement recommending sodium-glucose cotransporter-2 inhibitors(SGLT2i) and glucagon like peptide-1 receptor agonists(GLP-1RA) in patients with T2DM and established CVD. As a result of over a decade of randomized placebo controlled cardiovascular outcome trials, the aforementioned drugs have received FDA approval for risk reduction of cardiovascular(CV) events in patients with T2DM and established CV ***2i have been shown to have a stronger benefit in patients with congestiveheart failure and diabetic kidney disease when compared to their GLP-1RA counterparts. These benefits are not withstanding additional considerations such as cost and the multiple FDA Black Box warnings. This topic is currently an emerging research area and this mini-review paper examines the role of these two novel classes of drugs in patients with T2DM with both confirmed, and at risk for, CVD.

关键词： Type 2 diabetes mellitus Glucagon-like-peptide 1 agonists Sodium-glucose cotransporter-2 inhibitor Cardiovascular disease Major adverse cardiovascular event

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microstructure and hydrogen storage properties of as-cast and rapidly solidified Ti-rich Ti-V alloys

引用

Transactions of Nonferrous Metals Society of China 2012年第8期22卷 1831-1838页

作者： Suwarno SUWARNO Jan Ketil SOLBERG Jan Petter MAEHLEN Bente KROGH Bφrre Tore BφRRESEN Esther ochoa-FERNANDEZ Erling RYTTER Mario WILLIAMS Roman DENYS Volodymyr A.YARTYS Department of Materials Science and Engineering Norwegian University of Science and TechnologyNO-7491TrondheimNorway Institute for Energy Technology P.O.Box 40NO-2027KjellerNorway Statoil Research Centre RotvollN-7005TrondheimNorway University of the Western Cape Private Bag X17Bellville7535South Africa

The goal of the present work was to optimize the phase-structural composition and microstructure of binary Ti0.8-0.9V0.2-0.1 alloys with respect to their hydrogen sorption properties. Application of these alloys is for hydrogen absorption from gaseous mixtures containing substantial amounts of carbon monoxide （CO） at high temperatures. Irrespective of alloy composition, both α（HCP） and β（BCC） phases in Ti0.8-0.9V0.2-0.1 formed single phase FCC hydrides upon hydrogenation in pure H2. An in situ synchrotron X-ray diffraction study showed that only the β-phase transformed to the corresponding hydride when the alloy was hydrogenated in a mixture of H2＋10%CO. Rapid solidification （RS） of the alloy resulted in refined grain sizes both in the Ti0.8V0.2 and Ti0.9V0.1 alloys. Furthermore, RS was found to increase the β-phase fraction in Ti0.9V0.1, being twice larger than that of the as-cast alloy. Ti0.9V0.1 had a platelike microstructure as observed by scanning electron microscopy （SEM）, the plates were about 300 nm thick. The microstructure refinement resulted in a faster kinetics of H desorption as observed by temperature desorption spectroscopy （TDS）.

关键词： hydrogen storage Ti-V alloys rapid solidification synchrotron X-ray diffraction carbon monoxide

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Education in trauma： An educational alternative that promotes injury prevention

引用

Chinese Journal of Traumatology 2017年第5期20卷 275-277页

作者： Jose Daniel Charry Juan Daniel ochoa Jorman Harvey Tejada Sandra Liliana Navarro-Parra Nicolas Esquivel Yolercy Vasques Research Department Fundaci6n Universitaria Navarra Uninavarra Neiva Colombia Department of Medicine Universiclad Surcolombiana Neiva Colombia Research Department Universidad de Jaen Spain

Purpose： As trauma is a public health problem, different programs have been designed to prevent in- juries. The aim of this study was to evaluate the effectiveness of an educational model that measures the adolescents＇ attitudes towards the rules of road safety, alcohol and road accidents in Colombia. Methods： A pedagogical model evaluating the effect of road safety education and adolescents＇ attitudes towards and experiences of alcohol and road accidents in Colombia was created. After the education concluded, this educational process is analyzed by its impact on adolescents＇ behavior. The educational program included 160 adolescents with the mean age being 1Z5 years. Results： The test results indicated that before the educational program 80g of adolescents did not use a safety element when driving, while after the educational program the percentage of no helmet use among adolescents decreased from 72.5% to 24.3% （p = 0.0001 ） and driving a vehicle under the state of drunkenness from 49.3% to 8.1% （p = 0.0001）. Conclusion： An educational model aimed at preventing injuries caused by traffic accidents is shown to be effective in generating changes in adolescents＇ customs of and attitudes towards alcohol and road safety standards in Colombia.

关键词： Models Educational Trauma Injury prevention Alcohol

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Land cover changes and fragmentation in mountain neotropical ecosystems of Oaxaca, Mexico under community forest management

引用

Journal of Forestry Research 2019年第1期30卷 143-155页

作者： Rafael M~a Navarro Cerrillo Dennis J.Esteves Vieira Susana ochoa-Gaona Bernardus H.J.de Jong M~a del Mar Delgado Serrano Depto. Ingeniería Forestal Laboratorio de SelviculturaDendrocronología y Cambio Climático.Dendrodat Lab-ERSAF Universidad de Córdoba Depto. de Engenharia Florestal Faculdade de Engenharia Florestal Laboratório de Sensoriamento Remoto e Geotecnologia Universidade Federal de Mato Grosso Departamento de Ciencias de la Sustentabilidad El Colegio de la Frontera Sur-Unidad Campeche Depto. Economía Sociología y Política Agrarias Grupo de Evaluación y Restauración de Sistemas Agrícolas y Forestales-ERSAF Universidad de Córdoba

Changes in land cover have a direct impact on forest ecosystem goods and services. In this study, changes in land cover in Sierra de Juarez–Oaxaca ecosystems were estimated using a consistent processing of Landsat images and OBIA methodology. Additionally, landscape analyses using FRAGSTAT were conducted. In 2014, Sierra de Juarez–Oaxaca was covered by approximately 84% of forests, mainly pine-oak and cloud forests. After extensive deforestation until 2001, this trend was reversed and the forest cover surface area in 2014 was slightly higher than in 1979. The comparison of the landscape structure of the forested and agricultural lands suggests an increase in habitat heterogeneity. However, interspersion and juxtaposition indices, showing the patch shape by patch area and perimeter, were similar throughout the study period(1979–2014). Social and economic drivers can explain this situation: namely, community organization, forest enterprises, payment for ecosystem services programs, and changes of agricultural activity. Communities in the Sierra of Oaxaca have reforested degraded lands, created community forest enterprises, and preserved the forest under conservation schemes like those proposed by the Mexican payment for ecosystem services programs. However, their sustainable management faces internal challenges and has become highly dependent on political and institutional decisions beyond their control.

关键词： Tropical and temperate forests Social forestry Land uses segmentation OBIA FRAGSTAT

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

RESEARCH PROGRESS ON THE IMPACT OF NITROGEN DEPOSITION ON GLOBAL GRASSLANDS

引用

Frontiers of Agricultural Science and Engineering 2022年第3期9卷 425-444页

作者： Carly J.STEVENS Sofía BASTO Michael DBELL Tianxiang HAO Kevin KIRKMAN Raul ochoa-HUESO Lancaster Environment Centre Lancaster UniversityLancasterLA14YQUK Unidad de Ecologia y Sistematica Departamento de BiologiaFacultad de CienciasPontificia Universidad JaverianaCarrera 7 No.43-82 Ed.Jesus Emilio Ramirez(53)BogotaColombia National Park Service Air Resources DivisionLakewoodCO 80235USA Synthesis Research Center of Chinese Ecosystem Research Network Key Laboratory of Ecosystem Network Observation and ModelingInstitute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China College of Resources and Environmental Sciences National Academy of Agriculture Green DevelopmentKey Laboratory of Plant-Soil Interactions of Ministry of EducationBeijing Key Laboratory of Farmland Soil Pollution Prevention and RemediationChina Agricultural UniversityBeijing 100193China School of Life Sciences University of KwaZulu-NatalDurban4041South Africa Departamento de Biologia-IVAGRO Universidad de CadizCampus Rio San Pedro11510 Puerto RealSpain Department of Terrestrial Ecology Netherlands Institute of Ecology(NIOO-KNAW)P.O.Box 506700 ABWageningenthe Netherlands

Grasslands are globally-important ecosystems providing critical ecosystem *** species composition and characteristics of grasslands vary considerably across the planet with a wide variety of different grasslands ***,in many regions grasslands have been impacted by atmospheric nitrogen deposition originating from anthropogenic activities with effects on productivity,species composition and diversity widely *** vary across grassland habitats but many show declines in species richness and increases in biomass production related to soil eutrophication and *** a continental level,there is considerable variation in the research effort that has been put into understanding the impacts of nitrogen *** Europe,North America and parts of Asia,although there are unanswered research questions,there is a good understanding of N deposition impacts in most grassland *** is not the case in other regions with large knowledge gaps in some parts of the *** paper reviews the impacts of N deposition on grasslands around the world,highlighting recent advances and areas where research is still needed.

关键词： acidification biomass production critical load eutrophication species composition species richness

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recognition of a multiple antigen peptide containing sequence from mimotope of the dengue type 3 virus NS4B protein by human antibodies

引用

Asian Pacific Journal of Tropical Medicine 2016年第2期9卷 126-129页

作者： Nevis Amin Maritza Pupo Alicia Aguilar Susana Vázquez Yamira Caballero Rolando ochoa María G Guzmán Armando Acosta Implementation and Design of Clinical trials Clinical Research and Impact Evaluation Direction Finlay Institute ‘Pedro Kourí’Tropical Medicine Institute (IPK) PAHO/WHO Collaborating Center for the Study of Dengue and its Vector

Objective: To evaluate the recognition of NS4 B mimotope, as multiple antigen peptide(MAP), by dengue antibodies presents in serum samples from patients with different serotype infections. Methods: A MAP containing mimotope sequence was synthesized and used to evaluate the recognition of NS4 B mimotope as MAP by a panel of 66 human sera from dengue cases by an indirect ELISA assay. Results: The MAP differentiated between sera from dengue viruses infected patients and sera from healthy individuals and the best reactivity was shown by serum from dengue type 3 virus patients. The recognition was more intense with serum from patients with secondary infection. Conclusions: The findings suggest the potential use of NS4 B mimotope on the development of a multi-epitope diagnostic tool. These results are important for further immunogenicity studies.

关键词： MAP Antibodies NS4B Dengue virus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrated chromatin and transcriptomic profiling of patient-derived colon cancer organoids identifies personalized drug targets to overcome oxaliplatin resistance

引用

Genes & Diseases 2021年第2期8卷 203-214页

作者： Kuei-Ling Tung Kai-Yuan Chen Marcos negrete Tianyi Chen Alexias Safi Abed Alhalim Aljamal Lingyun Song Gregory E.Crawford Shengli Ding David S.Hsu Xiling Shen Department of Biological and Environmental Engineering Cornell UniversityIthacaNY14853USA Department of Biomedical Engineering Pratt School of EngineeringDuke UniversityDurhamNC27708USA Center for Genomics and Computational Biology Duke UniversityDurhamNC27708USA Department of Medical Oncology Duke University Medical CenterDurhamNC27708USA Department of Pediatrics Division of Medical GeneticsDuke UniversityDurhamNC27708USA Duke Cancer Institute Duke UniversityDurhamNC27708USA

Colorectal cancer is a leading cause of cancer *** colorectal cancer patients eventually develop chemoresistance to the current standard-of-care ***,we used patient-derived colorectal cancer organoids to demonstrate that resistant tumor cells undergo significant chromatin changes in response to oxaliplatin *** transcriptomic and chromatin accessibility analyses using ATAC-Seq and RNA-Seq identified a group of genes associated with significantly increased chromatin accessibility and upregulated gene ***/Cas9 silencing of fibroblast growth factor receptor 1(FGFR1)and oxytocin receptor(OXTR)helped overcome oxaliplatin ***,treatment with oxaliplatin in combination with an FGFR1 inhibitor(PD166866)or an antagonist of OXTR(L-368,899)suppressed chemoresistant ***,oxaliplatin treatment did not activate either FGFR1 or OXTR expression in another resistant organoid,suggesting that chromatin accessibility changes are *** use of patient-derived cancer organoids in combination with transcriptomic and chromatin profiling may lead to precision treatments to overcome chemoresistance in colorectal cancer.

关键词： Chromatin accessibility Drug screening Patient-derived organoids Personalized medicine Target discovery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Anaplerosis in cancer: Another step beyond the warburg effect

引用

American Journal of Molecular Biology 2012年第4期2卷 291-303页

作者： Estefania ochoa-Ruiz Rodrigo Diaz-Ruiz Facultad de Medicina Programa de Posgrado en Ciencias Médicas Odontológicas y de la Salud Universidad Nacional Autónoma de México Mexico City Mexico Unidad de Genética de la Nutrición Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México Mexico City Mexico

Biosynthesis is up-regulated in tumors and thus the demand for anabolic intermediates is increased. The metabolic routes providing the building blocks for macromolecules are thus a very attractive target as they are not normally up-regulated in a normal quiescent cell. Some routes for glycolysis-derived intermediates production have been identified, but these do not constitute the whole pool of biosynthetic molecules in the cell, as many of these derive from mitochondria in the Krebs cycle. Indeed, this metabolic pathway is considered a “biosynthetic hub” from which anabolism is fed. If a metabolite efflux is indeed occurring, anaplerotic reactions must keep a steady supply of substrates. In spite of this obvious relevance of anaplerosis, it has been poorly characterized in the malignant cell context. Glutaminolysis and and pyruvate carboxylation are two pathways that function in an anaplerotic fashion. In spite of the increasing evidence implicating these two processes in cancer metabolism their role as intermediate providers is overlooked. In this review we analyze the implications of an active anaplerosis in cancer and we discuss experimental evidence showing the relevance of these metabolic routes in tumor physiology.

关键词： Anaplerosis Biosynthesis Cancer Glutaminase Krebs Cycle Metabolism Mitochondria Pyruvate Carboxylase Warburg Effect

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dendritic nanoarchitecture imparts ZSM-5 zeolite with enhanced adsorption and catalytic performance in energy applications

引用

Journal of Energy Chemistry 2023年第5期80卷 77-88,I0003页

作者： María del Mar Alonso-Doncel Cristina ochoa-Hernández Gema Gómez-Pozuelo Adriana Oliveira JoséGonzález-Aguilar ángel Peral Raúl Sanz David P.Serrano Thermochemical Processes Unit IMDEA Energy InstituteAvda.Ramon de la Sagra3E28935MostolesMadridSpain Department of Heterogeneous Catalysis Max-Planck-Institut für KohlenforschungKaiser-Wilhem-Platz14540Muheim an der RuhGermay Department of Chemical and Environmental Technology Rey Juan Carlos UniversityC/Tulipan s/nE28933MostolesMadridSpain High Temperature Processes Unit IMDEA Energy InstituteAvda.Ramon de la Sagra3E28935MostolesMadridSpain Department of Chemical Energy and Mechanical TechnologyRey Juan Carlos UniversityC/Tulipan s/n28933MostolesMadridSpain

The development of zeolites possessing dendritic features represents a great opportunity for the design of novel materials with applications in a large variety of fields and,in particular,in the energy sector to afford its transition towards a low carbon *** the current work,ZSM-5 zeolite showing a dendritic3D nanoarchitecture has been synthesized by the functionalization of protozeolitic nanounits with an amphiphilic organosilane,which provokes the branched aggregative growth of zeolite *** ZSM-5 exhibits outstanding accessibility arising from a highly interconnected network of radially-oriented mesopores(3-10 nm)and large cavities(20-80 nm),which add to the zeolitic micropores,thus showing a well-defined trimodal pore size *** singular features provide dendritic ZSM-5 with sharply enhanced performance in comparison with nano-and hierarchical reference materials when tested in a number of energy related applications,such as VOCs(toluene)adsorption(improved capacity),plastics(low-density polyethylene)catalytic cracking(boosted activity)and hydrogen production by methane catalytic decomposition(higher activity and deactivation resistance).

关键词： Dendritic ZSM-5 VOCs adsorption Plastics cracking Methane decomposition Hydrogen production

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

First report of Phytopythium vexans causing the“Avocado sadness”in Michoacan,Mexico

引用

Phyton-International Journal of Experimental Botany 2019年第1期88卷 11-13页

作者： Hernandez Perez A E Cerna Chavez JC Delgado Ortiz M Beltran Beache LM Tapia Vargas YM ochoa Fuentes Estudiante del postgrado Universidad Autonoma Agraria Antonio Narro Departamento de ParasitologiaBuenavistaSaltilloCoahuilaMexico CP 25315 Universidad Autonoma Agraria Antonio Narro Departamento de ParasitologiaBuenavistaSaltilloCoahuilaMexico CP 25315 Catedratico CONACYT-UAAAN.Universidad Autonoma Agraria Antonio Narro Departamento de ParasitologiaBuenavistaSaltilloCoahuilaMexico CP 25315 CULTA S.A.de C.V. InvestigacionDesarrolloAltavistaEl ManteTamaulipasMexico CP 898800 INIFAP Campo Experimental Uruapan.Av.Latinoamericana No.1101Col.Revolucion CP.60500UruapanMichoacanMexico

Mexico is the main producer,consumer and exporter of avocado in the world,being Michoacan the main producer state contributing more than 80%of the national *** are phytopathogens that decimate the production causing the death of the *** samples were collected in avocado trees that showed the characteristic symptomatology of the disease known as avocado sadness,the sampling was carried out in four of the main avocado producing towns,in the state of Michoacan,*** isolation consisted in sowing root tissue in Petri dishes with V8R-PARPH culture medium,subsequently they were identified morphologically and for species level it was determined by molecular biology,with the PCR-ITS *** tests were performed in triplicate with avocado seedlings with more than six *** 24 hours,the inoculated plants expressed decay in the apical part,after 120 hours the leaves showed yellowing and after 15 days there was a generalized wilt on the stem and leaves,re-isolating the phytopathogen Phytopythium *** study confirms the first report of the oomycete *** affecting avocado trees in the most important producing region of the Mexican Republic.

关键词： Molecular identification Pathogenicity Phytopythium vexans Avocado.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：