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Influence of silybin on biophysical properties of phospholipid bilayers

Acta Pharmacologica Sinica 2007年第2期28卷 296-306页

作者： OlgaWESO￡OWSKA Barbara￡ANIA-PIETRZAK MichaKU~-D~-A￡ KamilaSTAN~CZAK DanielaMOSI PiotrDOBRYSZYCKI andrzejo~-yhar Magorzata KOMOROWSKA AndrzejBHENDRICH KrystynaMICHALAK Department of Biophysics Wroclaw Medical Universityul Chalubinskiego 1050-368 WroclawPoland DZ Division of Biochemistry Institute of Organic ChemistryBiochemistry and BiotechnologyWroclaw University of Technologyul Wybrzeze Wyspianskiego 2750-370 WroclawPoland Institute of Physics Wroclaw University of Technology ul Wybrzeze Wyspianskiego 2750-370 WroclawPoland skiego 2750-370 WroclawPoland

Aim:Silybin(silibinin)is major biologically active flavonolignan extracted frommilk thistle(Sylibum marianum).Its biological activities include hepato-protection,anticancer properties,and antioxidant-and membrane-stabilizing ***-though membranes are postulated to be one of the cellular targets for silybin,littleis known about its interaction with phospholipid ***:In the presentwork,the interactions of silybin with phosphatidylcholine bilayers were studiedin detail using fluorescence spectroscopy,microcalorimetry and electron spinresonance ***:The results showed that silybin interacted withthe surface of lipid *** affected the generalized polarization of the fluores-cent probe Prodan,while not influencing the more deeply located *** the main phospholipid phase transition temperature as judged bymicrocalorimetry,and caused the immobilization of spin probe Tempo-palmitatelocated on the surface of *** mobility of spin probes 5-and 16-doxylstearic acid was not affected by ***-induced quenching of 1,6-diphe-nyl-1,3,5-hexatriene fluorescence indicated that some flavonoid molecules parti-tioned into the hydrophobic region of membranes,which did not change signifi-cantly the biophysical properties of the deeper membrane ***:Such a behavior of silybin in membranes is in accordance with its postulatedbiological functions and neglectable side effects of therapies using silybin.

关键词： silybin(silibinin) phospholipid bilayer fluorescence spectroscopy microcalorimetry electron spin resonance flavonoids

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