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Possible Mechanism of Action of Neurokinin-1 Receptors （NK1R） Antagonists

Journal of Pharmacy and Pharmacology 2017年第11期5卷 787-797页

作者： Ozum Ozturk Esin Aki-Yalcin Tugba Ertan-Bolelli Kayhan Bolelli andry nur-hidayat Ozlem Bingol-Ozakpinar Filiz Ozdemir Ismail Yalcin Pharmacy Chemistry Department Faculty of Pharmacy Ankara University Ankara 06100 Turkey Bioinformatics Department Biotechnology Institution Ankara University Ankara 06100 Turkey Biochemistry Department Faculty of Pharmacy Marmara University Istanbu134722 Turkey Analytical Chemistry Department Faculty of Pharmacy Marmara University Istanbu134722 Turkey

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Recent antibacterial agents from biomass derivatives:Characteristics and applications

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Journal of Bioresources and Bioproducts 2024年第3期9卷 283-309页

作者： Nissa nurfajrin Solihat Alif Faturahman hidayat R.A.Ilyas Senthil Muthu Kumar Thiagamani nur Izyan Wan Azeele Fahriya Puspita Sari Maya Ismayati Mohammad Irfan Bakshi Zaharaddeen N.Garba M.Hazwan Hussin Witta Kartika Restu Wasrin Syafii Harits Atika Ariyanta Widya Fatriasari Research Center for Biomass and Bioproducts National Research and Innovation Agency(BRIN)Kawasan KST SoekarnoJl Raya Bogor KM 46 Cibinong Bogor 16911Indonesia Department of Bioproducts and Biosystems School of Chemical EngineeringAalto UniversityEspoo 16300Finland Department of Chemical Engineering Faculty of Chemical and Energy EngineeringUniversiti Teknologi MalaysiaJohor 81310Malaysia Centre for Advanced Composite Materials Universiti Teknologi MalaysiaJohor 81310Malaysia Institute of Tropical Forestry and Forest Products Universiti Putra MalaysiaSerdang 43400Malaysia Centre of Excellence for Biomass Utilization Universiti Malaysia PerlisPerlis 02600Malaysia Department of Mechanical Engineering Kalasalingam Academy of Research and EducationKrishnankoil 626126India Institute of Bioproduct Development(IBD) Universiti Teknologi MalaysiaJohor 81310Malaysia Department of Chemistry Ahmadu Bello UniversityZaria 810211Nigeria Materials Technology Research Group(MaTReC) School of Chemical SciencesUniversiti Sains MalaysiaMinden 11800Malaysia Research Center for Chemistry National Research and Innovation Agency(BRIN)Kawasan Puspiptek SerpongSouth Tangerang 15314Indonesia Department of Forest Products Faculty of Forestry and EnvironmentIPB UniversityBogor 16680Indonesia Department of Pharmacy Gunadarma UniversityDepok 16424Indonesia Research Collaboration Center of Biomass-Based Nano Cosmetic In collaboration with National Research and Innovation Agency(BRIN)SamarindaEast KalimantanIndonesia

Enhancing awareness of personal cleanliness and antibacterial resistance has intensified the antibacterial substance request on consumable products. Antibacterial agents that have been commercialized nowadays are produced from inorganic and non-renewable substances. This provides several drawbacks, particularly against health and environmental issues. Therefore, many scientists work on substituting fossil-fuel-based antibacterial agents with natural ones such as from biomass. Biomass derivatives, natural abundances of biopolymers in the world, amount to major compounds including polysaccharides (cellulose, hemicellulose, and chitosan) and polyphenol (tannin and lignin) substances which are capable to combat the growth of Gram-positive bacteria and Gram-negative bacteria. To date, no report focuses on a deep understanding of antibacterial properties derived from biomass and the internal and external factors effects. This work provides that gap because comprehensive knowledge is necessary before applying biomass to the products. The potency of biomass derivatives as antibacterial additives is also summarized. Basic knowledge of antibacterial characteristics to the application in products is highlighted in this review. Besides, the discussion about challenges and future perspectives is also delivered.

关键词： Antibacterial Application Biomass derivatives Challenge Future perspectives

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Cypermethrin triggers apoptosis, depletes granulosa cells, and induces endometrium thinning in female rats

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Asian pacific Journal of Reproduction 2019年第4期8卷 141-147页

作者： Novita Eka Kusuma Wardani Respatiningrum Respatiningrum Anis nur Laili Dwi Yuni nur hidayati Setyawati Soeharto hidayat Sujuti Midwifery Master Program Faculty of MedicineUniversity of BrawijayaMalangEast JavaIndonesia Midwifery Program Study of Bangkalan Midwifery Department of Health Polytechnic of Ministry of Health SurabayaEast JavaIndonesia Midwifery Program Health Polytechnic of Ministry of Health of TanjungpinangRiau ArchipelagoIndonesia Department of Microbiology Faculty of MedicineUniversity of BrawijayaMalangEast JavaIndonesia Department of Pharmacology Faculty of MedicineUniversity of BrawijayaMalangEast JavaIndonesia Program of Master of Biomedical Science Faculty of MedicineUniversity of BrawijayaMalangEast JavaIndonesia

Objective: To analyze the effects of subchronic cypermethrin on the ovary and endometrium as well as the involvement of apoptosis in the toxicity of cypermethrin. Methods: A total of 32 female Wistar rats were randomly divided into four groups, with 8 rats in each group. The control group received no treatment, and the other three groups received oral cypermethrin at 10, 15 or 20 mg/kg body weight for 28 days (sub-chronic). The granulosa cells were calculated histopathologically. The apoptotic index was determined by in situ technique. Histopathological examination was performed on the uterus and ovary. Results: There was no significant difference in the number of primary follicular granulosa cells between the treatment groups and the control group (P>0.05). However, the number of secondary and tertiary follicle granulosa cells in the treatment groups was significantly decreased compared to that of the control group (P all<0.05). The apoptotic index of primary follicular granulosa cells increased significantly in the groups treated with cypermethrin compared with the control group (P<0.05). The secondary, tertiary, and endometrial granulosa cell apoptosis index was significantly higher in all treatment groups compared to the control group (P<0.05). The higher the dose of cypermethrin was, the higher the apoptotic index of secondary, tertiary and endometrial granulosa cells was. There was a significant decrease in endometrial thickness in the three treatment groups compared to the control group (P<0.05). Thinning of the endometrial layer was seen in the cypermethrin exposure groups. Conclusions: Exposure to cypermethrin can suppress the number of secondary and tertiary follicular granulosa cells, and trigger thinning of the endometrium through induction of apoptosis.

关键词： Endocrine disruptor Pyrethroid pesticide Uterus Reproduction Apoptosis

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Neuropathy optic glaucomatosa induced by systemic hypertension through activation endothelin-1 signaling pathway in central retinal artery in rats

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International Journal of Ophthalmology(English edition) 2016年第11期9卷 1568-1577页

作者： Seskoati Prayitnaningsih hidayat Sujuti Maksum Effendi Aulia Abdullah Nanda Wahyu Anandita Febriani Yohana nur Permatasari Mohamad Aris Widodo Department of Ophthalmology Faculty of MedicineBrawijaya University Pharmacology Laboratory Faculty of MedicineBrawijaya University

AIM： To evaluate effect of hypertension on retinal ganglion cell（RGC） apoptosis, intraocular pressure（IOP）,and the activation of endothelin-1（ET-1） signaling pathway in central retinal artery（CRA） in ***： The experimental study was performed on20 male Sprague Dawley rats that were divided into control group, and hypertension groups. The hypertension was induced by subcutaneous deoxycorticoacetate（DOCA）10 mg/kg twice a week and administered 0.9% Na Cl solution daily for 2, 6, and 10 wk. Blood pressure（BP） was measured using animal BP analyzer. IOP was measured by handheld tonometry. Retinal tissue preparations by paraffin blocks were made after enucleation. The expression of ET-1, e NOS, ET-1 receptor A（ETRA）, ET-1receptor B（ETRB）, and phosphorylated myosin light chain kinase（MLCK）, and caldesmon（Ca D） in CRA and RGC apoptosis were evaluated through immunofluorescent staining method then observed using laser scanning confocal microscopy. RESULTS： BP significantly increased in all of the hypertension groups compared to control（P =0.001）.Peak IOP elevation（7.78±4.14 mm Hg） and RGC apoptosis（576.15±33.28 Au） occurred on 2wk of hypertension. ET-1expression（1238.6±55.1 Au） and e NOS expression（2814.2±70.7 Au） were found highest in 2wk of hypertension,although the ratio of ET-1/e NOS decreased since *** peak expression in 10 wk of hypertension（1219.4 ±6.3 Au）, while ETRBsignificantly increased only in 2 weeks group（1069.2 ±9.6 Au）. The highest MLCK expression（1190.09±58.32 Au）, Ca D（1670.28±18.36 Au）were also found in 2wk of ***： Hypertension effects to activation of ET-1 signaling pathway significantly in CRA, elevation of IOP, and RGC apoptosis. The highest value was achieved at 2wk, which is the development phase of hypertension.

关键词： hypertension central retinal artery endothelin- 1 signaling pathway rats

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Effect of lyophilized aqueous leaf extract of Aquilaria subintegra on aphrodisiacproperties in mice

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Asian pacific Journal of Reproduction 2019年第4期8卷 167-173页

作者： nur hidayat Che Musa Haniza Hanim Mohd Zain Mohammed Muayad TA Husni Ibrahim Biology Department Faculty of Science and MathematicsSultan Idris Education University35900 Tanjong MalimPerak Darul RidzuanMalaysia Environmental Research Centre University of TechnologyBaghdadIraq

Objective: To investigate the effects of Aquilaria subintegra leaf aqueous extracts on the aphrodisiac properties including sexual behaviour, testosterone level, percentage of pregnancy, number of offspring and male to female ratio of offspring in ICR mice. Methods: In this experiment, each male cohabitated with one female in a polysulfone cage. 30 ICR male mice were divided into 6 groups that received normal saline (the control group), 50 mg/kg, 100 mg/kg, 200 mg/kg, 500 mg/kg, and 1000 mg/kg body weight of Aquilaria subintegra leaf aqueous extracts orally for 21 days consecutively. Sexual behavior, percentage of pregnancy, number of offspring and male to female ratio of offspring in ICR mice were measured according to the established methods. Testosterone level was measured by using enzyme-linked immunosorbent assay. Results: Mice that received Aquilaria subintegra leaf aqueous extracts at 50 mg/kg body weight (day 0) had significantly higher mount frequency as compared to the control group;groups treated with 100, 500, 1000 mg/kg body weight extracts produced a greater number of offsprings when compared to the control group. All aphrodisiac parameters were similar between the treatment groups and the control group, indicating that Aquilaria subintegra leaf aqueous extract did not significantly alter the aphrodisiac parameters. Conclusions: Aquilaria subintegra leaf aqueous extracts have no effect on the aphrodisiac properties, but could increase the breeding rate in mice.

关键词： Aquilaria subintegra Aphrodisiac Sexual behaviour Testosterone Offspring

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Carvedilol vs endoscopic variceal ligation for primary and secondary prevention of variceal bleeding: Systematic review and metaanalysis

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World Journal of Hepatology 2019年第5期11卷 464-476页

作者： Michael Dwinata David Dwi Putera Muhamad Fajri Adda’i Putra nur hidayat Irsan Hasan Department of Internal Medicine Depati Hamzah General HospitalPangkalpinang 33684Indonesia School of Medicine and Public Health University of SydneySydney 2006Australia Faculty of Medicine Public Healthand NursingUniversitas Gadjah MadaYogyakarta 55281Indonesia Hepatobiliary Division Department of Internal MedicineFaculty of Medicine Universitas IndonesiaCipto Mangunkusumo National General HospitalJakarta 10430Indonesia

BACKGROUND Variceal hemorrhage is associated with high mortality and is the cause of death for 20–30%of patients with ***βblockers(NSBBs)or endoscopic variceal ligation(EVL)are recommended for primary prevention of variceal bleeding in patients with medium to large esophageal ***,combination of EVL and NSBBs is the recommended approach for the secondary *** has greater efficacy than other NSBBs as it decreases intrahepatic *** hypothesized that there was no difference between carvedilol and EVL intervention for primary and secondary prevention of variceal bleeding in cirrhosis *** To evaluate the efficacy of carvedilol compared to EVL for primary and secondary prevention of variceal bleeding in cirrhotic patients METHODS We searched relevant literatures in major journal databases(CENTRAL,MEDLINE,and EMBASE)from March to August *** with cirrhosis and portal hypertension,regardless of aetiology and severity,with or without a history of variceal bleeding,and aged≥18 years old were included in this *** randomized controlled trials(RCTs)that compared the efficacy of carvedilol and that of EVL for primary and secondary prevention of variceal bleeding and mortality in patients with cirrhosis and portal hypertension were considered,irrespective of publication status,year of publication,and *** Seven RCTs were *** four trials assessing the primary prevention,no significant difference was found on the events of variceal bleeding(RR:0.74,95%CI:0.37-1.49),all-cause mortality(RR:1.10,95%CI:0.76-1.58),and bleedingrelated mortality(RR:1.02,95%CI:0.34-3.10)in patients who were treated with carvedilol compared to *** three trials assessing secondary prevention,there was no difference between two interventions for the incidence of rebleeding(RR:1.10,95%CI:0.75-1.61).The fixed-effect model showed that,compared to EVL,carvedilol decreased all-cause mortality by 49%(RR:0.51,95

关键词： Carvedilol Liver cirrhosis Variceal hemorrhage Portal hypertension Prophylaxis

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谷胱甘肽和烟酸对高糖状态下人晶状体上皮细胞的影响（英文）

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国际眼科杂志 2020年第1期20卷 4-8页

作者： Nina Handayani nur Permatasari hidayat Sujuti Achmad Rudijanto 玛琅Saiful Anwar医院 Brawijaya大学医学院眼科印度尼西亚玛琅65145 Brawijaya大学医学院药理学系印度尼西亚玛琅65145 Brawijaya大学医学院生物化学与分子生物学系印度尼西亚玛琅65145 玛琅Saiful Anwar医院 Brawijaya大学医学院内科内分泌与代谢疾病科印度尼西亚玛琅65145

目的:评价还原性谷胱甘肽(GSH)和烟酸联合应用对蛋白质氧化应激、内质网应激(ER)、糖基化和聚合αβ晶状体蛋白的人晶状体上皮(HLE)细胞治疗高葡萄糖水平的影响。方法:培养HLE细胞并暴露于25 mmol/L葡萄糖中以促进高糖环境。各组细胞用... 详细信息

目的:评价还原性谷胱甘肽(GSH)和烟酸联合应用对蛋白质氧化应激、内质网应激(ER)、糖基化和聚合αβ晶状体蛋白的人晶状体上皮(HLE)细胞治疗高葡萄糖水平的影响。方法:培养HLE细胞并暴露于25 mmol/L葡萄糖中以促进高糖环境。各组细胞用三种不同的剂量组合进行联合治疗:10μmol/L GSH+2μmol/L烟酸,30μmol/L GSH+25μmol/L烟酸,100μmol/L GSH+25μmol/L烟酸。培养72h后,用ELISA法测定蛋白羰基(PCC)和葡萄糖反应蛋白(GRP78)的含量。培养2wk后,对糖基化终末产物(AGEs)进行检测,用Western Blot检测αβ晶状体蛋白的表达。所有数据分析均采用SPSS 18.0统计软件包。结果:与对照组相比,联合治疗组的PCC和GRP78水平没有显著降低(P>0.05)。相反,与对照组相比,GSH和烟酸联合治疗组的AGEs水平明显下降(P<0.05)。此外,高剂量葡萄糖给药后αβ晶状体蛋白表达增加,但GSH联合治疗组与GSH和烟酸联合治疗组αβ晶状体蛋白表达都有所降低。结论:结果表明,GSH和烟酸联合应用可抑制高血糖人HLE细胞蛋白质的聚合,防止糖基化,并且通过AGEs途径在预防糖尿病性白内障中发挥积极作用。

关键词：蛋白羰基葡萄糖反应蛋白糖基化终末产物 αβ晶状体蛋白糖尿病性白内障

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TNF-α(Tumor Necrosis Factor Alpha) and iNOS (Inducible Nitric Oxide Synthase) Expression in Rat Brain Infected by Mycobacterium tuberculosisStrain H37RV

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Journal of Tuberculosis Research 2017年第1期5卷 58-68页

作者： Dwi Yuni nur hidayati hidayat Sujuti Laksmi Wulandari Alan Darma Saputra Giovani Anggasta Santoso Microbiology Laboratory Medical FacultyUniversity of BrawijayaMalangIndonesia Biochemistry-Biomolecular Medical Faculty University of BrawijayaMalangIndonesia Pulmonology Department Dr.Sutomo Hospital/Medical FacultyAirlangga UniversitySurabayaIndonesia Education of Doctor Program Medical FacultyUniversity of BrawijayaMalangIndonesia

Tuberculosis is an infectious disease caused by the Mycobacterium tuberculosis. Mycobacterium tuberculosis will form the primary focus or Ghon focus in the lungs of infected people. The primary focus can break and get into the bloodstream and/or lymph to the entire body, including the central nervous system, especially the brain. Tuberculosis infection in the brain can cause microglia secrete inflammatory factors such as TNF-α and IL-1β is emerging as the body’s immune response. The factors that can trigger microglia to secrete iNOS (Inducible Nitric Oxide Synthase) in order to protect the brain from attacking bacteria. iNOS is shown to have an important role in tuberculosis infection in the brain. TNF-α is a pro-inflammatory cytokine which is mostly produced by macrophages/microglia through several mechanisms. Therefore, to investigate how the expression of TNF-α and iNOS in the brain tissue of the mice is not infected with tuberculosis, tuberculosis infection with an incubation period of 8 weeks and 16 weeks. This study is a semiquantitative study by comparing the amount of expression of TNF-α and iNOS and all three groups of samples with treatment as has been mentioned. The expressions observation of TNF-α and iNOS in brain cell tissue of mice was conducted using immunohistochemical staining, and was seen in a microscope with a magnification of ×100. Brain cells that express TNF-α and iNOS are brown core, cytoplasm and cell walls. The results were obtained by the longer exposure to infection of the higher expression of TNF-α (r > 0688) and the expression of iNOS decreased (–0.993).

关键词： TNF-α iNOS Immunohistochemistry Mycobacterium tuberculosis The Brain

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