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Endogenous motion of liver correlates to the severity of portal hypertension

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World Journal of Gastroenterology 2020年第38期26卷 5836-5848页

作者： Sigita Gelman andrius Sakalauskas Romanas Zykus andrius Pranculis Rytis Jurkonis Irma Kuliavienė Arūnas Lukoševičius Limas Kupčinskas Juozas Kupčinskas Department of Gastroenterology Medical AcademyLithuanian University of Health SciencesKaunas 44307Lithuania Biomedical Engineering Institute Kaunas University of TechnologyKaunas 51423Lithuania Department of Radiology Medical AcademyLithuanian University of Health SciencesKaunas 44307Lithuania Institute for Digestive Research and Department of Gastroenterology Medical AcademyLithuanian University of Health SciencesKaunas 44307Lithuania

BACKGROUND Degree of portal hypertension(PH)is the most important prognostic factor for the decompensation of liver cirrhosis and death,therefore adequate care for patients with liver cirrhosis requires timely detection and evaluation of the presence of clinically significant PH(CSPH)and severe PH(SPH).As the most accurate method for the assessment of PH is an invasive direct measurement of hepatic venous pressure gradient(HVPG),the search for non-invasive methods to diagnose these conditions is actively *** To evaluate the feasibility of parameters of endogenously induced displacements and strain of liver to assess degree of *** Of 36 patients with liver cirrhosis and measured HVPG were included in the casecontrol *** motion of the liver was characterized by derived parameters of region average tissue displacement signal(dantero,dretro,dRMS)and results of endogenous tissue strain imaging using specific radiofrequency signal processing *** endogenous strainμand standard deviationσof strain were assessed in the regions of interest(ROI)(1 cm×1 cm and 2 cm×2 cm in size)and different frequency subbands of endogenous motion(0-10 Hz and 10-20 Hz).RESULTS Four parameters showed statistically significant(P<0.05)correlation with HVPG *** strongest correlation was obtained for the standard deviation of strain(estimated at 0-10 Hz and 2 cm×2 cm ROI size).Three parameters showed statistically significant differences between patient groups with CSPH,but only dretro showed significant results in SPH *** to ROC analysis area under the curve(AUC)of theσROI[0…10Hz,2 cm×2 cm]parameter reached 0.71(P=0.036)for the diagnosis of CSPH;with a cut-off value of 1.28μm/cm providing 73%sensitivity and 70%*** for the diagnosis of CSPH forμROI[0…10Hz,1 cm×1 cm]was 0.78(P=0.0024);with a cut-off value of 3.92μm/cm providing 73%sensitivity and 80%*** parameter had an AUC of 0.86(P=0.0001)for the diagnos

关键词： Portal hypertension Endogenous motion Strain elastography Hepatic venous pressure gradient Radiofrequency parameters

Determining exact survival probability by setting discrete random variables in E. Sparre Andersen’s model

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Probability, Uncertainty and Quantitative Risk 2023年第4期8卷 445-462页

作者： andrius Grigutis Institute of Mathematics Vilnius UniversityNaugarduko 24VilniusLT-03225Lithuania

In this work,we propose an alternative to the Pollaczek-Khinchine formula for the ultimate time survival(or ruin)probability calculation in exchange for a few assumptions on the random variables that generate the renewal risk *** precisely,we demonstrate the expressibility of the distribution function n P(sup n≥1^(n)∑_(i=1)(X_(i)-cθ_(i))0 X cθindependent copies of X and respectively,wherein,and are independent,θnonnegative,and *** also assume that the support of is *** illustrate the applicability of the proven theoretical statements we present a few numerical outputs when the mentioned random variables adopt some particular distributions.

关键词： Ruin theory Renewal theory Queueing theory Random walk Survival probability Generating function Pollaczek–Khinchine formula Initial values

CAIRO5 study from a surgical perspective

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Hepatobiliary Surgery and Nutrition 2024年第1期13卷 105-108页

作者： andrius Meskauskas Maximiliano Gelli Gustave Roussy Département de AnesthésieChirurgie et InterventionnelVillejuifFrance UniversitéParis-Saclay Gustave RoussyINSERMDynamique des Cellules Tumorales(U-1279)VillejuifFrance

The assessment of resectability,as well as the optimal induction treatment to achieve secondary resectability in patients with colorectal cancer liver metastases(CRLM)remain *** et al.(1)recently presented the results... 详细信息

关键词： Metastatic colorectal cancer(metastatic CRC) liver metastasis immunotherapy

Channel-resolved subcycle interferences of electron wave packets emitted from H_(2) in two-color laser fields

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High Power Laser Science and Engineering 2016年第4期4卷 1-7页

作者： Xinhua Xie Stefan Roither Daniil Kartashov Li Zhang andrius Baltuska Markus Kitzler Photonics Institute Technische Universitat Wien Institute of Theoretical Chemistry University of Vienna

We report on the observation of subcycle interferences of electron wave packets released during strong field ionization of H_2 with cycle-shaped two-color laser fields. With a reaction microscope we measure three-dimensional momentum distributions of photoelectrons correlated with either H_2^+ or protons within different energy ranges generated by dissociation of H_2^+. We refer to these different types of photoelectrons as channels. Our results show that the subcycle interference structures of electron wave packets are very sensitive to the cycle shape of the two-color laser field. We explain this behavior by the dependence of the ionization time within an optical cycle on the shape of the laser field cycle. The subcycle interference structures can be further used to obtain insight into the subcycle dynamics of molecules during strong field interaction.

关键词： molecular dynamics strong field ionization wave packet interference

Multidisciplinary diagnostic dilemma in differentiating Madelung’s disease—the value of superb microvascular imaging technique:A case report

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World Journal of Clinical Cases 2021年第21期9卷 6145-6154页

作者： Goda Seskute Austeja Dapkute Dominyka Kausaite Sandra Strainiene andrius Talijunas Irena Butrimiene Clinic of Rheumatology Orthopaedics Traumatologyand Reconstructive SurgeryInstitute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius 01513Lithuania Clinic of Neurology and Neurosurgery Institute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius 01513Lithuania Faculty of Medicine Vilnius UniversityVilnius 01513Lithuania Clinic of Gastroenterology Nephrourology and SurgeryInstitute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius 01513Lithuania Institute of Dentistry Faculty of MedicineVilnius UniversityVilnius 01512Lithuania

BACKGROUND Madelung’s disease,also known as multiple symmetrical lipomatosis,is a rare,underrecognized disorder of fat metabolism that results in unusual accumulation of subcutaneous fat deposits around the neck,shoulders,upper arms,trunk,hips,and upper *** case demonstrates the importance of differential diagnosis and the value of a superb microvascular imaging technique for suspecting and confirming Madelung’s *** diagnosis and alcohol abstinence could prevent the progression of growing fatty masses and prevent *** SUMMARY A 62-year-old male was admitted to the Rheumatology center complaining of symmetric subcutaneous tumors in the area of the parotid and submandibular salivary glands,small soft masses in the occiput and upper third of the forearm,rashes on calves.A high titer of rheumatoid factor and low concentrations of serum complements were *** high-end ultrasound and magnetic resonance imaging examinations of all affected areas of the soft tissues showed predominantly adipose tissue(lipomas)without suspicion of *** biopsy from the small salivary gland revealed no *** evaluating the patient’s clinical presentation(symmetrical lipomatosis,cirrhosis,gynecomastia,anemia,hyperuricemia),Madelung’s disease,type I,along with the psoriatic rash and psoriatic arthritis and secondary liver cirrhosis were *** Madelung’s disease consists of many co-occurring disorders imitating and overlapping with other *** is the first choice for suspecting and confirming symmetrical lipomatosis.

关键词： Madelung’s disease Multiple symmetrical lipomatosis Cirrhosis Salivary gland tumors Superb microvascular imaging Case report

Hyper spectral resolution stimulated Raman spectroscopy with amplified fs pulse bursts

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Light(Science & Applications) 2024年第3期13卷 566-576页

作者： Hongtao Hu Tobias Flöry Vinzenz Stummer Audrius Pugzlys Markus Zeiler Xinhua Xie Aleksei Zheltikov andrius Baltuška Photonics Institute Technische Universität WienGußhausstraße 27-29Vienna A-1040Austria SwissFEL Paul Scherrer InstituteVilligen PSI 5232Switzerland Institute for Quantum Science and Engineering Department of Physics and AstronomyTexas A&M UniversityCollege StationTX 77843USA

We present a novel approach for Stimulated Raman Scattering(SRS)spectroscopy in which a hyper spectral resolution and high-speed spectral acquisition are achieved by employing amplified offset-phase controlled fs-pulse *** investigate the method by solving the coupled non-linear Schrödinger equations and validate it by numerically characterizing SRS in molecular nitrogen as a model *** spectral resolution of the method is found to be determined by the inverse product of the number of pulses in the burst and the intraburst pulse *** SRS spectrum is obtained through a motion-free scanning of the offset phase that results in a sweep of the Raman-shift *** to high spectral resolution and fast motion-free scanning the technique is beneficial for a number SRS-based applications such as gas sensing and chemical analysis.

关键词： compound spectral resolution

Solitary beam propagation in periodic layered Kerr media enables high-efficiency pulse compression and mode self-cleaning

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Light(Science & Applications) 2021年第4期10卷 464-474页

作者： Sheng Zhang Zongyuan Fu Bingbing Zhu Guangyu Fan Yudong Chen Shunjia Wang Yaxin Liu andrius Baltuska Cheng Jin Chuanshan Tian Zhensheng Tao State Key Laboratory of Surface Physics and Department of Physics Fudan UniversityShanghaiChina institute of Photonics TU WienGusshausstrasse 27/387ViennaAustria Department of Applied Physics Nanjing University of Science and TechnologyNanjingJiangsu 210094China

Generating intense ultrashort pulses with high-quality spatial modes is crucial for ultrafast and strong-field science and can be achieved by nonlinear supercontinuum generation(SCG)and pulse *** this work,we propose that the generation of quasi-stationary solitons in periodic layered Kerr media can greatly enhance the nonlinear lightmatter interaction and fundamentally improve the performance of SCG and pulse compression in condensed *** both experimental and theoretical studies,we successfully identify these solitary modes and reveal their unified condition for ***-time coupling is shown to strongly influence the stability of solitons,leading to variations in the spectral,spatial and temporal profiles of femtosecond *** advantage of the unique characteristics of these solitary modes,we first demonstrate single-stage SCG and the compression of femtosecond pulses from 170 to 22 fs with an efficiency>85%.The high spatiotemporal quality of the compressed pulses is further confirmed by highharmonic *** also provide evidence of efficient mode self-cleaning,which suggests rich spatiotemporal self-organization of the laser beams in a nonlinear resonator This work offers a route towards highly efficient,simple,stable and highly flexible SCG and pulse compression solutions for state-of-the-art ytterbium laser technology.

关键词： pulse resonator mode

An Investment Portfolio Management Using Software Agents that Rely on Fuzzy Logic and with Different Decision Arguments Combinations

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Computer Technology and Application 2012年第12期3卷 808-817页

作者： andrius Jurgutis Rimvydas Simutis The Treasury Department JSC Okio Bank Kaunas LT-44250 Lithuania The Department of Process Control Faculty of Electrical and Control Engineering Kaunas University of Technology Kaunas LT-51367. Lithuania

During the development of the intellectual multi-agent investment management information system （designed for the formation of investor＇s investment decisions）, it was established that there is a lack of both necessary comprehensive researches and analysis to invoke more than one decision-making aspect （argument） for the making of investment decision, and recommendations to combine these diverse parameters. It is possible to find a lot of articles and researches in which investment decisions or investment tactics are decided on the ground of either technical or fundamental analysis, or modeling and on the ground of intellectual calculating technique （for example, fuzzy logic, neural net, genetic programming）, whereas the issues of the coordination of different techniques are not decided at all. To fill this niche, the article offers the decision applied in multi-agent investment management information system which allows to provide rationale for investment decision taking into account four aspects （arguments）, i.e., to form the recommendation to purchase/hold/sell a security paper having evaluated the following four aspects （arguments）：（a） fundamental analysis, （b） technical analysis, （c） experts and analysts＇ recommendations and （d） risk assessment. These aspects （arguments） are chosen taking into account the real most commonly occurring process of investor＇s investment decision-making. The article gives the implementation of aspects （arguments） assessment by four corresponding software agents whose decisions are implemented with a help of fuzzy logic. Besides, the article offers the technique of the unification of these aspects （arguments）. The offered intellectual multi-agent investment management information system can be tested on the internet： ***/webapp （MADSYS project）.

关键词： Fuzzy logic portfolio management multi-agent systems.

Methodological Approaches to Development and Implementation of Multi-agents Investment DSS Using JADE Platform

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Computer Technology and Application 2014年第1期5卷 33-43页

作者： andrius Jurgutis Rimvydas Simutis Department of Automation Kaunas University of Technology Kaunas 51367 Lithuania

In these latter days software agents are used for the development and implementation of intellectual decision support systems. In order to implement intelligence in a system some or several dozen of software agents are used and the made system becomes multi-agent. For the development of these systems a set of methodologies, i.e., the sequence of consequent steps of analysis, designing and implementation, is offered. The carried out analysis of the methodologies showed that as a rule they are limited by the spectrum of their pending problem （within the pales of the requirements of specific applied task, within the pales of the possibilities of technical implementation） or within the pales of amount of detail. The variety of methodologies is influenced by the fact that for the development of these systems the requirements and attitudes are offered by the specialists of related spheres such as software, numeral intellect engineers. In the course of the development of hardware and software appeared possibilities to implement mobile multi-agents systems, however, there is no one united mobile multi-agent systems design methodology, whereas existing systems are underdeveloped and their number is small. In this article we introduce the course of the designing of an intellectual real time multi-agent investment management decision support information system adapting and combining some methodologies where the choice to use either communicating or mobile agents is the question of rather technical implementation than methodological. In the article we introduce two ways of system implementation by JADE platform： the first one-using communicating agents, and the second one-using mobile agents.

关键词： Decision support system intelligent systems multi-agent systems knowledge based systems software agents.