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Agmatine induces gastric protection against ischemic injury by reducing vascular permeability in rats

World Journal of Gastroenterology 2012年第18期18卷 2188-2196页

作者： Abeer A Al Masri Eman El eter Department of Physiology College of Medicine and King Khalid University HospitalKing Saud UniversityRiyadh 11461Saudi Arabia

AIM:To investigate the effect of administration of agmatine(AGM) on gastric protection against ischemia reperfusion(I/R) ***:Three groups of rats(6/group);sham,gastric I/R injury,and gastric I/R + AGM(100 mg/kg,*** 15 min prior to gastric ischemia) were *** injury was conducted by ligating celiac artery for 30 min and reperfusion for another 30 *** tissues were histologically studied and immunostained with angiopoietin 1(Ang-1) and *** endothelial growth factor(VEGF) and monocyte chemoattractant protein-1(MCP-1) were measured in gastric tissue *** assess whether AKt/phosphatidyl inositol-3-kinase(PI3K) mediated the effect of AGM,an additional group was pretreated with Wortmannin(WM)(inhibitor of Akt/PI3K,15 μg/kg,i.p.),prior to ischemic injury and AGM treatment,and examined histologically and *** set of experiments was run to study vascular permeability of the stomach using Evan's blue ***:AGM markedly reduced Evan's blue dye extravasation(3.58 ± 0.975 μg/stomach vs 1.175 ± 0.374 μg/stomach,P < 0.05),VEGF(36.87 ± 2.71 pg/100 mg protein vs 48.4 ± 6.53 pg/100 mg protein,P < 0.05) and MCP-1 tissue level(29.5 ± 7 pg/100 mg protein vs 41.17 ± 10.4 pg/100 mg protein,P < 0.01).It preserved gastric histology and reduced ***-1 and Ang-2 immunostaining were reduced in stomach sections of AGM-treated *** administration of WM abolished the protective effects of AGM and extensive hemorrhage and ulcerations were ***:AGM protects the stomach against I/R injury by reducing vascular permeability and *** protection is possibly mediated by Akt/PI3K.

关键词： Ischemia reperfusion injury Agmatine Wortmannin Vascular permeability Monocyte chemoattractant protein-1 Stomach Vascular endothelial growth factor

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Georgia Black Sea Coast Protection with Free Beaches

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Journal of Geoscience and Environment Protection 2018年第5期6卷 151-167页

作者： Alpenidze Melor Seperteladze Zurab Davitaia eter Gaprindashvili George Department of Geography Sokhumi State University Tbilisi Georgia Department of Geography Ivane Javakhishvili Tbilisi State University Tbilisi Georgia Department of Geology National Environmental Agency Tbilisi Georgia

In the paper, it is discussed reinforced coastal zones with resort-recreational functions, destructed in terms of anthropogenic pressure of the Black Sea, Georgia. Results of many years’ observations and researches prove low effectiveness of active methods of coastal protection, mostly causing and provoking intensive degradation of the beaches. Article highlights developing and constructing of free and unbounded beaches as an optimal coastal protection approach. Successful example of this approach was developing of coastal zone in 90s, in Gagra (West Georgia), Black Sea. Positive impact of this kind of artificial beach still survives. In the thesis, it is presented an attempt to scientifically prove extrapolation-traduction on the other similar coasts of the recovery of Gagra Zone beach. Based on morphodynamic analysis and comparison, according to the priorities of major features of reinforced coasts, it turned out that coast of three similar objects (Gagra, Ochamchire and Sokhumi) show homogenous aspects. Scientific expediency of providing extrapolation on other similar objects of etalon objects i.e. Gagra Beach recovered by successful coastal protection experiment. Thereby, for the purposes of creating free-artificial beach, choosing of wrecking zone of Ochamchire is based on coastal protection effectiveness and economical principals, including technical-economical effectiveness.

关键词： Georgia Black Sea Coast Beach Coastal Protection Extrapolation Analogue-Object

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小胶质细胞的嘌呤受体在脉络膜新生血管小鼠热损伤模型中的表达

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眼科新进展 2021年第2期41卷 105-109页

作者：李璐刘珏君许阿敏陈长征 Nicole eter 武汉大学人民医院眼科中心湖北省武汉市430060 德国明斯特大学医学院眼科中心德国明斯特D-48149

目的研究小胶质细胞的嘌呤受体(P2)在脉络膜新生血管(CNV)形成中的作用及其抑制剂磷酸吡哆醛-6-偶氮(苯-2,4-二磺酸)四钠盐水合物(PPADS)对小胶质细胞的功能和CNV形成的影响。方法选取6~8周龄C57BL/6J小鼠25只,随机分为正常对照组(5只)... 详细信息

目的研究小胶质细胞的嘌呤受体(P2)在脉络膜新生血管(CNV)形成中的作用及其抑制剂磷酸吡哆醛-6-偶氮(苯-2,4-二磺酸)四钠盐水合物(PPADS)对小胶质细胞的功能和CNV形成的影响。方法选取6~8周龄C57BL/6J小鼠25只,随机分为正常对照组(5只)和模型组(20只),模型组小鼠均制作激光诱导CNV模型,模型组小鼠在激光后第1、4、7、14天处死并取材视网膜和脉络膜组织。选取CX3CR1^(GFP/+)基因敲除小鼠15只,制作激光诱导CNV模型后随机分为3组,第1组和第2组分别于激光后在玻璃体内立即注射2μL PPADS(PPADS注射组)或磷酸盐缓冲液(PBS对照组),第3组在激光后每天一次PPADS局部滴眼(PPADS眼药组),共3 d。CX3CR1^(GFP/+)小鼠于激光后第4天麻醉后行视网膜自发荧光和荧光素眼底血管造影(FFA)检查后处死取材视网膜。各组小鼠取材后分别进行免疫荧光化学染色和实时荧光定量PCR检测P2受体(P2X4、P2X7、P2Y2和P2Y12)的表达。结果激光诱导CNV形成后,局部激活的小胶质细胞可表达P2受体(P2X4、P2X7、P2Y2和P2Y12)。与正常对照组相比,P2X4、P2X7、P2Y2、P2Y12 mRNA表达量在激光损伤后第1天即可增加,第4天达峰值(t=6.05、2.95、3.67、5.98,均为P<0.01);随后渐下降,至第14天时,仅有极少量激活的小胶质细胞表达目标受体。PPADS抑制P2受体后,与PBS对照组P2X4、P2X7、P2Y2和P2Y12受体mRNA的含量相比,PPADS注射组(t=5.54、9.82、3.86、7.91,均为P<0.01)和PPADS眼药组(t=3.24、5.89、6.75、4.97,均为P<0.01)均明显下降。与PBS对照组相比,PPADS眼药组与PPADS注射组的小胶质细胞的自发荧光强度均明显减弱(均为P<0.01),与PBS对照组相比,PPADS注射组和PPADS眼药组CNV渗漏荧光强度均明显减少(均为P<0.01)。但在PPADS注射组和PPADS眼药组之间,CNV荧光渗漏强度差异无统计学意义(P=0.864)。结论激光诱导CNV形成后,局部激活的小胶质细胞可表达P2受体,P2受体抑制剂PPADS可显著影响小胶质细胞的功能,并抑制CNV的形成。

关键词：嘌呤受体抑制剂脉络膜新生血管小胶质细胞

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Agro-Landscape Zoning of West Georgia for Spreading New Varieties of Tangerine in Order to Reveal Optimal Natural Conditions

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International Journal of Geosciences 2015年第12期6卷 1339-1352页

作者： Zurab Seperteladze eter Davitaia Shota Lamparadze Guram Memarne George Gaprindashvili Tamar Aleksidze Department of Geography Ivane Javakhishvili Tbilisi State University Tbilisi Georgia Batumi Shota Rustaveli State University Batumi Georgia Institute of Phytopathology and Biodiversity Batumi Shota Rustaveli State University Batumi Georgia

A landscape-multifactor method has been developed and established in West Georgia for agroresource potential spatial distribution regularities for Tangerine. The emphasis was made especially for the components (relief, climate, soils), having substantial impact on the growth and yield of citrus. Morpho-metric analysis (biometric indicators, end of fetal maturity, starting of maturity, frost resistance, etc.) of frost resistant Tangerine-Tiakhara Unshiu from Japan and Saadreo and Adreula (Early ripe) has been conducted. For the application of landscape multifactor (multi-component) method, which takes into account the role of each component in the spread of citrus, the most important parameters are the following: relief (dismemberment, slope, aspect), climate (temperature inversions, sum of active temperatures, hydrothermal coefficient, etc.), soil conditions. Using this method and morphometric analysis, it became possible ranking of frost resistant tangerine (GIS-technologies) based on the landscape, the result of which has been determined that the frost resistant tangerine varieties in western Georgia has a high yield in the higher subtropical zone.

关键词： Agro-Landscape Agriresource Potential Biometric Indicators Control Species Zoning Phenological Phases

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Natural Environment and Landscape Energy of Western Georgia

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Natural Resources 2023年第1期14卷 1-12页

作者： Zurab Seperteladze eter Davitaia Tariel Kikvadze George Gaprindashvili Tamar Aleksidze Nino Rukhadze Department of Geography Ivane Javakhishvili Tbilisi State University Tbilisi Georgia Department of Economy and Business Administration Georgian Technical University Tbilisi Georgia Department of Geology National Environmental Agency Tbilisi Georgia

The particularly great practical importance of modern physical geography and, in particular, landscape science, is first of all manifested in the detection and study of the resource potential of landscapes, as well as in the optimization of the environment. The resource potential, on the other hand, greatly depends on the balance of substance and energy exchange in the natural resources, i.e. the energy of the landscape. In this case, one of the important things is to study the functioning of natural-territorial complexes (NTC). Through it, it is possible and relatively easy to explain, model and, most importantly, predict many complex processes taking place in NTC, including the role of landscape energy balance in increasing the productivity and yield of agro-landscapes, which was the first attempt to research this problem in Georgia.

关键词： Landscape Energy Agro-Landscape Optimization Solar Radiation Energy Balance

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实验双相不锈钢显微组织和合金元素分布的测定

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长城技术 1993年第A期 96-102页

作者： potg.,JH 余建国

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Ranking of Feijoa (FEIJOA Sellowiana) in Subtropical Humidified Zone of Adjara and Forest Ecosystem by Multiple-Factor Approach

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Open Journal of Forestry 2021年第1期11卷 1-13页

作者： Zurab Seperteladze eter Davitaia Melor Alpenidze George Gaprindashvili Roman Maisuradze Guram Memarne Neli Khalvashi Nino Kedelidze Tamar Aleksidze Nino Rukhadze Tamar Khardziani Department of Geography Ivane Javakhishvili Tbilisi State University Tbilisi Georgia Department of Geography Sokhumi State University Tbilisi Georgia Department of Geology National Environmental Agency Tbilisi Georgia Institute of Phytopathology and Biodiversity Batumi Shota Rustaveli State University Batumi Georgia

It was elaborated a method of agro-ecosystem ranking for feijoa culture and forest ecosystem in one of regions of Western Georgia—Adjara subtropical humidified zone. On the basis of mineralogical and morphometric analysis (biometric parameters, beginning and end of growth, beginning of fruit ripening and mass ripening, frost resistance etc.) of feijoa culture (Feigoa selliowiana) and by multiple-factor approach we have evaluated culture’s rational disposition and optimal environment for development of land. The main accent was made on geomorphological (relief, inclination, exposition) and agro-climatic (sum of active temperatures, hydrothermal coefficient, temperature conditions, physical and chemical features of soil) factors. As a result of implemented zoning a landscape zone with agricultural resources potential and hypsometrical levels optimal for development of feijoa culture was revealed. During the research we also revealed corresponding agro-eco- system zone, compatible with feijoa zone, evaluation of quality of forest land and determination of ecosystem and its indicating character. For determination of compatibility of feijoa plants and distribution of forest ecosystem we have created a map of large-scale ecosystems and geo-information system. By Cartometric and geographic-informational analysis, it became possible to find information about types of forest ecosystems, areas occupied by them and their share in researched zone.

关键词： Agriculture Forestry Resource Potential Control Sorts Geography GIS

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玻璃体内注射曲安西龙后眼内压变化及穿刺术的必要性

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世界核心医学期刊文摘(眼科学分册) 2006年第2期 52-52页

作者： Dwinger M.C Pieper-Bodeewes I eter N Holz F.G. 王静波 Universitts-Augenklinik Bonn Ernst-AbbeStraé 2 53127 Bonn Germany Dr.

Background: Intravitreal triamcinolone injection (IVT) has become a treatment option for macular edema of heterogeneous etiology and neovascular retinal diseases includingAMD. Besides the risk for a steroid- induced secondary open-angle glaucoma, the acute rise in intravitreal volume induces IOP elevations immediately after injection. To decrease the intravitreal volume a paracentesis is advocated by many surgeons. The aim of this study was to determine variations in IOP at different time points immediately after IVT in order to assess the necessity for routine paracentesis. Methods: The IOP was recorded by Goldmann applanation tonometry preoperatively, 10 minutes, 1, 3 and 24 hours after intravitreal injection of 0.1 mL (4 mg) triamcinolone. A consecutive series of 32 eyes of 32 patients with diabetic macular edema, diffuse edema after central vein occlusion or occult subfoveal choroidal neovascularization due to age- related macular degeneration was included. Statistical analysis was performed with ANOVA test and Bonferroni correction. Results: Compared to baseline (15.24 ± 0.52 mm Hg) IOP was significantly elevated 10 min postoperatively (22.28 ± 1.4 mmHg; p< 0.05). One hour after injection IOP decreased to 15.58± 0.69 mmHg (p< 0.05). Three and 24 h after injection mean IOP was not significantly different from preoperative baseline levels. Immediately after IVT light perception was tested and retinal perfusion was evaluated by indirect ophthalmoscopy. In none of the patients was a paracentesis necessary. Conclusion: Intravitreal injection of 0.1 mL triamcinolone led to a moderate transient rise in IOP. Based on these results, a routinely performed paracentesis immediately before or after IVT is not required. As paracentesis bears an additional risk including endophthalmitis it should only be considered if functional testing following injection indicates a relevant impairment of retinal perfusion.

关键词：穿刺术玻璃体曲安西龙实验室诊断 IOP 体内注射黄斑变性

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