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Structure of human NCC:insights into the inhibition mechanism of thiazides

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Signal Transduction and Targeted Therapy 2023年第8期8卷 3549-3550页

作者： Livia de souza Goncalves Pattareeya Yottasan Onur Cil department of Pediatrics University of CaliforniaSan FranciscoSan FranciscoCAUSA

A recent study published in Nature by Fan et al.1 identified the structure of human NCC alone and in complex with a thiazide diuretic using cryo-electron *** extensive clinical use of NCC inhibitor thiazide diuretics since 1950s,the structure and inhibition mechanisms of NCC have remained elusive,and Fan et *** is a major step toward better understanding the NCC biology and mechanism of action of thiazide ***-chloride cotransporter(NCC,also known as SLC12A3)is expressed in the kidney where it facilitates electroneutral NaCl absorption.

关键词： azide mechanism

Graphene opens pathways to a carbon-neutral cement industry

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Science Bulletin 2022年第1期67卷 5-8,M0003页

作者： Felipe Basquiroto de souza Xupei Yao Wenchao Gao Wenhui Duan department of Civil Engineering Monash UniversityClaytonVictoria 3800Australia

Global cement production has increased 30 times since 1950 and nearly 4 times since 1990,becoming the third-largest source of anthropogenic carbon dioxide(CO_(2))emissions after fossil fuels and land-use changes[1].But the cement industry is under *** order to achieve the Paris Agreement’s targets and reach net-zero CO_(2)emissions by 2050.

关键词：水泥行业碳中和石墨烯

A numerical assessment of two geometries for reducing elbow erosion

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Particuology 2020年第2期18卷 117-133页

作者： Carlos Antonio Ribeiro Duarte Francisco Joséde souza Diego Nei Venturi Martin Sommerfeld department of Engineering Federal University of Goiás-Regional Catal(a)oAv.Dr.Lamartine Pinto de Avelar1120Catal(a)oGoiásBrazil School of Mechanical Engineering Federal University of Uberl(a)ndiaAv.Joāo Naves de(A)vila2121 Bloco 5PUberl(a)ndiaMinas GeraisBrazil Multiphase Flow Systems(MPS) Otto-von-Guericke-University MagdeburgZeppelinstraβe 1D-06130 Halle(Saale)Germany

Elbows in pneumatic conveying systems are normally prone to the erosive effects of conveyed *** are a number of solutions available to reduce such damage.A widely used geometric alternative for replacing the 90°elbow and reducing erosive wear is the plugged *** option,although less commonly used,is the vortex-chamber *** both cases,the effective reduction in erosion brought about is unclear,as it strongly depends on the operating *** present study assesses relative erosion among the plugged tee,vortex-chamber elbow,and standard elbow for a dilute gas-solid multiphase flow.A numerical model is employed to predict the penetration ratio and validated using experimental data for the plugged *** are run for the standard and vortex-chamber elbows and plugged tee under the same conditions to compare the mechanics involved and the relative erosion *** analysis uses variables relating to particle-wall interactions(impact angle,impact velocity,impact frequency)to illustrate the nature of the erosive process in each pipe *** general,the geometric configurations of both the plugged tee and vortex-chamber elbow promote changes in particle dynamics that reduce the rate of *** the basis of the relative erosion of the standard elbow,the plugged tee proves to be an interesting option in cases of a low mass loading,while the vortex-chamber elbow demonstrates its erosion reduction potential for higher mass loading ***,the advantages and disadvantages of each fitting are highlighted.

关键词： Relative erosion Plugged tee Erosion reduction Pipe fitting Computational fluid dynamics

Identification and characterization of resistance and pathogenicity of Enterococcus *** samples of donor breast milk

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World Journal of Clinical Pediatrics 2020年第3期9卷 53-62页

作者： Luana Andrade Mendes Santana Nivea Nara Novais Andrade Lucas Santana Coelho da Silva Caline Novais Teixeira oliveira Breno Bittencourt de Brito Fabricio Freire de Melo Claudio Lima souza Lucas Miranda Marques Marcio Vasconcelos oliveira oliveira Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

BACKGROUND Breast milk is the primary source of nutrition for *** babies frequently need nutritional support from Human Milk *** bacterial species of the genus Enterococcus are part of the microbiota of healthy donors,they may contaminate samples of pumped breast *** To identify and characterize the bacterial virulence and resistance in samples isolated from the nipple-areolar region,hands,and breast milk aliquots from donors at the Human Milk Bank of Municipal Hospital EsauMatos in the city of Vitória da Conquista,Bahia State,*** The personal hygiene and sanitation of donors were analyzed with the aim of identifying possible reasons for contamination of pumped *** samples as well as aliquots of unpasteurized and pasteurized milk from 30 participants were *** Enterococcus *** underwent a disk diffusion susceptibility test and molecular biology techniques to determine resistance and virulence *** Enterococcus *** identified in 30%of donors(n=9),and 11 specimens were *** to tetracycline was highly prevalent,being detectable in 63%of the isolates(n=7)and followed by intermediate sensitivity to ciprofloxacin,observed in 27%of the specimens(n=3).The efaA gene was found in 63%(n=7)of the isolates,while the ace gene was detected in 27%(n=3).CONCLUSION This study illustrates the importance of microbiological monitoring by Human Milk Banks and the need for alternatives to prevent the presence of Enterococcus *** hospital settings.

关键词： Enterococcus spp. Breast milk Virulence Human milk Pasteurization Antimicrobial resistanc

Success rates and predictors of outcomes of type I tympanoplasty performed by residents in a teaching tertiary hospital

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中华耳科学杂志:英文版 2023年第4期18卷 214-219页

作者： Lucas Resende Lucinda Mangia Nicole Tassia Amadeu Maurício da Silva oliveira Lucas Santin Patzer Eduardo de souza Somensi Rogerio Hamerschmidt department of Otolaryngology and Head and Neck Surgery Complexo Hospital de Clínicas-Universidade Federal Do Parana(CHC-UFPR)CuritibaBrazil Complexo Hospital de Clínicas-Universidade Federal Do Parana(CHC-UFPR) Curso de MedicinaCuritibaBrazil

Several technical variations of tympanoplasty have been reported,usually involving the type of graft and/or instruments *** studies have focused on the outcome of type-1 tympanoplasty specifically in teaching *** aimed to describe the results of type-1 tympanoplasty performed by residents,and to investigate potential predictive factors of surgical *** do so,we did a retrospective analysis of medical records of patients who underwent type-1 tympanoplasty in a tertiary university *** evaluated the tympanic membrane closure and audiometric outcomes during the first year of follow-up,and compared the results according to some clinical and surgical factors.130 operated ears were included in the *** closure rate reached 84.12%after one month and 72.72%after twelve months of *** mean air-bone gap was 22.98 dB preoperatively,and reached 10.55 dB after *** closure rates were 85%and 57.14%for those operated by endoscopic and microscopic-assisted approaches,respectively(p?0.004).The use of cartilage grafts and time without otorrhea of more than three months prior to surgery were also predictors of surgical success(p?0.002 and 0.041,respectively).Gender,age,perforation size,contralateral disease,operated side,reoperation,and degree of hearing loss did not significantly interfere with *** showed good overall results when performed by residents,although inferior to those reported by experienced *** use of the endoscope,cartilage grafting,and longer preoperative time without otorrhea were predictors of surgical success in this scenario.

关键词： Tympanoplasty Treatment outcome Video-assisted surgery

Increasing pancreatic cancer is not paralleled by pancreaticoduodenectomy volumes in Brazil:A time trend analysis

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Hepatobiliary & Pancreatic Diseases International 2019年第1期18卷 79-86页

作者： Lucila M Perrotta de souza Jessica PL Moreira Homero S Fogaca José Marcus Raso Eulálio Ronir R Luiz Heitor SP de souza department of Internal Medicine School of Medicine Federal University of Rio de Janeiro Institute of Public Health Studies (IESC) Federal University of Rio de Janeiro department of Surgery School of Medicine Federal University of Rio de Janeiro D’Or Institute for Research and Education

Background: Currently, surgical resection represents the only curative treatment for pancreatic cancer(PC), however, the majority of tumors are no longer resectable by the time of diagnosis. The aim of this study was to describe time trends and distribution of pancreaticoduodenectomies(PDs) performed for treating PC in Brazil in recent years. Methods: Data were retrospectively obtained from Brazilian Health Public System(namely DATASUS) regarding hospitalizations for PC and PD in Brazil from January 2008 to december 2015. PC and PD rates and their mortalities were estimated from DATASUS hospitalizations and analyzed for age, gender and demographic characteristics. Results: A total of 2364 PDs were retrieved. Albeit PC incidence more than doubled, the number of PDs increased only 37%. Most PDs were performed in men(52.2%) and patients between 50 and 69 years old(59.5%). Patients not surgically treated and those 70 years or older had the highest in-hospital mortality rates. The most developed regions(Southeast and South) as well as large metropolitan integrated municipalities registered 76.2% and 54.8% of the procedures, respectively. LMIM PD mortality fluctuated, ranging from 13.6% in 2008 to 11.8% in 2015. Conclusions: This study suggests a trend towards regionalization and volume-outcome relationships for PD due to PC, as large metropolitan integrated municipalities registered most of the PDs and more stable mortality rates. The substantial differences between PD and PC increasing rates reveals a limiting step on the health system resoluteness. Reduction in the number of hospital beds and late access to hospitalization, despite improvement in diagnostic methods, could at least in part explain these findings.

关键词： Pancreatic cancer Pancreaticoduodenectomy Time trend analysis Ecological study Hospitalization rates Mortality rates

Distribution and Prevalence of Serotypes of Group B Streptococcus Isolated from Pregnant Women in 30 Countries:A Systematic Review

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Maternal-Fetal Medicine 2023年第2期5卷 97-103页

作者： Marta Maria Silva Érica Alcântara Silva Caline Novais Teixeira oliveira Maria Luísa Cordeiro Santos Cláudio Lima souza Fabrício Freire de Melo Márcio Vasconcelos oliveira Instituto Multidisciplinar em Saúde Universidade Federal da BahiaBahia 45.029-094Brazil

Objective:This review aimed to compile scientific data on the distribution and prevalence of group BStreptococcus (GBS) serotypes isolated from pregnant women across 30 countries from 2010 to ***:This was a systematic review that addresses the distribution and prevalence of GBS in pregnant *** search included studies published between January 2010 and december 2019 in PubMed,Virtual Health Library (BVS),ScienceDirect,Scientific Electronic Library Online (SciELO),and LILACS *** also surveyed relevant articles published in English,Spanish,and Portuguese between February and April *** articles,communication,short report,theses,and dissertations were *** prevalence of GBS colonization,method for capsular serotyping,antimicrobial resistance,distribution and prevalence of serotypes were extracted from each ***:In all,795 publications were *** applying the eligibility criteria,48 articles were included for the final systematic analysis;most articles were from Asia and were published during the years 2014 to *** the identification of serotypes,most studies used the polymerase chain reaction *** were records of all 10 GBS serotypes,namely,Ia,Ib,and II–IX,among the countries *** susceptibility and resistance to antibiotics were addressed in 37.5% of the publications ***:This review showed that GBS serotypes are distributed differently in the 30 analyzed countries,with serotypes Ia,Ib,and II to V being the most ***,our results highlighted the relationship of GBS with maternal colonization,implications for neonates,and antibiotic resistance.

关键词： Streptococcus agalactiae Serotype Pregnant women

An online infertility clinical decision support system

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Asian pacific Journal of Reproduction 2017年第5期6卷 221-225页

作者： Fabio Diniz de souza MSc in Biomedical Engineering Pontificia Universidad Católica del PerúPerú

Objective:To explore some possibilities of computer applications in medicine, and to discuss an online infertility clinical decision support ***: Retrospective data were obtained from 52 couples, and then entered into the online tool. Both its results and the initial diagnoses obtained by the treating physicians were compared with the final diagnoses established by laparoscopy and other diagnostic tests (semen analysis, hormone analysis, endometrial biopsy, ultrasound and hysteroscopy). The initial hypothesis of the research was that the online tool's output was statistically associated with the final diagnoses. In order to verify that hypothesis, achi-square (x2) test with Yates' correction for continuity (Pder to assess the online tool's performance for that ***: The online tool tends to present more false-positives than false-negatives, whereas the expert physician tends to present more false-negatives than false-positives. Therefore, the online tool and the doctor seem to complement each other. Finally, the obtained results suggest that the infertility online tool discussed herein might be a useful research and instructional tool.

关键词： Computer applications Expert systems Reproductive medicine Infertility

In the lack of extreme pioneers:trait relationships and ecological strategies of 66 subtropical tree species

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Journal of Plant Ecology 2015年第4期8卷 359-367页

作者： Cristiane Forgiarini Alexandre F.souza Solon J.Longhi Juliano M.oliveira Programa de Pós-Graduação em Biologia Diversidade e Manejo da Vida SilvestreUniversidade do Vale do Rio dos SinosAv.UNISINOS 950C.P.275São Leopoldo 93022-000RSBrazil departamento de Ecologia CBUniversidade Federal do Rio Grande do NorteCampus UniversitárioLagoa NovaNatal 59072-970RNBrazil PPG-Engenharia Florestal Dep.de Ciências FlorestaisUniversidade Federal de Santa MariaAv.Roraimas/nBairro CamobiSanta Maria 97105-900RSBrazil Present address:departamento de Botânica Instituto BiociênciasUniversidade Federal do Rio Grande do SulAv.Bento Gonçalves9500Prédio 43433Campus AgronomiaPorto Alegre 91501-970RSBrazil.

Aims despite the growing interest in the topic of functional ecology,there are still forest regions that have not been examined,as most work has been done in the *** issues include the strength of a growth-mortality trade-off in trees(originally identified for seedlings)and the nature of the association between plant traits and vital rates,if *** objectives were to examine whether(i)ecological strategies in south american mixed forests are organ-ized along the fast competitor×slow stress-tolerator and height gradients as the main strategy axes depicted in the overall trait and vital rate correlation structure,and(ii)a tentative path model we proposed can explain the patterns of covariation among traits and vital *** We studied a different habitat(subtropical mixed conifer-hardwood forests)and region(brazilian atlantic Forest)from the majority of related studies in forests,carried out in the Neotropical *** on total height,stem slenderness,crown depth,wood density,specific leaf area,leaf and seed length,seed dispersal mode,annual mortality,diameter relative growth rate and relative growth rate under favorable conditions were measured in southern brazil for 66 tree *** were subjected to principal components analysis and path *** data on saplings and treelets were analyzed through *** Findingsstudied traits were reduced to four principal *** components analysis produced axes that fit the resource acquisition versus resource-conservation and the height-mortality trade-offs,although the former was split into two distinct *** size and seed dispersal mode appeared independently of these axes.a path model showed that leaf length and specific leaf area caused direct changes in trunk slenderness and,indirectly through growth,affected *** trade-offs between growth and survivorship and between wood density and stem slenderness trade-offs were not *** may

关键词： Araucaria angustifolia atlantic forest ecological strategies life-history trade-offs mixed forests