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Fundamentals of Presbyopia: visual processing and binocularity in its transformation

Eye and Vision 2018年第1期5卷 1-10页

作者： Olga I.Rozanova andrey g.shchuko Tatyana S.Mischenko Irkutsk branch of S.Fyodorov Eye Microsurgery Federal State Institution IrkutskRussian Federation Irkutsk State Medical University IrkutskRussian Federation

Background:The accommodation has considerable interactions with the pupil response,vergence response and *** transformation of visual reception processing and the changes of the binocular cooperation during the presbyopia development are still poorly ***,the regularities of visual system violation in the presbyopia formation need to be *** study aims to reveal the transformation of visual reception processing and to determine the role of disturbances in binocular interactions in presbyopia ***:This study included 60 people with emmetropic refraction,uncorrected distance visual acuity 1.0 or higher(decimal scale),normal color perception,without concomitant *** first group consisted of 30 people(from 18 to 27 years old)without presbyopia,the second cohort comprised 30 patients(from 45 to 55 years old)with *** eyeball anatomy and optics were evaluated using ultrasound biomicroscopy,aberrometry,and *** functional state of the visual system was investigated under monocular and binocular *** registration of the disparate fusional reflex limits was performed by the original technic using a diploptic device which facilitated investigation of the binocular interaction under natural conditions without the accommodation response,but with the different vergence *** disparate fusional reflex was analyzed using the proximal and distal fusion borders,and the convergence and divergence fusion *** calculation of the area of binocularity field was performed in ***:The presbyopia formation is characterized by a change in an intraocular anatomy,optics,visual processing,and *** processes of binocular interaction inhibition make a significant contribution to the misalignment of the visual *** modification of the proximal,distal and convergence fusion borders was *** was revealed that 87%of the presbyopic patients had binocularity sh

关键词： Presbyopia Binocularity Visual processing Visual reception

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Diagnostics and Prediction of glaucoma in Patients with Familial Congenital Iris Hypoplasia

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Open Journal of Ophthalmology 2015年第3期5卷 115-123页

作者： Tatiana Iureva andrey shchuko Yulia Pyatova Irkutsk Branch S. Fyodorov Eye Microsurgery Federal State Institution Irkutsk Russia Irkutsk State Medical Academy for Postgraduate Education Irkutsk Russia

Purpose: To identify the clinical features of the syndrome Frank-Kamenetsky and determine the criteria of early formation of glaucoma. Materials and Methods: We observed 52 patients. Follow up period was from 5 to 22 years. The first group (juvenile) consisted of males who had the first signs of glaucoma diagnosed before the age of 12 (n = 22). The average age of the group was 10.1 ± 2.4 years. The control group included healthy males (n = 30) in the same age range (average age 7.2 ± 1.6 years). The second group (adults) consisted of patients who had the first signs of glaucoma diagnosed after the age of 18 and elder. The average age of the group was 32.44 ± 6.28 years. The control group had males (n = 30) in the same age range (average age 26.59 ± 4.12 years). The inclusion criterion was: the presence of congenital bilateral mesodermal iris leaf hypoplasia, tra-becular dysgenesis signs, the presence of blood relatives on the maternal line (grandfather, uncle) male with similar changes iridociliary zone and glaucoma. Criteria of glaucoma formation were: increased IOP more than 21 mmHg with accompanying it expansion of the cup/disc ratio, reducing the thickness of the nerve fiber layer (RNFL) according to OCT. Results: It was found that Frank-Kamenetsky Syndrome had an X-linked with sex, recessive inheritance and was characterized by bilateral congenital irisdysgenesis and goniodysgenesis with the accession glaucoma. Predictors of glaucoma formation in early childhood are a combination of: 1) congenital subtotal atrophy of iris mesodermal layer (from 0 to 30 mkm) with signs of progressive dystrophy;2) nonprogressive congenital megalocornea (cornea diameter 12 - 14 mm);3) iridotrabecular dysgenesis of II-III degree;4) hyperopic refraction in axial myopia.

关键词： glaucoma Megalocornea Congenital Mesodermal Iris Atrophy goniodysgenesis

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Ultrastructural and Immunohistochemical Characteristics of Corneal Lenticule Extracted during Correction of Residual Myopia in the Long-Term Period after SMILE

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Open Journal of Ophthalmology 2023年第1期13卷 122-135页

作者： Olesya Pisarevskaya Boris Malyugin andrey shchuko Tatiana Iureva Lyudmila Vasilieva Nikolay Sudakov Igor Klimenkov Elena Likhoshvay Irkutsk Branch of S. Fyodorov “Eye Microsurgery” Federal State Institution of Ministry of Health of Russian Federation Ir-kutsk S. Fyodorov “Eye Microsurgery” Federal State Institution of Ministry of Health of Russian Federation Moscow Russia Irkutsk State Medical University of Ministry of Health of Russian Federation Irkutsk Russia Irkutsk Branch of Russian State Medical Academy of Postgraduate Education of Ministry of Health of Russian Federation Irkutsk Russia Limnological Institute Siberian Branch of Russian Academy of Sciences Irkutsk Russia

Purpose: To evaluate ultrastructural characteristics of lenticule surface extracted during correction of residual myopia in patients after small-incision lenticule extraction (SMILE). Methods and material: This study had a prospective, consecutive, comparative design. Sixteen patients (16 eyes) underwent additional intervention for residual myopia correction after SMILE. 16 specimens of removed lenticules underwent morphological examination. Markers and reagents were used to determine actin microfilaments, neutral fats and cell nuclei. The tissue was analyzed in layers in 2D slices form, volumetric Z-stacks, or selected areas were formed in orthogonal projections. The surface of the extracted lenticule was analyzed using scanning electron microscopy. Patients’ refractive outcomes were measured postoperatively (1 day;1 and 3 months). Results: Postoperatively uncorrected distance visual acuity (20/20 or better) was in 100% cases 3 months after surgery. Ultrastructural studies have shown the difference in surfaces of the newly formed lenticule. Structural changes of the posterior lenticule surface were characterized by ruptures of collagen fibers on its surface, degenerative changes in keratocytes with signs of colliquation necrosis, cell apoptosis and F-actin in cell cytoplasm. Conclusion: Collagen fibers are immersed in the stroma on the anterior surface of the lenticule. There is no complete structure restoration of collagen fibers explaining the lack of tight adhesion of anterior and posterior surfaces of the intrastromal space even in the long-term postoperative period. There are no degenerative changes of keratocytes on the anterior lenticule surface, that is, their changes in SMILE are reversible in most cases.

关键词： SMILE Residual Myopia Correction Lenticule Ultrastromal and Immunohistochemical Analysis

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