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CYP2C19＊2, CYP2C19＊3, CYP2C19＊17 Allele and Genotype Frequencies in Clopidogrel-Treated Patients with Coronary Heart Disease in Russian

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Journal of Pharmacy and Pharmacology 2014年第5期2卷 322-326页

作者： Karin Badavievich Mirzaev Dmitriy Alekseyevich Sychev Alia Sergeyevna Yugay andrey vladimirovich grachev Ruslan Yevgenyevich Kazakov Department of Clinical Pharmacology 1.M. Sechenov First Moscow State Medical University Moscow 119991 Russian Federation Department of Therapeutics and Clinical Pharmacology Russian Medical Academy of Postgraduate Education Moscow 123995Russian Federation Department of Cardiology "SM-clinic" Medical Center Moscow 134544 Russian Federation Center for Clinical Pharmacology Scientific Center on Expertise of Medical Application Products Moscow 109240 Russian Federation

Individual variation in the response to drug therapy has been mainly attributed to the genetic polymorphism of cytochrome P 450 isoenzymes. Mutation in the gene CYP2C19 （cytochrome P450 2C19） has been shown to influence the clinical efficiency of clopidogrel. The aim is to investigate the frequencies of CYP2C19＊2 （c.G681A; rs4244285）, CYP2C19＊3 （c.G636A; rs4986893）, CYP2C19＊17 （c.C806T; rs12248560） and to compare the allele and genotype frequencies of CYP2C19＊2 in patients with CHD （coronary heart disease） to healthy volunteers. We examined 53 patients with CHD received clopidogrel and 146 healthy volunteers. CYP2C19＊2, CYP2C19＊3, CYP2C19＊17 carriages were determined by a polymerase-chain reaction. The observed genotype distribution did not deviate from Hardy-Weinberg equilibrium, it was determined by a Chi-square test with Yates correction. The frequency of CYP2C19＂2 allele reported in patients with CHD and in the healthy volunteers was 16.6% and 13.3%, respectively （P = 0.584）. The results of the present study may be helpful in developing current and future directions for its management.

关键词： CYP2C19*2 CYP2C19*17 CYP2C19 polymorphism pharmacogenetics clopidogrel resistance Russian population.

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Merging bound states in the continuum in an open acoustic resonator

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun Huang Bin Jia Artem S.Pilipchuk Sibo Huang Chen Shen Almas F.Sadreev Yong Li andrey E.Miroshnichenko School of Physics and Electronic Sciences East China Normal University Institute of Acoustics Tongji University L.V.Kirensky Institute of Physics Department of Mechanical Engineering Rowan University School of Engineering and Technology University of New South Wales at Canberra

Bound states in the continuum （BICs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is very sensitive to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and Friedrich-Wintgen BIC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BICs move toward each other and merge into a single one at a critical *** to an individual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional to ΔL-4,whereΔL embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BICs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of Fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances

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Development of high-coercivity state in melt-spun Fe41Pd41B8Si6P4 ribbons

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Rare Metals 2020年第1期39卷 76-83页

作者： Oksana Aleksandrovna Golovnia Nina Ivanovna Vlasova Aleksandr Gervasievich Popov Vasiliy Semenovich Gaviko Vladimir vladimirovich Popov Jr. andrey vladimirovich Protasov Arti Kashyap M.N.Miheev Institute of Metal Physics of Ural Branch of Russian Academy of Sciences EkaterinburgRussia620990 Institute of Natural Sciences and Mathematics Ural Federal UniversityEkaterinburgRussia620002 Israel Institute of Metals Technion R&D FoundationTechnion City3200003HaifaIsrael Indian Institute of Technology Mandi KamandMandiHP175005India

The phase transformation and magnetic hysteresis properties of melt-spun Fe41 Pd41 B8 Si6 P4 ribbons subjected to the annealing at temperatures of 500-550℃were studied after holding for 0.1-60.0 h by transmission electron microscopy(TEM),X-ray diffraction(XRD)and thermomagnetic *** additions of P,B and Si to the FePd alloy allowed us to achieve the coercivity of124 kA·m-1,which is 2.6 times higher than that of the melt-spun ribbons of the binary equiatomic FePd *** high-coercivity Fe41Pd41B8 Si6 P4 alloy is nanocrystalline and is composed of the ordered L10-phase grains approximately 40 nm in size and inclusions of the Fe2(P,B)and Pd2(Si,B)*** coercivity kinetics is controlled by the phase transformation which can be divided into three stages:transformation from the bcc structure to nanosized regions of the fee and Fe2 P phases;transformation from the fee to L10 nanosized regions with somewhat different degrees of tetragonality and their ordering;and extensive growth of the weight fraction of L10 phase from the fee nanosized regions.P and B atoms occupy interstitial sites in the iron plane of L10 lattice,thus decreasing its Curie temperature(TC).

关键词： Fe-Pd-P-B-Si Melt spinning L10 Nanostructured materials Phase transformation Magnetic measurements

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NH_(3)laser THz emission under optical pumping by“long”(~100μs)CO_(2)laser pulses

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Chinese Optics Letters 2023年第2期21卷 133-137页

作者： andrey Alekseevich Ionin Igor Olegovich Kinyaevskiy Yuri Mikhailovich Klimachev andrey Yurievich Kozlov Darya Ivanovna Kormashova andrey Alexandrovich Kotkov Yury Alekseevich Mityagin Sergey Alexandrovich Savinov Adilya Maratovna Sagitova Dmitry Vasilievich Sinitsyn Maxim vladimirovich Ionin P.N.Lebedev Physical Institute of the Russian Academy of Sciences Moscow 119991Russia

Terahertz(THz)NH_(3) lasing with optical pumping by electron-beam-sustained discharge“long”(~100μs)CO_(2) laser pulses was *** NH3laser emission pulses and the“long”pulses of the CO_(2) pump laser were simultaneously measured with nanosecond response *** NH3 lasing duration and its delay with respect to the pump pulse were measured for various CO_(2) laser pulse *** the CO_(2) laser pump line 9R(30),three wavelengths of 67.2,83.8,and 88.9μm were *** the CO_(2) laser pump line 9R(16),only a single NH3 laser line with a wavelength of 90.4μm was detected.

关键词： NH3 laser CO_(2)laser terahertz emission nanosecond response time

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Deep learning as a highly efficient tool for digital signal processing design

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Light(Science & Applications) 2024年第11期13卷 2434-2435页

作者： andrey Pryamikov Prokhorov General Physics Institute of the Russian Academy of Sciences MoscowRussia

The backpropagation algorithm,the most widely used algorithm for training artificial neural networks,can be effectively applied to the development of digital signal processing schemes in the optical fiber transmission *** signal processing as a deep learning framework can lead to a new highly efficient paradigm for cost-effective digital signal processing designes with low complexity.

关键词： signal digital fiber

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Rising complexity of the OAM beam structure as a Way to a higher data capacity

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Light(Science & Applications) 2022年第8期11卷 1648-1649页

作者： andrey Pryamikov Prokhorov General Physics Institute of the Russian Academy of Sciences MoscowRussia

Standard vortex beams carrying different OAM (optical angular momentum) modes can provide independent communication channels for information transmission. However, they are unable to reach the capacity limit of a communication channel due to a rapid divergence of the beams with high values of the OAM order. The solution can be found by using multi-vortex geometric beams.

关键词： OAM communication vortex

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Gas fiber lasers may represent a breakthrough in creating powerful radiation sources in the mid-IR

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Light(Science & Applications) 2022年第2期11卷 153-155页

作者： andrey Pryamikov Prokhorov General Physics Institute of the Russian Academy of Sciences 38 Vavilov streetMoscowRussia

Continuous wave fiber laser created on the basis of silica glass negative curvature hollow core fiber filled with HBr make it possible to obtain efficient narrow linewidth mid-IR emission with a maximum laser power of about 500mW at wavelength of 4200 *** is for the first time that emission from a continuous wave fiber laser have been achieved at a wavelength of 4496 nm with the largest tuning range of 686 nm.

关键词： fiber tuning breakthrough

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Enhancing first-principles simulations of complex solid-state ion conductors using topological analysis of procrystal electron density

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npj Computational Materials 2022年第1期8卷 1777-1786页

作者： andrey Golov Javier Carrasco Centre for Cooperative Research on Alternative Energies(CIC energiGUNE) Basque Research and Technology Alliance(BRTA)01510Vitoria-GasteizSpain

Atomistic-level understanding of ion migration mechanisms holds the key to design high-performance solid-state ion conductors for a breadth of electrochemical ***-principles simulations play an important role in this ***,these methods are generally computationally-intensive,with limited access to complex,low-symmetry structures,such as *** we show how topological analysis of the procrystal electron density can be applied to efficiently mitigate this *** discuss how this methodology goes beyond current state of the art capabilities and demonstrate this with two *** the first,we examine Li-ion transport across grain boundaries in Li_(3)ClO ***,we compute diffusion coefficients as a function of charge carrier concentration in spinel LiTiS_(2) electrode *** two case studies do not exhaust the opportunities and might constitute motivations for still more complex applied materials.

关键词： analysis state holds

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Geochemical discriminations of sandstones from the Mohe Foreland basin,northeastern China:Tectonic setting and provenance

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Science China Earth Sciences 2005年第5期48卷 613-621页

作者： andrey A. Sorokin Far East Branch of Russian Academy of Sciences Blagoveshchensk 675000 Russia

Discrimination of sandstone geochemistry to tectonic settings and provenance has become an effective method in the studies of complex geological circumstances because of its higher sensitivity for the stability of tectonic settings in the period of basin deposition. Results of geochemical analyses in this paper show that sandstone samples of the Mesozoic Mohe basin fall in active continental margin settings on several kinds of tectonic discriminatory diagrams (Bhatia et al. 1983, 1986; Roser et al. 1986,1988,1999). The samples are also characterized by binary-system provenances, whose terrigenous clastic materials mainly derived from the oro- genic belt near the basin to the north and secondarily from the continental region in the south of the basin at the same time. The research results of rock geochemistry, combined with tectonic analysis, reflect that tectonic type of the basin is a foreland basin with nature of depositional ac- cumulation of molass, but not continental rift basin considered in the past. This finding provides important evidence of rock geochemistry for the original structural linkage between the Mohe Foreland Basin and Mongol-Okhotsk Orogen in Mesozoic.

关键词： Mohe Foreland Basin, sandstone geochemistry, tectonic setting, provenance, Jurassic.

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Early Jurassic Climate Warming in Eastern Siberia: First Macrofloristic Evidence from Irkutsk Basin, Russia

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Acta Geologica Sinica(English Edition) 2024年第4期98卷 1035-1050页

作者： andrey FROLOV Irina MASHCHUK Institute of the Earth's Crust Siberian Branch of the Russian Academy of SciencesIrkutsk664033Russia

Numerous new records of Ferganiella, Podozamites, and Schidolepium, including a new species, Ferganiella ivantsovii sp. nov., are described from the Early Jurassic(Toarcian) Middle Subformation of the Prisayan Formation from the Euro-Sinian paleofloristic region in the Irkutsk Basin, Eastern Siberia, Russia. An analysis of the paleogeographic distribution of Ferganiella and Podozamites shows that both genera were the most diverse and numerous in the East Asian province of the Euro-Sinian region and in the Northern Chinese province of the Siberian region during the Early and Middle Jurassic. These phytochoria were located in the subtropical and temperate subtropical climate zones, which allows us to consider Ferganiella and Podozamites as thermophilic plants, which are important indicators of the Early Toarcian climatic optimum. Their abundance in the Irkutsk Basin thus may indicate Early Toarcian warming;further abundant Schidolepium cones, which produced Araucariacites pollen, typical for Euro-Sinian flora complement the scenario. Thus, the new finds are the first macrofloristic indicators of the Toarcian climatic optimum in the Irkutsk Basin.

关键词： paleobotany Ferganiella Podozamites Schidolepium Toarcian climatic optimum paleobiogeography Siberian paleofloristic region Irkutsk

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