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Prospects for the use of olfactory mucosa cells in bioprinting for the treatment of spinal cord injuries

World Journal of Clinical Cases 2023年第2期11卷 322-331页

作者： Olga Vladislavovna Stepanova Grigorii Andreevich Fursa Svetlana Sergeevna Andretsova Valentina Sergeevna Shishkina Anastasia Denisovna Voronova andrey viktorovich chadin Ekaterina Konstantinovna Karsuntseva Igor Vladimirovich Reshetov Vladimir Pavlovich Chekhonin Department of Basic and Applied Neurobiology V.P.Serbsky National Medical Research Center for Psychiatry and NarcologyMoscow 119034Russia Department of Neurohumoral and Immunological Research National Medical Research Center of CardiologyMoscow 121552Russia Department of Biology Moscow State UniversityMoscow 119991Russia Department of Plastic Surgery I.M.Sechenov First Moscow State Medical UniversityMoscow 119435Russia Department of Medical Nanobiotechnologу N.I.Pirogov Russian National Research Medical UniversityMoscow 117997Russia

The review focuses on the most important areas of cell therapy for spinal cord *** mucosa cells are promising for *** these cells is safe for *** use of olfactory mucosa cells is effective in restoring motor function due to the remyelination and regeneration of axons after spinal cord *** cells express neurotrophic factors that play an important role in the functional recovery of nerve tissue after spinal cord *** addition,it is possible to increase the content of neurotrophic factors,at the site of injury,exogenously by the direct injection of neurotrophic factors or their delivery using gene *** advantages of olfactory mucosa cells,in combination with neurotrophic factors,open up wide possibilities for their application in threedimensional and four-dimensional bioprinting technology treating spinal cord injuries.

关键词： Olfactory mucosa cells Neurotrophic factors Cell therapy Injury of spinal cord Three-dimensional bioprinting Four-dimensional bioprinting

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3D pore-scale modeling of nanofluids-enhanced oil recovery

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Petroleum Exploration and Development 2021年第4期48卷 956-967页

作者： MINAKOV andrey viktorovich GUZEI Dmitriy viktorovich PRYAZHNIKOV Maxim Ivanovich FILIMONOV Sergey AnatoFyevich VORONENKOVA Yulia Olegovna Siberian Federal University Krasnoyarsk 660041Russia Kutateladze Institute of Thermophysics SB RASNovosibirsk 630090Russia

The numerical modeling of oil displacement by nanofluid based on three-dimensional micromodel of cores with different permeability was carried out by the volume of fluid(VOF)method with experimentally measured values of interfacial tension,contact angle and ***-based suspensions of SiO_(2) nanoparticles with a concentration of 0–1%and different particle sizes were considered to study the effect of concentration and size of nanoparticles,displacement fluid flow rate,oil viscosity and core permeability on the efficiency of oil displacement by *** oil recovery factor(ORF)increases with the increase of mass fraction of *** increase in nanoparticles’concentration to 0.5% allows an increase in ORF by about 19% compared to water *** ORF increases with the decrease of nanoparticle size,and declines with the increase of displacing *** has been shown that the use of nanosuspensions for enhanced oil recovery is most effective for low-permeable reservoirs with highly viscous oil in injection modes with capillary number close to the immobilization threshold,and the magnitude of oil recovery enhancement decreases with the increase of displacement *** higher the oil viscosity,the lower the reservoir rock permeability,the higher the ORF improved by nanofluids will be.

关键词： nanofluid flooding enhanced oil recovery pore scale modeling fluid volume method

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纳米流体驱提高原油采收率的三维孔隙尺度模拟

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石油勘探与开发 2021年第4期48卷 825-834页

作者： MINAKOV andrey viktorovich GUZEI Dmitriy viktorovich PRYAZHNIKOV Мaxim Ivanovich FILIMONOV Sergey Anatol'yevich VORONENKOVA Yulia Olegovna 西伯利亚联邦大学俄罗斯克拉斯诺亚尔斯克660041 库塔捷拉泽热物理研究所俄罗斯科学院西伯利亚分院俄罗斯新西伯利亚630090

基于不同渗透率岩心的三维微观模型,采用流体体积法对纳米流体驱油进行数值模拟;利用实验测得的含SiO_(2)纳米颗粒的悬浮液界面张力、接触角和黏度,针对质量分数为0~1%、具有不同粒径的SiO_(2)纳米颗粒的水基悬浮液,研究了纳米颗粒质量... 详细信息

基于不同渗透率岩心的三维微观模型,采用流体体积法对纳米流体驱油进行数值模拟;利用实验测得的含SiO_(2)纳米颗粒的悬浮液界面张力、接触角和黏度,针对质量分数为0~1%、具有不同粒径的SiO_(2)纳米颗粒的水基悬浮液,研究了纳米颗粒质量分数和粒径、驱替液流速、原油黏度和岩心渗透率对纳米流体驱油效率的影响。研究表明:采收率随着颗粒质量分数的增加而增加,纳米颗粒质量分数增加到0.5%时,与水驱相比采收率可提高约19%;纳米流体驱油采收率随着纳米颗粒粒径的减小而增加;在毛管数接近临界值的注入模式下使用纳米流体驱油对高黏低渗储集层提高采收率最为有效,且提高采收率幅度随着驱替速度的增加而减小;原油黏度越大,岩石渗透率越小,纳米流体驱油提高采收率的效果越明显。图16表2参37。

关键词：纳米流体驱油提高采收率孔隙尺度模拟流体体积法

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