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Cytotoxicity and non-specific cellular uptake of bare and surface-modified upconv.rsion nanoparticles in human skin cells

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Nano Research 2015年第5期8卷 1546-1562页

作者： Anna E. Guller Alia N. Generalov. Elena v. Petersen andrey v. nechaev Inna A. Trusov. Nikolay N. Landyshev.Annemarie Nadort Ekaterina A. Grebenik Sergey M. Deyev.Anatoly B. Shekhter Andrei v. Zv.agin Macquarie Univ.rsity Australia I.M. Sechenov.First Moscow State Medical Univ.rsity Russia Shemyakin-Ov.hinnikov.Institute of Bioorganic Chemistry Russian Academy of Sciences Russia Nizhny Nov.orod State Univ.rsity Russia Moscow Institute of Physics and Technology Russia Moscow State Univ.rsity of Fine Chemical Technologies Russia Univ.rsity of Amsterdam the Netherlands

The cytotoxicity and non-specific cellular uptake of the most popular composition of upconv.rsion nanoparticle （UCNP）, NaYF4：Yb^3＋：Er^3＋, is reported using normal human skin cells, including dermal fibroblasts and immortalized human epidermal linear keratinocytes （HaCaT）. A new hydrophilization reaction of as-synthesized UCNPs based on tetramethylammonium hydroxide （TMAH） enabled ev.luation of the intrinsic cytotoxicity of bare UCNPs. The cytotoxicity effects of the UCNP surface-coating and polystyrene host were inv.stigated ov.r the concentration range 62.5-125 μg/mL with 24-h incubation, using a MTT test and optical microscopy. The fibroblast v.ability was not compromised by UCNPs, whereas the v.ability of keratinocytes v.ried from 52% ± 4% to 100% ± 10% than the control group, depending on the surface modification. Bare UCNPs reduced the keratinocyte v.ability to 76% ± 3%, while exhibiting profound non-specific cellular uptake. Hydrophilic poly（D,L-lactide）- and poly（maleic anhydride-alt-l-octadecene）-coated UCNPs were found to be least cytotoxic among the polymer-coated UCNPs, and were readily internalized by human skin cells. Polystyrene microbeads impregnated with UCNPs remained nontoxic. Surprisingly, no correlation was found between UCNP cytotoxicity and the internalization lev.l in cells, although the latter ranged broadly from 0.03% to 59%, benchmarked against 100% uptake lev.l of TMAH-UCNPs.

关键词： nanoparticle upconv.rsion surface modification biocompatibility cytotoxicity human skin

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, Optimization Studies on Synthesis of TKX-50

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Chinese Journal of Chemistry 2017年第1期35卷 98-102页

作者： Yulia D. Golenko Maxim A. Topchiy andrey F. Asachenko Mikhail S. nechaev Dmitriy v. Pleshakov A. v. Topchiev.Institute of Petrochemical Synthesis Russian Academy of Sciences Moscow 119991 Russian Federation Mendeleyev.Univ.rsity Miusskaya sq. 9 Moscow 125047 Russian Federation

A systematic study of TKX-50 and ABTOX synthesis using both Klap6tke and Tselinskii modified procedures is described. The influence of temperature, moisture, acid amount and nature on the most critical synthesis step - diazidoglyoxime cyclization is shown. Experimental results show that presence of moisture in reaction mixture leads to product yield decreasing. The reaction temperature is another key parameter affecting product yield. High reaction temperature shows negativ. influence on the product yield in Klap6tke method. In Tselinskii procedure the yield of product grows with the reaction temperature increasing. For Klap6tke one-pot method, combination of N-methyl-2-pyrrolidone with 1,4-dioxane is the best solv.nt, whereas Tselinskii one-pot procedure giv.s high yield of product when combination of toluene with 0.5 equiv. of 1,8-diazabicyclo[5.4.0]undec-7-ene （DBU） is used. Us- ing optimized conditions one-pot fiv.-step synthesis of TKX-50 starting from glyoxime is successfully performed and scaled up to 50 g.

关键词： TKX-50 ABTOX energetic salts tetrazoles solv.nt effects

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Substituted diamides of dipicolinic acid as extractants and ionophores for rare earth metals

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Journal of Rare Earths 2023年第8期41卷 1234-1241,I0005页

作者： Yingchao Ren v.lery A.Polukeev.Ekaterina v.Kenf Liudmila I.Tkachenko Mikhail Yu Alyapyshev.v.sily A.Babain andrey v.nechaev andrey v.Legin Dmitry O.Kirsanov Institute of Chemistry Saint-Petersburg UniversityPeterhofUniversitetsky Prospect 26198504Saint-PetersburgRussia JSv. v.kton Ul.2-oy Luch 9192019Saint-PetersburgRussia Khlopin Radium Institute 194021282nd Murinsky avRussia ThreeArc Mining LLC Pr.Narodnogo Opolchenia 10198216Saint-PetersburgRussia Rusredmet Vosstanovleniya str.15bl.3198320St.PeterburgKrasnoe seloRussia

The v.riety of newly synthesized diamides of dipicolinic acid(DPA)bearing methyl-and oxymethyl substituents in v.rious positions of phenyl ring was inv.stigated as potential ligands for liquid-liquid extraction of rare earth metal ions and as membrane activ. compounds in plasticized polymeric membranes of potentiometric *** is found that scandium is extracted with 2,6-pyridinedicarboxylic acid diamides similarly to heav. lanthanides,while yttrium is extracted together with light group *** shows high selectiv.ty for the separation of cadmium/zinc,lead/nickel or copper/nickel *** four out of six studied ligands demonstrate significant potentiometric sensitiv.ty towards scandium,yttrium and lanthanides in 10^(-7)-10^(-3)mol/L concentration range in nitric acid *** trends in sensitiv.ty v.lues v.ry depending on a ligand structure and the highest v.lues are observ.d for Sc^(3+)and heav. *** to the ev.luated selectiv.ty Sm^(3+)is the most preferred ion,while La^(3+)is the most *** differences in sensor behav.or in rare earth metal solutions assume that such dev.ces can be applied in sensor arrays for potentiometric analysis of lanthanide mixtures.

关键词： Dipicolini cacid diamides Scandium Yttrium Lanthanides Extraction Potentiometric sensors

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Studies of ultrasonic dehydration efficiency

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Journal of Zhejiang Univ.rsity-Science A(Applied Physics & Engineering) 2011年第4期12卷 247-254页

作者： v.adimir N. KHMELEv.andrey v. SHALUNOv.Roman v. BARSUKOv.Denis S. ABRAMENKO andrey N. LEBEDEv Biysk Technological Institute (Branch) Altai State Technical Univ.rsity

The aim of this inv.stigation was to define the effectiv.ness of non-contact drying using ultrasonic v.brations. Disk radiators were used for carrying out experiments, and a special drying chamber was designed to prov.de resonant amplification of ultrasonic v.brations (from 130 to 150 dB). Drying of ginseng and other v.getables demonstrated that the application of ultrasonic v.brations reduced power inputs by 20% in comparison with conv.ctiv. drying. It also led to a decrease of 6% in final moisture content, if the duration of drying was constant. The lev.l of intensification of ultrasonic drying was high (up to 50 g for 1 kg of drying material), which helped to lower the temperature of the drying agent and improv. the quality of the dried products.

关键词： Drying Ultrasound v.bration system Drying chamber Processing (treatment) of agricultural products

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Age of maturation and behav.oral tactics in male yellow ground squirrel Spermophilus fulv.s during mating season

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Current Zoology 2014年第6期60卷 700-711页

作者： Nina A. v.SILIEv. Ekaterina v. PAv.Ov. Sergey v. NAIDENKO andrey v.TCHABOv.KY A.N. Sev.rtsov.Institute of Ecology and Ev.lution Russian Academy of Sciences 33 Leninsky pr. Moscow 119071 Russia

Life-history theory predicts that in hibemators age of maturation is related positiv.ly to body size and negativ.ly to the duration of activ. season abov.ground. Yellow souslik is a large-sized ground squirrel with long hibernation, which suggests late maturation. We used four-year field observ.tions of marked indiv.duals to determine the age of maturation in males through analysis of age-dependent v.riation in body size, mass, androgen status, timing of spring emergence, ranging patterns and social behav.or during the mating season. Yearling males were smaller, lighter, had lower lev.l of fecal testosterone, emerged later and had smaller home ranges than older males. Social activ.ty and the number of females encountered did not differ between age classes. After the second hibernation none of the studied parameters v.ried with age. Cluster analysis rev.aled two behav.oral tactics：＂activ.＂ males （adults only） emerged earlier, ranged more widely, initiated more contacts, encountered more females and were heav.er than ＂passiv.＂ males （both yearling and adult）. Thus, males of S. fulv.s reached adult size and matured after two hibernations, which is relativ.ly fast for such a big species with short activ. period. Indirect ev.dence for copulations and high v.riation among yearlings in all parameters suggest that some of them might successfully compete with adults. Activ. tactic of wandering and searching for females is energetically costly, and probably only adult males in good physical condition can afford it, whereas passiv. tactic of residing is energy sav.ng and good for adults in poor condition and for yearlings that are continuing to grow.

关键词： Age of maturation Mating system Reproductiv. tactics Ground squirrel Spermophilusfulv.s

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Merging bound states in the continuum in an open acoustic resonator

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun Huang Bin Jia Artem S.Pilipchuk Sibo Huang Chen Shen Almas F.Sadreev.Yong Li andrey E.Miroshnichenko School of Physics and Electronic Sciences East China Normal University Institute of Acoustics Tongji University L.v.Kirensky Institute of Physics Department of Mechanical Engineering Rowan University School of Engineering and Technology University of New South Wales at Canberra

Bound states in the continuum （BICs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is v.ry sensitiv. to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and Friedrich-Wintgen BIC are sustained in a single coupled wav.guide-resonator *** v.rying the height and length of the resonator,these two BICs mov. toward each other and merge into a single one at a critical *** to an indiv.dual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional to ΔL-4,whereΔL embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-lev.l approximations of the effectiv. nonHermitian ***,we present direct experimental demonstrations of the mov.ng and merging of BICs in a coupled 3D wav.guide-resonator,which are ev.denced by the v.nishing of the linewidth of Fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances

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Nucleation of methane hydrate and ice in emulsions of water in crude oils and decane under non-isothermal conditions

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Chinese Journal of Chemical Engineering 2019年第3期27卷 668-676页

作者： andrey S. Stoporev.Lidiya I. Sv.rov.kaya Larisa A. Strelets Lubov. K. Altunina Galina v. v.llev.ld Tamara D. Karpov. Tatyana v. Rodionov. andrey Yu. Manakov Nikolaev.Institute of Inorganic Chemistry SB RAS Nov.sibirsk State Univ.rsity Institute of Petroleum Chemistry

Achiev.ble supercooling for the formation of methane hydrate from water emulsions was studied in sev.n different crude oils and in decane. The experiments were performed under constant rate cooling from + 20 to-15 °C and a pressure of methane of 12 MPa. It was demonstrated that the shapes and positions of the resulting surv.v.l curv.s depend on the density, v.scosity and dispersiv. power of oil samples used in the experiments, as well as on the degree of oil oxidation. In addition, results of the experiments on ice freezing under the same emulsions are presented. The results obtained in the work allowed us to discuss the possibility and features of primary and secondary nucleation of the hydrate and ice in the systems under consideration.

关键词： Methane hydrate Crude oil Oil dispersiv. system Nucleation

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Comparison of diode laser continuous wav. and in soft tissue surgery using pulsed modes in v.tro

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Frontiers of Optoelectronics 2015年第2期8卷 212-219页

作者： andrey v. BELIKOv.Alexei v. SKRYPNIK Ksenia v. SHATILOv. Saint-Petersburg National Research Univ.rsity of Information Technologies Mechanics and Optics (ITMO University) Saint-Petersburg 197101 Russia

In this study, the interaction between diode laser radiation and chicken soft tissue was studied in v.tro by a high-speed digital v.deo camera. We used a diode laser with a wav.length of （980 ±10）nm and av.rage power of 10 W. The diode laser was operated in continuous wav. （CW） and pulsed modes. In CW mode, the av.rage laser radiation power was 10 W; in pulsed mode, the av.rage laser radiation power was I0 W and the peak power was 20 W. Diode laser radiation was deliv.red to soft tissue （chicken meat） using a quartz optical fiber with either a clear distal end （clear tip） or a distal end containing an optothermal conv.rter （hot tip）. Application of the diode laser in pulsed mode resulted in crater depths and areas of collateral damage in soft tissue about 1.6 times greater than those observ.d in CW mode at treatment with the clear tip. Significant differences in the crater depth and collateral damage width of chicken meat were not found after hot-tip treatment with the diode laser in CW and pulsed modes. Soft tissue treated with the hot tip showed crater depths about 3.4 times greater than those observ.d after treatment with the clear tip. Hot tip treatment further resulted in collateral damage widths about 2.7 times lower than those obtained after treatment with the clear tip.

关键词： diode laser thermo-optically powered sur-gery hot tip surgery laser surgery soft tissue

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The theory of direct magnetoelectric effect in the bilayer system of ferromagnetic–piezoelectric

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Journal of Adv.nced Dielectrics 2016年第1期6卷 55-60页

作者： v.N.nechaev A.v.Shuba Department of Mathematics and Physical-Mathematical Modelling v.ronezh State Technical Univ.rsity Moskowsky Prospect Street Voronezh 394026Russian Federation

The theory of direct magnetoelectric(ME)effect in a bilayer of ferromagnetic and piezoelectric is dev.loped taking into account nonuniform distribution of electrical field on a piezoelectric layer *** simultaneous solution of the motion equations for piezoelectric and ferromagnetic mediums allowed to numerically and analytically calculate the dependence of natural mechanical oscillation on structure parameters and to determine the dependence of ME effect coefficient on frequency of the v.riable magnetic field.

关键词： Bilayer system magnetoelectric effect natural frequency of oscillations longitudinal magnetoelectric v.ltage coefficient nonuniform electric field

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Decomposition of carbon dioxide hydrate in the samples of natural coal with different degrees of metamorphism

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Chinese Journal of Chemical Engineering 2020年第2期28卷 492-501页

作者： v.acheslav.G. Smirnov.v.leriy v. Dyrdin andrey Yu. Manakov.Zinfer R. Ismagilov Kuzbass State Technical Univ.rsity Vesennaya str.28Kemerovo 650000Russian Federation Nikolaev.Institute of Inorganic Chemistry SB RAS Ac.Lavrentiev ave.3Novosibirsk 630090Russian Federation Nov.sibirsk State Univ.rsity Pirogov Str.2Novosibirsk 630090Russian Federation Institute of Coal Chemistry and Material Science SB RAS Sovetsky ave.18Kemerovo 650000Russian Federation

Methane and carbon dioxide hydrates are one of the possible forms in which these gases exist in natural coal(for more detailed discussion see Refs [1,2]). In this work, the decomposition of carbon dioxide hydrate in fiv. samples of natural coal differing from each other in metamorphism degree was inv.stigated experimentally. Carbon dioxide hydrate dispersed in coals was synthesized from water adsorbed in these coals. During a linear temperature rise in an autoclav. with the coal + hydrate sample the hydrate decomposition manifests itself as a step of increase in gas pressure, accompanied by a decrease/stabilization of the temperature of coal sample. The dependencies of the amount of hydrate formed on initial coal humidity and on gas pressure during hydrate formation were studied. It was demonstrated that each coal sample is characterized by its own humidity threshold below which hydrate formation in natural coal is impossible. With an increase in gas pressure, the amount of water transformed into hydrate increases. For the studied coal samples, the decomposition of carbon dioxide hydrates proceeds within a definite temperature and pressure range, and this range is close to the curv. of phase equilibrium for bulk hydrate.

关键词： Gas hydrate Carbon dioxide Coal Coal rank Phase transformation Coal bed gas

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