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Photodynamic diagnostics of early gastric cancer:Complexity measures of gastric microcirculation and new model of metastatic adenocarcinoma of rat stomach

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Journal of Innovative Optical Health Sciences 2019年第2期12卷 64-73页

作者： Alexey Pavlov Ekaterina Borisova Olga Pavlova Ilana Agranovich Alexander Khorovodov andrey terskov Aysel Mamedova Maria Klimova Latchezar Avramov Oxana Semyachkina-Glushkovskaya Saratov State University 83 Astrakhanskaya Str.Saratov 410012Russia Institute of Electronics Bulgarian Academy of Sciences Tsarigradsko Chaussee Blvd.72Sofia 1784Bulgaria

The detection of early gastric cancer that often develops asymptomatically is crucial for improving patient *** photodynamic diagnosis(PDD)of gastric cancer using 5-aminolevulinic acid/protoporphyrin IX(5-ALA/PpIX)has been reported in several ***,the selectivity of PDD of gastric tumor is poor with often false-positive results that require the development of new methods to improve PDD for early gastric ***,a measure of the complexity of gastric microcirculation(multi-scale entropy,MSE)and the detrendedfluctuation analysis(DFA)were applied as additional tools to detect early gastric cancer in *** this experimental study,we used our original model of metastatic adenocarcinoma in the stomach of a *** induce a gastric tumor,we used a long-term combination(for 9 months,which is 1/2 of the life of rats)of two natural factors,such as chronic stress(overpopulation being typical for modern cities)and the daily presence of nitrites in food and drinks,which are common ingredients added to processed meat andfish to help preserve *** results clearly show that both methods,namely,PDD using 5-ALA/PpIX and complexity/correlation analysis,can detect early gastric cancer,which was confirmed by histological ***-cancerous areas in the stomach were detected as an intermediatefluorescent signal or MSE level between normal and malignant lesions of the ***,in some cases,PDD with 5-ALA/PpIX produced a false-positivefluorescence of exogenousfluorophores due to its accumulation in benign and inflammatory areas of the *** fact indicates that the PDD itself is not sufficient for the correct diagnosis of gastric cancer,and the use of additional characteristics,e.g.,complexity measures or scaling exponents,can significantly improve the diagnostic accuracy of PDD of gastric cancer that should be confirmed in further clinical studies and applications.

关键词： Experimental model of gastric cancer in animals highly heterogeneous adenocarcinoma photodynamic diagnosis complexity measures gastric microcirculation

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Optical in vivo and ex vivo imaging of glioma cells migration via the cerebral vessels:Prospective clinical application of the beta2-adrenoreceptors blockade for glioma treatment

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Journal of Innovative Optical Health Sciences 2018年第4期11卷 98-107页

作者： Olga Pavlova Alexander Shirokov Alexander Fomin Nikita Navolokin andrey terskov Alexander Khorovodov Anton Namykin Alexey Pavlov Valery Tuchin Oxana Semyachkina-Glushkovskaya Interdisciplinary Center of Critical Technologies in Medicine Saratov State University 83 Astrakhanskaya Str.Saratov 410012Russia Institute of Biochemistry and Physiology of Plants and Microorganisms Russian Academy of Sciences13 Entuziastov Ave.Saratov 410049Russia Saratov State Medical University 112 Bolshaya Kazachia Str. Saratov 410012Russia Department of Optics and Biophotonics Saratov State University 83 Astrakhanskaya Str.Saratov 410012Russia Yuri Gagarin State Technical University of Saratov 77 Politechnicheskaya Str. Saratov 410054Russia Laboratory of Laser Diagnostics of Technical and Living Systems Institute of Precision Mechanics and Control of RAS 24 Rabochaya Str.Saratov 410028Russia Laboratory of Biophotonics Tomsk State University 36 Lenin's Ave.Tomsk 634050Russia

Malignant gliomas are highly invasive tumors that 1use the cerebral vessels for invasion due to high vascular fragility of the blood--brain barrier(BBB).On one hand,glioma is characterized by the BBB disruption,on the other hand,drug brain delivery via the BBB is a big challenge in glioma *** limited information about vascular changes associated with glioma growth is a reason of slow progress in prevention of glioma ***,we present in vrivo and er vrivo study of the BBB disruption and glioma cells(GCs)migration in rats using fuorescence and confocal *** uncovered a local breach in the BBB in the main tumor mass but not within the border of normal and malignant cells,where the BBB was impermeable for high weight *** migr ation of GCs were observed via the cerebral vessels with the intact BBB that was associated with macrophages *** mechanisms underlying glioma progression remain umknown but there is an evidence that the sympathetic nervous system(SNS)via activation of vascular beta2-adrenoreceptors(B2-ADRs)can play an important role in tumor *** results clearly show an increase in the expression of vascular B2-ADRs and production of the beta arrestin-1-co-factor of B2-ADRs signaling pathway in rats with *** blockade of B2-ADRs reduces the BBB disruption,macrophages infiltration,GCs migration and increases survival *** data suggest that the blockade of B2-ADRs may be a novel adjuvant therapeutic strategy to reduce glioma progression and prevent metastasis。

关键词： Glioma macrophages blood-brain barrier beta-2 adrenoreceptors bet a arrestin-1

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Mechanisms of phototherapy of Alzheimer’s disease during sleep and wakefulness:the role of the meningeal lymphatics

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Frontiers of Optoelectronics 2023年第3期16卷 57-76页

作者： Semyachkina‑Glushkovskaya Oxana Shirokov Alexander Blokhina Inna Fedosov Ivan terskov andrey Dubrovsky Alexander Tsoy Maria Elovenko Daria Adushkina Viktoria Evsukova Arina Telnova Valeria Tzven Anna Krupnova Valeria Manzhaeva Maria Dmitrenko Alexander Penzel Thomas Kurths Jürgen Institute of Physics Humboldt UniversityBerlin 12489Germany Department of Biology Saratov State UniversitySaratov 410012Russia Institute of Biochemistry and Physiology of Plants and Microorganisms Russian Academy of SciencesSaratov 410049Russia Charité–Universitätsmedizin Berlin Berlin 10117Germany Department of Complexity Scienc Potsdam Institute for Climate Impact ResearchPotsdam 14473Germany

With the increase in the aging population,the global number of people with Alzheimer’s disease(AD)progressively increased *** situation is aggravated by the fact that there is no the efective pharmacological therapy of ***(PBM)is non-pharmacological approach that has shown very promising results in the therapy of AD in pilot clinical and animal ***,the mechanisms of therapeutic efects of PBM for AD are poorly *** this study on mice,we demonstrate that photodynamic efects of 5-aminolevulenic acid and laser 635 nm cause reduction of network of the meningeal lymphatic vessels(MLVs)leading to suppression of lymphatic removal of beta-amyloid(Aβ)from the right lateral ventricle and the *** the original protocol of PBM under electroencephalographic monitoring of wakefulness and sleep stages in non-anesthetized mice,we discover that the 7-day course of PBM during deep sleep *** provides better restoration of clearance of Aβfrom the ventricular system of the brain and the *** results shed light on the mechanism of PBM and show the stimulating efects of PBM on the brain lymphatic drainage that promotes transport of Aβvia the lymphatic *** efects of PBM on the brain lymphatics in sleeping brain open a new niche in the study of restorative functions of sleep as well as it is an important informative platform for the development of innovative smart sleep technologies for the therapy of AD.

关键词： Alzheimer’s disease Photobiomodulation Brain lymphatics Sleep Mechanisms

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