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Elucidating the Degradation Pathways of Human Insulin in the Solid State

journal of Analysis and Testing 2024年第03期8卷 288-299页

作者： andrew Fagan Lorraine M.Bateman joseph P.O'Shea Abina M.Crean SSPC the SFI Centre for Pharmaceutical Research School of Pharmacy University College Cork School of Pharmacy University College Cork Analytical and Biological Chemistry Research Facility (ABCRF) University College Cork School of Chemistry University College Cork

While there have been significant advances in the development of peptide oral dosage forms in recent years, highlighted by the clinical and commercial success of approved peptides such as Rybelsus?, there remain several barriers in the way of broad range applicability of this approach to peptide delivery. One such barrier includes the poor physical and chemical stability inherent to their structures, which persists in the solid state although degradation typically occurs at different rates and via different pathways in comparison to the solution state. Using insulin as a model peptide, this work sought to contribute to the development of analytical techniques for investigating common insulin degradation pathways. Chemically denatured,deamidated and aggregated samples were prepared and used to benchmark circular dichroism spectroscopy, reverse phase HPLC and size exclusion chromatography methods for the investigation of unfolding, chemical modifications and covalent aggregation of the insulin molecule respectively. Solid state degraded samples were prepared by heating insulin powder at 60 °C and 75% relative humidity for 1, 3, 5 and 7 d, and the degradation profiles of the samples were evaluated and compared with those observed in solution. While no unfolding was observed to occur, significant deamidation and covalent aggregation were detected. Reductive disulfide bond cleavage using dithiothreitol allowed for separation of the insulin A-and B-chains,offering a facile yet novel means of assessing the mechanisms of deamidation and covalent aggregation occurring in the solid state.

关键词： Biopharmaceutical analysis Covalent aggregation Deamidation Disulfide cleavage Insulin Solid state Stability

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Mitigating Carbon Emissions:A Comprehensive Analysis of Transitioning to Hydrogen-Powered Plants in japan’s Energy Landscape Post-Fukushima

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Energy Engineering 2024年第5期121卷 1143-1159页

作者： Nugroho Agung Pambudi andrew Chapman Alfan Sarifudin Desita Kamila Ulfa Iksan Riva Nanda Department of Mechanical Engineering Education Universitas Sebelas MaretSukoharjo57161Indonesia International Institute for Carbon-Neutral Reserch(WPI-I2CNER) Kyushu UniversityFukuoka819-0395Japan Postgraduate of Mechanical Engineering Universitas Sebelas MaretSurakarta57126Indonesia Energy and Society Laboratory Department of Mechanical Engineering EducationUniversitas Sebelas MaretSukoharjo57161Indonesia Department of Metallurgical and Material Engineering Universitas IndonesiaDepok16424Indonesia

One of the impacts of the Fukushima disaster was the shutdown of all nuclear power plants in japan,reaching zero production in *** response,the country started importing more fossil energy including coal,oil,and natural gas to fill the energy ***,this led to a significant increase in carbon emissions,hindering the efforts to reduce its carbon *** the current situation,japan is actively working to balance its energy requirements with environmental considerations,including the utilization of hydrogen ***,this paper aims to explore the feasibility and implications of using hydrogen power plants as a means to reduce emissions,and this analysis will be conducted using the energy modeling of the MARKAL-TIMES japan *** hydrogen scenario(HS)is assumed with the extensive integration of hydrogen into the power generation sector,supported by a hydrogen import ***,this scenario will be compared with the Business as Usual(BAU)*** results showed that the generation capacities of the BAU and HS scenarios have significantly different primary energy *** BAU scenario is highly dependent on fossil fuels,while the HS scenario integrates hydrogen contribution along with an increase in renewable energy,reaching a peak contribution of 2,160 Pj in *** the HS scenario,the target of reducing CO_(2) emissions by 80%is achieved through significant hydrogen *** 2050,the total CO_(2) emissions are estimated to be 939 million tons for the BAU scenario and 261 million tons for the Hydrogen *** addition,the contribution of hydrogen to electricity generation is expected to be 153 TWh,smaller than PV and wind power.

关键词： Business as usual(BAU)scenario hydrogen scenario CO_(2)emissions power generation sector

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Resection and reconstruction in high-grade pancreatic head injuries

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World journal of Gastrointestinal Surgery 2024年第5期16卷 1467-1469页

作者： jake Krige Eduard jonas andrew john Nicol Pradeep Harkson Navsaria HPB Surgery University of Cape Town Health Sciences FacultyCape Town 7925Western CapeSouth Africa Trauma Center Department of SurgeryGroote Schuur HospitalCape Town 7925Western CapeSouth Africa Department of Surgery Trauma CenterGroote Schuur HospCape Town 7925Western CapeSouth Africa

This study by Chui et al adds further important evidence in the treatment of highgrade pancreatic injuries and endorses the concept of the model of pancreatic trauma care designed to optimize treatment,minimize morbidity and enhance survival in patients with complex pancreatic *** the authors have demonstrated favorable outcomes based on their limited experience of 5 patients who underwent a pancreaticoduodenectomy(PD),including 2 patients who were“unstable”and did not have damage control surgery(DCS),we would caution against the general recommendations promoting index PD without DCS in“unstable”grade 5 pancreatic head injuries.

关键词： Pancreas Injury Surgery Pancreaticoduodenectomy

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Latest updates on structure and recommendations of cardiac rehabilitation programs in chronic heart failure

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World journal of Clinical Cases 2024年第8期12卷 1382-1387页

作者： Christos Kourek Alexandros Briasoulis Dimitrios E Magouliotis john Skoularigis andrew Xanthopoulos Medical School of Athens National and Kapodistrian University of AthensAthens 15772Greece Department of Clinical Therapeutics Alexandra HospitalFaculty of MedicineNational and Kapodistrian University of AthensAthens 11528Greece Department of Surgery University Hospital of LarissaLarissa 41110Greece of Cardiology University Hospital of LarissaLarissa 41110Greece

Chronic heart failure(HF)is a clinical syndrome with high morbidity and mor-tality *** rehabilitation(CR)is a medically supervised program designed to maintain or improve cardiovascular health of people living with HF,recommended by both American and European guidelines.A CR program con-sists of a multispecialty group including physicians,nurses,physiotherapists,trainers,nutritionists,and psychologists with the common purpose of improving functional capacity and quality of life of chronic HF *** activity,lifestyle,and psychological support are core components of a successful CR *** has been shown to be beneficial in all ejection fraction categories in HF and most patients,who are stable under medication,are capable of *** individualized exercise prescription should be developed on the basis of a baseline evaluation in all *** main modalities of exercise training are aerobic exercise and muscle strength training of different intensity and *** is important to set the appropriate clinical outcomes from the beginning,in order to assess the effectiveness of a CR *** are still significant limitations that prevent patients from participating in these programs and need to be solved.A significant limitation is the generally low quality of research in CR and the presence of negative trials,such as the rehabilitation after myocardial infarction trial,where comprehensive rehabilitation following myocardial infraction had no important effect on mortality,morbidity,risk factors,or health-related quality of life or *** the present editorial,we present all the updated knowledge and recommendations in CR programs.

关键词： Cardiac rehabilitation Heart failure Outcomes Exercise protocols Prescription Future perspectives Limitations

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Editorial for Multiscale&Multifield Coupling in Geomechanics

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journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 1919-1921页

作者： Min Wang Pengzhi Pan andrew H.C.Chan Y.T.Feng T-3 Fluid Dynamics and Solid Mechanics Theoretical DivisionLos Alamos National LaboratoryNew MexicoUSA Institute of Rock and Soil Mechanics Chinese Academy of SciencesWuhanChina School of Engineering University of TasmaniaTasmaniaAustralia College of Engineering Swansea UniversityWalesUK

We are delighted to serve as guest editors for this special issue in the journal of Rock Mechanics and Geotechnical *** purpose of this special issue is dedicated to gathering the latest research work on Multiscale&Multifield Coupling in Geomechanics,where we delve into the intricate interplay of various fields and scales that govern the behavior of *** total,30 manuscripts from USA,China,UK,Germany,Canada,India and United Arab Emirates are selected to be included in this issue.

关键词： materials. gathering mechanics

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Soluble epoxide hydrolase:a next-generation drug target for Alzheimer's disease and related dementias

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Neural Regeneration Research 2025年第09期 2585-2586页

作者： andrew Gregory Chengyun Tang Fan Fan Department of Physiology Medical College of GeorgiaAugusta University

Alzheimer's disease(AD) and Alzheimer's diseaserelated dementias(ADRD) represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging global *** the World Health Organization,AD/ADRD has affected more than 55 million individuals worldwide,with an additional 10 million cases diagnosed each year.

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A state-of-the-art review on delayed expansion of cemented paste backfill materials

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Rare Metals 2024年第8期43卷 3475-3500页

作者： Meng-Yuan Li Li-jie Guo Yue Zhao Lei Zhang Kai Yang Xiao-Peng Peng andrew Pan BGRIMM Technology Group Beijing 100160China National Centre for International Research On Green Metal Mining Beijing102628China Department of Civil and Mineral Engineering University of TorontoTorontoON M5S 1A4Canada

Utilizing delayed expansion cemented paste backfill materials(DECPB) in mine backfill operations offers an effective solution to the challenge of achieving proper contact between the in-situ cemented backfill mass and the roof in mined-out areas(backfill-roof contact).This article presents recent progress in both theoretical and experimental research concerning *** types and mechanisms of expansive additives,including expansive agents,foaming agents,and expansive mineral materials relevant to DECPB,are explained,along with their impact on the expansive properties and mechanical characteristics of *** composition,material characteristics,preparation methods,and controlled release mechanisms of microcapsules are *** methods for measuring the volume change rate of paste backfill slurries are *** indicates that an appropriate content of expansive additives not only enhances the expansive properties of cemented paste backfill materials but also contributes to improving their mechanical *** foaming agents and bentonite are found to be more suitable for preparing DECPB compared to expansive *** delayed expansion of cemented paste backfill material is influenced by microcapsules,with their wall materials,preparation parameters,and the alkaline slurry environment affecting their controlled release *** and optimizing precise measurement devices and methods forfor the volume change rate of cemented paste backfill materials is essential requirement for studying the performance of *** delayed expansion technology with retarding techniques in cemented paste backfill materials can provide a reliable solution for achieving proper backfill-roof contact in the future.

关键词： Paste backfill Delayed expansion Mining with backfill Expansive additives Tailings

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Prevalence of visual impairment and estimation of refractive errors among school children in Kakamega,Kenya

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International journal of Ophthalmology(English edition) 2024年第5期17卷 932-939页

作者： Isabel Signes-Soler Alfred Ragot Sheilah Nangena andrew Wekesa Raúl Montalbán Llamusí Department of Optics and Optometry and Vision Sciences Universidat de ValènciaBurjassotValencia 46010Spain NGO Vision Without Borders(Visio Sense Fronteres VSF)Calpe 03710AlicanteSpain Masinde Muliro University of Science and Technology P.O Box 190-50100KakamegaKenya Clinica Baviera Alicante C/Ausóy Monzó 16Alicante 03006Spain

AIM:To investigate the prevalence of visual impairment(VI)and provide an estimation of uncorrected refractive errors in school-aged children,conducted by optometry students as a community ***:The study was *** 3343 participants were included in the *** initial examination involved assessing the uncorrected distance visual acuity(UDVA)and visual acuity(VA)while using a+2.00 D *** inclusion criteria for a subsequent comprehensive cycloplegic eye examination,performed by an optometrist,were as follows:a UDVAjority of the children(89.7%)fell within the age range of 8 to *** the ethnic groups,the highest representation was from the Luhya group(60.6%)followed by Luo(20.4%).Mean logMAR UDVA choosing the best eye for each student was 0.29±0.17(range 1.70 to 0.22).Out of the total,246 participants(7.4%)had a full eye *** estimated prevalence of myopia(defined as spherical equivalent≤-0.5 D)was found to be 1.45%of the total *** around 0.18%of the total sample had hyperopia value exceeding+1.75 *** astigmatism(cil<-0.75 D)was found in 0.21%(7/3343)of the *** VI prevalence was 1.26%of the total *** our cases of VI,76.2%could be attributed to uncorrected refractive *** was detected in 0.66%(22/3343)of the screened *** was no statistically significant correlation observed between age or gender and refractive ***:The primary cause of VI is determined to be uncorrected refractive errors,with myopia being the most prevalent refractive error *** findings underscore the significance of early identification and correction of refractive errors in school-aged children as a means to alleviate the impact of VI.

关键词： visual impairment refractive errors myopia amblyopia sustainable development goals

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Guest Editorial:Special issue on advances in representation learning for computer vision

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CAAI Transactions on Intelligence Technology 2024年第1期9卷 1-3页

作者： andrew Beng jin Teoh Thian Song Ong Kian Ming Lim Chin Poo Lee Electrical and Electronic Engineering Department Yonsei UniversitySeoulSouth Korea Faculty of Information Science and Technology Multimedia UniversityMelakaMalaysia

Deep learning has been a catalyst for a transformative revo-lution in machine learning and computer vision in the past *** these research domains,methods grounded in deep learning have exhibited exceptional performance across a spectrum of *** success of deep learning methods can be attributed to their capability to derive potent representations from data,integral for a myriad of downstream *** representations encapsulate the intrinsic structure,fea-tures,or latent variables characterising the underlying statistics of visual *** these achievements,the challenge per-sists in effectively conducting representation learning of visual data with deep models,particularly when confronted with vast and noisy *** special issue is a dedicated platform for researchers worldwide to disseminate their latest,high-quality articles,aiming to enhance readers'comprehension of the principles,limitations,and diverse applications of repre-sentation learning in computer vision.

关键词： spite computer representation

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Spreadability of powders for additive manufacturing: A critical review of metrics and characterisation methods

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PARTICUOLOGY 2024年第10期93卷 211-234页

作者： Talebi, Fatemeh A. Haydari, Zobaideh Salehi, Hamid Mehrabi, Mozhdeh Gardy, jabbar Bradley, Mike Bayly, andrew E. Hassanpour, Ali Univ Leeds Sch Chem & Proc Engn Leeds LS2 9JT England Univ Greenwich Sch Engn Greenwich ME4 4TB England Cormica Ltd Listerhills Sci PkCampus Rd Bradford BD7 1HR England

Powder bed fusion methods of additive manufacturing (AM) require consistent, reproducible, and uniform layers of powder for the reliable production of high-quality parts, where properties of powder are central to achieving this. Among these properties, powder flowability and spreadability play critical roles in determining the quality of these powder layers. While extensive research has been conducted on powder flow and spreading behaviour, and on their characterisation, there is little critical comparison and review of these terms in the context of AM. Such a review is necessary to further develop and enhance our comprehension of spreading dynamics and its relation to powder properties in AM systems. This review paper aims to build a coherent understanding of the correlation between powder characteristics and spreading in powder based additive manufacturing and its impact on manufactured parts. It highlights the current progress in comprehending spreading dynamics, the influence of powder characteristics, environmental conditions, spreading system, and the development of testing tools to assess powder spreadability. Furthermore, the paper critically discusses the challenge of finding appropriate quantitative metrics and recent advances in the use of standardised methods for evaluating powder spreadability. (c) 2024 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences. Published by Elsevier B.V. This is an open access article under the CC BY license (http:// ***/licenses/by/4.0/).

关键词： Powder spreading Powder flowability Powder properties Quality of layer and final products DISCRETE ELEMENT SIMULATION PARTICLE-SIZE DISTRIBUTION SPREADING PROCESS FLOW PROPERTIES NUMERICAL-SIMULATION DENSITY BULK FLOWABILITY SEGREGATION BEHAVIOR

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