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Soluble epoxide hydrolase:a next-generation drug target for Alzheimer's disease and related dementias

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Neural Regeneration Research 2025年第9期20卷 2585-2586页

作者： andrew gregory Chengyun tang Fan Fan Department of Physiology Medical College of GeorgiaAugusta UniversityAugustaGAUSA

Alzheimer's disease(AD)and Alzheimer's diseaserelated dementias(ADRD)represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging global *** the World Health Organization,AD/ADRD has affected more than 55 million individuals worldwide,with an additional 10 million cases diagnosed each year.

关键词： Alzheimer population drug

Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel gruchot Laura Reiche andrew Chan Robert Hoepner Patrick Küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

Evaluation of natural goethite on the removal of arsenate and selenite from water

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Journal of Environmental Sciences 2019年第2期31卷 133-141页

作者： andrew t.Jacobson Maohong Fan Department of Chemical Engineering University of Wyoming

Elevated arsenic and selenium concentrations in water cause health problems to both humans and wildlife. Natural and anthropogenic activities have caused contamination of these elements in waters worldwide, making the development of efficient cost-effective methods in their removal essential. In this work, removal of arsenate and selenite from water by adsorption onto a natural goethite(α-FeO OH) sample was studied at varying conditions. the data was then compared with other arsenate, selenite/goethite adsorption systems as much of literature shows discrepancies due to varying adsorption conditions. Characterization of the goethite was completed using inductively coupled plasma mass spectrometry, X-ray diffraction, Fouriertransform infrared spectroscopy, scanning electron microscopy, and Brunauer–Emmett–teller surface area analysis. Pseudo-first order(PFO) and pseudo-second order(PSO) kinetic models were applied; including comparisons of different regression methods. Various adsorption isotherm models were applied to determine the best fitting model and to compare adsorption capacitates with other works. Desorption/leaching of arsenate and selenite was studied though the addition of phosphate and hydroxyl ions. Langmuir isotherm modeling resulted in maximum adsorption capacities of 6.204 and 7.740 mg/g for arsenate and selenite adsorption,respectively. the PSO model applied with a non-linear regression resulted in the best kinetic fits for both adsorption and desorption of arsenate and selenite. Adsorption decreased with increasing pH. Phosphate induced desorption resulted in the highest percentage of arsenate and selenite desorbed, while hydroxide induced resulted in the fastest desorption kinetics.

关键词： Arsenic Selenium Adsorption Desorption FeOOH Water treatment

Serrated neoplasia of the colorectum

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World Journal of gastroenterology 2007年第28期13卷 3792-3798页

作者： Nathan t Harvey andrew Ruszkiewicz Division of tissue Pathology Institute of Medical and Veterinary ScienceFrome RdAdelaideAustralia

Serrated polyps of the colorectum form a group of related lesions which include aberrant crypt foci (ACF), conventional hyperplastic polyps, mixed (admixed) polyps, serrated adenomas and sessile serrated adenomas. In recent years the molecular differences between these morphologically similar lesions have been highlighted, and their differing biological potential has been realised. In particular, the sessile serrated adenoma has become recognised as the precursor lesion to a group of sporadic colorectal carcinomas characterised by morphological and molecular features distinct from conventional adenomas. these recent findings have challenged the long held paradigm that all colorectal carcinomas arise via the traditional adenoma-carcinoma sequence. In addition, they present a major challenge for the early detection and management of colorectal cancer, which is no longer regarded as a homogeneous entity.

关键词： Serrated adenoma Serrated neoplasia Serrated adenocarcinoma Hyperplastic polyps Microsatellite instability

Scale up of reactors for carbon dioxide reduction

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Frontiers of Chemical Science and Engineering 2023年第1期17卷 116-122页

作者： andrew Nattestad Klaudia Wagner gordon g.Wallace Intelligent Polymer Research Institute and ARC Centre of Excellence for Electromaterials Science University of WollongongWollongong NSW 2522Australia School of Chemistry Monash UniversityClayton VIC 3800Australia

In recent times there has been a great deal of interest in the conversion of carbon dioxide into more useful chemical *** the other hand,the translation of these developments in electrochemical reduction of carbon dioxide from the laboratory bench to practical scale remains an underexplored *** we examine some of the major challenges,demonstrating some promising strategies towards such scale-up,including increased electrode area and stacking of electrode pairs in different *** observed that increasing the electrode area from 1 to 10 cm^(2) led to only a 4%drop in current density,with similarly small penalties realised when stacking sub-cells together.

关键词： CO_(2)reduction electrochemical cell electrosynthesis upscaling

Adaptivity and A Posteriori Error Control for Bifurcation Problems Ⅰ:the Bratu Problem

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Communications in Computational Physics 2010年第9期8卷 845-865页

作者： K.andrew Cliffe Edward J.C.Hall Paul Houston Eric t.Phipps andrew g.Salinger School of Mathematical Sciences University of NottinghamUniversity ParkNottingham NG72RDUK Computer Science Research Institute Sandia National LaboratoriesAlbuquerqueNew MexicoUSA

this article is concerned with the numerical detection of bifurcation points of nonlinear partial differential equations as some parameter of interest is *** particular,we study in detail the numerical approximation of the Bratu problem,based on exploiting the symmetric version of the interior penalty discontinuous galerkin finite element method.A framework for a posteriori control of the discretization error in the computed critical parameter value is developed based upon the application of the dual weighted residual(DWR)*** experiments are presented to highlight the practical performance of the proposed a posteriori error estimator.

关键词： Bifurcation theory Bratu problem a posteriori error estimation adaptivity discontinuous galerkin methods

Accelerating gW calculations through machine-learned dielectric matrices

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npj Computational Materials 2023年第1期9卷 437-445页

作者： Mario g.Zauchner andrew Horsfield Johannes Lischner Department of Materials Thomas Young CentreImperial College LondonSouth Kensington CampusLondon SW72AZUK

the gW approach produces highly accurate quasiparticle energies,but its application to large systems is computationally challenging due to the difficulty in computing the inverse dielectric *** address this challenge,we develop a machine learning approach to efficiently predict density–density response functions(DDRF)in *** atomic decomposition of the DDRF is introduced,as well as the neighborhood density–matrix descriptor,both of which transform in the same way under *** resulting DDRFs are then used to evaluate quasiparticle energies via the gW *** assess the accuracy of this method,we apply it to hydrogenated silicon clusters and find that it reliably reproduces HOMO–LUMO gaps and quasiparticle energy *** accuracy of the predictions deteriorates when the approach is applied to larger clusters than those in the training *** advances pave the way for gW calculations of complex systems,such as disordered materials,liquids,interfaces,and nanoparticles.

关键词： materials dielectric quasi

Novel ecosystems created by coal mines in central Queensland’s Bowen Basin

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Ecological Processes 2013年第1期2卷 368-379页

作者： Peter D Erskine andrew t Fletcher Centre for Mined Land Rehabilitation The University of QueenslandBrisbane QLD 4072Australia

Introduction:Open-cut coal mining began in central Queensland’s Bowen Basin approximately 50 years *** this period of time,mine rehabilitators have used a variety of tree,shrub,and groundcover species to create‘novel ecosystems’to stabilise soils and provide vegetative cover for pre-supposed final end-land *** examine post-mining rehabilitation from multiple soil and vegetation monitoring activities in the Bowen Basin to assess the similarity of landforms,plant composition,and trends in plant diversity compared to unmined reference ***:Rehabilitated spoil dumps and reference sites were assessed using soil and vegetation data contained in compliance monitoring reports from goonyella Riverside,Moura,Oaky Creek,Rolleston,and Blackwater ***,soil chemistry,and plant species mixes of rehabilitation aged from 2 to 22 years were compared to selected reference ***:Mines in this region have generally proposed one of two post-rehabilitation end-land uses:either pasture for cattle grazing or reconstructed native communities which potentially provide native fauna *** data from a selection of these mine sites suggest that when their rehabilitation was compared to nearby reference sites median slope values were between 2.5 and 7 times steeper and soil pH,electrical conductivity,and phosphorus levels were significantly *** steeply sloped landforms,poor soil characteristics,depauperate native species pool,and uniform presence of exotic pasture grasses in the rehabilitation indicate that most of these newly created ecosystems should not be used for cattle grazing and also have few natural ***:Legislative and community expectations have changed progressively over time and,although much of the rehabilitation is currently dominated by an assemblage of exotic buffel grass(Cenchrus ciliaris)and Acacia spp.,recent environmental authorities suggest these‘novel ecosystems’will be judged against native refere

关键词： Coal mining Completion criteria Environmental conditions Novel ecosystems

Primary parasitoids of red scale （Aonidiella aurantii） in Australia and a review of their introductions from Asia

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Insect Science 2017年第1期24卷 150-168页

作者： Hang t. Dao g. andrew C. Beattie Robert Spooner-Hart Markus Riegler Paul Holford University of Western Sydney Penrith NSW 2751 Australia Plant Protection Research Institute Chem Tu Liem Hanoi Vietnam

We used morphological and molecular differences to confirm the identities of red scale （Aonidiella aurantii） and yellow scale （A. citrina）, and their primary parasitoids, in Australia. An extension to the distribution of yellow scale was confirmed. Six primary parasitoids of red scale were identified： Aphytis chrysomphali, A. lingnanensis, A. melinus, Comperiella bifasciata, Encarsia citrina, and E. perniciosi. With the exception of A. lingnanensis, these parasitoids, and a species of Aphelinus, were detected in association with red scale during studies in citrus orchards in coastal New South Wales between 2009 and 2012. two races ofA. melinus were recorded： one from the Indian Subcontinent, the other previously only recorded in China. the studies, and reviews of historical records, led us to conclude that 4 parasitoids, A. lingnanensis, C. bifasciata, and both species of Encarsia, were present in Australia before successful or unsuccessful formal introductions between 1902 and 1970. the A. melinus race previously recorded in China may also have been present before the Indian Subcontinent race was formally introduced in 1961. We suggest the possibility that the natural distribution of some of the parasitoids may include East and Southeast Asia, and parts of Australasia. We found no reports of native armored scales being recorded on species and hybrids of Citrus introduced to Australia, and no reports of introduced armored scales being recorded on native Rutaceae, including 6 species of Citrus. However, we subsequently recorded yellow scale on geijera parviflora, a native rutaceous tree.

关键词： Aonidiella Aphytis citrus Comperiella Encarsia red scale