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Crohn’s and colitis in children and adolescents

World Journal of Gastroenterology 2012年第41期18卷 5862-5869页

作者： andrew S Day Oren Ledder Steven t Leach Daniel A Lemberg Department of Gastroenterology Sydney Children's HospitalRandwickSydneyNSW 2031Australia School of Women's and Children's Health University of New South WalesSydneyNSW 2031Australia Department of Paediatrics University of Otago ChristchurchChristchurch 8140New Zealand

Crohn＇s disease and ulcerative colitis can be grouped as the inflammatory bowel diseases （IBD）. these conditions have become increasingly common in recent years, including in children and young people. Although much is known about aspects of the pathogenesis of these diseases, the precise aetiology is not yet understood, and there remains no cure. Recent data has illustrated the importance of a number of genes-several of these are important in the onset of IBD in early life, including in infancy. Pain, diarrhoea and weight loss are typical symptoms of paediatric Crohn＇s disease whereas bloody diarrhoea is more typical of colitis in children. However, atypical symptoms may occur in both conditions： these include isolated impairment of linear growth or presentation with extra-intestinal manifestations such as erythma nodosum. Growth and nutrition are commonly compromised at diagnosis in both Crohn＇s disease and colitis. Consideration of possible IBD and completion of appropriate investigations are essential to ensure prompt diagnosis, the- reby avoiding the consequences of diagnostic delay. Patterns of disease including location and progression of IBD in childhood differ substantially from adult- onset disease. Various treatment options are available for children and adolescents with IBD. Exclusive enteral nutrition plays a central role in the induction of remission of active Crohn＇s disease. Medical and surgical therapies need to considered within the context of a growing and developing child. the overall management of these chronic conditions in children should include multi-disciplinary expertise, with focus upon maintaining control of gut inflammation, optimising nutrition, growth and quality of life, whilst preventing disease or treatment-related complications.

关键词： Children Adolescents Crohn's disease Ulcerative colitis Inflammatory bowel diseases

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Spatial Localization for Nonlinear Dynamical Stochastic Models for Excitable Media

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Chinese Annals of Mathematics,Series B 2019年第6期40卷 891-924页

作者： Nan CHEN andrew J.MAJDA Xin t.tONG Department of Mathematics University of Wisconsin-MadisonWI53705USA Department of Mathematics and Center for Atmosphere Ocean Science Courant Institute of Mathematical SciencesNew York UniversityNew YorkNY10012USA Center for Prototype Climate Modeling New York University AbuDhabiSaadiyat IslandAbuDhabiUAE Department of Mathematics National University of SingaporeSingapore 119076Singapore

Nonlinear dynamical stochastic models are ubiquitous in different *** statistical properties are often of great interest,but are also very challenging to *** excitable media models belong to such types of complex systems with large state dimensions and the associated covariance matrices have localized *** this article,a mathematical framework to understand the spatial localization for a large class of stochastically coupled nonlinear systems in high dimensions is *** mathematical analysis shows that the local effect from the diffusion results in an exponential decay of the components in the covariance matrix as a function of the distance while the global effect due to the mean field interaction synchronizes different components and contributes to a global *** analysis is based on a comparison with an appropriate linear surrogate model,of which the covariance propagation can be computed *** important applications of these theoretical results are *** are the spatial averaging strategy for efficiently sampling the covariance matrix and the localization technique in data *** examples of a linear model and a stochastically coupled Fitz Hugh-Nagumo model for excitable media are adopted to validate the theoretical *** latter is also used for a systematical study of the spatial averaging strategy in efficiently sampling the covariance matrix in different dynamical regimes.

关键词： Large state dimensions Diffusion Mean field interaction Spatial averaging strategy Efficiently sampling

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Cellular mechanisms regulating sperm-zona pellucida interaction

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Asian Journal of Andrology 2011年第1期13卷 88-96页

作者： andrew t Reid Kate Redgrove R John Aitken Brett Nixon Reproductive Science Group Discipline of Biological Sciences School of Environmental and Life Sciences University of Newcastle Callaghan NSW 2308 Australia ARC Centre of Excellence in Biotechnology and Development Discipline of Biological Sciences School of Environmental and Life Sciences University of Newcastle CaUaghan NSW 2308 Australia

For mammalian spermatozoa to exhibit the ability to bind the zona pellucida （ZP） they must undergo three distinct phases of maturation, namely, spermatogenesis （testis）, epididymal maturation （epididymis） and capacitation （female reproductive tract）. An impressive array of spermatozoa surface remodeling events accompany these phases of maturation and appear critical for recognition and adhesion of the outer vestments of the oocyte, a structure known as the ZP. It is becoming increasingly apparent that species-specific zona adhesion is not mediated by a single receptor. Instead, compelling evidence now points toward models implicating a multiplicity of receptor-ligand interactions. this notion is in keeping with emerging research that has shown that there is a dynamic aggregation of proteins believed to be important in sperm-ZP recognition to the regions of sperm that mediate this binding event. Such remodeling may in turn facilitate the assembly of a multimeric zona recognition complex （MZRC）. though formation of MZRCs raises questions regarding the nature of the block to polyspermy, formation and assembly of such a structure would no doubt explain the strenuous maturation process that sperm endure on their sojourn to functional maturity.

关键词： capacitation fertilization spermatozoa sperm-zona pellucida interaction

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Atomism,Communitarianism,and Confucian Familism

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Fudan Journal of the Humanities and Social Sciences 2022年第2期15卷 259-275页

作者： andrew t.W.Hung Division of Social Sciences Humanities and DesignCollege of Professional and Continuing EducationThe Hong Kong Polytechnic University8 Hung Lok RoadHung HomKowloonHong Kong

Charles taylor criticizes many liberal theories based on a kind of atomism that assumes the individual self-sufficiency outside the *** not only causes soft-relativism and political fragmentation but also undermines the solidarity of the community,that is,the very condition of the formation of autonomous *** thus argues for communitarian politics which protects certain cultural common goods for sustaining the solidarity of the ***,Brenda Lyshaug criticizes taylor’s communitarianism as suppressing plurality and enhancing hostility among cultural *** the face of such controversies,I argue for modern Confucian familism which emphasizes the family as a common good that provides a safe,stable,and nurturing environment for nurturing children and cultivating civility for future generations with a sense of community and autonomy.I also defend Confucian familism from four possible criticisms:insufficiency of familism,hierarchical relationship in the family,the danger of nepotism,and challenge from postmodern families.I argue that unlike traditional Confucianism,modern moderation of the Confucian family can greatly reduce the hierarchical problem;its emphasis on the family as one of the foundations of politics can avoid the danger of being atomistic liberalism and suppressive communitarianism.

关键词： Atomism Communitarianism Charles taylor Confucianism Familism

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A novel adaptive-impulsive synchronization of fractional-order chaotic systems

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Chinese Physics B 2015年第10期24卷 86-92页

作者： Leung Y.t.andrew Li Xian-Feng Chu Yan-Dong Zhang Hui Department of Architecture and Civil Engineering City University of Hong Kong School of Mathematics and Physics Lanzhou Jiaotong University School of Mechatronic Engineering Lanzhou Jiaotong University

A novel adaptive-impulsive scheme is proposed for synchronizing fractional-order chaotic systems without the necessity of knowing the attractors＇ bounds in priori. the nonlinear functions in these systems are supposed to satisfy local Lipschitz conditions but which are estimated with adaptive laws. the novelty is that the combination of adaptive control and impulsive control offers a control strategy gathering the advantages of both. In order to guarantee the convergence is no less than an expected exponential rate, a combined feedback strength design is created such that the symmetric axis can shift freely according to the updated transient feedback strength. All of the unknown Lipschitz constants are also updated exponentially in the meantime of achieving synchronization. two different fractional-order chaotic systems are employed to demonstrate the effectiveness of the novel adaptive-impulsive control scheme.

关键词： adaptive-impulsive synchronization fractional order chaotic systems combined feedbackstrength

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A survey of edge computing-based designs for Iot security

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Digital Communications and Networks 2020年第2期6卷 195-202页

作者： Kewei Sha t.andrew Yang Wei Wei Sadegh Davari Department of Computing Sciences University of Houston-Clear LakeHouston77058USA

Pervasive Iot applications enable us to perceive,analyze,control,and optimize the traditional physical ***,security breaches in many Iot applications have indicated that Iot applications may put the physical systems at *** resource constraints and insufficient security design are two major causes of many security problems in Iot *** an extension of the cloud,the emerging edge computing with rich resources provides us a new venue to design and deploy novel security solutions for Iot *** there are some research efforts in this area,edge-based security designs for Iot applications are still in its *** paper aims to present a comprehensive survey of existing Iot security solutions at the edge layer as well as to inspire more edge-based Iot security *** first present an edge-centric Iot ***,we extensively review the edge-based Iot security research efforts in the context of security architecture designs,firewalls,intrusion detection systems,authentication and authorization protocols,and privacy-preserving ***,we propose our insight into future research directions and open research issues.

关键词： Edge computing Internet of things(Iot) Security Architecture Secure protocols Firewall Intrusion detection Authentication Authorization Privacy

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与机器交流:人机传播领域的未来轨迹

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全球传媒学刊 2024年第1期11卷 71-105页

作者： Jihyun Kim Katrin Etzrodt andrew Prahl Chad Edwards 刘力铭(翻译) 美国中佛罗里达大学科尔森传播与媒体学院国际传播学会人机传播分会德国德累斯顿工业大学媒体与传播研究所新加坡南洋理工大学黄金辉传播与信息学院美国西密歇根大学传播学院清华大学新闻与传播学院

机器行为者(machine actor)融入日常生活的现象不仅模糊了人机之间的界限,更带来了机遇和挑战。在此背景下,人机传播研究立足前沿,探索新兴的人机互动现象。这个由机器驱动的时代正在快速发展,本研究展望未来,讨论人机传播领域如何继续... 详细信息

机器行为者(machine actor)融入日常生活的现象不仅模糊了人机之间的界限,更带来了机遇和挑战。在此背景下,人机传播研究立足前沿,探索新兴的人机互动现象。这个由机器驱动的时代正在快速发展,本研究展望未来,讨论人机传播领域如何继续发展和扩展其研究范式。具体而言,本研究深入探讨人机传播的理论基础和方法论,考量以社会临场感和信任为中心的两个研究前沿,从不同角度探讨人机传播的重要意义并对人机传播未来的研究提出方向。

关键词：人机传播机器人人工智能社会临场感信任

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two-Factor Cancelable Biometrics Authenticator

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Journal of Computer Science & technology 2007年第1期22卷 54-59页

作者：彭颖涵 andrew t. B. J David N. C. L Faculty of Information Science and technology Multimedia University dalan Ayev Keroh Lama 75450 Melaka Malaysia

Biometrics-based authentication system offers advantages of providing high reliability and accuracy. However the contemporary authentication system is impuissance to compromise. If a biometrics data is compromised, it cannot be replaced and rendered unusable. In this paper, a cancelable biometrics-based authenticator is proposed to solve this irrevocability issue. the proposed approach is a two-factor authentication system, which requires both of the random data and facial feature in order to access the system. In this system, tokenized pseudo-random data is coupled with momentbased facial feature via inner product algorithm. the output of the product is then discretized to generate a set of private binary code, coined as 2factor-Hashing code, which is acted as verification key. If this biometrics-based verification key is compromised, a new one can be issued by replacing a different set of random number via token replacement. then, the compromised one is rendered completely useless. this feature offers an extra protection layer against biometrics fabrication since the verification code is replaceable. Experimental results demonstrate that the proposed system provides zero Equal Error Rate in which there is a clear separation in between the genuine and the imposter distribution populations.

关键词： cancelable biometrics face recognition Geometric moments,pseudo Zernike moment

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Symmetry and Period-Adding Windows in a Modified Optical Injection Semiconductor Laser Model

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Chinese Physics Letters 2012年第1期29卷 1-4页

作者： LI Xian-Feng andrew Y-t.Leung CHU Yan-Dong Department of Mathematics Lanzhou Jiaotong UniversityLanzhou 730070 Department of Civil and Architectural Engineering City University of Hong KongHong Kong

Hierarchical structural symmetry of periodic islands embedded in the chaotic region of modified optical injection semiconductor lasers(MOISLs)is expounded upon in phase *** onset of the bifurcation cascade shows remarkable accumulation *** cascade follows a specific period-adding ***-similarities and infinite spiral nestings shrinking beyond a certain point of the periodic hub are revealed to affirm the existence of self-organized distribution of periodicity and chaos in phase diagrams.

关键词： periodic bifurcation symmetry

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two-dimensional magnetic transition metal chalcogenides

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SmartMat 2021年第2期2卷 139-153页

作者： Yu Li Huang Wei Chen andrew t.S.Wee Joint School of National University of Singapore and tianjin University International Campus of Tianjin UniversityFuzhouChina Department of Physics National University of SingaporeSingaporeSingapore Department of Chemistry National University of SingaporeSingaporeSingapore

the field of two-dimensional(2D)magnets has expanded rapidly during the past several years since the first demonstration of intrinsic 2D magnetism in atomically thin CrI_(3) and Cr_(2)Ge_(2)te_(6) in 2017.2D transition metal chalcogenides(tMCs),a class of strongly correlated materials,have exhibited a wide variety of novel electronic and optical properties,and more recently ***,we review recent experimental progress achieved in the growth of 2D magnetic tMC materials using chemical vapor deposition and molecular beam epitaxy *** examples include the demonstration of room temperature intrinsic and extrinsic ferromagnetism in monolayer VSe_(2),MnSe_(2),Cr_(3)te_(4),V-doped WSe_(2),and so on.A brief discussion on the origin of the exotic magnetic properties and emergent phenomena is also ***,we summarize the remaining challenges and future perspective on the development of 2D magnetic materials for next-generation spintronic devices.

关键词： chemical vapor deposition molecular beam epitaxy transition metal chalcogenides twodimensional magnets

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