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An implantable,wireless,battery-free system for tactile pressure sensing

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Microsystems & Nanoengineering 2023年第5期9卷 309-320页

作者： Lin Du Han Hao Yixiao Ding andrew Gabros Thomas C.E.Mier Jan Van der Spiegel Timothy H.Lucas Firooz Aflatouni andrew G.richardson Mark G.Allen Department of Electrical and Systems Engineering School of Engineering and Applied ScienceUniversity of PennsylvaniaPhiladelphiaPAUSA Department of Neurosurgery Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA Departments of Neurosurgery and Biomedical Engineering Ohio State UniversityColumbusOHUSA

The sense of touch is critical to dexterous use of the hands and thus an essential component of efforts to restore hand function after amputation or *** systems have addressed this goal with wearable tactile ***,such wearable sensors are suboptimal for neuroprosthetic systems designed to reanimate a patient’s own paralyzed ***,we developed an implantable tactile sensing system intended for subdermal *** system is composed of a microfabricated capacitive pressure sensor,a custom integrated circuit supporting wireless powering and data transmission,and a laser-fused hermetic silica *** miniature device was validated through simulations,benchtop assessment,and testing in a primate *** sensor implanted in the fingertip accurately measured applied skin forces with a resolution of 4.3 *** output from this novel sensor could be encoded in the brain with microstimulation to provide tactile *** broadly,the materials,system design,and fabrication approach establish new foundational capabilities for various applications of implantable sensing systems.

关键词： system battery fused

Wireless,battery-free,and fully implantable electrical neurostimulation in freely moving rodents

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Microsystems & Nanoengineering 2021年第4期7卷 127-138页

作者： Alex Burton Sang Min Won Arian Kolahi Sohrabi Tucker Stuart Amir Amirhossein Jong Uk Kim Yoonseok Park andrew Gabros John A.Rogers Flavia Vitale andrew G.richardson Philipp Gutruf Department of Biomedical Engineering University of ArizonaTucsonAZ 85721USA Department of Electrical and Computer Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Department of Neurosurgery Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Querrey Simpson Institute for Bioelectronics Northwestern UniversityEvanstonIL 60208USA Center for Bio-Integrated Electronics Northwestern UniversityEvanstonIL 60208USA Department of Mechanical Engineering Northwestern UniversityEvanstonIL 60208USA Department of Biomedical Engineering Northwestern UniversityEvanstonIL 60208USA Department of Materials Science and Engineering Northwestern UniversityEvanstonIL 60208USA Department of Neurological Surgery Feinberg School of MedicineNorthwestern UniversityChicagoIL 60611USA Department of Neurology BioengineeringPhysical Medicine&RehabilitationCenter for Neuroengineering and TherapeuticsUniversity of PennsylvaniaPhiladelphiaPA 19104USA Bio5 Institute and Neuroscience GIPP University of ArizonaTucsonAZ 85721USA Department of Electrical and Computer Engineering University of ArizonaTucsonAZ 85721USA

Implantable deep brain stimulation(DBS)systems are utilized for clinical treatment of diseases such as Parkinson's disease and chronic ***,long-term efficacy of DBS is limited,and chronic neuroplastic changes and associated therapeutic mechanisms are not well *** and mechanistic investigation,typically accomplished in small animal models,is difficult because of the need for chronic stimulators that currently require either frequent handling of test subjects to charge battery-powered systems or specialized setups to manage tethers that restrict experimental paradigms and compromise *** overcome these challenges,we demonstrate a fully implantable,wireless,battery-free platform that allows for chronic DBS in rodents with the capability to control stimulation parameters digitally in real *** devices are able to provide stimulation over a wide range of frequencies with biphasic pulses and constant voltage control via low-impedance,surface-engineered platinum *** devices utilize off-the-shelf components and feature the ability to customize electrodes to enable broad utility and rapid *** of the system is demonstrated with a readout of stimulation-evoked neural activity in vivo and chronic stimulation of the medial forebrain bundle in freely moving rats to evoke characteristic head motion for over 36 days.

关键词： stimulation battery moving

Microfabricated intracortical extracellular matrix-microelectrodes for improving neural interfaces

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Microsystems & Nanoengineering 2018年第1期4卷 141-155页

作者： Wen Shen Suradip Das Flavia Vitale andrew richardson Akshay Ananthakrishnan Laura A.Struzyna Daniel P.Brown Naixin Song Murari Ramkumar Timothy Lucas DKacy Cullen Brian Litt Mark G.Allen Krishna P.Singh Center for Nanotechnology University of PennsylvaniaPhiladelphiaPA 19104USA Department of Neurosurgery Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Department of Neurology Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Department of Mechanical Engineering and Applied Mechanics School of Engineering and Applied ScienceUniversity of PennsylvaniaPhiladelphiaPA 19104USA Department of Bioengineering School of Engineering and Applied ScienceUniversity of PennsylvaniaPhiladelphiaPA 19104USA Department of Electrical and Systems Engineering School of Engineering and Applied ScienceUniversity of PennsylvaniaPhiladelphiaPA 19104USA Department of Materials Science and Engineering School of Engineering and Applied ScienceUniversity of PennsylvaniaPhiladelphiaPA 19104USA Present address:Department of Mechanical and Aerospace Engineering University of Texas at ArlingtonArlingtonTX 76019USA

Intracortical neural microelectrodes,which can directly interface with local neural microcircuits with high spatial and temporal resolution,are critical for neuroscience research,emerging clinical applications,and brain computer interfaces(BCI).However,clinical applications of these devices remain limited mostly by their inability to mitigate inflammatory reactions and support dense neuronal survival at their *** we report the development of microelectrodes primarily composed of extracellular matrix(ECM)proteins,which act as a bio-compatible and an electrochemical interface between the microelectrodes and physiological *** ECM-microelectrodes are batch fabricated using a novel combination of micro-transfer-molding and excimer laser micromachining to exhibit final dimensions comparable to those of commercial silicon-based *** are further integrated with a removable insertion stent which aids in intracortical *** from electrochemical models and in vivo recordings from the rat’s cortex indicate that ECM encapsulations have no significant effect on the electrochemical impedance characteristics of ECM-microelectrodes at neurologically relevant ***-microelectrodes are found to support a dense layer of neuronal somata and neurites on the electrode surface with high neuronal viability and exhibited markedly diminished neuroinflammation and glial scarring in early chronic experiments in rats.

关键词： markedly neural matrix

Non-Assembly Walking Mechanism Utilizing a Hexapod Gait

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Journal of Artificial Intelligence and Technology 2022年第4期2卷 158-163页

作者： George Jackson-Mills andrew R.Barber andrew Blight andrew Pickering Jordan H.Boyle Bilal Kaddouh Robert C.richardson REAL Robotics Lab Institute of DesignRoboticsand Optimisation(iDRO)Mechanical EngineeringUniversity of LeedsLeeds LS29DYWest YorkshireUK Faculty of Industrial Design Engineering Delft University of TechnologyDelftNetherlands

Small inspection robots allow for the optimal exploration of environments and the collection of data from challenging areas,particularly where there may be small access points or tight and fragile *** robots can be custom-built for specific tasks,but the design and assembly process for this can be costly,both in resources and assembly *** use of 3D printing to create Non-Assembly mechanisms can assist in saving time and resources by reducing the number of different components required and removing the necessity for complex assembly *** iterating on previous work performed in the institute,this paper introduces a novel robot design to push the capabilities of Non-Assembly *** building on previous knowledge,this new walking robot improves on the previous iteration by creating a more robust and reliable system,more capable of effectively exploring challenging environments accurately,while still using practices designed to save on cost and production *** tests were performed to provide an accurate comparison against the previous design and highlight the robots marked improvements in positional accuracy over its predecessor.

关键词： robot 3D printing walking hexapod

NEW YEAR'S ROUNDUP Welcome 2015 with a bang

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城市漫步（上海版、英文） 2014年第12期 80-81页

作者： BETTY richardson andrew CHIN 不详

PARTIES DJ Santo Chino DADA isn't messing around for their New Year S Eve party,that's for *** Chino'been amassing quite the following over the past year with his monthly Same As It Ever Was *** takes t back to the basics with his all-vinyl sets that feature nothing but incredible music from disco to rock to funk.1 Dec 31 lpm-late,free *** 115 XingfuLu,by.

关键词： nothing party edible

CLASSIC(AL) ROCK Split Works and SSO's Contemporale Concerts Resume

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城市漫步（上海版、英文） 2016年第3期 42-43页

作者： andrew CHIN BETTY richardson(图) 不详

Seemingly at opposite ends of the musical spectrum,promoters Split Works and the Shanghai Symphony Orchestra have been making sweet music together with their Contemporale *** second season of the series resumes on Mar... 详细信息

关键词： Split resume Symphony

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重症急性牙源性感染的管理

英国医学杂志中文版 2016年第3期19卷 148-153页

作者： Douglas P Robertson William Keys Riina Rautemaa-richardson Ronnie Burns andrew J Smith 武昱杨波 Restorative Dentistry Glasgow DentalSchool. Glasgow G233Z UK Dundee Dental School University of Dundee UK Respiratory ResearchGroup School of Translational MedicineEducation and Research CentreWythenshawe Hospital Manchester.UK Parkhead Health Centre Glasgow UK Infection andImmunity Section Glasgo Dental SchoolGlasgow UK 中华检验医学杂志首都医科大学附属北京儿童医院口腔科

急性牙源性感染通常是细菌通过侵人牙髓（神经）后播散至牙周组织引起的。牙源性感染的周围骨组织常常有影像学改变，一项大型横断面系统研究表明，影像学改变占所有牙齿的0．5％～13．9％（平均为5．4％）。牙源性感染可以是局灶性的... 详细信息

急性牙源性感染通常是细菌通过侵人牙髓（神经）后播散至牙周组织引起的。牙源性感染的周围骨组织常常有影像学改变，一项大型横断面系统研究表明，影像学改变占所有牙齿的0．5％～13．9％（平均为5．4％）。牙源性感染可以是局灶性的，也可能扩散到周围或扩散人血，引起严重的播散感染，尤其是在有医疗受损的病例（有全身系统性疾病或免疫力低下的患者）中。

关键词：急性牙源性感染细菌牙髓(神经) 播散感染

Exogenous cytokinin application to Actinidia chinensis var. deliciosa ‘Hayward’ fruit promotes fruit expansion through water uptake

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Horticulture Research 2017年第1期4卷 131-141页

作者： Simona Nardozza Helen L Boldingh Mark W Wohlers andrew P Gleave Zhiwei Luo Guglielmo Costa Elspeth A MacRae Michael J Clearwater Annette C richardson The New Zealand Institute for Plant&Food Research Limited(PFR) Mt Albert Research CentrePrivate Bag 92169AucklandNew Zealand PFR Ruakura Research CentrePrivate Bag 3123HamiltonNew Zealand Dipartimento di Scienzie Agrarie Universitàdi BolognaVia Fanin 46Bologna40127Italy PFR Te Puke Research CentreTe Puke3182New Zealand PFR Kerikeri Research CentrePrivate Bag 23KerikeriNew Zealand Scion Te Papa Tipu Innovation ParkPrivate Bag 3020RotoruaNew Zealand University of Waikato School of SciencePrivate Bag 3105HamiltonNew Zealand

Exogenous application of a cytokinin-like compound forchlorfenuron(CPPU)can promote fruit growth,although often at the expense of dry matter(DM),an important indicator of fruit *** chinensis ***‘Hayward’fruit are very responsive to CPPU treatments,but the mechanism underlying the significant fruit weight increase and associated decrease in DM is *** this study,we hypothesised that CPPU-enhanced growth increases fruit carbohydrate demand,but limited carbohydrate supply resulted in decreased fruit *** fruit development,CPPU effects on physical parameters,metabolites,osmotic pressure and transcriptional changes were assessed under conditions of both standard and a high carbohydrate *** showed that CPPU increased fruit fresh weight but the dramatic DM decrease was not carbohydrate *** glucose and fructose concentrations contributed to an increase in soluble carbohydrate osmotic pressure,which was correlated with increased water accumulation in CPPU-treated fruit and up-regulation of water channel aquaporin gene PIP2.4 at 49 days after *** analysis suggested that the molecular mechanism contributing to increased glucose and fructose concentrations was altered by carbohydrate *** standard carbohydrate supply,the early glucose increase in CPPU fruit was associated with reduced starch synthesis and increased starch *** carbohydrate supply was high,the early glucose increase in CPPU fruit was associated with a general decrease in starch synthesis but up-regulation of vacuolar invertase and fructokinase *** conclude that CPPU affected fruit expansion by increasing the osmotically-driven water uptake and its effect was not carbohydrate supply-limited.

关键词： CPPU Actinidia expansion

Taking the pulse of COVID-19:a spatiotemporal perspective

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International Journal of Digital Earth 2020年第10期13卷 1186-1211页

作者： Chaowei Yang Dexuan Sha Qian Liu Yun Li Hai Lan Weihe Wendy Guan Tao Hu Zhenlong Li Zhiran Zhang John Hoot Thompson Zifu Wang David Wong Shiyang Ruan Manzhu Yu Douglas richardson Luyao Zhang Ruizhi Hou You Zhoua Cheng Zhong Yifei Tian Fayez Beaini Kyla Carte Colin Flynn Wei Liu Dieter Pfoser Shuming Bao Mei Li Haoyuan Zhang Chunbo Liu Jie Jiang Shihong Du Liang Zhao Mingyue Lu Lin Li Huan Zhou andrew Ding NSF Spatiotemporal Innovation Center George Mason Univ.FairfaxVAUSA Department of Geography and GeoInformation Science George Mason Univ.FairfaxVAUSA Department of Geographical Sciences University of MarylandCollege ParkMDUSA Center for Geographic Analysis Harvard UniversityCambridgeMAUSA Geoinformation and Big Data Research Lab Department of GeographyUniversity of South CarolinaColumbiaSCUSA Chinese Academy of Surveying and Mapping BeijingPeople’s Republic of China School of Resource and Environmental Sciences Wuhan UniversityWuhanPeople’s Republic of China Cloud Computeand Storage OperationsInformation Technology ServicesGeorge Mason UniversityFairfaxVAUSA Department of Geography Pennsylvania State UniversityState CollegePAUSA School of Business Management East China Normal UniversityShanghaiPeople’s Republic of China School of Mathematical Sciences East China Normal UniversityShanghaiPeople’s Republic of China Department of Psychology George Mason UniversityFairfaxVAUSA mDepartment of Computer Science George Mason UniversityFairfaxVAUSA Department of Information Technology George Mason UniversityFairfaxVAUSA Department of Biology George Mason UniversityFairfaxVAUSA College of Land Science and Technology China Agricultural UniversityBeijingPeople’s Republic of China China Data Institute Ann ArborMIUSA Institute of Remote Sensing and GIS Peking UniversityBeijingPeople’s Republic of China Aerospace Information Research Institute Chinese Academy of SciencesBeijingPeople’s Republic of China School of Geomatics and Urban Spatial Informatics Beijing University of Civil Engineering and ArchitectureBeijingPeople’s Republic of China School of Geographical Sciences Nanjing University of Information Science&TechnologyNanjingPeople’s Republic of China School of Geodesy and Geomatics Wuhan UniversityWuhanPeople’s Republic of China wFaculty of Environment University of WaterlooWaterlooCanada

The sudden outbreak of the Coronavirus disease(COVID-19)swept across the world in early 2020,triggering the lockdowns of several billion people across many countries,including China,Spain,India,the U.K.,Italy,France,Germany,Brazil,Russia,and the *** transmission of the virus accelerated rapidly with the most confirmed cases in the U.S.,India,Russia,and *** response to this national and global emergency,the NSF Spatiotemporal Innovation Center brought together a taskforce of international researchers and assembled implementation strategies to rapidly respond to this crisis,for supporting research,saving lives,and protecting the health of global *** perspective paper presents our collective view on the global health emergency and our effort in collecting,analyzing,and sharing relevant data on global policy and government responses,human mobility,environmental impact,socioeconomical impact;in developing research capabilities and mitigation measures with global scientists,promoting collaborative research on outbreak dynamics,and reflecting on the dynamic responses from human societies.

关键词： Big Data Earth system emergency geospatial sciences epidemics applications