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Neural Regeneration Research 2025年第9期20卷 2585-2586页

作者： andrew Gregory Chengyun Tang Fan Fan Department of physiology Medical College of GeorgiaAugusta UniversityAugustaGAUSA

Alzheimer's disease(AD)and Alzheimer's diseaserelated dementias(ADRD)represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging global *** the World Health Organization,AD/ADRD has affected more than 55 million individuals worldwide,with an additional 10 million cases diagnosed each year.

关键词： Alzheimer population drug

Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche andrew Chan Robert Hoepner patrick Küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

Experimental Study for Effect of Multi-Site Spark Ignition on Dedicated Hybrid Engine performance under High Dilution Condition

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Journal of Thermal Science 2025年第1期34卷 254-267页

作者： YAN Bowen WATERS Benjamin HAINES andrew MCGHEE Mike HU Tiegang DENG Wei pU Yongxian MA Tianyu powertrain Engineering R&D Center Chongqing Changan Automobile Co.Ltd. Changan UK R&D Centre Limited

In this study,a triple spark ignition scheme was first designed on a three-cylinder 1.5-L dedicated hybrid engine（DHE）.On this basis,the effect of different ignition modes on engine combustion and emission characteristics was studied,especially under high dilution *** results tested at 2000 r/min and 0.8 Mpa BMEp（brake mean effective pressure） show that with highly increased in-cylinder flow intensity,using only passive prechamber（ppC） has a lower lean limit than that with single central spark plug（CSp）,thereby leading to slightly higher minimum fuel consumption and nitrogen oxides（NOx） *** side spark plugs（SSp）based on ppC can result in improved capability of lean limit extension and engine performance than ***,the improvement level is lower than that with triple spark plugs（TSp）.As the excess air ratio λincreases,the advantage of ppC and ppC with SSp in improving the combustion phasing compared with CSp gradually ***,the increasing tendency of their ignition delay and combustion duration is more *** added SSp based on ppC can effectively shorten the ignition delay of leaner mixture,but the combustion duration can be only slightly *** a result,under extremely lean condition,the advantage of ppC and ppC with SSp in terms of combustion characteristics over CSp becomes much *** contrast,the TSp ignition can achieve much shorter ignition delay and combustion duration simultaneously under this *** to the highest available dilution level,the TSp ignition achieves the lowest raw ***,it can also reduce the raw carbon monoxide（CO） and hydrocarbons（HC） emissions compared to CSp due to a more thorough combustion of the end gas *** on the excellent performance of TSp,the highest engine brake thermal efficiency（BTE） was further *** results show that with normal RON 92 fuel,the engine finally achieved 43.69% and 45.02% BTE under stochiometric mode with exhaust

关键词： dedicated hybrid engine high dilution condition NOx emissions passive prechamber thermal efficiency triple spark plug scheme

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-Young Kim Yury I.miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

CO2-mediated bicarbonate conversion to concentrated formate in a CEM-based electrolyzer

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Journal of Energy Chemistry 2025年第1期100卷 605-611页

作者： Haocheng Xiong Donghuan Wu Haonan Li andrew Li Qikun Hu Siyao Song Bingjun Xu Qi Lu State Key Laboratory of Chemical Engineering Department of Chemical Engineering Tsinghua University College of Chemistry and Molecular Engineering Peking University Ordos Laboratory

Renewable energy-driven bicarbonate conversion to valuable chemicals presents an attractive strategy for mitigating CO2emissions,as bicarbonate can be efficiently generated from the capture of atmospheric CO2using alkaline solutions with reactive *** this work,we present a CO2-mediated bicarbonate conversion to pure formate using a cation exchange membrane-based electrolyzer with a 25 cm2electrode *** electrolysis achieved selectivities exceeding 75%for formate at a total current of 2.5 A,achieving formate concentrations up to 1.2 M and yields as high as 95%over extended *** techno-economic assessment confirmed the economic viability of the process,highlighting the potential for bicarbonate electrolysis as a sustainable method for producing valuable chemicals.

关键词： Electrocatalysis Techno-economic assessments Electrochemistry Flow electrolyzer

Technological,environmental and biological factors:referent variance values for infrared imaging of the bovine

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Journal of Animal Science and Biotechnology 2015年第4期6卷 469-484页

作者： Yuri R.Montanholi Melissa Lim Alaina Macdonald Brock A.Smith Christy Goldhawk Karen Schwartzkopf-Genswein Stephen p.miller Department of Animal and poultry Science University of Guelph Department of plant and Animal Sciences Dalhousie University Monsanto HeadingleyMB R3T 6E3Canada Agriculture and Agri-Food Canada Faculty of Veterinary Medicine University of Calgary Invermay Agricultural Centre AgResearch Limited

Background： Despite its variety of potential applications, the wide implementation of infrared technology in cattle production faces technical, environmental and biological challenges similar to other indicators of metabolic state. Nine trials, divided into three classes （technological, environmental and biological factors） were conducted to illustrate the influence of these factors on body surface temperature assessed through infrared imaging. Results： Evaluation of technological factors indicated the following： measurements of body temperatures were strongly repeatable when taken within ]0 s; appropriateness of differing infrared camera technologies was influenced by distance to the target; and results were consistent when analysis of thermographs was compared between judges. Evaluation of environmental factors illustrated that wind and debris caused decreases in body surface temperatures without affecting metabolic rate; additionally, body surface temperature increased due to sunlight but returned to baseline values within minutes of shade exposure. Examination/investigation/exploration of animal factors demonstrated that exercise caused an increase in body surface temperature and metabolic rate. Administration of sedative and anti-sedative caused changes on body surface temperature and metabolic rate, and during late pregnancy a foetal thermal imprint was visible through abdominal infrared imaging. Conclusion： The above factors should be considered in order to standardize operational procedures for taking thermographs, thereby optimizing the use of such technology in cattle operations.

关键词： Body heat loss Convective heat loss Infrared imaging Oxygen consumption pharmacodynamics

Nitro-pAH exposures of occupationally-exposed traffic workers and associated urinary 1-nitropyrene metabolite concentrations

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Journal of Environmental Sciences 2016年第11期28卷 213-221页

作者： Justin p.miller-Schulze Michael paulsen Takayuki Kameda Akira Toriba Kazuichi Hayakawa Brandon Cassidy Luke Naeher Manuel Aguilar Villalobos Christopher D.Simpson Department of Chemistry University of Washington WA 98195-1700 USA. Department of Environmental and Occupational Health Sciences University of Washington WA 98195 Seattle USA Laboratory of Hygienic Chemistry Instkute of Medical Pharmaceutical and Health Sciences Faculty of Pharmacy Kanazawa UniversityKakurna-machi Kanazawa Ishikawa 920-1192 Japan Graduate School of Natural Science and Technology Kanazawa University Kakma-machi Kanazawa Ishikawa 920-1192 Japan Department of Enuironmental Health Sciences University of Georgia Athens CA 30602-2102 USA Asociacion del Aire Ambiental Lima Peru

The assessment of occupational exposure to diesel exhaust（DE） is important from an epidemiological perspective. Urinary biomarkers of exposure have been proposed as a novel approach for measuring exposure to DE. In this study, we measured the concentrations of two urinary metabolites of 1-nitropyrene（1Np）, a nitrated polycyclic aromatic hydrocarbon that has been suggested as a molecular marker of diesel particulate matter. These two metabolites, 6-hydroxy-1-nitropyrene and 8-hydroxy-1-nitropyrene, were determined in urine samples（10 m L） from a small group of workers who were occupationally-exposed to vehicle exhaust in Trujillo, peru, before and after their workshifts. Workshift exposures to1 Np, as well as pM_（2.5）, 2-nitropyrene and 2-nitrofluoranthene, were also *** to 1Np were similar in all studied workers, averaging 105 ± 57.9 pg/m^3（±standard deviation）. Median urinary concentrations of the average of the pre- and post-exposure samples for 6-hydroxy-1-nitropyrene and 8-hydroxy-1-nitropyrene, were found to be 3.9 and 2.3 pg metabolite/mg creatinine, respectively in the group of occupationally-exposed subjects（n = 17） studied. A direct relationship between workshift exposure to 1Np and urinary 1Np metabolites concentrations was not observed. However,the 1Np exposures and the creatinine-corrected urinary concentrations of the hydroxynitropyrene metabolites in these peruvian traffic workers were similar to occupationally-exposed taxi drivers in Shenyang, China, and were higher than biomarker levels in office workers from Trujillo without occupational exposure to vehicle *** study provides further evidence that urinary metabolites of 1Np are associated with exposure to DE and may serve as a useful exposure biomarker.

关键词： Urinary biomarkers 1-Nitropyrene Diesel particulate matter

Vascular disease in the older adult

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Journal of Geriatric Cardiology 2016年第9期13卷 727-732页

作者： andrew p.miller Christopher M Huff Gary S Roubin Cardio Vascular Associates Birmingham Alabama USA

1 Introduction Among older adults, incidence and prevalence of aortic disease, peripheral arterial disease （pAD）, and venous thromboembolism （VTE） increase as age-related alterations in vascular structure and function are compounded by longer exposure to cardiovascular disease （CVD） risk factors. This review highlights the unique presentations and treatment strategies for aortic dissection, abdominal aortic aneurysm （AAA）, pAD, and VTE in older adults.

关键词： Aortic diseases Cardiovascular disease peripheral arterial disease The elderly

Cardiovascular care for older adults： hypertension and stroke in the older adult

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Journal of Geriatric Cardiology 2016年第5期13卷 373-379页

作者： andrew p.miller Ann M Navar Gary S Roubin Suzanne Oparil CardioVascular Associates Birmingham Alabama USA Duke Clinical Research Institute Durham North Carolina USA Vascular Biology & Hypertension program Division of Cardiovascular Disease University of Alabama at Birmingham Birmingham Alabama USA

1 Introduction Hypertension and cerebrovascular disease incidence and prevalence rise dramatically with age, owing to longer exposure time to age-associated alterations in vascular function and structure and cardiovascular risk factors. This chapter is aimed at connecting age-related alterations in vascular function and structure to the resultant target organ damage, and to raise awareness of unique presentations and treatment strategies for hypertension and stroke in older adults.

关键词： Aging Cerebrovascular disease Clinical trials Hypertension Stroke