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影响林木种子贮藏的因素(英文)

南京林业大学学报（自然科学版） 2006年第1期30卷 1-7页

作者： Ben S P Wang j Dale simpson Natural Resources Canada Canadian Forest Service Petawawa Research Forest P.O.Box 2000Chalk RiverONCanada K0J 1J0 Natural Resources Canada Canadian Forest ServiceAtlantic Forestry Centre P.O.Box 4000FrederictonNBCanada E3B 5P7

为了每年提供造林新需的具有生活力的种子及长期保存种质资源,贮藏种子是必要的手段。种子寿命具有遗传性,且因树种而异。种子的贮藏特性可以分成5类:正常型、亚正常型、温带顽拗型、热带顽拗型和中间型。种子含水量和贮藏温度是影响种... 详细信息

为了每年提供造林新需的具有生活力的种子及长期保存种质资源,贮藏种子是必要的手段。种子寿命具有遗传性,且因树种而异。种子的贮藏特性可以分成5类:正常型、亚正常型、温带顽拗型、热带顽拗型和中间型。种子含水量和贮藏温度是影响种子贮藏是否成功的两个最重要因素。但因树种及其贮藏特性不同,种子含水量和贮藏温度的最适值也不同。为了保持正常型和亚正常型种子的生活力,这类种子必须密封贮藏;但对顽拗型种子,因其需要保持种子的代谢活性及要进行有氧呼吸,则需要气体交换。

关键词：种子寿命贮藏方式贮藏条件正常型种子顽拗型种子

原发性卵巢功能不全与卵巢早衰的病因学研究进展

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中华妇产科杂志 2008年第12期43卷 897-899页

作者：陈子江秦莹莹 simpson j.L. 山东大学附属省立医院生殖医学中心济南250021 College of Medicine Miami Florida International University USA

目前，卵巢早衰（premature ovarian failure，POF）是被广泛接受和应用的专业术语，通常是指女性40岁之前闭经，伴有高卵泡刺激素（FSH）和低雌激素水平。由于临床治疗很棘手，如何预防和预测POF的发生风险，成为临床医生关注的焦点。... 详细信息

目前，卵巢早衰（premature ovarian failure，POF）是被广泛接受和应用的专业术语，通常是指女性40岁之前闭经，伴有高卵泡刺激素（FSH）和低雌激素水平。由于临床治疗很棘手，如何预防和预测POF的发生风险，成为临床医生关注的焦点。尽管在POF发病机制的探讨中，染色体结构或数目异常、自身免疫功能、医源性及环境等相关因素与POF发病的相关性研究已取得很大进展，但仍有部分POF患者的病因不清，称为“特发性POF”。

关键词：原发性卵巢功能不全卵巢早衰病因学低雌激素水平自身免疫功能发病机制卵泡刺激素 POF

Hepatitis E virus in patients with acute severe liver injury

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World journal of Hepatology 2014年第6期6卷 426-434页

作者： Claire Louise Crossan Kenneth j.simpson Darren G Craig Christopher Bellamy janice Davidson Harry R Dalton Linda Scobie Department of Life Sciences Glasgow Caledonian UniversityGlasgowG4 0BAUnited Kingdom Scottish Liver Transplant Unit Royal Infirmary of EdinburghEdinburghEH16 4SAUnited Kingdom Department of Pathology University of EdinburghEdinburghEH16 4SBUnited Kingdom Gastrointestinal Unit Royal Cornwall Hospitaland European Centre for the Environment and Human HealthUniversity of Exeter Medical SchoolTruroTR1 3HDUnited Kingdom Department of Life Sciences School of Health and Life SciencesGlasgow Caledonian UniversityGlasgowG40BAUnited Kingdom

AIM: To examine the incidence of hepatitis E(HepE) in individuals with acute liver injury severe enough to warrant treatment at a transplant ***: Hepatitis E virus(HEV) is an emerging pathogen in developed countries causing severe illness, particularly in immunocompromised patients or those with underlying chronic liver disease. HepE infection isoften under diagnosed, as clinicians can be reluctant to test patients who have not travelled to regions traditionally considered hyperendemic for HepE. There are few data regarding the significance of HEV in patients with very severe acute liver injury in developed countries. Eighty patients with acute severe liver injury attending the Scottish Liver Transplant unit were tested for HEV and anti-HEV IgG and IgM. Severe acute liver injury was defined as a sudden deterioration in liver function confirmed by abnormal liver function tests and coagulopathy or presence of hepatic encephalopathy. Eighty percent of these patients were diagnosed with paracetomol overdose. No patients had a history of chronic or decompensated chronic liver disease at time of sampling. IgG positive samples were quantified against the World Health Organization anti-HEV IgG standard. Samples were screened for HEV viral RNA by quantitative reverse transcription polymerase chain ***: Four cases of hepatitis E were identified. Three of the four cases were only diagnosed on retrospective testing and were initially erroneously ascribed to drug-induced liver injury and decompensated chronic liver disease, with the cause of the decompensation uncertain. One case was caused by HEV genotype 1 in a traveller returning from Asia, the other three were autochthonous and diagnosed on retrospective testing. In two of these cases(where RNA was detected) HEV was found to be genotype 3, the most prevalent genotype in developed countries. Three patients survived, two of whom had been misdiagnosed as having drug induced liver injury. The fourth patient

关键词： Virology Infection Acute liver injury Hepatitis E virus

真菌Drechslera catenaria聚酮类代谢产物及聚酮合成酶基因的初步研究

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中国抗生素杂志 2011年第12期36卷 905-911页

作者：史彦斌宋中枢 Tom j.simpson 支德娟兰州大学药学院兰州730000 School of Chemistry University of Bristol

目的分离分析内脐蠕孢真菌(Drechslera catenaria)的次级聚酮类代谢产物,初步分析其非还原型I型聚酮合成酶基因组成,为该菌株中大黄酚生物合成机制的阐明奠定理论基础。方法应用Czapek Dox培养基发酵培养,酸化乙酸乙酯提取,硅胶柱层析... 详细信息

目的分离分析内脐蠕孢真菌(Drechslera catenaria)的次级聚酮类代谢产物,初步分析其非还原型I型聚酮合成酶基因组成,为该菌株中大黄酚生物合成机制的阐明奠定理论基础。方法应用Czapek Dox培养基发酵培养,酸化乙酸乙酯提取,硅胶柱层析及薄层制备等方法,对该菌株产生的聚酮类代谢产物进行分离纯化;利用紫外(UV),液相-质谱联用(LC-MS)和核磁共振谱(1H-NMR)鉴定化学结构;基于真菌聚酮合成酶保守序列设计引物,克隆与代谢产物合成相关的聚酮合成酶基因。结果与结论从试验菌株菌丝体及发酵液中分离获得4个芳香聚酮类化合物,其结构分别为大黄酚(chrysophanol),长蠕孢素(helminthosporin),冰岛青霉素(islandicin),链蠕孢素(catenarin),其中后3个为首次从该真菌中得到。从基因组DNA中得到一段非还原性聚酮合成酶(PKS)基因序列(约5.3kb),与Pyrenophora tritici-repentis Pt-1C-BFP中黄色色素合成相关的基因片段有较高类似度,很有可能与内脐蠕孢真菌中大黄酚的生物合成有关;在距离该基因2.5kb处克隆到一段基因序列(0.79kb),与***-repentis Pt-1C-BFP中β-酮酯酰基-ACP-还原酶(KR)基因完全相似,其很可能负责大黄素的6位羰基经还原形成大黄酚。

关键词：内脐蠕孢真菌聚酮类代谢产物聚酮合成酶基因

Quantitative trait loci controlling Phytophthora cactorum resistance in the cultivated octoploid strawberry(Fragaria×ananassa)

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Horticulture Research 2019年第1期6卷 965-978页

作者： Charlotte F.Nellist Robert j.Vickerstaff Maria K.Sobczyk César Marina-Montes Fiona M.Wilson David W.simpson Adam B.Whitehouse Richard j.Harrison Department of Genetics Genomics and BreedingNIAB EMRNew RoadEast Malling ME196BJUK

The cultivated strawberry,Fragaria×ananassa(Fragaria spp.)is the most economically important global soft *** cactorum,a water-borne oomycete causes economic losses in strawberry production globally.A biparental cross of octoploid cultivated strawberry segregating for resistance to ***,the causative agent of crown rot disease,was screened using artificial *** putative resistance quantitative trait loci(QTL)were identified and *** major effect QTL(FaRPc6C,FaRPc6D and FaRPc7D)explained 37%of the variation *** were no epistatic interactions detected between the three major *** a subset of the mapping population progeny against a range of *** isolates revealed no significant interaction(p=0.0593).However,some lines showed higher susceptibility than predicted,indicating that additional undetected factors may affect the expression of some quantitative resistance *** historic crown rot disease score data from strawberry accessions,a preliminary genome-wide association study(GWAS)of 114 individuals revealed an additional locus associated with resistance to *** of the Fragaria vesca Hawaii 4 v1.1 genome revealed candidate resistance genes in the QTL regions.

关键词： straw Fragaria

Intestinal heme absorption in hemochromatosis gene knock-out mice

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World journal of Hematology 2017年第1期6卷 17-23页

作者： Abas H Laftah Robert j.simpson Gladys O Latunde-Dada Vascular Sciences NHLIImperial Centre for Translational and Experimental MedicineImperial College London Faculty of Life Sciences and Medicine Division of Diabetes and Nutritional SciencesKing’s College London

AIM To investigat the influence of hemochromatosis gene(Hfe) mutation on ^(59)Fe labelled duodenal heme absorption in *** Heme absorption was measured in Hfe wild type and Hfe^((-/-)) mice by the duodenal tied loop and by oral gavage methods. The m RNA expression of heme oxygenase(HO-1), Abcg2 and Flvcr1 genes and levels were determined by quantitative polymerase chain *** Heme absorption was significantly increased in homozygous Hfe^((-/-)) mice despite significant hepatic and splenic iron overload. While duodenal HO-1 mRNA was highly expressed in the wild type and Hfe^((-/-)) heme-treated group following 24 h heme administration, Flvcr1 a mRNA decreased. However, Abcg2 mRNA expression levels in duodenum remained unchanged. CONCLUSION Heme absorption was enhanced in Hfe^((-/-)) mice from both duodenal tied-loop segments and by oral gavage methods. HO-1 m RNA levels were enhanced in mice duodenum after 24 h of heme feeding and may account for enhanced heme absorption in Hfe^((-/-)) mice. Implications for dietary recommendations on heme intake by Hfe subjects to modulate iron loading are important clinical considerations.

关键词： Hemochromatosis gene Heme Gavage Iron Absorption

Structural confirmation of sulconazole sulfoxide as the primary degradation product of sulconazole nitrate

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journal of Pharmaceutical Analysis 2018年第2期8卷 96-102页

作者： Qun Xu Ashraf Khan Di Gao Kristie M.Adams Fatkhulla Tadjimukhamedov Shane Tan john T.simpson Compendial Development Laboratory United States Pharmacopeia

Sulconazole has been reported to degrade into sulconazole sulfoxide via sulfur oxidation; however,structural characterization data was lacking and the potential formation of an N-oxide or sulfone could not be excluded. To clarify the degradation pathways and incorporate the impurity profile of sulconazole into the United States Pharmacopeia–National Formulary(USP–NF) monographs, a multifaceted approach was utilized to confirm the identity of the degradant. The approach combines stress testing of sulconazole nitrate, chemical synthesis of the degradant via a hydrogen peroxide-mediated oxidation reaction,semi-preparative HPLC purification, and structural elucidation by LC–MS/MS and NMR *** determination was primarily based on the comparison of spectroscopic data of sulconazole and the oxidative degradant. The mass spectrometric data have revealed a Mc Lafferty-type rearrangement as the characteristic fragmentation pathway for alkyl sulfoxides with a β-hydrogen atom, and was used to distinguish the sulfoxide from N-oxide or sulfone derivatives. Moreover, the generated sulconazole sulfoxide was utilized as reference material for compendial procedure development and validation, which provides support for USP monograph modernization.

关键词： Sulconazole nitrate Sulconazole sulfoxide Forced degradation Structural characterization LC–MS/MS

Synthesis and Crystal Structure of Ethyl 2-(6-(1,3-Dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-7-fluoro-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl) Butanoate

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Chinese journal of Structural Chemistry 2009年第5期28卷 585-589页

作者：吴道新罗斐贤莫洪波王晓光任叶果 simpson jim 黄明智 School of Chemistry and Biological Engineering Changsha University of Science and TechnologyChangsha Hunan 410076 China Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China) Hunan Normal UniversityChangsha 410081 China National Engineering Research Center for Agrochemicals Hunan Research Institute of Chemical IndustryChangsha 410007 China Department of Chemistry University of OtagoPO Box 56 Dunedin New Zealand

The title compound ethyl 2-（6-（1,3-dioxo-4,5,6,7-tetrahydro-lH-isoindol-2（3H）- yl）-7-fluoro-3-oxo-2H-benzo[b][1,4]oxazin-4（3H）-yl） butanoate 3 was synthesized by the reaction of ethyl 2-（6-amino-7-fluoro-3-oxo-2H-benzo[b][1,4]oxazin-4（3H）-yl） butanoate with 4,5,6,7- tetraydrophthalic anhydride, and its structure was determined by X-ray single-crystal diffraction. The crystal belongs to the monoclinic system, space group P2 1/n with a = 9.3469（2）, b = 16.7715（5）, c = 13.7153（4） A, β= 104.9680（10）°, μ = 0.107 mm^-1, Mr = 430.42, V= 2077.08（10） ,A3, Z= 4, Dc = 1.376 g/cm3, F（000） = 904, T= 296（2） K, R = 0.0508 and wR = 0.1478.

关键词： synthesis crystal structure ethyl 2-(6-amino-7-fluoro-3-oxo-2H-benzo[b]oxazin-4(3H)-yl) butanoate herbicidal protox inhibitors

Distinct vibrational signatures and complex phase behavior in metallic oxygen

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Matter and Radiation at Extremes 2024年第2期9卷 4-11页

作者： Philip Dalladay-simpson Bartomeu Monserrat Li Zhang Federico Gorelli Center for High Pressure Science Technology Advanced Research 1690 Cailun RoadShanghai 201203China Department of Materials Science and Metallurgy University of Cambridge27 Charles Babbage RoadCambridge CB3 OFSUnited Kingdom Cavendish Laboratory University of CambridgeJ.J.Thomson AvenueCambridge CB3 OHEUnited Kingdom Istituto Nazionale di Ottica Consiglio Nazionale delle Ricerche(CNR-INO)50125 FlorenceItaly Shanghai Advanced Research in Physical Sciences(SHARPS) ShanghaiChina

Evidence for metallization in dense oxygen has been reported for over 30 years[Desgreniers et al.,***.94,1117(1990)]at a now routinely accessible 95 GPa[Shimizu et al.,Nature 393,767(1998)].However,despite the longevity of this result and the technological advances since,the nature of the metallic phase remains poorly constrained[Akahama et al.,***.74,4690(1995);Goncharov et al.,***.B 68,224108(2003);Ma,***.B 76,064101(2007);and Weck et al.,***.102,255503(2009)].In this work,through Raman spectroscopy,we report the distinct vibrational characteristics of metallicζ-O_(2) from 85 to 225 *** comparison with numerical simulations,weﬁnd reasonable agreement with the candidate structure up to about 150 *** higher pressures,the C2/mstructure is found to be unstable and incompatible with experimental *** candidate structures,and Ci,with C2/m C2/conly two molecules in the primitive unit cell,are found to be stable and more compatible with measurements above 175 GPa,indicative of the dissociation of(O_(2))4 ***,we report and discuss a strong hysteresis and metastability with the precursory phaseϵ-O_(2).Theseﬁndings will reinvigorate experimental and theoretical work into the dense oxygen system,which will have importance for oxygen-bearing chemistry,prevalent in the deep Earth,as well as fundamental physics.

关键词： metallic phase vibrational