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Coordinated regulation of plant immunity by poly(ADP-ribosyl)ation and K63-linked ubiquitination

Molecular Plant 2021年第12期14卷 2088-2103页

作者： Dongsheng yao Marcus A.Arguez Ping He andrew F.Bent Junqi Song Texas A&M AgriLife Research Center at Dallas Texas A&M University SystemDallasTX 75252USA Department of Biochemistry and Biophysics Texas A&M UniversityCollege StationTX 77843USA Department of Plant Pathology University of Wisconsin-MadisonMadisonWI 53706USA Department of Plant Pathology and Microbiology Texas A&M UniversityCollege StationTX 77843USA

Poly(ADP-ribosyl)ation(PARylation)is a posttranslational modification reversibly catalyzed by poly(ADP-ribose)polymerases(PARPs)and poly(ADP-ribose)glycohydrolases(PARGs)and plays a key role in multi-ple cellular *** molecular mechanisms by which PARylation regulates innate immunity remain largely unknown in *** we show that Arabidopsis UBC13A and UBC13B,the major drivers of lysine 63(K63)-linked polyubiquitination,directly interact with PARPs/*** of pathogen-associated molecular pattern(PAMP)-triggered immunity promotes these interactions and enhances PARylation of *** parp1 parp2 and ubc13a ubc13b mutants are compromised in immune responses with increased accumulation of total pathogenesis-related(PR)proteins but decreased accu-mulation of secreted PR *** disulfide-isomerases(PDIs),essential components of endo-plasmic reticulum quality control(ERQC)that ensure proper folding and maturation of proteins destined for secretion,complex with PARPs/PARGs and are PARylated upon PAMP ***,PARylation of UBC13 regulates K63-linked ubiquitination of PDIs,which may further promote their disulfide isomerase activities for correct protein folding and subsequent *** together,these results indicate that plant immunity is coordinately regulated by PARylation and K63-linked ubiquitination.

关键词： UBC13 PARP1 PARP2 PDI poly(ADP-ribosyl)ation K63-linked ubiquitination secretory pathway PAMP-triggered immunity systemic acquired resistance

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Characteristics of Stellite 6 Deposited by Supersonic Laser Deposition Under Optimized Parameters

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Journal of Iron and Steel Research International 2013年第2期20卷 52-57页

作者： LUO Fang Lupoi Rocco Cockburn andrew Sparkes Martin O'neill William yao Jian-hua College of Zhijiang Zhejiang University of Technology College of Mechanical Engineering Zhejiang University of Technology Department of Mechanical and Manufacturing Engineering Trinity College Dublin Institute for Manufacturing Department of EngineeringUniversity of Cambridge

Stellite 6 powders were deposited on low carbon steel using SLD （supersonic laser deposition） under optimized parameters. The structure, line scan of elements and porosity of coating were examined and analyzed using SEM （scanning electron microscope）, OM （optical microscope） and XRD （X-ray diffraction）. The adhesion strength between coating and substrate was tested by PAT-ADHESION/TENSILE and E900STM adhesive. The results showed the deposition characteristics of optimized coating with N2 at a pressure of 3.0 MPa, a temperature of 450 ℃ and a laser power of 1.5 kW were compared with those of Stellite 6 coating deposited by the HVOF （high velocity oxygen fuel）.

关键词： Stellite 6 supersonic laser deposition deposition characteristic HVOF

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One-step nanoarchitectonics of a multiple functional hydrogel based on cellulose nanocrystals for effective tumor therapy

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Nano Research 2022年第9期15卷 8636-8647页

作者： Tianxing Chen Tengteng yao Hui Pan Hui Peng andrewKWhittaker yao Li Shenmin Zhu Zhaoyang Wang State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Ophthalmology Shanghai Tenth People’s HospitalTongji UniversityShanghai 200092China Department of Ophthalmology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Australian Institute for Bioengineering and Nanotechnology and ARC Centre of Excellence in Convergent Bio-Nano Science and Technology The University of QueenslandBrisbaneQLD 4072Australia

Hypoxia is a huge barrier for the development of photodynamic therapy(PDT).Chemodynamic therapy(CDT)could provide a possible solution to this *** this work,a controlled Schiff-base reaction was conducted between amido groups on the surface of carbon dots(CDs)and aldehyde groups on aldehyde-modified cellulose nanocrystals(mCNCs)as well as aldehydemCNCs decorated with Fe_(3)O_(4)*** this process,the mCNCs not only prevent the agglomeration of Fe_(3)O_(4)but also form hydrogels with *** CDs act as both photothermal agent and *** hypoxia could be effectively relieved through the Fenton reaction due to the addition of Fe_(3)O_(4),and the·OH produced in the reaction further induces CDT and enhances tumor therapy *** therapy performance was further verified through in vitro cell experiments and in vivo animal *** convenient method provides inspirations for the design and preparation of advanced biomaterials with multiple functions for cancer therapy.

关键词： injectable hydrogel tumor therapy carbon dots cellulose nanocrystals magnetic nanoparticles

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Field report:Research along the Yarlung Suture Zone in Southern Tibet,a persistent geological frontier

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Geoscience Frontiers 2018年第2期9卷 591-594页

作者： andrew K.Laskowski Lin Ding Fu-Long Cai yao-Fei Chen Song-Lin He Department of Earth Sciences Montana State UniversityBozemanMTUSA Key Laboratory of Continental Collision and Plateau Uplift Institute of Tibetan Plateau Researchand Center for Excellence in Tibetan Plateau Earth SciencesChinese Academy of SciencesBeijing 100101China

The Yarlung Suture Zone in Southern Tibet marks the boundary between India and Asia-formerly separated by an ocean basin-and is a critical record of the tectonic processes that created the Tibetan Plateau. The Yarlung Suture Zone is also a frontier research area, as difficulty of access has limited research activity, providing ample opportunities for new discoveries. This paper documents field research conducted by the authors along the Yarlung suture zone in eastern Xigaze(Shigatse, Rikaze)County, ~250 km west of the city of Lhasa, in July 2017. The goal of this research was to map the Suture Zone structure in detail, and more specifically to understand the branching relationships between two major fault systems-the Great Counter Thrust and Gangdese Thrust. A summary of early geological exploration is included to provide context for this research.

关键词： Tibetan Plateau Himalaya Field work Structural geology Suture zone HP metamorphism UHP metamorphism History of geology

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Lesson Learned from COVID-19 Retrospective Study: An Entropy-Based Clinical-Interpretable Scorecard for Mortality Risk Control at ICU Admission

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Tsinghua Science and Technology 2024年第1期29卷 34-45页

作者： Chong yao Chonghui Huangqi Anpeng Huang Laboratory of Network Information Security Beihang UniversityBeijing 100191China andrew and Erna Viterbi School of Engineering University of Southern CaliforniaLos AnglesCA 90089USA Beijing Goodwill Information and Technology Co. Ltd.and Mobile Health LaboratoryPeking UniversityBeijing 100871China

With severe acute respiratory syndrome coronavirus 2 spreading globally and causing 2019 coronavirus disease(COVID-19),a challenge that we unprepared for was about how to optimally plan and distribute limited top-medical resources for patients in need of urgent *** address this challenge,physicians desperately needed a scientific tool to methodically differentiate between cases with varying *** this study,the unique data of COVID-19 intensive care unit(ICU)patients provided by the national medical team in Wuhan were classified into discrete and continuous variable *** continuous data were discretized using an entropy-based method and transformed into serial information margins,in which each information margin is related to a specific symptom or clinical ***,all these native and processed discrete data were used to configure a readable scorecard through logistic regression,which is the desired scientific tool aforementioned.A total of 322 ICU patients(age:[median:64,interquartile range:54-75],males:178[55.28%],and death:72[22.36%])were included in the *** of mortality in COVID-19 patients can be evaluated using a scorecard model(calibration slope:1.343,Brier:0.048,Dxy=0.972,and population stability index=0.071),with desired model performances(accuracy=0.948,area under curve=0.99,sensitivity=1,and specificity=0.939).This new model can interpret clinical meanings from complex data,and compare it with existing machine learning methods through a black-box *** new data-information model answers a critical question of how a computing algorithm produces clinically meaningful results that will help physicians logically allocate medical resources for COVID-19 ***,this tool has limitations,giving that this research is a retrospective ***,this tool will be tested further and optimized for adaptation to similar clinical cases in the future.

关键词： COVID-19 scorecard clinical-interpretable machine learning ICU admission control

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Statistical properties of kinetic-scale magnetic holes in terrestrial space

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Earth and Planetary Physics 2021年第1期5卷 63-72页

作者： ShuTao yao ZongShun Yue QuanQi Shi Alexander William Degeling HuiShan Fu AnMin Tian Hui Zhang andrew Vu RuiLong Guo ZhongHua yao Ji Liu Qiu-Gang Zong XuZhi Zhou JingHuan Li WenYa Li HongQiao Hu YangYang Liu WeiJie Sun Shandong Provincial Key Laboratory of Optical Astronomy and Solar-Terrestrial Environment Institute of Space SciencesShandong UniversityWeihai Shandong 264209China State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China School of Space and Environment Beihang UniversityBeijing 100191China Physics Department and Geophysical Institute University of Alaska FairbanksFairbanksAK99775USA Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Laboratoire de Physique Atmosphérique et Planétaire STAR InstituteUniversitéde LiègeLiègeB-4000Belgium School of Earth and Space Sciences Peking UniversityBeijing 100871China SOA Key Laboratory for Polar Science Polar Research Institute of ChinaShanghai 200136China Department of Climate and Space Sciences and Engineering University of MichiganAnn ArborMI48109USA

Kinetic-scale magnetic holes(KSMHs)are structures characterized by a significant magnetic depression with a length scale on the order of the proton *** structures have been investigated in recent studies in near-Earth space,and found to be closely related to energy conversion and particle acceleration,wave-particle interactions,magnetic reconnection,and turbulence at the ***,there are still several major issues of the KSMHs that need further study—including(a)the source of these structures(locally generated in near-Earth space,or carried by the solar wind),(b)the environmental conditions leading to their generation,and(c)their spatio-temporal *** this study,KSMHs in near-Earth space are investigated statistically using data from the Magnetospheric Multiscale *** 200,000 events were observed from September 2015 to March *** rates of such structures in the solar wind,magnetosheath,and magnetotail were *** find that KSMHs occur in the magnetosheath at rates far above their occurrence in the solar *** indicates that most of the structures are generated locally in the magnetosheath,rather than advected with the solar ***,KSMHs occur in the downstream region of the quasi-parallel shock at rates significantly higher than in the downstream region of the quasi-perpendicular shock,indicating a relationship with the turbulent plasma *** to the magnetopause,we find that the depths of KSMHs decrease as their temporal-scale *** also find that the spatial-scales of the KSMHs near the subsolar magnetosheath are smaller than those in the ***,their global distribution shows a significant dawn-dusk asymmetry(duskside dominating)in the magnetotail.

关键词： kinetic scale magnetic hole magnetic dip electron vortex turbulence

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Performance characterization of Ni60-WC coating on steel processed with supersonic laser deposition

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Defence Technology（防务技术） 2015年第1期11卷 35-47页

作者： Fang LUO andrew COCKBURN Martin SPARKES Rocco LUPOI Zhi-jun CHEN William O'NEILL Jian-hua yao Rong LIU College of Zhijiang Zhejiang University of Technology Institute for Manufacturing Department of Engineering University of Cambridge Department of Mechanical & Manufacturing Engineering Trinity College Dublin College of Mechanical Engineering Zhejiang University of Technology Department of Mechanical & Aerospace Engineering Carleton University 1125 Colonel By Drive Ottawa Ontario K1S 5B6 Canada

Ni60-WC particles are used to improve the wear resistance of hard-facing steel due to their high hardness. An emerging technology that combines laser with cold spraying to deposit the hard-facing coatings is known as supersonic laser deposition. In this study, Ni60-WC is deposited on low-carbon steel using SLD. The microstructure and performance of the coatings are investigated through SEM, optical microscopy, EDS, XRD, microhardness and pin-on-disc wear tests. The experimental results of the coating processed with the optimal parameters are compared to those of the coating deposited using laser cladding.

关键词： Ni60-WC Supersonic laser deposition Laser cladding Microstructure Wear

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The involvement of PybZIPa in light-induced anthocyanin accumulation via the activation of PyUFGT through binding to tandem G-boxes in its promoter

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Horticulture Research 2019年第1期6卷 82-94页

作者： Hainan Liu Jun Su Yangfan Zhu Gaifang yao andrew C.Allan Charles Ampomah-Dwamena Qun Shu Kui Lin-Wang Shaoling Zhang Jun Wu Centre of Pear Engineering Technology Research State Key Laboratory of Crop Genetics and Germplasm EnhancementNanjing Agricultural University210095 NanjingChina Institute of Horticulture Yunnan Academy of Agricultural Sciences650205 KunmingChina The New Zealand Institute for Plant&Food Research Limited AucklandNew Zealand School of Biological Sciences University of AucklandAucklandNew Zealand

To gain insight into how anthocyanin biosynthesis is controlled by light in fruit,transcriptome and metabolome analyses were performed in the Chinese sand pear cultivar“Mantianhong”(Pyrus pyrifolia)after bagging and bag *** investigated transcriptional and metabolic changes and gene-metabolite correlation *** tests of anthocyanin content and transcriptional changes revealed that 1,530 transcripts were strongly correlated with 15 anthocyanin derivatives(R2>0.9,P-value<0.05),with the top 130 transcripts categorized as being associated with flavonoid metabolism,transcriptional regulation,and light *** connection network revealed a new photosensitive transcription factor,PybZIPa,that might play an important role during light-induced anthocyanin *** overexpression of PybZIPa promoted anthocyanin accumulation in pear and strawberry fruit as well as tobacco *** luciferase and Y1H assays further verified that PybZIPa directly activated the expression of PyUFGT by binding to tandem G-box motifs in the promoter,which was key to differential anthocyanin accumulation in debagged pear skin,and the number of G-box motifs affected the transcriptional activation of PyUFGT by *** results indicate that the light-induced anthocyanin biosynthesis regulatory mechanism in pear differs from that described in previous reports suggesting that a bZIP family member co-regulates anthocyanin biosynthesis with other transcription factors in apple and *** was found that,in response to light,PybZIPa promoted anthocyanin biosynthesis by regulating important transcription factors(PyMYB114,PyMYB10,and PyBBX22)as well as structural genes(PyUFGT)via binding to G-boxes within *** activation was amplified by the self-binding of PybZIPa to activate its own ***,we demonstrate the utility of a multiomics integrative approach for discovering new functional genes and pathways underlying light-induced anthocyanin

关键词： cultivar activation metabolism

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Temperate Stutzerimonas Phage Encoding Toxin-Antitoxin System Genes Represents a Novel Genus

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Journal of Ocean University of China 2024年第4期23卷 1087-1101页

作者： ZHANG Hong GUO Ruizhe GAO Chen ZHENG Kaiyang XIONG yao DONG Yue LIU Yundan WANG Ziyue CHEN Ying WANG Hongmin SHAO Hongbing SUNG Yeong Yik MOK Wen Jye WONG Li Lian MCMINN andrew WANG Min LIANG Yantao College of Marine Life Sciences Institute of Evolution and Marine BiodiversityMOE Laboratory of Evolution and Marine BiodiversityFrontiers Science Center for Deep Ocean Multispheres and Earth SystemCenter for Ocean Carbon NeutralityOcean University of ChinaQingdao 266003China UMT-OUC Joint Center for Marine Studies Qingdao 266003China Institute of Marine Biotechnology Universiti Malaysia Terengganu21030 Kuala TerengganuMalaysia Institute for Marine and Antarctic Studies University of TasmaniaHobartTAS 7001Australia Haide College Ocean University of ChinaQingdao 266100China The Affiliated Hospital of Qingdao University Qingdao 266001China

Stutzerimonas have been extensively studied due to their remarkable metabolic and physiological ***,research on its phages is currently *** this study,we isolated a novel double-stranded DNA(dsDNA)phage,vB_SstM-PG1,from the marine environment that infects Stutzerimonas stutzeri *** dsDNA genome is 37204 bp long with a G/C content of 64.14%and encodes 54 open reading *** phage possesses a tail packaging structure that is different from known Stutzerimonas stutzeri phages and exhibits structural protein characteristics similar to those of temperate *** addition,two genes of toxin-antitoxin system,including YdaS_antitoxin and HEPN_SAV_6107,were found in the vB_SstM-PG1 genome and play important roles in regulating host growth and *** phylogenetic tree and comparative genomic analysis,it has been determined that vB_SstM-PG1 is not closely related to any phages previously identified in the GenBank ***,it has a connection with enigmatic,uncultured ***,the vB_SstM-PG1 virus exhibits an average nucleotide identity of over 70%with six uncultivated viruses identified in the IMG/VR v4 *** significant finding has resulted in the identification of a novel viral genus known as Metabovirus.

关键词： Stutzerimonas vB_SstM-PG1 Metabovirus temperate phage genomic and phylogenetic analysis

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Single-cell transcriptome atlases of soybean root and mature nodule reveal new regulatory programs that control the nodulation process

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Plant Communications 2024年第8期5卷 69-91页

作者： Sergio Alan Cervantes-Perez Prince Zogli Sahand Amini Sandra Thibivilliers Sutton Tennant Md Sabbir Hossain Hengping Xu Ian Meyer Akash Nooka Pengchong Ma Qiuming yao Michael J.Naldrett andrew Farmer Olivier Martin Samik Bhattacharya Jasper Klaver Marc Libault Department of Agronomy and Horticulture University of Nebraska-LincolnLincolnNE 68503USA Division of Plant Science and Technology College of AgricultureFoodand Natural ResourcesUniversity of Missouri-ColumbiaColumbiaMO 65211USA Interdisciplinary Plant Group of Missouri-Columbia ColumbiaMO 65211USA School of Computing University of Nebraska-LincolnLincolnNE 68503USA Proteomics and Metabolomics Facility Center for BiotechnologyUniversity of Nebraska-LincolnLincolnNE 68588USA National Center for Genome Resources Santa FeNM 87505USA INRAE UniversiteParis-SaclayInstitut des Sciences des Plantes de Paris SaclayIPS2Batiment 630 Plateau du MoulonRue Noetzlin91192 Gif sur Yvette CedexFrance Resolve Biosciences Monheim am RheinGermany Present address:The School of Plant Sciences University of ArizonaTucsonAZ 85721USA Present address:GALY Co. 100 Hood Park Dr.BostonMA 02126USA

The soybean root system is *** addition to being composed of various cell types,the soybean root system includes the primary root,the lateral roots,and the nodule,an organ in which mutualistic symbiosis with N-fixing rhizobia occurs.A mature soybean root nodule is characterized by a central infection zone where atmospheric nitrogen is fixed and assimilated by the symbiont,resulting from the close cooperation between the plant cell and the *** date,the transcriptome of individual cells isolated from developing soybean nodules has been established,but the transcriptomic signatures of cells from the mature soybean nodule have not yet been *** single-nucleus RNA-seq and Molecular Cartography technologies,we precisely characterized the transcriptomic signature of soybean root and mature nodule cell types and revealed the co-existence of different sub-populations of ***-infected cells in the mature soybean nodule,including those actively involved in nitrogen fixation and those engaged in *** of the single-cell-resolution nodule transcriptome atlas and the associated gene co-expression network confirmed the role of known nodulation-related genes and identified new genes that control the nodulation *** instance,we functionally characterized the role of GmFWL3,a plasma membrane microdomain-associated protein that controls rhizobial *** study reveals the unique cellular complexity of the mature soybean nodule and helps redefine the concept of cell types when considering the infection zone of the soybean nodule.

关键词： soybean root nodule single-cell RNA-seq nanodomains

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